메뉴 건너뛰기




Volumn 123, Issue 3, 1996, Pages 239-249

The α2 antagonist idazoxan remediates certain attentional and executive dysfunction in patients with dementia of frontal type

Author keywords

Cognitive enhancer; Executive function; Frontal cortex; Frontal dementia; Idazoxan; Memory; 2 Adrenoceptor

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; IDAZOXAN; PLACEBO;

EID: 0030045515     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02246578     Document Type: Article
Times cited : (78)

References (64)
  • 1
    • 0018759336 scopus 로고
    • Locus coeruleus stimulation decreases deoxyglucose uptake in ipsilateral cerebral cortex
    • Abraham WC, Delanoy RL, Dunn AJ, Zornetzer SF (1979) Locus coeruleus stimulation decreases deoxyglucose uptake in ipsilateral cerebral cortex. Brain Res 172:387-392
    • (1979) Brain Res , vol.172 , pp. 387-392
    • Abraham, W.C.1    Delanoy, R.L.2    Dunn, A.J.3    Zornetzer, S.F.4
  • 2
    • 0027375710 scopus 로고
    • Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine
    • Arnsten AFT, Cai JX (1994) Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: indirect effects of yohimbine versus direct effects of clonidine. Neurobiol Aging 14:597-603
    • (1994) Neurobiol Aging , vol.14 , pp. 597-603
    • Arnsten, A.F.T.1    Cai, J.X.2
  • 3
    • 0022379837 scopus 로고
    • Alpha-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates
    • Arnsten AFT, Goldman-Rakic PS (1985) Alpha-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science 230:1273-1276
    • (1985) Science , vol.230 , pp. 1273-1276
    • Arnsten, A.F.T.1    Goldman-Rakic, P.S.2
  • 4
    • 0025788205 scopus 로고
    • Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggest a role in vigilance
    • Barnes CD, Pompeiano O (eds) Elsevier Science Publishers, Amsterdam
    • Aston-Jones G, Chiang C, Alexinsky T (1991) Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggest a role in vigilance. In: Barnes CD, Pompeiano O (eds) Progress in brain research, vol. 88. Elsevier Science Publishers, Amsterdam, pp 501-520
    • (1991) Progress in Brain Research , vol.88 , pp. 501-520
    • Aston-Jones, G.1    Chiang, C.2    Alexinsky, T.3
  • 5
    • 0004030013 scopus 로고
    • Oxford University Press, Oxford
    • Baddeley A (1986) Working memory. Oxford University Press, Oxford
    • (1986) Working Memory
    • Baddeley, A.1
  • 6
    • 0019984378 scopus 로고
    • 2-adrenoceptor involvement in the central cardiovascular action of clonidine in the conscious renal hypertensive cat
    • 2-adrenoceptor involvement in the central cardiovascular action of clonidine in the conscious renal hypertensive cat. Eur J Pharmacol 82: 155-160
    • (1982) Eur J Pharmacol , vol.82 , pp. 155-160
    • Beckett, P.J.1    Finch, L.2
  • 7
    • 6844255355 scopus 로고
    • Differential effects of frontal lobe disease
    • Benton AL (1968) Differential effects of frontal lobe disease. Neuropsychologia 6:53-60
    • (1968) Neuropsychologia , vol.6 , pp. 53-60
    • Benton, A.L.1
  • 10
    • 0029023964 scopus 로고
    • Contrasting effects of clonidine and diazepam on tests of working memory and planning
    • Coull JT, Middleton HC, Robbins TW, Sahakian BJ (1995a) Contrasting effects of clonidine and diazepam on tests of working memory and planning. Psychopharmacology 120:311-321
    • (1995) Psychopharmacology , vol.120 , pp. 311-321
    • Coull, J.T.1    Middleton, H.C.2    Robbins, T.W.3    Sahakian, B.J.4
  • 11
    • 0029057070 scopus 로고
    • Clonidine and diazepam have differential effects on tests of attention and learning
    • Coull JT, Middleton HC, Robbins TW, Sahakian BJ (1995b) Clonidine and diazepam have differential effects on tests of attention and learning. Psychopharmacology 120:322-332
    • (1995) Psychopharmacology , vol.120 , pp. 322-332
    • Coull, J.T.1    Middleton, H.C.2    Robbins, T.W.3    Sahakian, B.J.4
  • 13
    • 0023182579 scopus 로고
    • 2-adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline (as measured by in vivo dialysis) in the rat
    • 2-adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline (as measured by in vivo dialysis) in the rat. J Pharmacol Exp Ther 241:642-649
