Pharmacological effects and pharmacokinetics of atipamezole, a novel alpha 2‐adrenoceptor antagonist‐a randomized, double‐blind cross‐over study in healthy male volunteers.

British Journal of Clinical Pharmacology

Volumn 30, Issue 1, 1990, Pages 97-106

  Karhuvaara, S ^a   Kallio, A ^a   Scheinin, M ^a   Anttila, M ^a   Salonen, JS ^a   Scheinin, H ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ATIPAMEZOLE; CYCLIC AMP; NORADRENALIN;

ADULT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; CROSSING OVER; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NERVOUSNESS; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RANDOM SAMPLING; RESTLESSNESS; SALIVATION; SIDE EFFECT; SWEATING; TREMOR;

ADRENERGIC ALPHA-ANTAGONISTS; ADULT; BLOOD GLUCOSE; BLOOD PRESSURE; C-PEPTIDE; CATECHOLAMINES; CYCLIC AMP; DOUBLE-BLIND METHOD; HEART RATE; HUMAN; HYDROCORTISONE; IMIDAZOLES; MALE; MODELS, BIOLOGICAL; RANDOM ALLOCATION; SALIVATION;

EID: 0025327966     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1990.tb03748.x     Document Type: Article

References (45)

1. The use of analogue scales in rating subjective feelings
2. Analysis of vanillylmandelic and homovanillic acids in urine using solid phase sample preparation and high pressure liquid chromatography with electrochemical detection
3. The physiological and pharmacological role of presynaptic α‐ and β‐adrenoceptors in man
4. 2‐adrenoceptor stimulation contributes to the sympatholytic effect of guanfacine in man
5. 2‐adrenoceptor stimulation and antagonism in man
6. Alpha‐2A and alpha‐2B adrenergic receptor subtypes: Antagonist binding in tissues and cell lines containing only one subtype
7. 2‐adrenoceptor antagonists
8. 2‐adrenoceptor antagonist in depression—a preliminary investigation
9. 2‐adrenoceptors
10. The alpha adrenoceptor antagonist properties of idazoxan in normal subjects
11. Comparison between the effects of inhaled isoprenaline and fenoterol on plasma cyclic AMP and heart rate in normal subjects
12. 2‐adrenoceptors in the anaesthetized dog
13. 2‐adrenoceptor
14. The effect of clonidine on centrally and peripherally evoked submaxillary salivation
15. Fashion, Darwin, and anesthetics as poisons
16. Differentiated sympathetic activation during mental stress evoked by the Stroop test
17. Clonidine
18. High‐performance liquid chromatography with electrochemical detection for the simultaneous determination of the methoxylated amines, normetanephrine, metanephrine and 3‐methoxytyramine, in urine
19. 2‐adrenoceptor agonist, on hemodynamic control mechanisms
20. 2‐adrenoceptor antagonist, in healthy male volunteers. An open dose‐finding study
21. 2‐adrenergic blocker (DG‐5128) improves insulin secretion and in vivo glucose disposal in NIDDM patients
22. The analysis of repeated measures design in medical research
23. Presynaptic regulation of the release of catecholamines
24. Presynaptic regulation of monoaminergic neurons
25. Reduced glucose tolerance after guanfacine in normal and obese subjects
26. Alpine anesthesia: can pretreatment with clonidine decrease the peaks and valleys?
27. Anxiogenic effects of yohimbine in healthy subjects: comparison with caffeine and antagonism by clonidine and diazepam
28. Induction of defective insulin secretion and impaired glucose tolerance by clonidine
29. Evidence for a peripheral component in the sympatholytic actions of clonidine and guanfacine in man
30. 2‐adrenoceptors modulating insulin release from isolated pancreatic islets
31. 2‐adrenoceptor blockade does not enhance glucose‐induced insulin release in normal subjects or patients with noninsulin‐dependent diabetes
32. 2‐adrenergic receptor function in depression. The Cortisol response to yohimbine
33. The effect of yohimbine, Wy 26392 and idazoxan on sympathetic nerve activity
34. The clinical pharmacology of clonidine and related central antihypertensive agents
35. Functions mediated by alpha‐2 adrenergic receptors
36. 2‐adrenoceptor agonists of the secretion of catecholamines from isolated adrenal medullary cells
37. 2‐adrenoceptor antagonist
38. 2‐adrenoceptor agonist, in healthy volunteers
39. Hypokalemia and other non‐bronchial effects of inhaled fenoterol and salbutamol: A placebo‐controlled dose‐response study in healthy volunteers
40. 2‐receptor blockade facilitates the insulin response to adrenaline but not to glucose in man
41. 2‐adrenoceptors by atipamezole
42. 2‐adrenoceptor antagonist, with use of intravenous clonidine