Oral rehydration therapy: New explanations for an old remedy

Annual Review of Physiology

Volumn 66, Issue , 2004, Pages 385-417

  Rao, Mrinalini C ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Chloride secretion; Diarrhea; Glucose; Short chain fatty acid; Sodium absorption

Indexed keywords

ANTIBIOTIC AGENT; CHLORIDE CHANNEL; ENTEROTOXIN; PREBIOTIC AGENT; PROBIOTIC AGENT; SHORT CHAIN FATTY ACID; SODIUM CHLORIDE; SUGAR; VACCINE;

CHLORIDE TRANSPORT; CHOLERA; COLON; DIARRHEA; FATTY ACID TRANSPORT; GLUCOSE TRANSPORT; HUMAN; INTESTINE FLUID; ION TRANSPORT; MICROFLORA; MORTALITY; NONHUMAN; ORAL REHYDRATION THERAPY; PRIORITY JOURNAL; REVIEW; ROTAVIRUS; SIGNAL TRANSDUCTION; SMALL INTESTINE ABSORPTION; TRADITIONAL MEDICINE; TRAVELLER DIARRHEA; WATER TRANSPORT; ANIMAL; BODY FLUID; FLUID THERAPY; INFECTION; INTESTINE; METABOLISM; MICROBIOLOGY;

ANIMALS; BODY FLUIDS; DIARRHEA; FLUID THERAPY; HUMANS; INFECTION; INTESTINES;

EID: 2342559299     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.66.032902.134726     Document Type: Review

References (163)

1. Farthing MJ. 2002. Oral rehydration: an evolving solution. J. Pediatr. Gastroenterol. Nutr. 34 (Suppl. 1):S64-67
2. Greenough WB 3rd, Khin-Maung-U. 1991. Oral rehydration therapy. In Diarrheal Diseases; Current Topics in Gastroenterology, ed. M Field, pp. 485-500. New York: Elsevier
3. Snow J. 1855. On the mode of communication of cholera. London: Churchill. 139 pp.
4. Editorial series. 1978. Water with sugar and salt. Lancet 2:300-1
5. Guarino A, Albano F, Guandalini S, et al. 2001. Oral rehydration: toward a real solution. J. Pediatr. Gastroenterol. Nutr. 33(Suppl. 2):S2-12
6. Thillainayagam AV, Hunt JB, Farthing MJ. 1998. Enhancing clinical efficacy of oral rehydration therapy: Is low osmolality the key? Gastroenterology 114:197-210
7. Dwivedi L, ed. 1999. Uttaratantrum. In Suśruta Samhita: Kalpasthana-Uttartantra, III:370-409. Varanasi, India: Chowkhamba (transl. KK Bhishagratna)
8. Farnsworth NR, Bunyapraphatsara, N. 1992. Thai Medicinal Plants: Recommended for Primary Health Care System. Bangkok, Thail.: Med. Plant Inf. Cent., Mahidol Univ. 402 pp.
9. Rolston DK. 1990. Oral rehydration therapy in developing countries. In Textbook of Secretory Diarrhea, ed. E Lebenthal, ME Duffey, pp. 371-82. New York: Raven
10. Ramanna M. 2002. Western Medicine and Public Health in Colonial Bombay 1845-1895. Chapter 4, Coping With Diseases, pp. 123-61. New Dehli: Orient Longman. 270 pp.
