Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity: Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction

Cell and Tissue Research

Volumn 306, Issue 2, 2001, Pages 257-264

  García, José Ramón Conejo ^a   Jaumann, Florian ^b   Schulz, Sandra ^a   Krause, Alexander ^a   Rodríguez Jiménez, Javier ^a   Forssmann, Ulf ^a   Adermann, Knut ^a   Klüver, Enno ^a   Vogelmeier, Claus ^b   Becker, Dirk ^c   Hedrich, Rainer ^c   Forssmann, Wolf Georg ^a   Bals, Robert ^b  

^a IPF PHARMACEUTICALS GMBH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Antimicrobial peptide; Burkholderia cepacia; Cystic fibrosis; Human; Innate host defense; Defensin

Indexed keywords

CHEMOATTRACTANT; DEFENSIN; GAMMA INTERFERON; HUMAN BETA DEFENSIN 1; HUMAN BETA DEFENSIN 2; HUMAN BETA DEFENSIN 3; PEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; EPITHELIUM; FUNGUS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOST RESISTANCE; HUMAN; HUMAN CELL; MEMBRANE; MICROORGANISM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE; XENOPUS LAEVIS;

BACTERIA (MICROORGANISMS); BURKHOLDERIA; BURKHOLDERIA CEPACIA; FUNGI; NEGIBACTERIA; POSIBACTERIA; XENOPUS LAEVIS;

EID: 0001475281     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410100433     Document Type: Article

References (29)

1. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
2. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface
3. Transduction of well-differentiated airway epithelium by recombinant adeno-associated virus is limited by vector entry
4. Changes in voltage activation, Cs+ sensitivity, and ion permeability in H5 mutants of the plant K+ channel KAT1
5. hBD-1: A novel β-defensin from human plasma
6. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
7. Prediction of complete gene structures in human genomic DNA
8. The innate immune response of the respiratory epithelium
9. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
10. Peptide antibiotics
11. Mapping of the gene encoding human beta-defensin-2 (DEFB2) to chromosome region 8p22-p23.1
12. A peptide antibiotic from human skin
13. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic
14. Real time quantitative PCR
15. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL
16. Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia
17. Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
18. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3
19. A 450-kb contig of defensin genes on human chromosome 8p23
20. Innate immunity
21. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
22. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium
23. HCC-2, a human chemokine: Gene structure, expression pattern, and biological activity
24. Matind and Matinspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data
25. Production of beta-defensins by human airway epithelia
26. Human β-defensin-1: An antimicrobial peptide of urogenital tissues
27. β-Defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
28. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells
29. Human β-defensin-1: A urinary peptide present in variant molecular forms and its putative functional implication