메뉴 건너뛰기




Volumn 4, Issue 6, 2001, Pages 662-676

α2-Adrenoceptor antagonists

Author keywords

[No Author keywords available]

Indexed keywords


EID: 2342667989     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (150)
  • 1
    • 33746974227 scopus 로고    scopus 로고
    • 9(1):41-55. McGrath JC, Brown CM, Wilson VG: Alpha-adrenoceptors: a critical review. Med Res Rev (1989) 9:408-533. Berlan M, Montastruc JL, Lafontan M: Pharmacological prospect for o,-adrenoeeptor antagonist therapy. Trends Pharmacol Sei (1992) 13:277-282. Timmermans PB, Chiu AT, Thoolen M: a-Adrenergic receptors. In: Comprehensive Medicinal Chemistry Volume 3. Emmett JC (Ed), Pergamon Press, London (1990):133-185.
    • Timmermans PB, Van Zwieten PA: a-Adrenoceptor agonists and antagonists. Drugs Future (1984) 9(1):41-55. McGrath JC, Brown CM, Wilson VG: Alpha-adrenoceptors: a critical review. Med Res Rev (1989) 9:408-533. Berlan M, Montastruc JL, Lafontan M: Pharmacological prospect for o,-adrenoeeptor antagonist therapy. Trends Pharmacol Sei (1992) 13:277-282. Timmermans PB, Chiu AT, Thoolen M: a-Adrenergic receptors. In: Comprehensive Medicinal Chemistry Volume 3. Emmett JC (Ed), Pergamon Press, London (1990):133-185.
    • Van Zwieten PA: A-Adrenoceptor Agonists and Antagonists. Drugs Future (1984)
    • Timmermans, P.B.1
  • 6
    • 0027176936 scopus 로고    scopus 로고
    • 91:1997-2003. Lafontan M, Berlan M: Fat cell ccj-adrenoceptors: The regulation of fat cell function and lipotysis. Endocrine Re v (1995)16(6):716-738. Berlan M, Lafontan M: The 0,-adrenergic receptor of human fat cells: comparative study of 0,-adrenergic radioligand binding and biological response. J Physiol (1982) 78:279-287.
    • Galitzky J, Lafontan M, Nordenström J, Amer P: Rote of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human tissue. J Clin Invest (1993) 91:1997-2003. Lafontan M, Berlan M: Fat cell ccj-adrenoceptors: The regulation of fat cell function and lipotysis. Endocrine Re v (1995)16(6):716-738. Berlan M, Lafontan M: The 0,-adrenergic receptor of human fat cells: comparative study of 0,-adrenergic radioligand binding and biological response. J Physiol (1982) 78:279-287.
  • 7
    • 33747007876 scopus 로고    scopus 로고
    • 0,-Adrenoceptors and depression. J Psychopharmacol (1996) 3:35-42. Broekkamp CL, Leysen D, Peelers BW, Pinder RM: Prospects for improved antidepressants. J Med Chem (1995) 38(23):4615-4633. Dickinson SL: o,-Adrenoceptor antagonism and depression. Drug News Perspect 1991 4(4): 197-203. Leysen D, Pinder RM: Toward third generation antidepressants. In: Annual Reports in Medicinal Chemistry Bristol JA (Ed), Academic Press Inc, San Diego (1994) 29:1-12. Pinder RM, Wieringa JH: Thirdgeneration antidepressants. Med Res fie v (1993) 13(3):259-325.
    • Nutt DJ, Finder RM: 0,-Adrenoceptors and depression. J Psychopharmacol (1996) 3:35-42. Broekkamp CL, Leysen D, Peelers BW, Pinder RM: Prospects for improved antidepressants. J Med Chem (1995) 38(23):4615-4633. Dickinson SL: o,-Adrenoceptor antagonism and depression. Drug News Perspect 1991 4(4): 197-203. Leysen D, Pinder RM: Toward third generation antidepressants. In: Annual Reports in Medicinal Chemistry Bristol JA (Ed), Academic Press Inc, San Diego (1994) 29:1-12. Pinder RM, Wieringa JH: Thirdgeneration antidepressants. Med Res fie v (1993) 13(3):259-325.
    • Finder RM
    • Nutt, D.J.1
  • 10
    • 0030471021 scopus 로고    scopus 로고
    • 1996 3:26-34.
    • Coupland NJ, Wilson SJ, Nutt DJ: -Adrenoceptors in panic and anxiety disorders. J Psychopharmacol ( 1996) 3:26-34.
  • 13
    • 0030463627 scopus 로고    scopus 로고
    • 3:49-52.
    • Myles JS: o,-Adrenoceptors in addiction. J Psychopharmacol (1996) 3:49-52.