11. Colwell RR, Huq A, Islam MS, Aziz KM, Yunus M, et al. 2003. Reduction of cholera in Bangladeshi villages by simple filtration. Proc. Natl. Acad. Sci. USA 100:1051-55
12. 11a. Ghishan FK. 1990. Oral rehydration solutions. In Textbook of Secretory Diarrhea, ed. E Lebenthal, ME Duffey, pp. 365-70. New York: Raven
13. Field M. 1974. Intestinal secretion. Gastroenterology 66:1063-84
14. Reuss L. 2000. One-hundred years of inquiry: the mechanism of glucose absorption in the intestine. Annu. Rev. Physiol. 62:939-46
15. Field M. 2003. Intestinal ion transport and the pathophysiology of diarrhea. J. Clin. Invest. 111:931-43
16. Pierce NF, Banwell JG, Rupak DM, Mitra RC, Caranasos GJ, et al. 1968. Effect of intragastric glucose-electrolyte infusion upon water and electrolyte balance in Asiatic cholera. Gastroenterology 55:333-43
17. Hirschhorn N, Kinzie JL, Sachar DB, Northrup RS, Taylor JO, et al. 1968. Decrease in net stool output in cholera during intestinal perfusion with glucose-containing solutions. N. Engl. J. Med. 279:176-81
18. http://www.who.int/child-adolescent-health. 2002
19. http://www.icddrb.org. 2003
20. Victora CG, Bryce J, Fontaine O, Monasch R. 2000. Reducing deaths from diarrhoea through oral rehydration therapy. Bull. World Health Organ. 78:1246-55
21. Greenough WB 3rd. 1980. Oral replacement therapy in diarrhea: consensus and controversy. In Secretory Diarrhea, ed. M Field, JS Fordtran, SG Schultz, pp. 179-85. Baltimore: Am. Physiol. Soc.
22. Guandalini S. 2002. The treatment of acute diarrhea in the third millennium: a pediatrician's perspective. Acta Gastroenterol. Belg. 65:33-36
23. Davidson G, Barnes G, Bass D, Cohen M, Fasano A, et al. 2002. Infectious diarrhea in children: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J. Pediatr. Gastroenterol. Nutr. 35(Suppl. 2):S143-50
24. International Study Group Reduced-Osmolarity ORS Solutions. 1995. Multicentre evaluation of reduced-osmolarity oral rehydration salts solution. Lancet 345:282-85
25. 23a. Hirschhorn N, Nalin DR, Cash RA, Greenough WB 3rd. 2002. Formulation of oral rehydration solution. Lancet 360:340-41
26. Gore SM, Fontaine O, Pierce NF. 1992. Impact of rice based oral rehydration solution on stool output and duration of diarrhoea: meta-analysis of 13 clinical trials. Brit. Med. J. 304:287-91
27. Dutta D, Bhattacharya MK, Deb AK, Sarkar D, Chatterjee A, et al. 2000. Evaluation of oral hypo-osmolar glucose-based and rice-based oral rehydration solutions in the treatment of cholera in children. Acta Paediatr. 89:787-90
28. Fayad IM, Hashem M, Duggan C, Refat M, Bakir M, et al. 1993. Comparative efficacy of rice-based and glucose-based oral rehydration salts plus early reintroduction of food. Lancet 342:772-75
29. Ramakrishna BS, Venkataraman S, Srinivasan P, Dash P, Young GP, Binder HJ. 2000. Amylase-resistant starch plus oral rehydration solution for cholera. N. Engl. J. Med. 342:308-13
30. Rabbani GH, Teka T, Zaman B, Majid N, Khatun M, Fuchs GJ. 2001. Clinical studies in persistent diarrhea: dietary management with green banana or pectin in Bangladeshi children. Gastroenterology 121:554-60
31. Alam NH, Meier R, Schneider H, Sarker SA, Bardhan PK, et al. 2000. Partially hydrolyzed guar gum-supplemented oral rehydration solution in the treatment of acute diarrhea in children. J. Pediatr. Gastroenterol. Nutr. 31:503-7
