The effects of a specific α2-adrenoceptor antagonist, atipamezole, on cognitive performance and brain neurochemistry in aged Fisher 344 rats

European Journal of Pharmacology

Volumn 387, Issue 2, 2000, Pages 141-150

  Haapalinna, Antti ^a   Sirviö, Jouni ^a   MacDonald, Ewen ^b   Virtanen, Raimo ^a   Heinonen, Esa ^a  

^a ORION CORPORATION   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

2 Adrenoceptor; Ageing; Atipamezole; Cholinergic system; Memory; Noradrenergic system

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ATIPAMEZOLE; CHOLINE ACETYLTRANSFERASE; DOPAMINE; NORADRENALIN; SEROTONIN;

AGED; AGING; AKINESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; COGNITION; CONTROLLED STUDY; DOPAMINE METABOLISM; DRUG EFFECT; DRUG SPECIFICITY; ENZYME ACTIVITY; FRONTAL CORTEX; MALE; MAZE TEST; NEUROCHEMISTRY; NONHUMAN; PALLIATIVE THERAPY; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SEROTONIN METABOLISM; TASK PERFORMANCE;

ADRENERGIC ALPHA-ANTAGONISTS; AGING; ANIMALS; BIOGENIC MONOAMINES; BRAIN; CHOLINE O-ACETYLTRANSFERASE; COGNITION; IMIDAZOLES; MALE; MAZE LEARNING; RATS; RATS, INBRED F344; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 0033964782     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00819-5     Document Type: Article

References (63)

