Antifungal peptides: Novel therapeutic compounds against emerging pathogens

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 1, 1999, Pages 1-11

  De Lucca, Anthony J ^a   Walsh, Thomas J ^b  

^a SOUTHERN REGIONAL RESEARCH CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACULEACIN A; ANTIFUNGAL AGENT; AUREOBASIDIN DERIVATIVE; BACTERICIDAL PERMEABILITY INCREASING PROTEIN; CECROPIN DERIVATIVE; CEPACIDINE DERIVATIVE; DEFENSIN DERIVATIVE; DERMASEPTIN; DROSOMYCIN; ECHINOCANDIN B DERIVATIVE; FR 900403; GALLINACIN DERIVATIVE; HELIOFERIN DERIVATIVE; HOLOTRICIN 3; ITURIN A DERIVATIVE; LACTOFERRICIN; MAGAININ 2; MULUNDOCANDIN DERIVATIVE; NIKKOMYCIN; PEPTIDE; PNEUMOCANDIN DERIVATIVE; POLYOXIN D; PROTEGRIN DERIVATIVE; SCHIZOTRIN A; SYRINGOMYCIN; THANATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; WF 11899; ZEAMATIN;

AMPHIBIA; ANTIFUNGAL ACTIVITY; HUMAN; INSECT; MAMMAL; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0032958766     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.1.1     Document Type: Short Survey

References (192)

1. Abruzzo, G. K., A. M. Flattery, C. J. Gill, L. Long, J. G. Smith, D. Krupa, V. B. Pikounis, H. Kroop, and K. Bartizal. 1995. Evaluation of water-soluble pneumocandin analogs L-733560, L-705589, and L-731373 with mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimiciob. Agents Chemother. 39:1077-1081.
2. Abruzzo, G. K., A. M. Flattery, C. J. Gill, L. Long, J. G. Smith, V. B. Pikounis, J. M. Balkovec, A. F. Bouffard, J. F. Droponski, H. Rosen, H. Kropp, and K. Bartizal. 1997. Evaluation of the echinocandin antifungal MK-0991 (L-743,8872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob. Agents Chemother. 41:2333-2338.
3. Alcouloumbre, M. S., M. A. Gharinoum, A. S. Ibrahim, M. E. Selsted, and J. E. Edwards. 1993. Fungicidal properties of defensin NP-1 and activity against Cryptococcus neoformans in vitro. Antimicrob. Agents Chemother. 37:2628-2632.
4. Ammons, S., K. Aardalen, S. Froebel, and R. Little. 1997. Efficacy of domain III peptide from bactericidal/permeability-increasing protein (BPI) in murine disseminated aspergillosis. abstr. B-16, p. 29. In Program and abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
5. Appenzeller, L., E. Lim, P. Wang, M. Fadem, P. Motchinik, M. Bakalinsky, and R. Little. 1996. In vivo fungicidal activity of optimized domain III peptides derived from bactericidal/permeability-increasing protein (BPI), abstr. F187, p. 132. In Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
6. Arai, T., Y. Mikami, T. Fukushima, T. Utsumi, and K. Yazawa. 1973. A new antibiotic, leucinostatin, derived from Penicillium lilacinum. J. Antibiot. 26:1606-1612.
7. Aumelas, A., M. Mangoni, C. Roumestand, L. Chiche, E. Despaux, G. Grassy, B. Calas, and A. Chavanieu. 1996. Synthesis and solution structure of the antimicrobial peptide protegrin-1. Eur. J. Biochem. 237:575-583.
8. Baguley, B. C., G. Rommele, J. Gruner, and W. Wehrlli. 1979. Papulacandin B: an inhibitor of glucan synthesis in yeast spheroplasts. Eur. J. Biochem. 97:345-351.
9. Balkovec, J. 1994. Lipopeptide antifungal agents. Expert Opin. Invest. Drugs 3:65-82.
10. Balkovec, J. M., R. M. Black, M. L. Hammond, J. V. Heck, R. A. Zambias, G. Abruzzo, K. Bartizal, H. Kroop, C. Trainor, R. E. Schwartz, D. C. McFadden, K. H. Nollstadt, L. A. Pittarelli, M. A. Powles, and D. M. Schmatz. 1992. Synthesis, stability, and biological evaluation of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia. J. Med. Chem. 35:194-198.
11. Bartizal, K., G. Abruzzo, C. Trainor, D. Krupa, K. Nollstadt, D. Schmatz, R. Schwartz, M. Hammond, J. Balkovec, and F. Vanmiddlesworth. 1992. In vitro antifungal activities and in vivo efficacies of 1,3-β-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin. Antimicrob. Agents Chemother. 36:1648-1657.
12. Bartizal, K., T. Scott, G. K. Abnizzo, C. J. Gill, C. Pacholok, L. Lynch, and H. Kropp. 1995. In vitro evaluation of the pneumocandin antifungal agent L-733560, a new water-soluble hybrid of L-705589 and L-731,373. Antimicrob. Agents Chemother. 39:1070-1076.
13. Beaulieu, D. J. Tang, D. J. Zeckner, and T. R. Parr. 1993. Correlation of cilofungin in vivo efficacy with its activity against Aspergillus fumigatus (1,3)-β-D-glucan synthase. FEMS Microbiol. Lett. 108:133-138.
14. Becker, J. M., N. L. Covert, P. Shenbagamurthi, A. S. Steinfeld, and F. Naider. 1983. Polyoxin D inhibits growth of zoopathogenic fungi. Antimicrob. Agents Chemother. 23:926-929.
15. Becker, J. M., S. Marcus, J. Tullek, D. Miller, E. Krainer, R. K. Khare, and F. Narder. 1988. Use of the chitin synthesis inhibitor nikkomycin to treat disseminated candidiasis in mice. J. Infect. Dis. 157:212-214.
16. Bellamy, W., M. Takase, K. Yamauchi, H. Wakabayashi, K. Kawase, and M. Tomita. 1992. Identification of the bactericidal domain of lactoferrin. Biochem. Biophys. Acta 1121:130-136.
