The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity

Cellular and Molecular Life Sciences

Volumn 58, Issue 7, 2001, Pages 978-989

  Yang, D ^a   Chertov, O ^b   Oppenheim, J J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

Antimicrobial; Cathelicidin; Cathepsin G; Chemokine; Complement; Defensin; Immunity; Receptor

Indexed keywords

AZUROCIDIN; CATHELICIDIN; CATHEPSIN G; CELL ENZYME; CELL PROTEIN; CHEMOKINE; CHYMASE; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C5A; CYTOKINE; DEFENSIN; FPRL 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR; PEPTIDE; PROTEIN HBD1; PROTEIN HBD2; PROTEIN HBD3; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; BINDING AFFINITY; CELL GRANULE; CELL MIGRATION; CELLULAR IMMUNITY; COMPLEMENT ACTIVATION; CYTOKINE PRODUCTION; ENZYME DEGRADATION; HOST RESISTANCE; IMMUNE RESPONSE; NONHUMAN; PHAGOCYTOSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN TRANSPORT; RECEPTOR INTRINSIC ACTIVITY; REVIEW;

EID: 0034960109     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000914     Document Type: Review

References (150)

1. Peptide antibiotics and their role in innate immunity
2. Phylogenetic perspectives in innate immunity
3. Gene-encoded peptide antibiotics and the concept of innate immunity: An update review
4. Plant defensins: Novel antimicrobial peptides as components of host defense system
5. Antimicrobial peptides in insects: Structure and function
6. Antimicrobial peptides of vertebrates
7. Antimicrobial peptides in mammalian and insect host defense
8. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils
9. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
10. Mobilization of various types of leukocytes by human granulocyte-derived antimicrobial proteins: Identification of novel activities and/or receptors for defensins, cathelicidin, and eosinophil-derived neurotoxin (EDN)
11. A peptide antibiotic from human skin
12. Coordinate induction of two antibiotic genes in thacheal epithelial cells exposed to inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha
13. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
14. β-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
15. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins
16. Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens
17. Monocyte retention and migration in pulmonary inflammation. Requirement for neutrophils
18. A clinical and experimental study of the function of neutrophils in the inflammatory response
19. Chemotaxis of mononuclear cells
20. T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo
21. Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils
22. Structure, function, and control of neutrophil proteinases
23. Neutrophil-mediated proteolysis: Differential roles for cathepsin G and elastase
24. Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3
25. Stimulation of human lymphocytes by cathepsin G
26. Serpins: Implications of a mobile reactive centre
27. The biology and biochemistry of antichymotrypsin and its potential role as a therapeutic agent
28. DNA strongly impairs the inhibition of cathepsin G by alpha(1)-antichymotrypsin and alpha(1)-proteinase inhibitor
29. Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection
30. Down-regulation of the chemokine receptor CCR5 by activation of chemotactic formyl peptide receptor in human monocytes
31. Neutrophil cathepsin G is specifically decreased under vitamin A deficiency
32. Vitamin A deficiency alters rat neutrophil function
33. Normal neutrophil function in cathepsin G-deficient mice
34. Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice
35. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G
36. Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo
37. Chymase is a potent chemoattractant for human monocytes and neutrophils
38. Mammalian chymotrypsin-like enzymes: Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors
39. Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate
40. Antibiotic proteins of human polymorphonuclear leukocytes
41. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes
42. Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases
43. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity
44. Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin: Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities
45. Synthetic bactericidal peptide based on CAP37: A 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes
46. Heparin binding protein (CAP37) is an opsonin for Staphylococcus aureus and increases phagocytosis in monocytes
47. Heparin-binding protein (CAP37) is internalized in monocytes and increases LPS-induced monocyte activation
48. Endocytosis of heparin-binding protein (CAP37) is essential for the enhancement of lipopolysaccharide-induced TNF-alpha production in human monocytes
49. Uber die nahere Natur der bakterientoden Substanz in Blutserum
50. Complement: Historical perspectives and some current issues
51. Complement defense mechanisms
52. The lectin pathway of the complement system
53. Clinical complementology: Recent progress and future trends
54. The molecular biology of leukocyte chemoattractant receptors
55. C5a anaphylatoxin and its seven transmembrane-segment receptor
56. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli
57. Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokine
58. Expression and modulation of C5a receptor (CD88) on skin dendritic cells: Chemotactic effect of C5a on skin migratory dendritic cells
59. Differential regulation of responsiveness to fMLP and C5a upon dendritic cell maturation: Correlation with receptor expression
60. Chemotaxis of germinal center B cells in response to C5a
61. rC5a directs the in vitro migration of human memory and naive tossillar B lymphocytes: Implications for B cell trafficking in secondary lymphoid tissues
62. Human T cells express the C5a receptor and are chemoattracted to C5a
63. The CD19/CR2/TAPA-1 complex of B lymphocytes: Linking natural to acquired immunity
64. Impaired mast cell-dependent natural immunity in complement C3-deficient mice
65. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen
66. The C5a chemoattactant receptor mediates mucosal defense to infection
67. C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
68. Purification and antibacterial activities of antimicrobial peptides of rabbit granulocytes