  • 14
    • 0029824446 scopus 로고    scopus 로고
    • 0,-adrenoceptors. Prog Drug Res (1996) 47:81-130. Hieble JP, Ruffolo Jr RR: Recent advances in the identification of a,- and
    • Hieble JP, Ruffdo RR Jr. Subclassification and nomenclature of o,and 0,-adrenoceptors. Prog Drug Res (1996) 47:81-130. Hieble JP, Ruffolo Jr RR: Recent advances in the identification of a,- and
    • Ruffdo RR Jr. Subclassification and Nomenclature of O,and
    • Hieble, J.P.1
  • 17
    • 0032521675 scopus 로고    scopus 로고
    • 18:3035-3042. Björklund M, Sirviö J, Puolivâli J, Sallinen J, Jäkäiä P, Scheinin M, Kobilka BK, Riekkinen P: o-adrenoceptoroverexpressing mice are impaired in executing nonspatial and spatial escape strategies. Mol Pharmacol (1998) 54:569-576. Sallinen J, Haapalinna A, MacDonald E, Viitamaa T, Lahdesmaki J, Rybnikova E, Pelto-Huiko M, Kobilka B, Scheinin M: Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels. Mol Psychiatry (1999) 4(5):443-452. Björklund M, Sirviö J, Riekkinen M, Sallinen J, Scheinin M, Riekkinen P: Overexpression of o-adrenoceptors impairs water maze navigation. Neuroscience (2000) 95(2):481-487.
    • Sallinen J, "Haapalinna T, Viitamaa T, Kobilka BK, Scheinin M: Adrenergic a-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice. J Neurosci (1998) 18:3035-3042. Björklund M, Sirviö J, Puolivâli J, Sallinen J, Jäkäiä P, Scheinin M, Kobilka BK, Riekkinen P: o-adrenoceptoroverexpressing mice are impaired in executing nonspatial and spatial escape strategies. Mol Pharmacol (1998) 54:569-576. Sallinen J, Haapalinna A, MacDonald E, Viitamaa T, Lahdesmaki J, Rybnikova E, Pelto-Huiko M, Kobilka B, Scheinin M: Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels. Mol Psychiatry (1999) 4(5):443-452. Björklund M, Sirviö J, Riekkinen M, Sallinen J, Scheinin M, Riekkinen P: Overexpression of o-adrenoceptors impairs water maze navigation. Neuroscience (2000) 95(2):481-487.
  • 19
    • 0023241854 scopus 로고    scopus 로고
    • 26(9):1431-1440.
    • Colpaert F: Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat. Neumpharmacology (1987) 26(9):1431-1440.
  • 21
    • 33746957827 scopus 로고    scopus 로고
    • 23(New Oreleans):Abs291.4.
    • Henry B, Plowright A, Fox SH, Crossman AR, Brotchie JM: o,Adrenergic antagonists reduce symptoms in animal models of Ldopa-induced dyskinesia. Soc Neurosci Abstr (1997) 23(New Oreleans):Abs291.4.
  • 25
    • 0031974639 scopus 로고    scopus 로고
    • 159:433-436. Toleken C, Rhoden EL, Sogari P, Dambros M, Souto CAV: Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol (1998) 159:122-124. Knoll LD, Benson RC, Bilhartz DL, Minich PJ, Furlow WL: A randomized crossover study using yohimbine and isoxsuprine versus pentoxifylline in the management of vasculogenic impotence. J Urol (1996) 155:144-146.
    • Ernst E, Pittler MH: Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. J Urol (1998) 159:433-436. Toleken C, Rhoden EL, Sogari P, Dambros M, Souto CAV: Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol (1998) 159:122-124. Knoll LD, Benson RC, Bilhartz DL, Minich PJ, Furlow WL: A randomized crossover study using yohimbine and isoxsuprine versus pentoxifylline in the management of vasculogenic impotence. J Urol (1996) 155:144-146.
  • 30
    • 33746969553 scopus 로고    scopus 로고
    • 12-sulfonyl derivatives of 5,8,8a,9,10,11,12, 12a,13,13a-decahydro-6/fisoquino[2,1-g][1,6]naphthyridines at cxadrenoceptors. J Med Chem (1991) 34:705-717. Clark R, Repke DB, Kilpatrick AT, Brown CM, MacKinnon AC, Clague RU, Spedding M: (8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro3-metrKxy-12meriylsulionyl- 6>ffe2,1-1,6lnaphttiyridine, a potent and highly selective alpha 2-adrenoceptor antagonist. J Med Chem (1989) 32:2034-6. MacKinnon AC, Kilpatrick AT, Kenny BA, Spedding M, Brown CM: [!H]-RS-15385-197, a selective and high affinity radioligand for o,-adrenoceptors: implications for receptor classification. Br J Pharmacol (1992) 106:1011-1018. Brown CM, MacKinnon AC, Redfem WS, Hicks PE, Kilpatrick AT, Small C, Ramcharan M, Clague RU, Clark RD, MacFarlane CB, Spedding M:
    • Clark R, Repke DB, Berger J, Nelson JT, Kilpatrick AT, Brown CM, MacKinnon AC, Clague RU, Spedding M: Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12, 12a,13,13a-decahydro-6/fisoquino[2,1-g][1,6]naphthyridines at cxadrenoceptors. J Med Chem (1991) 34:705-717. Clark R, Repke DB, Kilpatrick AT, Brown CM, MacKinnon AC, Clague RU, Spedding M: (8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro3-metrK)xy-12meriylsulionyl)- 6>ffe[2,1-[1,6lnaphttiyridine, a potent and highly selective alpha 2-adrenoceptor antagonist. J Med Chem (1989) 32:2034-6. MacKinnon AC, Kilpatrick AT, Kenny BA, Spedding M, Brown CM: [!H]-RS-15385-197, a selective and high affinity radioligand for o,-adrenoceptors: implications for receptor classification. Br J Pharmacol (1992) 106:1011-1018. Brown CM, MacKinnon AC, Redfem WS, Hicks PE, Kilpatrick AT, Small C, Ramcharan M, Clague RU, Clark RD, MacFarlane CB, Spedding M: The pharmacology of RS-15385-197, a potent and selective o,adrenoceptor antagonist. Br J Pharmacol (1993) 108:516-525. Redfem WS, MacKinnon AC, Brown CM, Martin AB, Kilpatrick AT, Clague RU, Spedding M: Modulation of central noradrenergic function by RS-15385-197. Br J Pharmacol (W93) 108:526-533.