17. Bellamy, W., H. Wakabayashi, M. Takase, S. Shimamura, and M. Tomita. 1993. Role of cell-binding in the antibacterial mechanism of lactoferricin. J. Appl. Bacteriol. 75:478-484.
18. Benz, F., F. Knuesel, J. Nuesch, H. Treicher, W. Voser, R. Nyfeler, and W. Keller-Schlerein. 1985. Echinocandin B, ein neuartiges Polypetid Antibioticum aus Aspergillus nidulans var echinlatus: Isolierung and Baudsteine. Helv. Chim. Acta 57:2459-2477.
19. Besson, F., M. Peypoux, J. Quentin, and G. Michel. 1984. Action of antifungal peptolipids from Bacillus subtilis on the cell membrane of Saccharomyces cerevisiae. J. Antibiot. 37:172-177.
20. Bloquiaux, S., and L. Delcambre. 1956. Essais de traitement de dermatomycoses par l'iturine. Arch. Belg. Derm. Syph. 12:224.
21. Boman, H. G., and D. Hultmark. 1987. Cell-free immunity in insects. Annu. Rev. Microbiol. 41:103-126.
22. Borgmeyer, J. R., C. E. Smith, and Q. Khai Hutnk. 1992. Isolation and characterization of a 25 kDa antifungal protein from flax seeds. Biochem. Biophys. Res. Commun. 187:480-487.
23. 1HNMR studies on the structure of a new thionin from barely endosperm. Biopolymers 36:751-763.
24. Bruix, M., M. A. Jimenez, J. Santora, C. Gonzales, F. J. Colilla, E. Mendez, and M. Rico. 1993. Solution structure of γ-1-P thionins from barley and wheat endosperm determined by 1H-NMR: a structural motif common to toxic arthropod proteins. Biochemistry 132:715-724.
25. Bullen, J. J. 1981. The significance of iron in infection. Rev. Infect. Dis. 3:1127-1138.
26. Cammue, B. P. A., K. Thevissen, M. Hendricks, K. Eggermont, I. J. Goderis, P. Proost, J. Van Damme, R. W. Osborn, F. Guerbette, J.-C. Kader, and W. F. Broekaert. 1995. A potent antimicrobial protein from onion seeds showing sequence homology to plant lipid transfer protein. Plant Pathol. 109:445-455.
27. Chapman, T., O. Kinsman, and J. Houston. 1992. Chitin biosynthesis in Candida albicans grown in vitro and in vivo and its inhibition by nikkomycin Z. Antimicrob. Agents Chemother. 36:1909-1914.
28. Chen, H.-C., J. H. Boman, J. L. Morell, and C. M. Huang. 1988. Synthetic magainin analogues with improved antimicrobial activity. FEBS Lett. 236: 462-466.
29. Christensen, B., J. Fink, R. B. Merrifield, and D. Mauzerall. 1988. Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes. Proc. Natl. Acad. Sci. USA 85:5072-5076.
30. Clairbois, J. P., and L. Delcambre. 1958. A propos d'essais cliniques et biologiques sur l'iturine, antifongique noveau. Arch. Belg. Derm. Syph. 14:63.
31. Cociancich, S., A. Ghazi, A. Hetru, J. A. Hoffman, and L. Letellier. 1993. Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus. J. Biol. Chem. 260:19239-19245.
32. Debono, M., B. J. Abbott, D. Fukuda, M. Barnhart, K. E. Willard, R. M. Molloy, K. H. Michel, J. R. Turner, T. F. Bulter, and A. H. Hunt. 1989. Synthesis of new analogs of echinocandin B by enzymatic deacylation and chemical reacylation of the echinocandin B peptide: synthesis of the antifungal agent cilofungin (LY121019). J. Antibiot. 42:389-397.
33. Debono, M., B. J. Abbott, J. R. Turner, L. C. Howard, R. S. Gordee, A. S. Hunt, M. Barnhart, R. M. Molloy, K. E. Willard, D. Fukuda, T. F. Butler, and D. J. Zeckner. 1988. Synthesis and evaluation of LY12019, a member of a series of semisynthetic analogues of the antifungal lipopeptide echinocandin B. Annu. Rev. N. Y. Acad. Sci. 544:152-167.
34. Debono, M., and R. S. Gordee. 1994. Antibiotics that inhibit fungal cell wall development. Annu. Rev. Microbiol. 48:471-497.
35. Del Porta, M., W. A. Schell, and J. R. Perfect 1997. In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds. Antimicrob. Agents Chemother. 41:1835-1836.
36. De Lucca, A. J., J. M. Bland, C. Grimm, T. J. Jacks, J. W. Cary, J. M. Jaynes, T. E. Cleveland, and T. J. Walsh. 1998. Fungicidal properties, sterol binding, and proteolytic resistance of the synthetic peptide, D4E1. Can. J. Microbiol. 44:514-520.
37. De Lucca, A. J., J. M. Bland, T. J. Jacks, C. Grimm, T. E. Cleveland, and T. J. Walsh. 1997. Fungicidal activity of cecropin A. Antimicrob. Agents Chemother. 41:481-483.
38. De Lucca, A. J., J. M. Bland, T. J. Jacks, C. Grimm, and T. J. Walsh. 1998. Fungicidal and binding properties of the natural peptides cecropin B and dermaseptin. Med. Mycol. 36:291-298.
39. De Lucca, A. J., T. J. Jacks, and W. F. Broekaert. Fungicidal and binding properties of three plant peptides. Submitted for publication.
40. Denning, D. W., and D. A. Stephans. 1991. Effiicacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis. Antimicrob. Agents Chemother. 35:1329-1333.
41. Diamond, G., M. Zasloff, H. Eck, M. Brasseur, W. L. Maloy, and C. L. Bevins. 1991. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of cDNA. Proc. Natl. Acad. Sci. USA 88:3952-3956.
42. Eisenhauer, P., S. Harwig, D. Szlarek, T. Ganz, M. Selsted, and R. Lehrer. 1989. Purification and antimicrobial properties of three defensins from rat neutrophils. Infect. Immun. 57:2021-2027.
