Heterogeneous ligand-mediated Ca++ responses at wt and mutant α(2A)- adrenoceptors suggest multiple ligand activation binding sites at the α(2A)- adrenoceptor

Neuropharmacology

Volumn 39, Issue 11, 2000, Pages 2101-2111

  Pauwels, P J ^a   Colpaert, F C ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Ca++ response; Differential signalling; Intrinsic ligand activity; Mutagenesis; Recombinant human (2A) AR

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 2 (2 ETHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ATIPAMEZOLE; BRIMONIDINE; CALCIUM; CLONIDINE; DELEQUAMINE; DEXEFAROXAN; IDAZOXAN; LIGAND; MEDETOMIDINE; OXYMETAZOLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; DRUG RESPONSE; HUMAN; LIGAND BINDING; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CALCIUM SIGNALING; CHO CELLS; CRICETINAE; HUMANS; IDAZOXAN; LIGANDS; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 0033837404     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00040-X     Document Type: Article

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