Fungicidal properties, sterol binding, and proteolytic resistance of the synthetic peptide D4E1

Canadian Journal of Microbiology

Volumn 44, Issue 6, 1998, Pages 514-520

  De Lucca, A J ^a   Bland, J M ^a   Grimm, C ^a   Jacks, T J ^a   Cary, J W ^a   Jaynes, J M ^b   Cleveland, T E ^a   Walsh, T J ^c  

^a SOUTHERN REGIONAL RESEARCH CENTER   (United States)

^b Demeter Biotechnologies Ltd   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Aspergillus spp.; Fungicidal; Fusarium spp.; Peptides; Sterols

Indexed keywords

CECROPIN A; CHOLESTEROL; ERGOSTEROL; PEPTIDE D4E1; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; FUNGICIDAL ACTIVITY; FUSARIUM MONILIFORME; FUSARIUM OXYSPORUM; GERMINATION; HOST RESISTANCE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING;

ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; FUSARIUM MONILIFORME; FUSARIUM OXYSPORUM;

EID: 0031865111     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/w98-032     Document Type: Article

References (34)

1. Agerberth, B., Lee, J.-Y., Bergman, T., Carlquist, M., Boman, H.G., Mutt, V., and Jörnvall, H. 1991. Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-rich antibacterial peptides. Eur. J. Biochem. 202: 849-854.
2. Andreu, D., Merrifield, R.B., Steiner, H., and Boman, H.G. 1985. N-terminal analogues of cecropin A: synthesis, antibacterial activity, and conformational properties. Biochemistry, 24: 1683-1688.
3. Andreu, D., Pons, M., Ubach, J., Fernández, I., Boman, I.A., Boman, H.G., Mitchell, S.A., and Merrifield, R.B. 1992. Antibacterial, conformational and membrane-active properties of small size cecropin A-melittin hybrids. In Proceedings of the 22nd European Peptide Symposium, Interlaken, Switzerland, 13-19 Sept. Edited by C.H. Schneider and A.N. Eberle. ESCOM Science Publishers. Leiden, the Netherlands. pp. 763-765.
4. Barbier, M. 1972. The chemistry of some amino acid derived phytotoxins. In Phytotoxins in plant diseases. Edited by R.K.S. Wood, A. Balllio, and A. Graniti. Academic Press, London. pp. 91-93.
5. Boman, H.G., and Hultmark, D. 1987. Cell-free immunity in insects. Ann. Rev. Microbiol. 41: 103-126.
6. Chen, Y.-H., and Yang, J.T. 1971. A new approach to the calculation of secondary structures of globular proteins by optical rotary dispersion and circular dichroism. Biochem. Biophys. Res. Commun. 44: 1285-1291.
7. Christensen, B., Fink, J., Merrifield, R.B., and Mauzerall, D. 1988. Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes. Proc. Natl. Acad. Sci. U.S.A. 85: 5072-5076.
8. Ciegler, A. 1975. Mycotoxins: occurrence, chemistry, biological activity. Lloydia, 38: 21-34.
9. De Lucca, A.J., Daigle, D.A., and Walsh, T.J. 1996. N-Acetylcysteine inhibits germination and growth of Aspergillus and Fusarium spp. Antimicrob. Agents Chemother. 40: 1274-1276.
10. De Lucca, A.J., Bland, J.M., Jacks, T.J., Grimm, C., Cleveland, T.E., and Walsh, T.J. 1997. Fungicidal activity of cecropin A. Antimicrob. Agents Chemother. 41: 481-483.
11. Florack, D., Allefs, S., Bollen, R., Bosch, D., Visser, B., and Stiekema, W. 1995. Expression of giant silkmoth cecropin B genes in tobacco. Transgenic Res. 4: 132-141.
12. Gaumann, E. 1957. Fusaric acid as a wilt toxin. Phytopathology, 47: 342-357.
13. th General Meeting for the American Society for Microbiology. Abstr. E-46. p. 274.
14. Hultmark, D., Engström, Å., Bennish, H., Kapur, R., and Boman, H.G. 1982. Insect immunity. Isolation and structure of cecropin D and four minor antibacterial components from cecropia pupae. Eur. J. Biochem. 127: 207-217.