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 642-649
    • Dennis, T.1    L'Heureux, R.2    Carter, C.3    Scatton, B.4
  • 14
    • 0028214582 scopus 로고
    • Imidazoline receptors, non-adrenergic idazoxan binding sites and alpha-2 adrenoceptors in the human central nevous system
    • De Vos H, Bricca G, De Keyser J, De Backer JP, Bousquet P, Vauquelin G (1994) Imidazoline receptors, non-adrenergic idazoxan binding sites and alpha-2 adrenoceptors in the human central nevous system. Neuroscience 59:589-598
    • (1994) Neuroscience , vol.59 , pp. 589-598
    • De Vos, H.1    Bricca, G.2    De Keyser, J.3    De Backer, J.P.4    Bousquet, P.5    Vauquelin, G.6
  • 15
    • 0024845352 scopus 로고
    • Impaired extradimensional shift performance in medicated and unmedicated Parkinson's disease: Evidence for a specific attentional dysfunction
    • Downes JJ, Roberts AC, Sahakian BJ, Evenden JL, Morris RG, Robbins TW (1989) Impaired extradimensional shift performance in medicated and unmedicated Parkinson's disease: evidence for a specific attentional dysfunction. Neuropsychologia 27:1329-1344
    • (1989) Neuropsychologia , vol.27 , pp. 1329-1344
    • Downes, J.J.1    Roberts, A.C.2    Sahakian, B.J.3    Evenden, J.L.4    Morris, R.G.5    Robbins, T.W.6
  • 17
    • 0027265505 scopus 로고
    • Neuropsychological findings in frontal lobe dementia
    • Elfgren C, Passant U, Risberg J (1993) Neuropsychological findings in frontal lobe dementia. Dementia 4:214-219
    • (1993) Dementia , vol.4 , pp. 214-219
    • Elfgren, C.1    Passant, U.2    Risberg, J.3
  • 19
    • 0016823810 scopus 로고
    • "Mini-Mental State": A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR (1975) "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 22
    • 0023636736 scopus 로고
    • The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action
    • Frith CD (1987) The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychol Med 17:631-648
    • (1987) Psychol Med , vol.17 , pp. 631-648
    • Frith, C.D.1
  • 23
    • 0017667820 scopus 로고
    • Memory formation: Evidence for a specific neurochemical system in the amygdala
    • Gallagher M, Kapp BS, Musty RE, Driscoll PA (1977) Memory formation: evidence for a specific neurochemical system in the amygdala. Science 198:423-425
    • (1977) Science , vol.198 , pp. 423-425
    • Gallagher, M.1    Kapp, B.S.2    Musty, R.E.3    Driscoll, P.A.4
  • 25
    • 0027742968 scopus 로고
    • Dementia of frontal type and the focal lobar atrophies
    • Gregory CA, Hodges JR (1993) Dementia of frontal type and the focal lobar atrophies. Int Rev Psychiatry 5:397-406
    • (1993) Int Rev Psychiatry , vol.5 , pp. 397-406
    • Gregory, C.A.1    Hodges, J.R.2
  • 26
    • 0027272449 scopus 로고
    • Clinical picture of frontal lobe degeneration of non-Alzheimer type
    • Gustafson L (1993) Clinical picture of frontal lobe degeneration of non-Alzheimer type. Dementia 4:143-148
    • (1993) Dementia , vol.4 , pp. 143-148
    • Gustafson, L.1
  • 27
    • 0026733220 scopus 로고
    • Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease
    • Jones GMM, Sahakian BJ, Levy R, Warburton DM, Gray JA (1992) Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology 108:485-494
    • (1992) Psychopharmacology , vol.108 , pp. 485-494
    • Jones, G.M.M.1    Sahakian, B.J.2    Levy, R.3    Warburton, D.M.4    Gray, J.A.5
  • 28
    • 0026695552 scopus 로고
    • Dose-response relationships for oral idazoxan effects in healthy human subjects: Comparison with oral yohimbine
    • Krystal JH, McDougle CJ, Woods SW, Price LH, Heninger GR, Charney DS (1992) Dose-response relationships for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine. Psychopharmacology 108:313-319
    • (1992) Psychopharmacology , vol.108 , pp. 313-319
    • Krystal, J.H.1    McDougle, C.J.2    Woods, S.W.3    Price, L.H.4    Heninger, G.R.5    Charney, D.S.6
  • 29
    • 0019192903 scopus 로고
    • Recent developments in noradrenergic neurotransmission and its relevance to the mechanism of action of certain antihypertensive agents
