A‐80426, a potent and selective α2‐adrenoceptor antagonist with serotonin uptake‐blocking activity and putative antidepressant‐like effects: II. Pharmacology profile

Drug Development Research

Volumn 35, Issue 4, 1995, Pages 246-260

  Giardina, William J ^a   Buckner, Steven A ^a   Brune, Michael E ^a   Hancock, Arthur A ^a   Wismer, Carol T ^a   Milicic, Ivan ^a   Rattin, Anthony J ^a   Roux, Sylvain ^b   Wettstein, Joseph G ^b   Meyer, Michael D ^a   Porsolt, Roger D ^b   Kerwin, James F ^a   Williams, Michael ^a  

^a ABBOTT LABORATORIES   (United States)

^b ITEM Labo ^*  (France)

Author keywords

adrenergic receptor blocker; antidepressant; serotonin uptake inhibitor

Indexed keywords

A 80426; ALPHA 2 ADRENERGIC RECEPTOR; ANTIDEPRESSANT AGENT; CLOZAPINE; FLUOXETINE; HALOPERIDOL; IDAZOXAN; IMIPRAMINE; N [2 (6 BENZOFURANYL)ETHYL] N METHYL N (1,2,3,4 TETRAHYDRO 5 METHOXY 1 NAPHTHYLMETHYL)AMINE; RAUWOLSCINE; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; HYPERACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SEROTONIN UPTAKE;

EID: 0029149770     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.430350406     Document Type: Article

References (30)

1. Alpha‐2 adrenoceptor agonists induce mydriasis in the rat by an action within the central nervous system
2. Action de la cafeine sur la motilité spontanée de la souris
3. Serotonin‐mimetic and antidepressant drugs on passive avoidance learning of olfactory bulbectomized rats
4. Influence of the new 5‐HT‐uptake inhibitor paroxetine on hypermotility in rats produced by p‐chloroamphetamine (PCA) and 4, α‐dimethyl‐m‐tyramine (H 77/77)
5. The α2‐adrenoceptor antagonist Org 3770 enhances serotonin transmission in vivo
6. The pharmacology and therapeutic potential of serotonin receptor agonists and antagonists
7. The rat‐pull test procedure: a method for assessing the strength of rats
8. 2‐adrenoceptor antagonist with serotonin uptake blocking activity and putative antidepressant like effects. I. Biochemical profile
9. Preclinical pharmacological actions of (+)(1′R*, R3*)‐3‐phenyl‐1‐[(1′,2′,3′,4′‐tetrahydro‐5′,6′‐methlylene‐dioxy‐1′‐naphthalenyl)methyl)] pyrrolidine methanesulfonate (ABT200), a potential antidepressant agent which inhibits the neuronal uptake of norepinephrine and antagonizes α2‐adrenergic receptors
10. Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse
11. Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham‐operated rats
12. The effects of fluoxetine and zimeldine on the behavior of olfactory bulbectomized rats
13. The role of serotonin in eating disorders
14. Autoreceptors and α2‐adrenoceptors at the serotonergic axons of rabbit brain cortex
15. Cholinergic drug effects on antidepressant‐induced behavior in the forced swimming test
16. Effects of long‐term alpha‐2 adrenergic antagonists and electroconvulsive treatments on the alpha‐2 adrenoceptors modulating serotonin neurotransmission
17. Napamezole, an alpha‐2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro
18. 2‐adrenoceptors
19. Third‐generation antidepressants
20. Animal models of affective disorders
21. Behavioral despair in mice: a primary screening test for antidepressants
22. Behavioral despair in rats: a new method sensitive to antidepressant treatments
23. 2‐adrenoceptors in the human cereral cortex
24. Recherche d'une interaction avec stereotypies provoquées par l'amphetamine chez le rat
25. The tail suspension test: a new method for screening antidepressants in mice
26. The automatic tail suspension test: a computerized device which differentiates psychotropic drugs
27. A simple and reliable conflict Procedure for testing anti‐anxiety agents
28. The validity of animal models of depression