43. Elsbach, P., and J. Weiss. 1997. The bactericidal/permiability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide. Immunobiology 187:417-429.
44. Endo, M., K. Takesako, I. Kato, and H. Yamaguchi. 1997. Fungicidal action of aureobasidin A, a cyclic depsipeptide antifungal antibiotic, against Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 41:672-676.
45. Ernst, M. E., M. E. Klepser, E. J. Wolfe, and M. A. Pfaller. 1996. Antifungal dynamics of LY 303366, an investigational echinocandin B analog, against Candida spp. Diagn. Microbiol. Infect. Dis. 26:125-131.
46. Fehlbaum, P., P. Bulet, S. Chernych, J.-P. Briand, J. P. Roussel, L. Letellier, C. Hetru, and J. A. Hoffmman. 1996. Structure-activity analysis of thanatin, a 21 -residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc. Natl. Acad. Sci. USA 93:1221-1225.
47. Fehlbaum, P., P. Bulet, L. Michaut, N. Laguex, W. F. Broekaert, C. Hetru, and J. A. Hoffmman. 1994. Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. J. Biol. Chem. 269:33159-33163.
48. Feign, A. M., J. Y. Takemoto, R. Wangspa, J. H. Teeter, and J. G. Brand. 1996. Properties of voltage-gated ion channels formed by syringomycin-E in planar lipid bilayers. J. Membr. Biol. 149:41-47.
49. Franzot, S., and A. Casadevall. 1997. Pneumocandin L-743,872 enhances the activities of amphotericin B and fluconazole against Cryptococcus neoformans in vitro. Antimicrob. Agents Chemother. 41:331-336.
50. Fromtling, R., and G. K. Abruzzo. 1989. L-671,329, a new antifungal agent. III. In vitro activity, toxicology, and efficacy in comparison to aculeacin. J. Antibiot. 42:174-178.
51. Fuji, K., E. Fujita, Y. Takaishi, T. Fujita, I. Arita, M. Komatsu, and N. Hirasuka. 1978. New antibiotics, trichopolyns A and B: isolation and biological activity. Experientia 34:237-239.
52. Fujita, T., Y. Takaishi, A. Okamura, E. Fujita, K. Fuji, N. Hirasuka, M. Komatsu, and I. Arita. 1981. New peptide antibiotics, tricopolyns I and II, from Trichoderma polysporum. J. Chem. Soc. Chem. Commun. 1981:585-587.
53. Fukushima, K., T. Arai, Y. Mori, M. Tsuboi, and M. Suzuki. 1983. Studies on peptide antibiotics, leucinostatins. I. Separation, physico-chemical properties and biological activities of leucinostatins A and B. J. Antibiot. 36: 1606-1612.
54. Gàlvez, A., M. Maqueda, M. Martinez-Bueno, M. Lebbadi, and E. Valdivia. 1993. Isolation and physico-chemical characterization of an antifungal and antibacterial peptide produced by Bacillus licheniformis A 12. Appl. Microbiol. Biotechnol. 38:438-442.
55. Ganz, T., M. E. Selsted, and R. I. Lehrer. 1990. Defensins Eur. J. Haematol. 44:1-8.
56. Ganz, T., M. E. Selsted, D. Szklarek, S. S. L. Harwig, K. Daher, D. F. Bainton, and R. I. Lehrer. 1985. Defensins: natural peptide antibiotics of human neutrophils. J. Clin. Invest. 76:1427-1435.
57. Georgopapadakou, N. H., and T. J. Walsh. 1996. Antifungal agents: chemotherapeutic targets and immunologic strategies. Antimicrob. Agents Chemother. 40:279-291.
58. Gera, J. F., and A. Lichenstein. 1991. Human neutrophil peptide defensins induce single strand DNA breaks in target cells. Cell. Immunol. 138:108-120.
59. Gordee, R. S., D. J. Zeckner, L. F. Ellis, A. L. Thakker, and L. C. Howard. 1984. In vitro and in vivo anti-Candida activity and toxicology of LY121019. J. Antibiot. 37:1054-1065.
60. Gardee, R. S., D. J. Zeckner, L. C. Howard, W. E. Alborn, Jr., and M. Debono. 1988. Anti-Candida activity and toxicology of LY121019, a novel polypeptide antifungal antibiotic. Ann. N. Y. Acad. Sci. 544:294-301.
61. Gottlieb, S., Z. Altboum, D. C. Savage, and E. Segal. 1991. Adhesion of Candida albicans to epithelial cells effect of polyoxin D. Mycopathology 115:197-216.
62. Gournelis, D. C., G. G. Laskaris, and R. Verpoorte. 1997. Cyclopeptide alkaloids. Nat. Prod. Rep. 14:75-82.
63. Gräfe, U., W. Ihn, M. Ritzau, W. Schade, C. Stengel, B. Schlegel, W. F. Fleck, W. Kunkel, A. Hartle, and W. Gutsche. 1995. Helioferins: novel antifungal lipopeptides from Mycogone rosea: screening, isolation, structures, and biological properties. J. Antibiot. 48:126-133.
64. Gruner, J., and P. Traxler. 1977. Papulacandin, a new antibiotic, active especially against yeasts. Experientia 33:137.
65. Haggius, S. D., W. A. Reed, M. B. Fatemi, K. L. White, F. M. Enright, and P. H. Elzer. 1996. The brucellacidal activity in transgenic mice expressing a synthetic cecropin-like peptide or in mice following exogenous peptide treatment, abstr. E-46, p. 274. In Abstracts of the 96th General Meeting of the American Society for Microbiology 1996. American Society for Microbiology, Washington, D.C.
66. Hajdu, R., R. Thompson, J. G. Sundelof, B. A. Pelak, F. A. Bouffard, J. F. Dropinski, and H. Kropp. 1997. Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872). Antimicrob. Agents Chemother. 41:2339-2344.