32. Rao MC. 2000. Absorption and secretion of water and electrolytes. In Small Bowel Disorders, ed. RN Ratnaike, pp. 116-33. New York: Arnold/Oxford Univ. Press
33. Chang EB, Rao MC. 1994. Intestinal water and electrolyte transport. In Physiology of the Gastrointestinal Tract, ed. LR Johnson, DH Alpers, J Christensen, ED Jacobson, JH Walsh, 2:2028-81. New York: Raven
34. Kunzelmann K, Mall M. 2002. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol. Rev. 82:245-89
35. Greger R. 2000. Role of CFTR in the colon. Annu. Rev. Physiol. 62:467-91
36. Barrett KE, Keely SJ. 2000. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu. Rev. Physiol. 62:535-72
37. Venkatasubramanian J, Sahi J, Rao MC. 2000. Ion transport during growth and differentiation. Ann. NY Acad. Sci. 915:357-72
38. Pacha J. 2000. Development of intestinal transport function in mammals. Physiol. Rev. 80:1633-67
39. Hooper LV, Midtvedt T, Gordon JI. 2002. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu. Rev. Nutr. 22:283-307
40. + exchanger. J. Biol. Chem. 277:9668-75
41. + exchange near the base of mouse colonic crypts. Am. J. Physiol. Cell Physiol. 283:C358-72
42. Fasano A. 2002. Toxins and the gut: role in human disease. Gut 50(Suppl. 3):9-14
43. Berkes J, Viswanathan VK, Savkovic SD, Hecht G. 2003. Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut 52:439-51
44. Edidin M. 2003. The state of lipid rafts: from model membranes to cells. Annu. Rev. Biophys. Biomol. Struct. 16:16
45. Dorn GW II, Mochly-Rosen D. 2002. Intracellular transport mechanisms of signal transducers. Annu. Rev. Physiol. 64:407-29
46. Jilling T, Kirk KL. 1997. The biogenesis, traffic, and function of the cystic fibrosis transmembrane conductance regulator. Int. Rev. Cytol. 172:193-241
47. Frizzell RA, Quinton PM, Sheppard DN, Welsh MJ, Dawson DC, et al. 1990. Ten years with CFTR. 1999. Physiol. Rev. 79(Suppl. 1):S1-S246
48. Rao MC, deJonge HR. 1990. Ca and phospholipid-dependent protein kinases. In Textbook of Secretory Diarrhea, ed. E Lebenthal, M Duffey, pp. 209-32. New York: Raven
49. deJonge HR, Rao MC. 1990. Cyclic nucleotide-dependent kinases. See Ref. 46, pp. 191-207
50. Mitic LL, Van Itallie CM, Anderson JM. 2000. Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins. Am. J. Physiol. Gastrointest. Liver Physiol. 279:G250-54
51. Cereijido M, Shoshani L, Contreras RG. 2000. Molecular physiology and pathophysiology of tight junctions. I. Biogenesis of tight junctions and epithelial polarity. Am. J. Physiol. Gastrointest Liver Physiol. 279:G477-82
52. Nusrat A, Turner JR, Madara JL. 2000. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am. J. Physiol. Gastrointest Liver Physiol. 279:G851-57
53. Field M, Semrad CE. 1993. Toxigenic diarrheas, congenital diarrheas, and cystic fibrosis: disorders of intestinal ion transport. Annu. Rev. Physiol. 55:631-55
54. +-ATPase. J. Clin. Invest. 110:1739-47
55. Haas M, Forbush B 3rd. 2000. The NaK-Cl cotransporter of secretory epithelia. Annu. Rev. Physiol. 62:515-34
56. +-Cl- cotransporter. Mol. Endocrinol. 14:2054-65
57. Flagella M, Clarke LL, Miller ML, Erway LC, Giannella RA, et al. 1999. Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. J. Biol. Chem. 274: 26946-55
58. Soleimani M, Ulrich CD 2nd. 2000. How cystic fibrosis affects pancreatic ductal bicarbonate secretion. Med. Clin. N. Am. 84:641-55
59. - cotransporter NKCCl in the normal and CFTR-deficient murine colon. J. Physiol. 549:525-36