    • Repke DB, Berger J, Nelson JT, Kilpatrick AT, Brown CM, MacKinnon AC, Clague RU, Spedding M: Structure-affinity Relationships of
    • Clark, R.1
  • 32
    • 33746972379 scopus 로고    scopus 로고
    • 1. The erectile response to erotic stimuli in volunteers. Psychopharmacology (1994) 115:463-470. Munoz M, Bancroft J, Turner M: Evaluation of the effects of an alpha-2 adrenoceptor antagonist on erectile function in the human male. 2. The erectile response to erotic stimuli in men with erectile dysfunction, in relation to age and in comparison with normal volunteers. Psychopharmacology (1994)115:471-477.
    • Munoz M, Bancroft J, Turner M : Evaluation of the effects of an alpha-2 adrenoceptor antagonist on erectile function in the human male. 1. The erectile response to erotic stimuli in volunteers. Psychopharmacology (1994) 115:463-470. Munoz M, Bancroft J, Turner M: Evaluation of the effects of an alpha-2 adrenoceptor antagonist on erectile function in the human male. 2. The erectile response to erotic stimuli in men with erectile dysfunction, in relation to age and in comparison with normal volunteers. Psychopharmacology (1994)115:471-477.
    • Bancroft J, Turner M : Evaluation of the Effects of An Alpha-2 Adrenoceptor Antagonist on Erectile Function in the Human Male.
    • Munoz, M.1
  • 36
    • 33746976048 scopus 로고    scopus 로고
    • 245(1 ):32-40. Sciberras DG, Reed JW, Elliott C, Blain PG, Goldberg MR: The effects of a peripherally selective ct,-adrenoceptor antagonist, MK-467, on the metabolic and cardiovascular response to exercise in healthy man. Br J Clin Pharmacol (1994) 37:39-44.
    • Clineschmidt BV. Pettibone DJ, Lotti VJ, Hucker HB, Sweeney BM, Reiss DR, Lis EV, Huff JR, Vacca J: A peripherally acting alpha-2 adrenoceptor antagonist: L-659066. J Pharmacol Exp Ther (1988) 245(1 ):32-40. Sciberras DG, Reed JW, Elliott C, Blain PG, Goldberg MR: The effects of a peripherally selective ct,-adrenoceptor antagonist, MK-467, on the metabolic and cardiovascular response to exercise in healthy man. Br J Clin Pharmacol (1994) 37:39-44.
  • 38
    • 0028863081 scopus 로고    scopus 로고
    • 5-HT uptake inhibition. Bioorg Med Chem Lett (1995) 5(19):2287-2292. Meyer DM, Hancock AA, Tietje K, Sippy KB, Prasad R, Stout DM, Arendsen DL, Donner BG, Carroll WA: Structure-activity studies for a novel series of NarylethyI-W-1,2,3,4-tetrahydronaphtalen-1ylmethyl}-W-methylamines possessing dual 5-HT. uptake inhibiting and ct,-antagonistic activities. J Med Chem (1997) 40(7): 1049-1062.
    • Meyer DM, Hancock AA, Tietje K, Sippy KB , Giardina WJ, Kerwin Jr JF: Synthesis and pharmacological characterization of A-80426: a putative novel antidepressant combining a-2 antagonism with 5-HT uptake inhibition. Bioorg Med Chem Lett (1995) 5(19):2287-2292. Meyer DM, Hancock AA, Tietje K, Sippy KB, Prasad R, Stout DM, Arendsen DL, Donner BG, Carroll WA: Structure-activity studies for a novel series of NarylethyI)-W-(1,2,3,4-tetrahydronaphtalen-1ylmethyl}-W-methylamines possessing dual 5-HT. uptake inhibiting and ct,-antagonistic activities. J Med Chem (1997) 40(7): 1049-1062.
  • 40
    • 0027255855 scopus 로고    scopus 로고
    • 2AminobenzyM,2,3,4-tetrahydroisoquinolines: a new class of ct,adrenergic receptor antagonists. Eur J Med Chem (1993) 28:427432.
    • Stambach JF, Kanmacher l, Jung L, Schott C, Heitz C, Stodet JC: 2AminobenzyM,2,3,4-tetrahydroisoquinolines: a new class of ct,adrenergic receptor antagonists. Eur J Med Chem (1993) 28:427432.
    • Kanmacher L, Jung L, Schott C, Heitz C, Stodet JC
    • Stambach, J.F.1
  • 46
    • 0025804278 scopus 로고    scopus 로고
    • 20-year-old Java Monkey with MPTP-induced parkinsonian signs. Brain Res u//(1991) 26:627-631. The first in vivo evidence concerning the role of an aadrenoceptor antagonist for the treatment of the MPTP-lnduced parkinsonian symptoms.