67. Hani, K., P. Nicolas, and A. Mor. 1994. Structure-function relationships of antimicrobial dermaseptins, p. 47-49. In H. L. S. Maia (ed.). Proceedings of the 23rd European Peptide Symposium. Escom, Leiden, The Netherlands.
68. Harrison, L., D. B. Teplow, M. Rinaldi, and G. Strobel. 1991. Pseudomycins, a family of novel peptides from Pseudomonas syringae possing broad-spectrum antifungal activity. J. Gen. Microbiol. 137:2857-2865.
69. Harwig, S. S. L., K. M. Swiderek, V. N. Kokryakov, L. Tan, T. D. Lee, E. A. Panyutich, G. M. Aleshina, O. V. Shamova, and R. I. Lehrer. 1994. Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes. FEBS Lett. 342:281-285.
70. Harwig, S. S. L., K. M. Swiderek, T. D. Lee, and R. I. Lehrer. 1995. Determination of disulfide bridges in PG-2, an antimicrobial peptide from porcine leukocytes. J. Pept. Res. 3:207-215.
71. Harwig, S. S. L., L. A. Waring, H. J. Yang, Y. Cho, L. Tan, and R. I. Lehrer. 1996. Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations. Eur. J. Biochem. 240:352-357.
72. Hector, R. F., and K. Schaller. 1992. Positive interaction of nikkomycins and azoles against Candida albicans in vitro and in vivo. Antimicrob. Agents Chemother. 36:1284-1289.
73. Hector, R. F., B. L. Zimmer, and D. Pappagianis. 1990. Evaluation of nikkomycins X and Z in murine models of coccodomycosis, histoplasmosis, and blastomycosis. Antimicrob. Agents Chemother. 34:587-593.
74. Hector, R. F., B. L. Zimmer, and D. Pappagianis. 1991. Inhibition of cell wall synthesis: nikkomycins, p. 341-353. In H. Yamaguchi, G. S. Kobayashi, and H. Takahish (ed.), Recent progress in antifungal chemotherapy. Marcel Dekker, Inc., New York, N.Y.
75. Hóhne, H. 1974. Nikkomycin, ein neuer Hemmstoff der mikrobiellen Chitin Synthese. Ph.D. dissertation. Universität Tubingen, Tubingen, Germany.
76. Hori, M., J. Eguchi, K. Kakiki, and T. Misato. 1974. Studies of the mode of action of polyoxins. VI. Effect of polyoxin B on chitin synthesis in polyoxin-resistant strains of Alternaria kikuchiana. J. Antibiot. 27:260-266.
77. Hori, M., K. Kakiki, and T. Misato. 1974. Interaction between polyoxin and active center of chitin synthetase. Agric. Biol. Chem. 38:699-705.
78. Horwitz, A., P. Motchink, and R. Nadell. 1997. Fungicidal properties from bactericidal/permiability-increasing protein (BPI) act synergistically with fluconazole on a variety of Candida strains, abstr. F-102, p. 163. In Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society of Microbiology, Washington, D.C.
79. Iijima, R., S. Kurata, and S. Natori. 1993. Purification, characterization, and cDNA cloning of an antifungal protein from the hemolymph of Sarcophaga peregina (flesh fly) larvae. J. Biol. Chem. 268:12055-12061.
80. Ikai, K., K. Shiomi, K. Takesako, S. Mizutanis, J. Yamamoto, Y. Ogawa, M. Ueno, and I. Kato. 1991 Structures of the aureobasidins B to R. J. Antibiot. 44:1187-1198.
81. Ikai, K., K. Takesako, K. Shiomi, M. Moriguchi, J. Yamamoto, I. Kato, and H. Naganawa. 1991. Structure of aureobasidin-A. J. Antibiot. 44:925-933.
82. Isogai, A., A. Suzuki, S. Higashikawa, S. Kuyama, and S. Tamura. 1980. Constituents of a peptidal antibiotic P168 produced by Paecilomyces lilacinus (Thom) Samson. Agric. Biol. Chem. 44:3029-3031.
83. Isogai, A., A. Suzuki, S. Higashikawa, S. Kuyama, and S. Tamura. 1980. Structure of peptidal antibiotic P168 produced by Paecilomyces lilacinus (Thom) Samson. Agric. Biol. Chem. 44:3033-3035.
84. Isono, K., K. Asahi, and S. Suzuki. 1969. Studies on polyoxins, antifungal antibiotics. XIII. The structure of polyoxins. J. Am. Chem. Soc. 91:7490-7505.
85. Iwamoto, T., A. Fuji, K. Nitta, S. Hashimoto, M. Okuhara, and M. Kohsaka. 1994. WF11899A, B, and C novel antifungal lipopeptides. II. Biological properties. J. Antibiot. 47:1092-1097.
86. Iwamoto, T., A. Fujiie, Y. Tsurumi, K. Nanbata, and K. Shibuya. 1990. FR900403, a new antifungal produced by a Kernia sp. J. Antibiot. 43:1183-1185.
87. Keller-Juslen, C., M. Huhn, H. R. Loosli, T. P. Petcher, H. P. Weber, and A. Von Wartburg. 1976. Strucktur des Cyclopeptid-Antibiotikums SL7810 (= echinocandin B). Tetrahedron Lett. 46:4147-4150.
88. Klich, M. A., A. R. Lax, and J. M. Bland. 1991. Inhibition of some mycotoxigenic fungi by iturin A, a peptidolipid produced by Bacillus subtilis. Mycotpathology 116:77-80.
89. Kokryakov, V. N., S. S. L. Harwig, E. A. Panyutich, A. A. Shevchenko, G. M. Aleshina, O. V. Shanova, H. A. Korneva, and R. I. Lehrer. 1993. Protegrins: leucocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins. FEBS Lett. 327:231-236.
90. Krishnarao, T. V., and J. N. Galgiani. 1997. Comparison of the in vitro activities of the echinocadin LY303366, the pneumocandin MK-0991, and fluconazole against Candida species and Cryptococcus neoformans. Antimicrob. Agents Chemother. 41:1957-1960.