60. Ameen NA, Martensson B, Bourguinon L, Marino C, Isenberg J, McLaughlin GE. 1999. CFTR channel insertion to the apical surface in rat duodenal villus epithelial cells is upregulated by VIP in vivo. J. Cell Sci. 112:887-94
61. - channels: a newly emerging anion transport family. News Physiol. Sci. 15:165-71
62. Jentsch TJ, Stein V, Weinreich F, Zdebik AA. 2002. Molecular structure and physiological function of chloride channels. Physiol. Rev. 82:503-68
63. Lipecka J, Bali M, Thomas A, Fanen P, Edelman A, Fritsch J. 2002. Distribution of ClC-2 chloride channel in rat and human epithelial tissues. Am. J. Physiol. Cell Physiol. 282:C805-16
64. Alrefai WA, Tyagi S, Mansour F, Saksena S, Syed I, et al. 2001. Sulfate and chloride transport in Caco-2 cells: differential regulation by thyroxine and the possible role of DRA gene. Am. J. Physiol. Gastrointest. Liver Physiol. 280:G603-13
65. - exchange in rabbit, rat, and human duodenum. Gastroenterology 122:709-24
66. - exchanger in the small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 282:G573-79
67. - secretion. J. Physiol. 505:411-23
68. Musch M, Arvans D, Field M, Wu G, Chang E. 2003. DRA is an apical intestinal anion exchanger functionally coupled to NHE2 and NHE3 to mediate electroneutral NaCl absorption. Gastroenterology 124:299(A-40)
69. + exchangers. J. Biol. Chem. 275:1-4
70. + exchangers. Physiol. Rev. 77:51-74
71. Gawenis LR, Stien X, Shull GE, Schultheis PJ, Woo AL, et al. 2002. Intestinal NaCl transport in NHE2 and NHE3 knockout mice. Am. J. Physiol. Gastrointest. Liver Physiol. 282:G776-84
72. + exchange expression and activity in region- and tissue-specific manner. Am. J. Physiol. Cell Physiol. 267:C796-803
73. Musch MW, Bookstein C, Rocha F, Lucioni A, Ren H, et al. 2002. Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection. Am. J. Physiol. Gastrointest. Liver Physiol. 283:G975-85
74. + exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3. J. Physiol. 537:537-52
75. Lamprecht G, Weinman EJ, Yun CH. 1998. The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3. J. Biol. Chem. 273:29972-78
76. + exchange. Biochemistry 41:12336-42
77. Binder HJ, Sandle GI. 1994. Electrolyte transport in the mammalian colon. See Ref. 31, pp. 2133-71
78. + exchanger. J. Biol. Chem. 274:22855-61
79. Naftalin RJ, Pedley KC. 1999. Regional crypt function in rat large intestine in relation to fluid absorption and growth of the pericryptal sheath. J. Physiol. 514:211-27
80. Matkowskyj KA, Danilkovich A, Marrero J, Savkovic SD, Hecht G, Benya RV. 2000. Galanin-1 receptor up-regulation mediates the excess colonic fluid production caused by infection with enteric pathogens. Nat. Med. 6:1048-51
81. Reidl J, Klose KE. 2002. Vibrio cholerae and cholera: out of the water and into the host. FEMS Microbiol. Rev. 26:125-39
82. Sougioultzis S, Pothoulakis C. 2003. Bacterial infections: small intestine and colon. Curr. Opin. Gastroenterol. 19:23-30
83. Lencer WI. 2001. Microbes and microbial toxins: paradigms for microbial-mucosal toxins. V. cholera: invasion of the intestinal epithelial barrier by a stably folded protein toxin. Am. J. Physiol. Gastrointest. Liver Physiol. 280:G781-86
84. Lundgren O. 2002. Enteric nerves and diarrhoea. Pharmacol. Toxicol. 90:109-20
85. Nocerino A, Iafusco M, Guandalini S. 1995. Cholera toxin-induced small intestinal secretion has a secretory effect on the colon of the rat. Gastroenterology 108:34-39