    • Colpaert FC, Degryse AD, van Cranendonck H: Effect of an a, antagonist in a 20-year-old Java Monkey with MPTP-induced parkinsonian signs. Brain Res u//(1991) 26:627-631. The first in vivo evidence concerning the role of an aadrenoceptor antagonist for the treatment of the MPTP-lnduced parkinsonian symptoms.
    • Degryse AD, Van Cranendonck H: Effect of An A, Antagonist in A
    • Colpaert, F.C.1
  • 50
    • 33747005035 scopus 로고    scopus 로고
    • 6 Jan: 17.
    • Oa, Antagonist Investigational Drugs Weekly Highlights (1999) 6 Jan: 17.
  • 54
    • 0025865577 scopus 로고    scopus 로고
    • 4:197-203.
    • Drugs News Perspect (1991 ) 4:197-203.
  • 55
    • 37049076770 scopus 로고    scopus 로고
    • 1 (1994): 1773-1777. Kitchin J, Borthwick AD, Brodie AC, Cherry PC, Crame AJ, Pipe AJ, Procopiou PA, Seaman MA, Tumbull JP: Synthesis of benzodioxinopyrroles as selective o,-adrenoceptor antagonists. Bioorg Med Chem (1995) 3(12): 1595-1603. Procopiou PA, Brodie AC, Deal MJ, Hayman DF, Smith GM: Novel cyclodehydration reaction of hydroxyphenols. An alternative to the M'rtsunobu reaction. J Chem Soc Perkin Trans 1 (1996):2249-2256.
    • Procopiou PA, Cherry PC, Deal MJ, Lamont RB: A reinvestigation of the synthesis of trans-(±)-1|2,3,4,4a,10a-hexahydro[1,4]benzodixono[2,3-c]pyridine. J Chem Soc Perkin Trans 1 (1994): 1773-1777. Kitchin J, Borthwick AD, Brodie AC, Cherry PC, Crame AJ, Pipe AJ, Procopiou PA, Seaman MA, Tumbull JP: Synthesis of benzodioxinopyrroles as selective o,-adrenoceptor antagonists. Bioorg Med Chem (1995) 3(12): 1595-1603. Procopiou PA, Brodie AC, Deal MJ, Hayman DF, Smith GM: Novel cyclodehydration reaction of hydroxyphenols. An alternative to the M'rtsunobu reaction. J Chem Soc Perkin Trans 1 (1996):2249-2256.
    • Cherry PC, Deal MJ, Lamont RB: A Reinvestigation of the Synthesis of Trans-(±)-1|2,3,4,4a,10a-hexahydro[1,4]benzodixono[2,3-c]pyridine. J Chem Soc Perkin Trans
    • Procopiou, P.A.1
  • 58
    • 33746978616 scopus 로고    scopus 로고
    • 10(Suppl 4):19-23. Nutt D: Mirtazapine: pharmacology in relation to adverse effects. Acta Psychiatr Scand (1997) 96(Suppl 391):31-37. De Boer T, Nefkens F, Van Helvoirt A, Van Delft AMI: Differences in modulation of noradrenergic and serotonergic transmission by alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan. J PharmacolExp 77ier(1996) 277:852-860.
    • Murphy DL, Mitchell PB, Potter WZ: Novel pharmacological approaches to the treatment of depression. In : Psychopharmacology, the fourth generation of progress. Bloom FE, Kupfer DJ (Eds), Raven Press, New York (1995):1143-1153. De Boer T: Th effects of mirtazapine on central noradrenergic and serotonergic neurotransmission. Int Clin Psychopharm (1995) 10(Suppl 4):19-23. Nutt D: Mirtazapine: pharmacology in relation to adverse effects. Acta Psychiatr Scand (1997) 96(Suppl 391):31-37. De Boer T, Nefkens F, Van Helvoirt A, Van Delft AMI: Differences in modulation of noradrenergic and serotonergic transmission by alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan. J PharmacolExp 77ier(1996) 277:852-860.
  • 59
    • 0030611252 scopus 로고    scopus 로고
    • 5-HT and a, antagonist, in the treatment of sexual dysfunction induced by serotonin reuptake inhibitors. Clin Neuropharmacol (1997) 20(3):210-214.
    • Aizenberg D, Gur S, Zemishlany Z, Granek M, Jeczmien P, Weizman A: Mianserin, a 5-HT and a, antagonist, in the treatment of sexual dysfunction induced by serotonin reuptake inhibitors. Clin Neuropharmacol (1997) 20(3):210-214.
    • Gur S, Zemishlany Z, Granek M, Jeczmien P, Weizman A: Mianserin, A
    • Aizenberg, D.1
  • 63
    • 0033153199 scopus 로고    scopus 로고
    • 9(Suppl 5):S329 Abs P.4.030.
    • Neuropsychopharmacol (1999) 9(Suppl 5):S329 Abs P.4.030.
  • 66
    • 33746962568 scopus 로고    scopus 로고
    • 1 (2):262-267. Graul A, Castaner J: Phentolamine mesylate. Drugs Future (1998) 23(7):725-728.
    • Qureshi A: Vasomax Zonagen. Curr Opin Cent Peripheral Nerv Syst Invest Drugs (1999) 1 (2):262-267. Graul A, Castaner J: Phentolamine mesylate. Drugs Future (1998) 23(7):725-728.
  • 71
    • 0030045515 scopus 로고    scopus 로고
    • 123:239-249.