91. Kurmoe, T., K. Inami, T. Inoue, K. Ikai, K. Takesako, I. Kato, and T. Shiba. 1996. Total synthesis of an antifungal cyclic depsipeptide aureobasidin A. Tetrahedron 52:4327-4356.
92. Kurtz, M. B., E. M. Bernard, F. F. Edwards, J. A. Marrinan, J. Dropinski, C. M. Douglas, and D. Armstrong. 1995. Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis. Antimicrob. Agents Chemother. 39:1784-1789.
93. Kurtz, M. B., and C. M. Douglas. 1997. Lipopeptide inhibitors of fungal glucan synthase. J. Med. Vet. Mycol. 35:79-86.
94. Landy, M., G. H. Warren, S. B. Roseman, and L. G. Colio. 1948. Bacillomycin, an antibiotic from Bacillus subtilis active against pathogenic fungi. Proc. Soc. Exp. Biol. Med. 67:539-541.
95. Latoud, C., F. Peypoux, and G. Michel. 1987. Action of iturin A, an antifungal antibiotic from Bacillus subtilis on the yeast Saccharomyces cerevisiae. Modification of membrane permeability and lipid composition. J. Antibiot. 40:1588-1595.
96. Latoud, C., F. Peypoux, G. Michel, R. Genet, and J. L. Morgat. 1986. Interactions of antibiotics of the iturin group with human erythrocytes. Biochim. Biophys. Acta 856:526-535.
97. Lawyer, C., S. Pai, M. Watebe, P. Borgia, T. Mashimo, L. Eagleton, and K. Watebe. 1996. Antimicrobial activity of a 13-amino acid tryptophan-rich peptide derived from a putative porcine precursor protein of a novel family of antibacterial peptides. FEBS Lett. 390:95-98.
98. Lawyer, C. S., S. Pal, M. Watebe, H. Bakir, L. Eagleton, and K. Watebe. 1996. Effects of synthetic form of tracheal antimicrobial peptide on respiratory pathogens. J. Antimicrob. Chemother. 37:599-604.
99. Lebbadi, M., A. Galvez, M. Maqueda, M. Martinez-Bueno, and E. Valdivia. 1994. Fungicin M-4: a narrow spectrum peptide antibiotic from Bacillus licheniformis M-4. J. Appl. Bacteriol. 77:49-53.
100. Lee, C. H-, S. H. Kim, B. C. Hyun, J. W. Suh, C. Yon, C. O. Kim, Y. A. Lim, and C. S. Kim. 1994. Cepacidine A, a novel antifungal antibiotic produced by Pseudomonas cepacia. I. Taxonomy, production, isolation, and biological activity. J. Antibiot. 47:1402-1405.
101. Lee, S. Y., H.-J. Moon, S. Kurata, S. Natori, and B. L. Lee. 1995. Purification and cDNA cloning of an antifungal protein from the hemolymph of Holotrichia diomphalia larvae. Biol. Pharm. Bull. 18:1049-1052.
102. Lehrer, R. I., A. Barton, K. A. Daher, S. S. L. Harwig, T. Ganz, and M. E. Selsted. 1989. Interaction of human defensins with Escherichia coli. Mechanism of activity. J. Clin. Invest. 84:553-561.
103. Lehrer, R. I., T. Ganz, D. Szklarek, and M. E. Selsted. 1988. Modulation of the in situ candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J. Clin. Invest. 81:1829-1835.
104. Lehrer, R. I., A. K. Lichtenstein, and T. Ganz. 1993. Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu. Rev. Immunol. 11:105-128.
105. Lehrer, R. I., D. Szklarek, T. Ganz, and M. E. Selsted. 1985. Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity. Infect. Immun. 49:207-211.
106. Lehrer, R. I., D. Szklarek, T. Ganz, and M. E. Selsted. 1986. Synergistic activity of rabbit granulocyte peptides against Candida albicans. Infect. Immun. 52:902-904.
107. Levitz, S. M., M. E. Selsted, T. Ganz, R. I. Lehrer, and R. D. Diamond. 1986. In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages. J. Infect. Dis. 154:483-489.
108. Levy, O., J. Weiss, K. Zarember, C. E. Ooi, and P. Elsbach. 1993. Antibacterial 15-kDa isoforms (p15s) are members of a novel family of leukocyte proteins. J. Biol. Chem. 268:6058-6063.
109. Lim, E., P. Wong, M. Fadem, P. Motchinik, M. Bakalinsky, and R. Little. 1996. Fungicidal activity derived from bactericidal/permeability-increasing protein (BPI), abstr. F185, p. 132. In Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
110. Lim, Y., J.-W. Suh, S. Kim, B. Hyun, C. Kim, and C. H. Lee. 1994. Cepacidine A, a novel antifungal antibiotic produced by Pseudomonas cepacia. II. Physico-chemical properties and structure elucidation. J. Antibiot. 47:1406-1416.
111. Ludtke, S., K. He, and H. Huang. 1995. Membrane thinning by magainin 2. Proc. Natl. Acad. Sci. USA 34:16764-16769.
112. Magoni, M. E., A. Aumelas, P. Chamet, C. Roumestand, L. Chiche, E. Despaux, G. Grassy, B. Calas, and A. Chavanieu. 1996. Change in membrane permeability induced by protegrin 1: implication of disulfide bridges for pore formation. FEBS Lett. 383:93-98.
113. Martinez-Suarez, J. V., and J. L. Rodriguez-Tudela. 1996. In vitro activities of semisynthetic pneumocandin L-733,560 against fluconazole-resistant and -susceptible Candida albicans isolates. Antimicrob. Agents Chemother. 40: 1277-1279.
114. McCarthy, P., D. J. Newman, L. J. Nisbet, and W. D. Kingsbury. 1985. Relative rates of transport of peptidyl drugs by Candida albicans. Antimicrob. Agents Chemother. 28:494-499.
115. McCarthy, P. J., P. F. Troke, and K. Gull. 1985. Mechanism of action of nikkomycin and the peptide transport system of Candida albicans. J. Gen. Microbiol. 131:775-780.