1. 2-receptor stimulation improves memory in aged monkeys: indirect effects of yohimbine versus direct effects of clonidine. Neurobiol. Ageing. 14:1993;597-603.
2. Aston-Jones G., Chiang C., Alexinsky T. Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. Barnes C.D., Pompeiano O. Neurobiology of the Locus Coeruleus. 88:1991;501-520 Elsevier, Amsterdam.
3. Beani L., Tanganelli S., Antonelli T., Bianchi C. Noradrenergic modulation of cortical acetycholine release is both direct and γ-aminobutyric acid-mediated. J. Pharmacol. Exp. Ther. 236:1986;230-236.
4. Berridge C.W., Arnsten A.F.T., Foote S.L. Noradrenergic modulation of cognitive function - clinical implications of anatomical, electrophysiological and behavioural studies in animal models. Psychol. Med. 23(3):1993;557-564.
5. 3H]atipamezole. Eur. J. Pharmacol. 224:1992;27-38.
6. Bunsey M.D., Strupp B.J. Specific effects of idazoxan in a distraction task: evidence that endogenous norepinephrine plays a role in selective attention in rats. Behav. Neurosci. 109:1995;903-911.
7. Buzsáki G., Laszlovszky I., Lajtha A., Vadász C. Spike-and-wave neocortical patterns in rats: genetic and aminergic control. Neuroscience. 38:1990;323-333.
8. Cedarbaum J.M., Aghajanian G.K. Catecholamine receptors on locus coeruleus neurons: pharmacological characterization. Eur. J. Pharmacol. 44:1977;375-385.
9. 2-adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesion of the nirgostriatal pathway. J. Pharmacol. Exp. Ther. 288:1999;789-804.
10. Collier T.J., Gash D.M., Sladek J.R. Transplantation of norepinephrine neurons into aged rats improved performance of a learned task. Brain Res. 448:1987;77-87.
11. Conover W., Iman R. Rank transformation as a bridge between parametric and nonparametric statistics. Am. Stat. 35:1981;124-128.
12. 2-Adrenoceptors in the treatment of dementia: an attentional mechanism. J. Psychopharm. 10:1996;43-48.
13. 2 antagonists idazoxan remediates certain attentional and executive dysfunction in patients with dementia of frontal type. Psychopharmacology. 123:1996;239-249.
14. 2 adrenoceptor autoregulation of norepinephrine release. J. Gerontol. 44:1989;B59-B66.
15. 2-adrenoceptors in rat cerebral cortex: effects of neonatal treatment with 6-hydroxydopamine. Eur. J. Pharmacol. 78:1982;15-20.
16. Decker M.W. The effect of ageing on hippocampal and cortical projections of the forebrain cholinergic system. Brain Res. Rev. 12:1987;423-438.
17. Decker M.W., McGaugh J.L. The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse. 7:1991;151-168.
18. Devauges V., Sara S.J. Activation of the noradrenergic system facilitates an attentional shift in the rat. Behav. Brain Res. 39:1990;19-28.
19. Dickinson S.L., Gadie B., Woodmansey N.R. Effect of repeated idazoxan treatment on radial arm maze performance in adult and in aged rats. Br. J. Pharmacol. 97:1989;P384.
20. 2- and β-adrenergic receptors in the rat after DSP-4, a selective noradrenergic neurotoxin. Neuroscience. 9:1983;889-898.
21. Fonnum F. A rapid radiochemical method of the determination of choline acetyltransferase. J. Neurochem. 24:1975;407-409.
22. Friedemann M.N., Gerhardt G.A. Regional effects of ageing on dopaminergic function in the Fischer-334 rat. Neurobiol. Ageing. 13:1992;325-332.
23. 2-adrenoceptors in the ageing mouse brain. J. Neural Transm. 79:1990;131-136.
24. 2-adrenoceptors. J. Neurochem. 53:1989;519.
25. Haapalinna A., MacDonald E., Viitamaa T., Salonen J.S., Sirviö J., Virtanen R. Comparison of the effects of acute and subchronic administration of atipamezole on reaction to novelty and active avoidance learning in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 359:1999;194-203.
26. 2-adrenoceptor antagonist, atipamezole. Eur. J. Pharmacol. 347(1):1998;29-40.
27. 2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine. Naunyn-Schmiedeberg's Arch. Pharmacol. 356:1997;570-582.
28. Harley C.W. A role for norepinephrine in arousal, emotion and learning? Limbic modulation by norepinephrine and the Kety hypothesis. Prog. Neuropsychopharmacol. Biol. Psychiatry. 11:1987;419-458.
29. Jellinger K.A. Post mortem studies in Parkinson's disease - is it possible to detect brain areas for specific symptoms? J. Neural Transm. 56:1999;1-29.
30. 3H]p-aminoclonidine binding in prefrontal cortex. Neurobiol. Ageing. 12:1991;131-136.
31. 2-adrenoceptor antagonists potentiate anti-parkinsonian effects of levodopa and apomorphine and reduce dopaminergic adverse effects. Soc. Neurosci. Abstr. 23:1997;414.
32. Liljequist R., Haapalinna A., Åhlander M., Ying H.L., Männistö P.T. Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats. Behav. Brain Res. 82:1997;195-202.