86. Fasano A. 2001. Intestinal zonulin: open sesame! Gut 49:159-62
87. Rao MC, Guandalini S, Laird WJ, Field M. 1979. Effects of heat-stable enterotoxin of Yersinia enterocolitica on ion transport and cyclic guanosine 3′,5′-monophosphate metabolism in rabbit ileum. Infect. Immun. 26:875-78
88. Rao MC. 1985. Toxins which activate guanylate cyclase: heat-stable enterotoxins. Ciba Found. Symp. 112:74-93
89. Vaandrager AB. 2002. Structure and function of the heat-stable enterotoxin receptor/guanylyl cyclase C. Mol. Cell. Biochem. 230:73-83
90. Selvaraj NG, Prasad R, Goldstein JL, Rao MC. 2000. Evidence for the presence of cGMP-dependent protein kinase-II in human distal colon and in T84, the colonie cell line. Biochim. Biophys. Acta 1498:32-43
91. Scott RO, Thelin WR, Milgram SL. 2002. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. J. Biol. Chem. 277:22934-41
92. Field M, Rao MC, Chang EB. 1989. Intestinal electrolyte transport and diarrheal disease. N. Engl. J. Med. 321:800-6, 79-83
93. Lucas ML. 2001. A reconsideration of the evidence for Escherichia coli STa (heat stable) enterotoxin-driven fluid secretion: a new view of STa action and a new paradigm for fluid absorption. J. Appl. Microbiol. 90:7-26
94. Menard LP, Dubreuil JD. 2002. Enteroaggregative Escherichia coli heat-stable enterotoxin 1 (EAST1): a new toxin with an old twist. Crit. Rev. Microbiol. 28:43-60
95. Morris AP, Estes MK. 2001. Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VIII. Pathological consequences of rotavirus infection and its enterotoxin. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G303-10
96. - influx into intestinal crypts of CF mice. Am. J. Physiol. Gastrointest. Liver Physiol. 277:G431-44
97. Alpers DH. 1994. Digestion and absorption of carbohydrates and proteins. See Ref. 31, pp. 1723-49
98. Henning S, Rubin D, Shulman R. 1994. Ontogeny of the intestinal mucosa. See Ref. 31, pp. 571-610
99. Daniel H. 2004. Molecular and integrative absorption. Annu. Rev. Physiol. 66: In press
100. Wright EM, Hirayama BA, Loo DDF, Turk E, Hager K. 1994. Intestinal sugar transport. See Ref. 31, pp. 1751-72
101. +/glucose cotransporter. Acta Physiol. Scand. Suppl. 643:257-64
102. Wright EM, Turk E, Martin MG. 2002. Molecular basis for glucose-galactose malabsorption. Cell Biochem. Biophys. 36:115-21
103. Cheeseman CI. 2002. Intestinal hexose absorption: transcellular or paracellular fluxes. J. Physiol. 544:336
104. Kellett GL. 2001. The facilitated component of intestinal glucose absorption. J. Physiol. 531:585-95
105. Ferraris RP. 2001. Dietary and developmental regulation of intestinal sugar transport. Biochem. J. 360:265-76
106. Field M. 1971. Ion transport in rabbit ileal mucosa. II. Effects of cyclic 3′,5′-AMP. Am. J. Physiol. 221:992-97
107. Field M, Fromm D, al-Awqati Q, Greenough WB 3rd. 1972. Effect of cholera enterotoxin on ion transport across isolated ileal mucosa. J. Clin. Invest. 51:796-804
108. Guandalini S, Migliavacca M, de Campora E, Rubino A. 1982. Cyclic guanosine monophosphate effects on nutrient and electrolyte transport in rabbit ileum. Gastroenterology 83:15-21
109. Rabbani GH, Lu RB, Horvath K, Lebenthal E. 1991. Short-chain glucose polymer and anthracene-9-carboxylic acid inhibit water and electrolyte secretion induced by dibutyryl cyclic AMP in the small intestine. Gastroenterology 101:1046-53