116. Merck & Co. May 21,1996. Press release, business wire. Data on file. Merck & Co., White House Station, N.J.
117. Mhammedi, A., F. Peypoux, F. Besson, and G. Michel. 1982. Bacillomycin F, a new antibiotic of iturin group. Isolation and characterization. J. Antibiot 35:306-311.
118. Michaut, L., P. Fehlbaum, M. Moniatte, A. Van Dorsselaer, J.-M. Rechart, and P. Bulet, 1996. Determination of the disulfide array of the first inducible antifungal peptide from insects: drosomycin from Drosophila melanogaster. FEBS Lett. 395:6-10.
119. Mizoguchi, J., T. Saito, K. Mizuno, and K. Hayano. 1977. On the mode of action of a new antifungal antibiotic, aculeacin A: inhibition of cell wall synthesis in Saccharomyces cerevisiae. J. Antibiot. 30:308-313.
120. Mizuno, K., A. Yagi, S. Satoi, M. Takada, M. Hayashi, K. Asano, and T. Matsuda. 1977. Studies on aculeacin. I. Isolation and characterization of aculeacin A. J. Antibiot. 30:297-302.
121. Moneton, P., P. Sarthow, and F. Le Gaffic. 1986. Transport and hydrolysis of peptides in Saccharomyces cerevisiae. J. Gen. Microbiol. 132:2147-2153.
122. Moore, A. J., D. A. Devine, and M. C. Bibby. 1994. Preliminary experimental anticancer activity of cecropins. Pept. Res. 7:265-269.
123. Mor, A., M. Amiche, and P. Nicolas. 1994. Structure, synthesis, and activity of dermaseptin b, a novel vertebrate defensive peptide from frog skin: relationship to adenoregulin. Biochemistry 33:6642-6650.
124. Mor, A., K. Hani, and P. Nicolas. 1994. The vertebrate peptide antibiotics dermaseptins have overlapping structural features but target specific organisms. J. Biol. Chem. 269:31635-31641.
125. Mar, A., V. H. Nguyen, A. Delfour, D. Migliore-Samour, and P. Nicolas. 1991. Isolation, amino acid sequence of dermaseptin, a novel antimicrobial peptide of amphibian skin. Biochemistry 30:8824-8830.
126. Mori, Y., M. Suzuki, K. Fukushima, and T. Arai. 1983. Structure of leucinostatin B, an uncoupler on mitochondria. J. Antibiot. 36:1084-1086.
127. Mukhopadhyay, T., and B. N. Ganguli. 1986. Mulundocandin, a new lipopeptide antibiotic. II. Structure elucidation. J. Antibiot. 40:281-289.
128. Mukhopadhyay, T., T. K. Roy, R. G. Bhat, S. N. Sawant, J. Blumbach, B. N. Ganguli, H. W. Fehlhaber, and H. Kogler. 1992. Deoxymulundocandin - a new echinocandin type antifungal antibiotic. J. Antibiot. 45:618-623.
129. Nagiec, M. N., E. E. Nagiec, J. A. Baltisburger, G. R. Well, R. L. Lester, and R. L. Dickson. 1997. Sphingolipid synthesis as a target for antifungal drugs. J. Biol. Chem. 272:9809-9817.
130. Oita, S., M. Horita, and S, O. Yanagi. 1996. Purification and properties of a new chitin-binding antifungal CB-1 from Bacillus licheniformis M-4. Biosci. Biotech. Biochem. 60:481-483.
131. Osborn, R. W., G. W. De Samblax, K. Thevissen, I. Goderis, S. Torrekens, F. Van Leuven, S. Attenborough, S. B. Rees, and W. F. Broekaert 1995. Isolation and characterization of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanceae, and Saxifragaceae. FEBS Lett. 368:257-262.
132. Panday, V. B., and S. Devi. 1990. Biologically active cyclopeptide alkaloids from Rhamnaceae plants. Planta Med. 56:649-650.
133. Patterson-Delafield, J., D. Szklarek, R. J. Martinez, and R. I. Lehrer. 1981. Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes. Infect. Immun. 31:723-731.
134. Perez, P., R. Varona, I. Garcia-Acha, and A. Duran. 1981. Effect of papulacandin B and aculeacin A on beta-(1,3) glucan synthase from Geotrichum latis. FEBS Lett. 129:249-252.
135. Pergament, I., and S. Carmelli. 1994. Schizotrin A: novel antimicrobial cyclic peptide from a cyanobacterium. Tetrahedron Lett. 35:8473-8476.
136. Peypoux, F., M. Guinand, G. Michel, L. Delcambre, B. C. Das, P. Varenne, and E. Lederer. 1973. Isoelement de l'acide 3-amino 12-mèthyl tétradé-canöique à partir de l'iturine, antibiotique de Bacillus subtilis. Tetrahedron 29:3455-3459.
137. Pfaller, M., R. Gordee, T. Gerarden, M. Yu, and R. Wenzel. 1989. Fungicidal activity of cilofungin (LY121019) alone and in combination with anticapsin or other antifungal agents. Eur. J. Clin. Microbiol. Infect. Dis. 8:564-567.
138. Pfaller, M. A., S. A. Meisser, and S. Coffman. 1997. In vitro susceptibilities of clinical yeast isolates to a new echinocandin derivative, LY303366, and other antifungal agents. Antimicrob. Agents Chemother. 41:763-766.
139. Pouny, Y., D. Rapaport, A. Mor, P. Nicolas, and Y. Shai. 1992. Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes. Biochemistry 31:12416-12423.
140. Radics, L. M., M. Katjar-Perady, C. G. Casinovi, C. Rossi, M. Ricci, and L. Tuttobelo. 1987. Leucinostatins H and K, two novel peptide antibiotics with tertiary amino-oxide terminal group from Paecilomyces marquandii. Isolation, structure and biological activity. J. Antibiot. 40:714-716.
141. Reed, W. A., P. H. Elzer, F. M. Enright, J. M. Jaynes, J. D. Morrey, and K. L. White. 1997. Interleukin 2 promoter/enhancer controlled expression of a synthetic cecropin-class lytic peptide in transgenic mice and subsequent resistance to Brucella abortus. Transgenic Res. 6:337-347.