33. Lowry O., Rosebrough N., Farr A., Randall R. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
34. Luine V., Bowling D., Hearns M. Spatial memory deficits in aged rats: contributions of monoaminergic systems. Brain Res. 537:1990;271-278.
35. MacDonald E., Scheinin H., Scheinin M. Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative. Eur. J. Pharmacol. 158:1988;119-127.
36. MacIntosh H.H., Westfall T.C. Influence of ageing on catecholamine levels, accumulation and release in F-344 rats. Neurobiol. Ageing. 8:1987;233-239.
37. Matsumoto M., Yoshioka M., Togashi H., Mori K., Ueno K., Saito H. Effects of idazoxan on dopamine release in the prefrontal cortex of freely moving rat. Eur. J. Pharmacol. 343:1998;165-170.
38. McEntee W.J., Crook T.H. Age-associated memory impairment: a role for catecholamines. Neurology. 40:1990;526-530.
39. McEntee W.J., Crook T.H. Serotonin, memory, and the ageing brain. Psychopharmacology. 103:1991;143-149.
40. 1A receptors in the rat brain. Eur. J. Pharmacol. 312:1996;358-388.
41. 2-adrenoceptor ligands at alpha-2A and 5-HT-1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha-2A adrenoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 358:1998;197-206.
42. 2-adrenoceptors in rat brain. J. Neurochem. 64:1995;1118-1126.
43. 2-adrenoceptors: an autoradiographic study in human brain. Neurosci. Lett. 133:1991;279-283.
44. Qi S.-B., Nomura Y. Age related changes in the inhibitory effect of clonidine on high K-evoked noradrenaline release from brain slices of rats. J. Pharmacobio-Dyn. 11:1988;483-485.
45. 2-adrenoceptors in the human cerebral cortex. Naunyn-Schmiedeberg's Arch. Pharmacol. 342:1990;508-512.
46. Robbins T.W., McAlonan G., Muir J.L., Everitt B.J. Cognitive enhancers in theory and practice: studies of the cholinergic hypothesis of cognitive deficits in Alzheimer's disease. Behav. Brain Res. 83:1997;15-23.
47. Sara S.J., Devauges V. Idazoxan, an α-2 antagonist, facilitates memory retrieval in the rat. Behav. Neural Biol. 51:1989;401-411.
48. Sara S.J., Vankov A., Hervé A. Locus coeruleus-evoked responses in behaving rats: a clue to the role of noradrenaline in memory. Brain Res. Bull. 35:1994;457-465.
49. Savontaus S., Raasmaja A., Rouru J., Koulu M., Pesonen U., Virtanen R., Savola J.-M., Huupponen R. Anti-obesity effect of MPV-1743 A III, a novel imidazoline derivative, in genetic obesity. Eur. J. Pharmacol. 328:1997;207-215.
50. 2-adrenoceptor antagonist. Eur. J. Pharmacol. 157:1988;243-244.
51. Schwartz P., Bernabel A.A., Spencer C.J. Loss of muscarinic M1 receptors with ageing in the cerebral cortex of Fisher 344 rats. Pharmacol. Biochem. Behav. 35:1990;589-593.
52. 2-receptor blockade increases responsiveness of locus coeruleus neurons to excitatory stimulation. J. Neurosci. 7:1987;1732-1740.
53. 2-antagonist, on the performance of rats in a five-choice serial reaction time task. Pharmacol. Biochem. Behav. 45:1993;123-129.
54. Sirviö J., Lahtinen H., Riekkinen P.J., Riekkinen P. Spatial learning and noradrenaline content in the brain and periphery of young and aged rats. Exp. Neurol. 125:1994;312-315.
55. Sirviö J., Rinne J.O., Valjakka A., Rinne U.K., Riekkinen P.J., Paljärvi L. Different forms of brain acetylcholinesterase and muscarinic binding in Parkinson's disease. J. Neurol. Sci. 90:1989;23-32.
56. 2-adrenoceptor agonists and antagonists. J. Neurochem. 68:1997;778-785.
57. Trendelenburg A.U., Starke K., Limberger N. Presynaptic alpha-2A-adrenoceptors inhibit the release of endogenous dopamine in rabbit caudate nucleus slices. Naunyn-Schmiedeberg's Arch. Pharmacol. 350:1994;473-481.
58. 2-adrenoceptors by atipamezole. Arch. Int. Pharmacodyn. Ther. 297:1989;190-204.
59. Winter J.C., Rabin R.A. Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination. J. Pharmacol. Exp. Ther. 263:1992;682-689.
60. Yavich L., Sirviö J., Haapalinna A., Puumala T., Koivisto E., Heinonen E., Riekkinen P.J. The systemic administration of tacrine or selegiline facilitate spatial learning in aged Fisher 344 rats. J. Neural Transm. 103:1996;619-626.
61. 2-adrenoceptors, facilitates the excitability of the dentate gyrus and improves the retention of the radial arm maze. Soc. Neurosci. Abstr. 22:1996;680.
62. Zornetzer S.F. Catecholamine system involvement in age-related memory dysfunction. Ann. N.Y. Acad. Sci. 444:1985;242-254.
63. Zsilla G., Zelles T., Mike A., Kékes-Szabó A., Milusheva E., Vizi E.S. Differential changes in presynaptic modulation of transmitter release during ageing. Int. J. Dev. Neurosci. 12:1997;107-115.