Synthesis and pharmacological characterization of A-80426: A putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition

Bioorganic and Medicinal Chemistry Letters

Volumn 5, Issue 19, 1995, Pages 2287-2292

  Meyer, Michael D ^a   Hancock, Arthur A ^a   Tietje, Karin ^a   Sippy, kevin B ^a   Giardina, William J ^a   Kerwin Jr , James F ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A 80426; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; DOPAMINE; FLUOXETINE; N [2 (6 BENZOFURANYL)ETHYL] N METHYL N (1,2,3,4 TETRAHYDRO 5 METHOXY 1 NAPHTHYLMETHYL)AMINE; NORADRENALIN; PAROXETINE; RAUWOLSCINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

AMINE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN CORTEX; CONTROLLED STUDY; DEPRESSION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIVER; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STEREOCHEMISTRY;

EID: 0028863081     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(95)00398-D     Document Type: Article

References (19)

1. Functional evidence for subsensitivity of noradrenergic α2 receptors after chronic desipramine treatment
2. A-80426, a potent and selective ?2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile
3. Influence of the new 5-HT-uptake inhibitor paroxetine on hypermotility in rats produced by p-chloroamphetamine (PCA) and 4,?-dimethyl-m-tyramine (H 77/77)