142. Reidl, H. H., and J. Y. Takemoto. 1987. Mechanism of action of bacterial phytotoxin, syringomycin. Simultaneous measurement of early responses in yeasts and maize. Biochim. Biophys. Acta 898:56-59.
143. Reiter, B. 1983. The biological significance of lactoferrin. Int. J. Tissue React. 5:87-96.
144. Roberts, W. K., and C. P. Selitrennikoff. 1990. Zeamatin, an antifungal protein from maize with membrane-permeabilizing activity. J. Gen. Microbiol. 136:1771-1778.
145. Rossi, C., L. Tuttobello, M. Ricci, C. G. Casinovi, and L. Radics. 1987. Leucinostatin D, a novel peptide from Paecilomyces marquandii. J. Antibiot. 40:130-132.
146. Rouse, M. S., B. M. Tallan, J. M. Steckelberg, N. K. Henry, and W. R. Wilson. 1992. Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits. Antimicrob. Agents Chemother. 36:56-58.
147. Roy, K., T. Mukhopadyay, G. C. S. Reddy, K. R. Desikan, and B. N. Ganguli. 1986. Mulundocandin, a new lipopeptide antibiotic. I. Taxonomy, fermentation, isolation, and characterization. J. Antibiot. 40:275-280.
148. Sato, M., T. Beppu, and K. Arima. 1980. Properties and structure of a peptide antibiotic no. 1907. Agric. Biol. Chem. 44:3037-3040.
149. Satoi, S., A. Yagi, K. Asano, K. Mizuno, and T. Watanabe. 1977. Studies of aculeacin. II. Isolation and characterization of aculeacins B, C, D, E, F. and G. J. Antibiot. 30:303-307.
150. Sawistowska-Schroder, E. T., D. Kerridge, and H. Perry. 1984. Echinocandin inhibition of (1,3)-beta-D-glucan synthase from Candida albicans. FEBS Lett. 173:134-138.
151. Schmatz, D. M., M. A. Powles, D. C. McFadden, L. Pittarelli, J. Balkovec, M. Hammond, R. Zambias, P. Liberator, and J. Anderson. 1992. Antipneumocystis activity of water-solubilized lipopeptide. Antimicrob. Agents Chemother. 36:1964-1970.
152. Schmatz, D. M., M. A. Romancheck, L. A. Pittarelli, R. E. Schwartz, and R. Fromtling. 1990. Treatment of Pneumocystis carinii pneumonia with 1,3-β-glucan synthesis inhibitors. Proc. Natl. Acad. Sci. USA 87:5950-5954.
153. Segal, G. P., R. I. Lehrer, and M. E. Selsted. 1985. In vitro effect of phagocyte cationic peptides on Coccidioides immitis. J. Infect. Dis. 151:890-894.
154. Segre, A., R. C. Bachmann, A. Ballio, F. Bossa, I. Grgurina, N. S. Iacobellis, G. Marino, P. Pucci, M. Simmaco, and J. Y. Takemoto. 1989. The structure of syringomycins A1, E, and G. FEBS Lett. 255:27-31.
155. Selsted, M., and S. Harwig. 1987. Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin. Infect. Immun. 55:2281-2286.
156. Selsted, M., S. Harwig, T. Ganz, J. Schilling, and R. Lehrer. 1985. Primary structures of three human neutrophil defensins. J. Clin. Invest. 76:1436-1439.
157. Selsted, M., D. Szklarek, T. Ganz, and R. Lehrer. 1985. Activity of rabbit leukocyte peptides against Candida albicans. Infect. Immun. 49:202-206.
158. Shai, Y. 1995. Molecular recognition between membrane-spanning polypeptides. TIBS 20:460-464.
159. Sorensen, K. N., K.-H. Kim, and J. Y. Takemoto. 1996. In vitro antifungal and fungicidal activities and erythrocyte toxicities of cyclic lipodepsinonapeptides produced by Pseudomonas syringae pv. syringae. Antimicrob. Agents Chemother. 40:2710-2713.
160. Sorensen, K. N., A. A. Wangstrom, S. D. Allen, and J. Y. Takemoto. 1998. Efficacy of syringomycin E in a murine model of vaginal candidiasis. J. Antibiot. 51:743-749.
161. Spitzer, E. D., S. J. Travis, and G. S. Kobayashi. 1988. Comparitive in vitro activity of LY121019 and amphotericin B against isolates of Candida species. Eur. J. Clin. Microbiol. Infect. Dis. 7:80-81.
162. Steiner, H., D. Hultmark, A. Engstrom, H. Bennich, and H. G. Boman. 1981. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292:246-248.
163. Storici, P., G. Del Sal, C. Schneider, and D. Romeo. 1992. cDNA sequence of an antibiotic dodecapeptide from neutrophils. FEBS Lett. 314:187-190.
164. Suzuki, S., K. Isono, J. Nagatsu, T. Mizutani, Y. Kawashima, and T. Mizuno. 1965. A new antibiotic, polyoxin A. J. Antibiot. 18:131.
165. Taft, C. S., T. Stark, and C. P. Selitrannikoff. 1988. Cilofungin (LY121019) inhibits Candida albicans (1,3)-β-D-glucan synthase activity. Antimicrob. Agents Chemother. 32:1901-1903.
166. Tailor, R., D. Acland, S. Attenborough, B. P. A. Cammue, I. J. Evans, R. W. Osboro, J. Ray, S. B. Rees, and W. F. Broekaert. 1997. A novel family of small cysteine-rich antimicrobial peptides from seed in Impatiens balsamina. J. Biol. Chem. 272:24480-24487.
167. 2+ transport, p. 167-175. In A. Graniti, R. D. Durbin, and A. Ballio (ed.), Phytotoxins and plant pathogenesis. Springer-Verlag, Berlin, Germany.
168. Takemoto, J. Y., Y. Yaxin, S. D. Stock, and T. Miyakawa. 1993. Yeast genes involved in growth inhibition by Pseudomonas syringae pv. syringae syringomycin family lipodepsipeptides. FEMS Microbiol. Lett. 114:339-342.