    • Coull JT, Sahakian BJ, Hodges JR: The (-antagonist idazoxan remediates certain attentional and executive dysfunction in patients w'rth dementia of frontal type. Psychopharmacology (1996) 123:239-249.
  • 73
    • 0032588996 scopus 로고    scopus 로고
    • 0,-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances arrtiparkinsonian action of L-dopa in the MPTP-lesioned primate model of Parkinson's disease. Mov Disord (1999) 14(5):744-753. Bezard E, Brefel C, Tison F, Peyro-SaJnt-Paul H, Ladure P, Rased O, Gross CE: Effect of the a, adrenoceptor antagonist, idazoxan, on motor disabilities in MPTPtreated monkey. Prog Neuro Psychopharmacol Biol Psychiatry (1999) 23:1237-1246. Grondin R, Hadj Tahar A, Doan VD, Ladure P, Bedard PJ: Noradrenoceptor antagonism with idazoxan improves L-dopa-induced dyskinesias in MPTP monkeys. Naunyn Schmiedeberg's Arch Pharmacol (2000)361:181-186.
    • Henry B, Fox SH, Peggs D, Crossman AR, Brotchie JM: The 0,-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances arrtiparkinsonian action of L-dopa in the MPTP-lesioned primate model of Parkinson's disease. Mov Disord (1999) 14(5):744-753. Bezard E, Brefel C, Tison F, Peyro-SaJnt-Paul H, Ladure P, Rased O, Gross CE: Effect of the a, adrenoceptor antagonist, idazoxan, on motor disabilities in MPTPtreated monkey. Prog Neuro Psychopharmacol Biol Psychiatry (1999) 23:1237-1246. Grondin R, Hadj Tahar A, Doan VD, Ladure P, Bedard PJ: Noradrenoceptor antagonism with idazoxan improves L-dopa-induced dyskinesias in MPTP monkeys. Naunyn Schmiedeberg's Arch Pharmacol (2000)361:181-186.
  • 75
    • 0029949349 scopus 로고    scopus 로고
    • 168:571-579.
    • Potter WZ: Idazoxan and response to typical neuroteptics in treatmentresistant schizophrenia. BrJ Psychiatry (1996) 168:571-579.
  • 81
    • 0032587644 scopus 로고    scopus 로고
    • 0,-Adrenoceptor modulation of cortical acetylcholine release In vivo. Neuroscience (1999) 89(4):1041-1050. Martel JC, Chopin P, Colpaert F, Marien M: Neuroprotective effect of the 0,-adrenoceptor antagonists, (+)efaroxan and (±)-idazoxan, against quinolinic acid-induced lesions of the rat striât um. Exp Neural (1998) 154:595-601.
    • Tellez S, Colpaert F, Marien M: 0,-Adrenoceptor modulation of cortical acetylcholine release In vivo. Neuroscience (1999) 89(4):1041-1050. Martel JC, Chopin P, Colpaert F, Marien M: Neuroprotective effect of the 0,-adrenoceptor antagonists, (+)efaroxan and (±)-idazoxan, against quinolinic acid-induced lesions of the rat striât um. Exp Neural (1998) 154:595-601.
    • Colpaert F, Marien M
    • Tellez, S.1
  • 83
    • 33747007837 scopus 로고    scopus 로고
    • 9:3021-3022. Couture K, Gouverneur V, Mioskowski C: A new approach to the synthesis of efaroxan. Bioorg Med Chem Lett (1999) 9:3023-3026.
    • Mayer P, Brunei P, Imbert T: A new efficient synthesis of efaroxan. Bioorg Med Chem Lett (1999) 9:3021-3022. Couture K, Gouverneur V, Mioskowski C: A new approach to the synthesis of efaroxan. Bioorg Med Chem Lett (1999) 9:3023-3026.
  • 87
    • 0025079257 scopus 로고    scopus 로고
    • 7r?er(1990) 254(2):471-475.
    • Perrone MH, Hamel LT, Ferrari RA, Haubrich DR: Napamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro. J Pharmacol Exp 7r?er(1990) 254(2):471-475.
  • 95
    • 33746960129 scopus 로고    scopus 로고
    • Psychopharmaco/ogy (1988) 96(Suppl):Abs 31.02.28.
    • 31.02.28.
    • Abs1
  • 96
    • 0025327966 scopus 로고    scopus 로고
    • 0,-adrenoceptor antagonist - a randomized, double-blind cross-over study in healthy male volunteers. Br J Clin Pharmacol (1990)30:97-106.
    • Kartiuvaara S, KaJIo A, Scheinin M, Anttila M, Salonen JS, Scheinin H: Pharmacological effects and pharmacokinetics of atipamezole, a novel 0,-adrenoceptor antagonist - a randomized, double-blind cross-over study in healthy male volunteers. Br J Clin Pharmacol (1990)30:97-106.
  • 100
    • 0033964782 scopus 로고    scopus 로고
    • 347:29-40. Haapalinna A, Sirviô J, MacDonald E, Virtanen R, Heinonen E: The effects of a specific o,-adrenoceptor antagonist, atipamezole, on cognitive performance and brain neurochemistry in aged Fisher 344 rats. Eur J Pharmacol (2000) 387:141-150.
    • Ear J Pharmacol (1998) 347:29-40. Haapalinna A, Sirviô J, MacDonald E, Virtanen R, Heinonen E: The effects of a specific o,-adrenoceptor antagonist, atipamezole, on cognitive performance and brain neurochemistry in aged Fisher 344 rats. Eur J Pharmacol (2000) 387:141-150.