69. Defensins: Natural peptide antibiotics of human neutrophils
70. Defensins
71. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins
72. NMR studies of defensin antimicrobial peptides: 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1
73. Characterization of the disulfide motif in BNBD-12, an antimicrobial β-defensin peptide from bovine neutrophils
74. NMR studies of defensin antimicrobial peptides: 2. Three-dimensional structures of rabbit NP-2 and human HNP-1
75. Solution structure of bovine neutrophil β-defensin-12: The peptide fold of the β-defensins is identical to that of the classical defensins
76. Purification, primary structures and antimicrobial activities of β-defensins, a new family of antimicrobial peptides from bovine neutrophils
77. Epithelial antibiotics induced at sites of inflammation
78. Paneth cell defensins: Endogenous peptide components of intestinal host defense
79. Detection of cryptdin in mouse skin
80. Mouse β-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract
81. A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide
82. Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs
83. A novel murine β-defensin expressed in tongue, esophagus, and trachea
84. Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family
85. The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations
86. Human enteric defensins: Gene structure and developmental expression
87. Localization of human intestinal defensin 5 in Paneth cell granules
88. Widespread expression of β-defensin hBD-1 in human secretory glands and epithelial cells
89. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells
90. Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation
91. The human β-defensin-1 and α-defensins are encoded by adjacent genes: Two peptide families with differing disulfide topology share a common ancestry
92. A 450-kb contig of defensin genes on human chromasome 8p23
93. Structure and diversity of the murine cryptdin gene family
94. The mouse genome encodes a single homolog of the antimicrobial peptide human β-defensin 1
95. Enhancement of phagocytosis by corticostatin I (CSI) in cultured mouse peritoneal macrophages
96. Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides
97. Neutrophil defensins induce histamine secretion from mast cells: Mechanisms of action
98. Effect of neutrophil serine proteinases and defensins on lung epithelial cells: Modulation of cytotoxicity and IL-8 production
99. Effect of defensins on interleukin-8 synthesis in airway epithelial cells
100. Critical protective role of mast cells in a model of acute septic peritonitis
101. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNFα
102. Properties of the novel proinflammatory super-gene "intercrine" cytokine family
103. Interleukin-8 and related chemotactic cytokines: CXC and CC chemokines
104. Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation
105. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes
106. Identification of defensin binding to C1 complement
107. Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmembrane glycoprotein gp41 of HIV-1
108. Inhibition of activation of classical pathway of complement by human neutrophil defensins
109. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells
110. The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules
111. Dendritic cells and the control of immunity
112. Origin, maturation and antigen presenting function of dendritic cells
113. CD28/B7 system of T cell costimulation
114. Cutting edge: Immature dendritic cells generated from monocytes in the presence of TGF-β1 express functional C-C chemokine receptor 6
115. Selective recruitment of immature and mature dendritic cells by distinct chemokine expressed in differert anatomic sites
116. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation
117. Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia
118. Large-scale synthesis and functional elements for the antimicrobial activity of defensins
119. Isolation and structure of corticostatin peptides from rabbit fetal and adult lung
120. Effects of corticostatin-I on rat adrenal cells in vitro
121. Corticostatic peptides
122. Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides
123. Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection
124. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis
125. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
126. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
127. Purification and characterization of defensins from cystic fibrosis sputum
128. Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency
129. A marked decrease in defensin mRNA in the only case of congenital neutrophil-specific granule deficiency reported in Japan
130. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense
131. Cathelicidins: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain
132. FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis
133. hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules
134. A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity
135. Human CAP18: A novel antimicrobial lipopolysaccharide-binding protein
136. The human gene FALL-39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes
137. The expression of the gene coding for the antimicrobial peptide LL-37 is induced in human keratinocytes during inflammatory disorders
138. Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity
139. Secondary structure and membrane interaction of PR-39, a Pro+Arg-rich antibacterial peptide
140. PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox
141. Synthesis and solution structure of the antimicrobial peptide protegrin-1
142. Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes
143. The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6
144. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad anti-microbial activity at the airway surface
145. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils
146. Protective effects of a human 18-kilodalton cationic antimicrobial protein (CAP18)-derived peptide against murine endotoxemia
147. Chemoattractant properties of PR-39, a neutrophil antibacterial peptide
148. Evaluation of the effects of antimicrobial human β-defensin-1/2 and CAP18/LL-37 on mast cell functions
149. The antimicrobial peptide LL-37 upregulates HLA-DR molecules on dendritic cells
150. Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide