Synthesis and pharmacological characterization of ABT-200: a putative novel antidepressant combining potent α-2 antagonism with moderate NE uptake inhibition

Bioorganic and Medicinal Chemistry Letters

Volumn 4, Issue 11, 1994, Pages 1319-1322

  Zelle, Robert E ^a   Hancock, Arthur A ^a   Buckner, Steven A ^a   Basha, Fatima Z ^a   Tietje, Karin ^a   DeBernardis, John F ^a   Meyer, Michael D ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYL 1 [(1,2,3,4 TETRAHYDRO 5,6 METHYLENEDIOXY 1 NAPHTHYL)METHYL]PYRROLIDINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; CLONIDINE; IDAZOXAN; IMIPRAMINE; PRAZOSIN; RAUWOLSCINE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CATECHOLAMINE UPTAKE; CONTROLLED STUDY; DOG; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; HYPOTHALAMUS; LIVER; NONHUMAN; RAT; VAS DEFERENS; VEIN;

EID: 0028319235     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)80353-X     Document Type: Article

References (14)