  • 101
    • 33747027127 scopus 로고    scopus 로고
    • 0,-adrenoceptor antagonists for the treatment for Alzheimer's disease and palliative treatment for demented Parkinsonian patients.
    • The results presented are relevant for the potential use of 0,-adrenoceptor antagonists for the treatment for Alzheimer's disease and palliative treatment for demented Parkinsonian patients.
    • Presented Are Relevant for the Potential Use of
    • Results, T.1
  • 102
    • 33747024424 scopus 로고    scopus 로고
    • 11(Suppl 1):Abs P550. Leino T, Haapalinna A, Heinonen E: Alpha 2-adrenoceptor antagonists potentiate antiparkinsonian effects of levodopa and apomorphine and reduce dopaminergic adverse effects. Soc Neurosci (1997) 23(New Oi1eans):Abs 165.18.
    • Haapalinna A, Virtanen S, Heinonen E: Atipamezole enhances the effects of levodopa and apomorphine in a rodent Parkinson model. Mov Disord (1996) 11(Suppl 1):Abs P550. Leino T, Haapalinna A, Heinonen E: Alpha 2-adrenoceptor antagonists potentiate antiparkinsonian effects of levodopa and apomorphine and reduce dopaminergic adverse effects. Soc Neurosci (1997) 23(New Oi1eans):Abs 165.18.
    • Virtanen S, Heinonen E: Atipamezole Enhances the Effects of Levodopa and Apomorphine in A Rodent Parkinson Model. Mov Disord (1996)
    • Haapalinna, A.1
  • 104
    • 33747019152 scopus 로고    scopus 로고
    • 4(5)-{2-ethyl-2,3-dihydro-2-silainden2-ylimidazole, a silicon analogue of atipamezole. Eur J Med Chem
    • Heinonen P, Sipilä H, Neuvonen K, Lonnberg H, Cockcroft VB, Wurster S, Virtanen R, Savota MKT, Salonen JS, Savda JM: Synthesis and pharmacological properties of 4(5)-{2-ethyl-2,3-dihydro-2-silainden2-yl)imidazole, a silicon analogue of atipamezole. Eur J Med Chem
  • 106
    • 0022645477 scopus 로고    scopus 로고
    • 7/ier(1986) 236:90-96.
    • Hieble JP, DeMarinis RD, Fowler PJ, Matthews WD: Selective alpha-2 adrenoceptor blockade by SK&F-86466: in vitro characterization of receptor selectivity. J Pharmacol Exp 7/ier(1986) 236:90-96.
  • 107
    • 0029824446 scopus 로고    scopus 로고
    • 0,-adrenoceptors. In: Progress In Drug Research. E Jucker (Ed) BirkhauserVelag, Basel (1996)47:81-130.
    • Hieble JP, Rutfolo RR: Subclassification and nomenclature of a,and 0,-adrenoceptors. In: Progress In Drug Research. E Jucker (Ed) BirkhauserVelag, Basel (1996)47:81-130.
    • Rutfolo RR: Subclassification and Nomenclature of A,and
    • Hieble, J.P.1
  • 109
    • 0029062993 scopus 로고    scopus 로고
    • 30(Suppl):299s-310s.
    • J Med Chem (1995) 30(Suppl):299s-310s.
  • 112
    • 0033976615 scopus 로고    scopus 로고
    • 8327 (1-{2-[4-{6-fluoro-1,2-benzisoxazol-3yl)piperid-1-yl]ethyl3-phenyl-imida2olin-2- one, a'novel, potential antipsychotic displaying marked antagonist properties at a,- and ctradrenergic receptors: I. Receptorial, neurochemical, and electrophysiological profile. J Pharmacol Exp Ther (2000) 292:38-53.
    • Millan MJ, Gobert A, Newmann-Tancredi A, Lejeune F, Cussac D, Rivet JM, Audinot V, Adhumeau A, Brocco M, Nicolas JP, Boutin JA, Despaux N, Peglion JL: SI 8327 (1-{2-[4-{6-fluoro-1,2-benzisoxazol-3yl)piperid-1-yl]ethyl)3-phenyl-imida2olin- 2-one), a'novel, potential antipsychotic displaying marked antagonist properties at a,- and ctradrenergic receptors: I. Receptorial, neurochemical, and electrophysiological profile. J Pharmacol Exp Ther (2000) 292:38-53.
    • Gobert A, Newmann-Tancredi A, Lejeune F, Cussac D, Rivet JM, Audinot V, Adhumeau A, Brocco M, Nicolas JP, Boutin JA, Despaux N, Peglion JL: SI
    • Millan, M.J.1
  • 116
    • 33747005024 scopus 로고    scopus 로고
    • 25(Miami Beach):Abs 541.19. Savola JM, Merivuori H, Engström M, Wurster S, Honkanen A: JP-1730, a novel antagonist of alpha-2adrenoceptors, has potential as new treatment for Parkinson's disease. Mov Disord (2000) 15(Suppl 3):24 Abs P.247. These studies with JP-1730 support and reinforce the role of or,adrenoceptor antagonists forthe treatment of Parkinson's disease.