    • Langer SZ, Cavero I, Massinham R (1980) Recent developments in noradrenergic neurotransmission and its relevance to the mechanism of action of certain antihypertensive agents. Hypertension 2:372-382
    • (1980) Hypertension , vol.2 , pp. 372-382
    • Langer, S.Z.1    Cavero, I.2    Massinham, R.3
  • 30
    • 0023150624 scopus 로고
    • Schizophrenic syndromes, cognitive performance and neurological dysfunction
    • Liddle PF (1987) Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychol Med 17:49-57
    • (1987) Psychol Med , vol.17 , pp. 49-57
    • Liddle, P.F.1
  • 33
    • 0022588255 scopus 로고
    • Cognitive enhancement in Korsakoff's pyschosis by clonidine: A comparison with L-dopa and ephedrine
    • Mair RG, McEntee WJ (1986) Cognitive enhancement in Korsakoff's pyschosis by clonidine: a comparison with L-dopa and ephedrine. Psychopharmacology 88:374-380
    • (1986) Psychopharmacology , vol.88 , pp. 374-380
    • Mair, R.G.1    McEntee, W.J.2
  • 34
    • 0028209903 scopus 로고
    • Clonidine-induced changes in the spectral distribution of heart-rate variability correlate with performance on a test of sustained attention
    • Middleton HC, Coull JT, Sahakian BJ, Robbins TW (1994) Clonidine-induced changes in the spectral distribution of heart-rate variability correlate with performance on a test of sustained attention. J Psychopharmacol 8:1-7
    • (1994) J Psychopharmacol , vol.8 , pp. 1-7
    • Middleton, H.C.1    Coull, J.T.2    Sahakian, B.J.3    Robbins, T.W.4
  • 35
    • 0001894547 scopus 로고
    • Some effects of frontal lobectomy in man
    • Warren JM, Akert K (eds) McGraw-Hill, New York
    • Milner B (1964) Some effects of frontal lobectomy in man. In: Warren JM, Akert K (eds) The frontal granular crotex and behaviour. McGraw-Hill, New York, pp 313-331
    • (1964) The Frontal Granular Crotex and Behaviour , pp. 313-331
    • Milner, B.1
  • 39
    • 0025737761 scopus 로고
    • Dementia of frontal lobe type
    • Orrell MW, Sahakian BJ (1991) Dementia of frontal lobe type. Psychol Med 21:553-556
    • (1991) Psychol Med , vol.21 , pp. 553-556
    • Orrell, M.W.1    Sahakian, B.J.2
  • 41
    • 4243962391 scopus 로고
    • Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man
    • in press
    • Owen AM, Morris RG, Sahakian BJ, Polkey CE, Robbins TW (1995a) Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man. Brain (in press)
    • (1995) Brain
    • Owen, A.M.1    Morris, R.G.2    Sahakian, B.J.3    Polkey, C.E.4    Robbins, T.W.5
  • 42
    • 0028945150 scopus 로고
    • Visuo-spatial short-term recognition memory and learning after temporal lobe excisoins, frontal lobe excisions or amygdalohippocampectomy in man
    • Owen AM, Sahakian BJ, Semple J, Polkey CE, Robbins TW (1995b) Visuo-spatial short-term recognition memory and learning after temporal lobe excisoins, frontal lobe excisions or amygdalohippocampectomy in man. Neuropsychologia 33:1-24
    • (1995) Neuropsychologia , vol.33 , pp. 1-24
    • Owen, A.M.1    Sahakian, B.J.2    Semple, J.3    Polkey, C.E.4    Robbins, T.W.5
  • 43
    • 0021165674 scopus 로고
    • Cortical noradrenaline, attention and arousal
    • Robbins TW (1984) Cortical noradrenaline, attention and arousal. Psychol Med 14:13-21
    • (1984) Psychol Med , vol.14 , pp. 13-21
    • Robbins, T.W.1
  • 44
    • 0023216837 scopus 로고
    • Cholinergic effects on constructional abilities and on mnemonic processes: A case report
    • Sahakian BJ, Joyce E, Lishman WA (1987) Cholinergic effects on constructional abilities and on mnemonic processes: a case report. Psychol Med 17:329-333
    • (1987) Psychol Med , vol.17 , pp. 329-333
    • Sahakian, B.J.1    Joyce, E.2    Lishman, W.A.3
  • 45
    • 0023904094 scopus 로고
    • A comparative study of visuospatial memory and learning in Alzheimer type dementia and Parkinson's disease
    • Sahakian BJ, Morris RGM, Evenden JL, Heald A, Levy R, Philpot M, Robbins TW (1988) A comparative study of visuospatial memory and learning in Alzheimer type dementia and Parkinson's disease. Brain 111:695-718
    • (1988) Brain , vol.111 , pp. 695-718
    • Sahakian, B.J.1    Morris, R.G.M.2    Evenden, J.L.3    Heald, A.4    Levy, R.5    Philpot, M.6    Robbins, T.W.7
  • 46
