The human β-defensin-1 and α-defensins are encoded by adjacent genes: Two peptide families with differing disulfide topology share a common ancestry

Genomics

Volumn 43, Issue 3, 1997, Pages 316-320

  Liu, Lide ^a   Zhao, Chengquan ^a   Heng, Henry H Q ^b   Ganz, Tomas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YORK UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN; DEFENSIN; DISULFIDE; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME 8; DNA SEQUENCE; GENE LOCATION; GENE LOCUS; GENE MAPPING; HUMAN; IN SITU HYBRIDIZATION; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 0031213832     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.4801     Document Type: Article

References (28)

1. Bensch, K. W., Raida, M., Magert, H. J., Schulz-Knappe, P., and Forssmann, W. G. (1995). hBD-1: A novel beta-defensin from human plasma. FEBS Lett. 368: 331-335.
2. Bevins, C. L. (1994). Antimicrobial peptides as agents of mucosal immunity. Ciba. Found. Symp. 186: 250-260. [Discussion 261-269]
3. Diamond, G., Jones, D. E., and Bevins, C. L. (1993). Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc. Natl. Acad. Sci. USA 90: 4596-4600.
4. Eisenhauer, P. B., Harwig, S. S., and Lehrer, R. I. (1992). Cryptdins: Antimicrobial defensins of the murine small intestine. Infect. Immun. 60: 3556-3565.
5. Fidlerova, H., Senger, G., Kost, M., Sanseau, P., and Sheer, D. (1994). Two simple procedures for releasing chromatin from routinely fixed cells for fluorescence in situ hybridization. Cytogenet. Cell Genet. 65: 203-205.
6. Gabay, J. E., Scott, R. W., Campanelli, D., Griffith, J., Wilde, C., Marra, M. N., Seeger, M., et al. (1989). Antibiotic proteins of human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. USA 86: 5610-5614.
7. Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S., Daher, K, Bainton, D. F., and Lehrer, R. I. (1985). Defensins: Natural peptide antibiotics of human neutrophils. J. Clin. Invest. 76: 1427-1435.
8. Ganz, T., and Lehrer, R. I. (1995). Defensins. Pharmacol. Ther. 66: 191-205.
9. Goldman, M., Anderson, G., Stolzenberg, E. D., Kari, U. P., Zasloff, M., and Wilson, J. M. (1997). Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88: 553-560.
10. Harwig, S. S., Swiderek, K. M., Kokryakov, V. N., Tan, L., Lee, T. D., Panyutich, E. A., Aleshina, G. M., et al. (1994). Gallinacins: Cysteine-rich antimicrobial peptides of chicken leukocytes. FEBS Lett. 342: 281-285.
11. Heng, H. H., Squire, J., and Tsui, L. C. (1992). High-resolution mapping of mammalian genes by in situ hybridization to free chromatin. Proc. Natl. Acad. Sci. USA 89: 9509-9513.
12. Heng, H. H., and Tsui, L. C. (1993). Modes of DAPI banding and simultaneous in situ hybridization. Chromosoma 102: 325-332.
13. Heng, H. H., and Tsui, L. C. (1994). FISH detection on DAPI-banded chromosomes. Methods Mol. Biol. 33: 35-49.
14. Heng, H. H. Q., Tsui, L. C., Windle, B., and Parra, I. (1995). Chromatin fiber mapping. In "Current Protocols for Human Genetics" (N. C. Dracopoli, J. Haines, B. R. Korf, C. Morton, C. E. Seidman, J. G. Seidman, D. T. Moir, and D. Smith, Eds.), pp. 4.5.1-4.5.26, Greene and Wiley, New York.
15. Joiner, K. A., Ganz, T., Albert, J., and Rotrosen, D. (1989). The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes. J. Cell Biol. 109: 2771-2782.
16. Jones, D. E., and Bevins, C. L. (1992). Paneth cells of the human small intestine express an antimicrobial peptide gene. J. Biol. Chem. 267: 23216-23225.
17. Jones, D. E., and Bevins, C. L. (1993). Defensin-6 mRNA in human Paneth cells: Implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett. 315: 187-192.
18. Linzmeier, R., Michaelson, D., Liu, L., and Ganz, T. (1993). The structure of neutrophil defensin genes. FEBS Lett. 321: 267-273.
19. Qu, X. D., Lloyd, K. C., Walsh, J. H., and Lehrer, R. I. (1996). Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells. Infect. Immun. 64: 5161-5165.
20. Russell, J. P., Diamond, G., Tarver, A. P., Scanlin, T. F., and Bevins, C. L. (1996). Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect. Immun. 64: 1565-1568.
21. Satoh, Y. (1988). Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice. Cell Tissue Res. 251: 87-93.
22. Satoh, Y., Ishikawa, K., Oomori, Y., Yamano, M., and Ono, K. (1989). Effects of cholecystokinin and carbamylcholine on Paneth cell secretion in mice: A comparison with pancreatic acinar cells. Anat. Rec. 225: 124-132.
23. Satoh, Y., Ishikawa, K., Oomori, Y., Takeda, S., and Ono, K. (1992). Bethanechol and a G-protein activator, NaF/AlCl3, induce secretory response in Paneth cells of mouse intestine. Cell Tissue Res. 269: 213-220.
24. Schonwetter, B. S., Stolzenberg, E. D., and Zasloff, M. A. (1995). Epithelial antibiotics induced at sites of inflammation. Science 267: 1645-1648.
25. Selsted, M. E., Miller, S. I., Henschen, A. H., and Ouellette, A. J. (1992). Enteric defensins: Antibiotic peptide components of intestinal host defense. J. Cell Biol. 118: 929-936.
26. Tang, Y. Q., and Selsted, M. E. (1993). Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils. J. Biol. Chem. 268: 6649-6653.
27. Zhao, C., Wang, I., and Lehren, R. I. (1996). Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett. 396: 319-322.
28. Zimmermann, G. R., Legault, P., Selsted, M. E., and Pardi, A. (1995). Solution structure of bovine neutrophil beta-defensin-12: The peptide fold of the beta-defensins is identical to that of the classical defensins. Biochemistry 34: 13663-13671.