    • Honkanen A, Ingman K, Korpi ER, Savola JM: JP-1730, a novel o,adrenoceptor antagonist enhances apomorphine- and L-dopainduced circling behavior in the rat. Soc Neuroscience -4bs(r(1999) 25(Miami Beach):Abs 541.19. Savola JM, Merivuori H, Engström M, Wurster S, Honkanen A: JP-1730, a novel antagonist of alpha-2adrenoceptors, has potential as new treatment for Parkinson's disease. Mov Disord (2000) 15(Suppl 3):24 Abs P.247. These studies with JP-1730 support and reinforce the role of or,adrenoceptor antagonists forthe treatment of Parkinson's disease.
  • 117
    • 0034674747 scopus 로고    scopus 로고
    • 398:185-191. Pauwels PJ, tardif S, Wurch T, Colpaert F: Facilitation of constitutive Ou-adrenoceptor activity by both single amino acid mutation (Thr'"Lys) and G protein coexpression: evidence for inverse agonism. J Pharmacol Exp Ther (2000) 292:654-663.
    • Murrin LC, Gerety ME, Happe K, Bylund DB: Inverse agonism at o,adrenoceptors in native tissue. EUT J Pharmacol (2000) 398:185-191. Pauwels PJ, tardif S, Wurch T, Colpaert F: Facilitation of constitutive Ou-adrenoceptor activity by both single amino acid mutation (Thr'"Lys) and G protein coexpression: evidence for inverse agonism. J Pharmacol Exp Ther (2000) 292:654-663.
    • Gerety ME, Happe K, Bylund DB: Inverse Agonism at O,adrenoceptors in Native Tissue. EUT J Pharmacol (2000)
    • Murrin, L.C.1
  • 119
    • 0033837404 scopus 로고    scopus 로고
    • 39:2101-2111. Pauwels PJ, Colpaert FC: Disparate ligand-mediated Ça" responses by wild-type, mutant Ser Ala and SerAla o-adrenoceptor: G0l, fusion proteins: evidence for multiple ligand-activation binding sites. Br J Pharmacol (2000) 130:1505-1512. Molderings GJ, Menzel S, Kathrnann M, Schlicker E, Göthert M: Dual interaction of agmatine with the rat o-adrenoceptor: competitive antagonism and allosteric activation. BrJ Pharmacol (2000) 130:1706-1712.
    • Pauwels PJ, Colpaert FC: Heterogeneous ligand-mediated Ca" responses at wt and mutant o-adrenoceptors suggest multiple ligand activation binding sites at o-adrenoceptor. Neuropharmacology (2000) 39:2101-2111. Pauwels PJ, Colpaert FC: Disparate ligand-mediated Ça" responses by wild-type, mutant Ser Ala and SerAla o-adrenoceptor: G0l, fusion proteins: evidence for multiple ligand-activation binding sites. Br J Pharmacol (2000) 130:1505-1512. Molderings GJ, Menzel S, Kathrnann M, Schlicker E, Göthert M: Dual interaction of agmatine with the rat o-adrenoceptor: competitive antagonism and allosteric activation. BrJ Pharmacol (2000) 130:1706-1712.
  • 121
    • 33746963056 scopus 로고    scopus 로고
    • 2antagonists for the treatment of neurodegenerative diseases. US05281607-A (1994). SAVOLA JUHA-MATTI (Haapalinna A, Viitamaa T, Sallinen J, Scheinin M, Savola JM): A method for the treatment of mental illness in mammals and a composition therefor. WO09851310 (1998).
    • NEW YORK UNIVERSITY (Stone EA, Bing G): Method of using alpha 2antagonists for the treatment of neurodegenerative diseases. US05281607-A (1994). SAVOLA JUHA-MATTI (Haapalinna A, Viitamaa T, Sallinen J, Scheinin M, Savola JM): A method for the treatment of mental illness in mammals and a composition therefor. WO09851310 (1998).
  • 123
    • 33747000408 scopus 로고    scopus 로고
    • 2000 LTD (Gomy P): Medicine containing yohimbine and arginine for treating erectile dysfunction. WO-U9901132 (1999).
    • REAL 2000 LTD (Gomy P): Medicine containing yohimbine and arginine for treating erectile dysfunction. WO-U9901132 (1999).
  • 125
    • 33746955559 scopus 로고    scopus 로고
    • 20,21Dinorebumam'me derivatives, substituted in position 15, process for their preparation and novel intermediates so obtained, their use as medicines and compositions containing them. EP-00424248 (1991).
    • ROUSSEL UCWF SA (Clémence F, Haesslein JL, Oberländer C): 20,21Dinorebumam'me derivatives, substituted in position 15, process for their preparation and novel intermediates so obtained, their use as medicines and compositions containing them. EP-00424248 (1991).
  • 127
    • 33746941204 scopus 로고    scopus 로고
    • 0,-adrenergic receptor antagonists for the production of pharmaceutical compositions for treating colonie spasm, irritable bowel syndrome and constipation and process for preparing such pharmaceutical compositions. EP-
    • MERCK AND Co INC (Pendelton RG : Us of 0,-adrenergic receptor antagonists for the production of pharmaceutical compositions for treating colonie spasm, irritable bowel syndrome and constipation and process for preparing such pharmaceutical compositions. EP-
  • 129
    • 33746961079 scopus 로고    scopus 로고
    • 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds. US-05192789 (1993).
    • GJ, Merriman MC, Palermo MG): Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds. US-05192789 (1993).
