Development of protegrins for the treatment and prevention of oral mucositis: Structure-activity relationships of synthetic protegrin analogues

Biopolymers - Peptide Science Section

Volumn 55, Issue 1, 2000, Pages 88-98

  Chen, Jie ^a   Falla, Timothy J ^a   Liu, Hongjian ^a   Hurst, Malinda A ^a   Fujii, Craig A ^a   Mosca, Deborah A ^a,b   Embree, Jay R ^a   Loury, David J ^a   Radel, Peggy A ^a,c   Cheng Chang, Conway ^a,d   Gu, Leo ^a   Fiddes, John C ^a  

^a IntraBiotics Pharmaceuticals Inc   (United States)

^b Elitra Pharmaceuticals   (United States)

^c Prototek Inc   (United States)

^d APPLIED BIOSYSTEMS   (United States)

Author keywords

Antimicrobial peptides; Cathelicidins; Clinical development; Disulfides; IB 367; Microbiology; Oral mucositis; Protegrins; Structure activity relationships; sheets

Indexed keywords

ANTIBIOTICS; BACTERIA; DRUG THERAPY; HYDROGEN BONDS; MOLECULAR STRUCTURE; ONCOLOGY; YEAST;

ANTIMICROBIAL PEPTIDES; HYDROPHOBICITY; ORAL MUCOSITIS;

AMINO ACIDS;

IB 367; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEGRIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; CLINICAL TRIAL; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HAMSTER; HUMAN; MOUTH DISEASE; MUCOSA INFLAMMATION; NONHUMAN; PEPTIDE SYNTHESIS; PHASE 2 CLINICAL TRIAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CRICETINAE; DISEASE MODELS, ANIMAL; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MOUTH MUCOSA; PEPTIDES; PEPTIDES, CYCLIC; PROTEINS; STOMATITIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033858613     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0282(2000)55:1<88::AID-BIP80>3.0.CO;2-K     Document Type: Article

References (32)