15. Jaynes, J.M., Nagpala, P., Destéfano-Beltrán, L., Huang, J.H., Kim, J.-H., Denney, T., and Cetiner, S. 1993. Expression of a cecropin B lytic peptide analog in transgenic tobacco confirs enhanced resistance to bacterial wilt caused by Pseudomonas solanacearum. Plant Sci. 104: 17-22.
16. Jelinek, C.F., Pohland, A.E., and Wood, G.E. 1989. Worldwide occurrance of mycotoxins in foods and feeds: an update. J. Assoc. Off. Anal. Chem. 72: 223-230.
17. Lee, J.-Y., Boman, A., Sun, C., Anderson, M., Jörnvall, H., Mutt, V., and Boman, H.G. 1989. Antimicrobial peptides from pig intestine: isolation of a mammalian cecropin. Proc. Natl. Acad. Sci. U.S.A. 86: 9159-9162.
18. Loeffler, R.S.T., Butters, J.A., and Hollomon, D.W. 1992. The sterol composition of powdery mildews. Phytochemistry, 31: 1561-1563.
19. Marassas, W.F.O. 1991. Toxigenic fusaria. In Mycotoxins and animal foods. Edited by J.E. Smith and R.E. Henderson. CRC Press, Boca Raton, Fla. pp. 119-139.
20. Marassas, W.F.O., Nelson, P.E., and Tousson, T.A. 1984. Toxigenic Fusarium species: identity and mycotoxicology. Pennsylvania State University Press, University Park, Penn.
21. Merrifield, R.B., Bowman, H.G., Andreu, D., White, K.L., Enright, F.M., and Elzer, P.H. 1990. In Proceedings of the 21st European Peptide Symposium, Platja d'Aro, Spain, 2-8 Sept. Edited by E. Giralt and D. Andreu. ESCOM Science Publishers, Leiden, the Netherlands. pp. 3-16.
22. Mills, D., Hammerschlag, F.A., Nordeen, R.O., and Owens, L.D. 1994. Evidence for the breakdown of cecropin B by proteinases in the intercellular fluid peach leaves. Plant Sci. 104: 17-22.
23. Palmgren, M.S., and Ciegler, A. 1983. Aflatoxins. In Plant and fungal toxins. Vol. 1. Edited by R.F. Keeler and A.T. Tu. Marcel Dekker, New York. pp. 299-323.
24. Qu, X.-M., Steiner, H., Engström, Å., Bennish, H., and Boman, H.G. 1982. Insect immunity: isolation and structure of cecropins B and D from pupae of the Chinese oak silk moth, Antheraea pernyi. Eur. J. Biochem. 127: 219-224.
25. Smith, J.E., and Ross, K. 1991. The toxigenic Aspergilli. In Mycotoxins and animal foods. Edited by J.E. Smith and R.S. Henderson. CRC Press, Boca Raton, Fla. pp. 102-118.
26. Steiner, H. 1982. Secondary structure of the cecropins: antibacterial peptides from the moth Hyalophora cecropia. FEBS Lett. 137: 283-287.
27. Steiner, H., Hultmark, D., Engström, Å, Bennish, H., Kapur, R., and Boman, H.G. 1981. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature (London), 292: 246-248.
28. Tamari, K., and Kaji, J. 1954. Studies on the mechanisms of the growth inhibitory action of fusaric acid on plants. J. Bacteriol. 41: 143-165.
29. Todd, W.J., Henk, W.G., White, K.L., and Jaynes, J. 1991. Design and synthesis of lytic peptides. J. Cell Biochem. 15G(Suppl.): 218.
30. Tronchin, G., Bouchara, J.P., Ferron, M., Larcher, G., and Chabasse, D. 1995. Cell surface properties of Aspergillus fumigatus conidia: correlation between adherence, agglutination, and rearrangements of the cell wall. Can. J. Microbiol. 41: 714-721.
31. Ueno, Y., Ishhii, K., Sawano, M., Ohtsubo, K., Mutsuda, Y., Tanaka, T., Kurata, H., and Ichinoe, M. 1977. Toxicological approaches to the metabolites of Fusuria. Jpn. J. Exp. Med. 47: 177-184.
32. Waddell, W.R. 1956. A simple ultraviolet spectrophotometric method for the determination of protein. J. Lab. Clin. Med. 48: 311-314.
33. Wade, D., Merrifield, R.B., and Bowman, H.G. 1989. Effects of cecropin and melittin analogs and hybrids on pro- and eucaryotic cells. In Proceedings of the 11th American Peptide Symposium, La Jolla, Calif., 9-14 July. Edited by J.E. Rivier and G.R. Marshall. ESCOM Science Publishers, Leiden, the Netherlands. pp. 120-121.
34. Weete, J.D., and Laseter, J.L. 1974. Distribution of sterols in fungi. I. Fungal spores. Lipids, 8: 575-581.