  • 130
    • 33746937713 scopus 로고    scopus 로고
    • 1Aminomethyl-1,2,3,4-tetrahydronaphthalenes. US-05128362 (1992). ABBOTT LABORATORIES (Meyer Ml, DeBemardis JF, Prasad R, Sippy KB, Tietje KR): Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors. WO-09312754 (1993).
    • ABBOTT LABORATORIES (DeBemardis JF, Zelle RE, Basha Z): 1Aminomethyl-1,2,3,4-tetrahydronaphthalenes. US-05128362 (1992). ABBOTT LABORATORIES (Meyer Ml, DeBemardis JF, Prasad R, Sippy KB, Tietje KR): Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors. WO-09312754 (1993).
    • (DeBemardis JF, Zelle RE, Basha Z)
    • Laboratories, A.1
  • 132
    • 33746954504 scopus 로고    scopus 로고
    • 6-Substftuted1,2,3,4-tetrahydroisoquinolines. US-04963563 (1990).
    • ABBOTT LABORATORIES (DeBemardis JF, Zelle RE): 6-Substftuted1,2,3,4-tetrahydroisoquinolines. US-04963563 (1990).
  • 133
    • 33746990626 scopus 로고    scopus 로고
    • 1Ä3.4Tetrahydro-benzofuro[3,2-c]pvridine derivatives. WO-O9845297 (1998).
    • JANSSEN PHARMACEUTICA NV (Kenne LEJ, Love CH, Bischoff FP): 1Ä3.4Tetrahydro-benzofuro[3,2-c]pvridine derivatives. WO-O9845297 (1998).
    • NV (Kenne LEJ, Love CH, Bischoff FP)
    • Pharmaceutica, J.1
  • 135
    • 33746938718 scopus 로고    scopus 로고
    • 4-substituted by an imidazolidinon-1yl-ethyl and 1,3-diazepinon-1-yl-ethyl group, and use thereof as o,adrenergic receptor antagonists. WO-09728157 (1997).
    • PIERRE-FABRE MEDICAMENT (Vidaluc JL, Imbert T, Marien M, Briley M): Novel piperidine derivatives 4-substituted by an imidazolidinon-1yl-ethyl and 1,3-diazepinon-1-yl-ethyl group, and use thereof as o,adrenergic receptor antagonists. WO-09728157 (1997).
  • 138
    • 33746955558 scopus 로고    scopus 로고
    • 8-(1,4)-benzodioxane-2-ylmethyl}-8-azabicyclo[3,2] octane-3-alkyl urée ou imidazolidinones, leur procédé- de préparation et leurs applications en thérapeutique pour traiter les maladies neurodegeneratives. FR-02789681 (2000).
    • PIERRE-FABRE MEDICAMENT (Mayer P, Imbert T, Marien M): Nouveaux
  • 141
    • 33746962563 scopus 로고    scopus 로고
    • 2,3dihydrobenzofurane-2,2-disubstmjés. FR-02780967 (2000).
    • PIERRE FABRE MEDICAMENT (Mayer P, Imbert T, Couture K, Gouverneur V, Mioskowski C): Procédé de préparation de dérives 2,3dihydrobenzofurane-2,2-disubstmjés. FR-02780967 (2000).
  • 142
    • 33746981732 scopus 로고    scopus 로고
    • 5,6-Dihydro-4H feno[3,4-c]pyrrole derivatives, their preparation and their therapeutic use. EP-00682028 (1995).
    • SYNTHéLABO (Bedoya Z M, Diaz MJA, Del Sol MG, Martin EPU, Jimenez BMD, Romanach FM): 5,6-Dihydro-4H feno[3,4-c]pyrrole derivatives, their preparation and their therapeutic use. EP-00682028 (1995).
    • Z M, Diaz MJA, Del Sol MG, Martin EPU, Jimenez BMD, Romanach FM
    • Bedoya, S.1
  • 144
    • 33746978102 scopus 로고    scopus 로고
    • 4-Dihydroinden-2-yl, 4-tetrahydronaphty-2-yl, and 4dihydrobenzofuran-2-ylimidazotes, useful to block a,-adrenergic receptors. US-04689339 (1987).
    • FARMOS YHTYMA OY (Karjalainen AJ, Virtanen RE, Kaijalainen AL, Kurkela KOA): 4-Dihydroinden-2-yl, 4-tetrahydronaphty-2-yl, and 4dihydrobenzofuran-2-ylimidazotes, useful to block a,-adrenergic receptors. US-04689339 (1987).
  • 146
    • 33747011586 scopus 로고    scopus 로고
    • 4-{5-fluoro-2,3dihydro-1H-inden-2-yi-1H-imidazole. WO-09500492 (1995).
    • ORION CORP (Karjalainen AJ, Virtanen RE, Kaijalainen AL, Parhi SSL, Eloranta MM, Haapalinna AS): Enantiomers of 4-{5-fluoro-2,3dihydro-1H-inden-2-yi)-1H-imidazole. WO-09500492 (1995).
  • 149
    • 33746989643 scopus 로고    scopus 로고
    • 2adrenergic blocking agents. WO-09601813 (1996).
    • ALLERGAN INC (Munk SA, Garst ME, Burke JA): Conformationally rigid bicyclic and adamantane derivatives useful as alpha 2adrenergic blocking agents. WO-09601813 (1996).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.