169. 2+ transport. J. Gen. Microbiol. 137:653-659.
170. Takesako, K., K. Ikai, F. Haruna, M. Endo, K. Shimanaka, E. Sono, T. Nakamura, I. Kato, and J. Yamaguchi. 1991. Aureobasidins, new antifungal antibiotics: taxonomy, fermentation, isolation, and properties. J. Antibiot. 44:919-924.
171. Takesako, K., H. Kuroda, T. Inoue, F. Haruna, Y. Yosikawa, I. Kato, K. Uchida, T. Hiratani, and H. Yamaguchi, 1993. Biological properties of aureobasidin A, a cyclic depsipeptide antifungal antibiotic. J. Antibiot. 46:1414-1420.
172. Tariq, V. N., and P. L. Develin. 1996. Sensitivity of fungi to nikkomycin Z. Fungal Genet. Biol. 20:4-11.
173. Terras, F. R. G., I. J. Goderis, F. Van Leuven, J. Vanderleyden, and B. P. A. Cammue. 1992. Analysis of two novel classes of antifungal proteins from radish (Raphanus sativus L.) seeds. J. Biol. Chem. 267:15301-15309.
174. Thevissen, K., A. Ghazi, G. W. De Samblanx, C. Brownlee, R. W. Osborn, and W. F. Broekaert. 1996. Fungal membrane responses induced by plant defensins and thionins. J. Biol. Chem. 271:15018-15025.
175. Thimon, L., F. Peypoux, R. Maget-Dana, and G. Michel. 1992. Surface-active properties of antifungal lipopeptides produced by Bacillus subtilis. J. Am. Oil Chem. Soc. 69:92-93.
176. Tomita, M., W. Bellamy, M. Takase, K. Tamauchi, H. Wakabayashi, and K. Kawase. 1991. Potent antimicrobial peptides generated by pepsin digest of lactoferrin. J. Dairy Sci. 74:4137-4142.
177. Traber, R., C. Keller-Juslen, H. R. Loosli, M. Huhn, and A. Von Wartburg. 1979. Cyclopeptide-antibiotika aus Aspergillus arten. Structur der echinocandine C und D. Helv. Chim, Acta 62:1252-1267.
178. Turner, W. W., and W. L. Current. 1997. Echinocandin antifungal agents, p. 315-334. In W. R. Strohl (ed.), Biotechnology of antibiotic, 2nd ed. Marcel Dekker, Inc., New York, N.Y.
179. Tyler, E. M., G. M. Anatharamaiah, D. E. Walker, V. K. Mishra, M. M. Palgunachan, and J. P. Segrest. 1995. Molecular basis for prokaryotic specificity of magainin-induced lysis. Biochemistry 34:4393-4401.
180. Uzun, O., S. Kocagöz, Y. Çetinkaya, S. Arikan, and S. Ünal. 1997. In vitro activity of a new echinocandin. LY303366, compared with those of amphotericin B and fluconazole against clinical yeast isolates. Antimicrob. Agents Chemother. 41:1156-1157.
181. Vigers, A. J., W. K. Roberts, and C. P. Selitrennikoff. 1991. A new family of antifungal proteins. Mol. Plant-Microbe Interact. 4:315-323.
182. Wade, D., R. B. Merrifield, and H. G. Boman. 1989. Effects of cecropin and melittin analogs and hybrids on pro- and eukaryotic cells, p. 120-121. In J. E. River and G. R. Marshall (ed.), Peptides: chemistry, structure, and biology. Proceedings of the 11th Peptide Symposium. Escom, Leiden, The Netherlands.
183. Walsh, T. J., J. W. Lee, P. Kelly, J. Bacher, J. Lecciones, V. Thomas, C. Lyman, D. Coleman, R. Gordee, and P. A. Pizzo. 1991. Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-β-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis. Antimicrob. Agents Chemother. 35:1321-1328.
184. Westerhoff, H. V., V. D. Juretic, R. W. Hendler, and M. Zasloff. 1989. Magainins and the disruption of membrane-linked free-energy transduction. Proc. Natl. Acad. Sci. USA 86:6597-6601.
185. White, S. H., W. C. Wimley, and M. E. Selsted. 1995. Structure, function, and membrane integration of defensins. Curr. Opin. Struct. Biol. 5:521-527.
186. Yamauchi, K., M. Tomita, T. J. Giehl, and R. T. Ellison. 1993. Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment. Infect. Immun. 61:719-728.
187. Zambias, R. A., M. L. Hammond, J. V. Heck, K. Bartizal, C. Trainor, G. Abruzzo, D. M. Schmatz, and K. M. Nollstadt. 1992. Preparation and structure-activity relationships of simplified analogues of the antifungal agent cilofungin: total synthesis approach. J. Med. Chem. 35:2843-2855.
188. Zambias, R. A., C. James, G. K. Abruzzo, K. F. Bartizal, R. Hajdu, R. Thompson, K. H. Nollstadt, J. Marrinan, and J. M. Balkovec. 1997. Lipopeptide antifungal agents: amine conjugates of the semi-synthetic pneumocandins L-731,373 and L-733,560. Bioorg. Med. Chem. Lett. 7:2021-2026.
189. Zanetti, M., G. Del Sal, P. Storici, C. Schneider, and D. Romeo. 1993. The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics. J. Biol. Chem. 268:522-526.
190. Zasloff, M. 1987. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. USA 84:5449-5453.
191. Zhanel, G. C., J. A. Karlowsky, G. A. Harding, T. V. Balko, S. A. Zelenitsky, M. Freisen, A. Kabani, M. Turik, and D. J. Hoban. 1997. In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatidis, and Aspergillus species. Antimicrob. Agents Chemother. 41:863-865.
192. Zhang, L., and J. Y. Takemoto. 1987. Effects of Pseudomonas syringae phytotoxin, syringomycin, on plasma membrane fractions of Rhodotorula pilimanae. Phytopathology 77:297-303.