a-Adrenoreceptor Reagents. 3.1, 2Synthesis of Some 2-Substituted 1, 4-Benzodioxans as Selective Presynaptic α2-Adrenoreceptor Antagonists

Journal of Medicinal Chemistry

Volumn 28, Issue 8, 1985, Pages 1054-1062

  Stillings, Michael R ^a   Chapleo, Christopher B ^a   Butler, Richard C M ^a   Davis, J Alfred ^a   England, C David ^a   Myers, Malcolm ^a   Myers, Peter L ^a   Tweddle, Neil ^a   Welbourn, Anthony P ^a   Doxey, John C ^a   Smith, Colin F C ^a  

^a Reckitt & Colman   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; BRIMONIDINE; CLONIDINE; IDAZOXAN; IDAZOXAN DERIVATIVE; NEW DRUG; NORADRENALIN; PHENYLEPHRINE; PRESYNAPTIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANOCOCCYGEUS MUSCLE; ARTICLE; BIOLOGICAL MODEL; DOSE RESPONSE; DRUG ANALYSIS; DRUG ANTAGONISM; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; GREAT BLOOD VESSEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE GENITAL SYSTEM; MOUSE; MUSCLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; VAS DEFERENS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DIOXANES; DIOXINS; IDAZOXAN; MALE; MICE; MUSCLE CONTRACTION; RATS; RATS, INBRED STRAINS; RECEPTORS, ADRENERGIC, ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPSES; VAS DEFERENS;

EID: 0021865411     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00146a013     Document Type: Article

References (11)

1. Part 1: Chapleo, C. B.; Myers, P. L.; Butler, R. C. M.; Doxey, J. C.; Roach, A. G.; Smith, C. F. C. J. Med. Chem. 1983, 26, 823.
2. Part 2: Chapleo, C. B.; Myers, P. L.; Butler, R. C. M.; Davis, J. A.; Doxey, J. C.; Higgins, S. D.; Myers, M.; Roach, A. G.; Smith, C. F. C.; Stillings, M. R.; Welbourn, A. P. J. Med. Chem. 1984, 27, 570.
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