    • 0024385514 scopus 로고
    • The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type
    • Sahakian BJ, Jones GMM, Levy R, Gray JA, Warburton DM (1989) The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type Br J Psychiatry 154:797-800
    • (1989) Br J Psychiatry , vol.154 , pp. 797-800
    • Sahakian, B.J.1    Jones, G.M.M.2    Levy, R.3    Gray, J.A.4    Warburton, D.M.5
  • 47
    • 0027526076 scopus 로고
    • Further analysis of the cognitive effects of tetrahydroaminoacradine (THA) in Alzheimer's disease: Assessment of attentional and mnemonic function using CANTAB
    • Sahakian BJ, Owen AM, Morant NJ, Eagger SA, Boddington S, Crayton L, Crockford HA, Crooks M, Levy R (1993) Further analysis of the cognitive effects of tetrahydroaminoacradine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB. Psychopharmacology: 110:395-401
    • (1993) Psychopharmacology , vol.110 , pp. 395-401
    • Sahakian, B.J.1    Owen, A.M.2    Morant, N.J.3    Eagger, S.A.4    Boddington, S.5    Crayton, L.6    Crockford, H.A.7    Crooks, M.8    Levy, R.9
  • 48
    • 0023081892 scopus 로고
    • Some limitations of indices derived from signal detection theory: Evaluation of an alternative index for measuring bias in memory tasks
    • Sahgal A (1987) Some limitations of indices derived from signal detection theory: evaluation of an alternative index for measuring bias in memory tasks. Psychopharmacology 91: 517-520
    • (1987) Psychopharmacology , vol.91 , pp. 517-520
    • Sahgal, A.1
  • 51
    • 0020490787 scopus 로고
    • Specific impairments in planning
    • Shallice T (1982) Specific impairments in planning. Philos Trans R Soc Lond B298:199-209
    • (1982) Philos Trans R Soc Lond , vol.B298 , pp. 199-209
    • Shallice, T.1
  • 52
    • 0026806215 scopus 로고
    • 2-adrenoceptor antagonist idazoxan on mood, memory and attention in normal volunteers
    • 2-adrenoceptor antagonist idazoxan on mood, memory and attention in normal volunteers. J Psychopharmacol 6:376-381
    • (1992) J Psychopharmacol , vol.6 , pp. 376-381
    • Smith, A.P.1    Wilson, S.J.2    Glue, P.3    Nutt, D.J.4
  • 53
    • 0016441432 scopus 로고
    • Memory enhancement by central administration of norepinephrine
    • Stein L, Belluzzi JD, Wise CD (1975) Memory enhancement by central administration of norepinephrine. Brain Res 84:329-335
    • (1975) Brain Res , vol.84 , pp. 329-335
    • Stein, L.1    Belluzzi, J.D.2    Wise, C.D.3
  • 57
    • 0027381618 scopus 로고
    • The diagnostic utility of savings scores: Differentiating Alzheimer's and Huntington's disease with the logical memory and visual reproduction tests
    • Troster AI, Butters N, Salmon DP, Cullum CM, Jacobs D, Brandt J, White RF (1993) The diagnostic utility of savings scores: differentiating Alzheimer's and Huntington's disease with the logical memory and visual reproduction tests. J Clin Exp Neuropsychol 15:773-788
    • (1993) J Clin Exp Neuropsychol , vol.15 , pp. 773-788
    • Troster, A.I.1    Butters, N.2    Salmon, D.P.3    Cullum, C.M.4    Jacobs, D.5    Brandt, J.6    White, R.F.7
  • 59
    • 0038218463 scopus 로고
    • The Psychological Corporation, Harcourt Brace Jovanovich, New York
    • Wechsler D (1987) Wechsler memory scale - revised. The Psychological Corporation, Harcourt Brace Jovanovich, New York
    • (1987) Wechsler Memory Scale - Revised
    • Wechsler, D.1
  • 60
    • 0021363544 scopus 로고
    • Effects of scopolamine and nicotine on human rapid information processing performance
    • Wesnes K, Warburton DM (1984) Effects of scopolamine and nicotine on human rapid information processing performance. Psychopharmacology 82:147-150
    • (1984) Psychopharmacology , vol.82 , pp. 147-150
    • Wesnes, K.1    Warburton, D.M.2
  • 63
    • 0022651275 scopus 로고
    • Electrophysiologic evidence of increased distractability after dorsolateral prefrontal lesions
    • Woods DL, Knight RT (1986) Electrophysiologic evidence of increased distractability after dorsolateral prefrontal lesions. Neurology 36:212-216
    • (1986) Neurology , vol.36 , pp. 212-216
    • Woods, D.L.1    Knight, R.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.