110. Reuss L, Hirst BH. 2002. Water transport controversies - an overview. J. Physiol. 542.1:1-87
111. Spring KR. 1998. Routes and mechanism of fluid transport by epithelia. Annu. Rev. Physiol. 60:105-19
112. Agre P, King LS, Yasui M, Guggino WB, Ottersen OP, et al. 2002. Aquaporin water channels - from atomic structure to clinical medicine. J. Physiol. 542:3-16
113. Itoh A, Tsujikawa T, Fujiyama Y, Bamba T. 2003. Enhancement of aquaporin-3 by vasoactive intestinal polypeptide in a human colonic epithelial cell line. J. Gastroenterol. Hepatol. 18:203-10
114. Ma T, Verkman AS. 1999. Aquaporin water channels in gastrointestinal physiology. J. Physiol. 517:317-26
115. Wang KS, Ma T, Filiz F, Verkman AS, Bastidas JA. 2000. Colon water transport in transgenic mice lacking aquaporin-4 water channels. Am. J. Physiol. Gastrointest. Liver Physiol. 279:G463-70
116. Loo DD, Wright EM, Zeuthen T. 2002. Water pumps. J. Physiol. 542:53-60
117. +-glucose cotransporter. J. Physiol. 542:61-62
118. Cook SI, Sellin JH. 1998. Review article: short-chain fatty acids in health and disease. Aliment. Pharmacol. Ther. 12:499-507
119. Sellin JH. 1999. SCFAs: the enigma of weak electrolyte transport in the colon. News Physiol. Sci. 14:58-64
120. Said HM. 2004. Water-soluble vitamin absorption. Annu. Rev. Physiol. 66: In press
121. Russell JB, Rychlik JL. 2001. Factors that alter rumen microbial ecology. Science 292:1119-22
122. Roediger WE. 1980. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21:793-98
123. Xu J, Bjursell MK, Himrod J, Deng S, Carmichael LK, et al. 2003. A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science 299:2074-76
124. Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, Gordon JI. 2001. Molecular analysis of commensal host-microbial relationships in the intestine. Science 291:881-84
125. Charney AN, Dagher PC. 1996. Acid-base effects on colonic electrolyte transport revisited. Gastroenterology 111: 1358-68
126. Rajendran VM, Binder HJ. 2000. Characterization and molecular localization of anion transporters in colonic epithelial cells. Ann. NY Acad. Sci. 915:15-29
127. Maouyo D, Chu S, Montrose MH. 2000. pH heterogeneity at intracellular and extracellular plasma membrane sites in HT29-Cl cell monolayers. Am. J. Physiol. Cell Physiol. 278:C973-81
128. Tyagi S, Venugopalakrishnan J, Ramaswamy K, Dudeja PK. 2002. Mechanism of n-butyrate uptake in the human proximal colonic basolateral membranes. Am. J. Physiol. Gastrointest. Liver Physiol. 282:G676-82
129. Ritzhaupt A, Wood IS, Ellis A, Hosie KB, Shirazi-Beechey SP. 1998. Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. J. Physiol. 513:719-32
130. Hadjiagapiou C, Schmidt L, Dudeja PK, Layden TJ, Ramaswamy K. 2000. Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. Am. J. Physiol. Gastrointest. Liver Physiol. 279:G775-80
131. Binder HJ, Mehta P. 1989. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 96:989-96
132. Dagher PH, Egnor RW, Taglietta-Kohlbrecher A, Charney AN. 1996. Short-chain fatty acids inhibit cAMP-mediated chloride secretion in rat colon. Am. J. Physiol. Cell Physiol. 271:C1853-60
133. Resta-Lenert S, Truong F, Barrett KE, Eckmann L. 2001. Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity. Am. J. Physiol. Cell Physiol. 281:C1837-49
134. - secretory capacity by butyrate. J. Clin. Invest. 101:2072-79
135. Sellin J, Shelat H. 1996. Short-chain fatty acid (SCFA) volume regulation in proximal and distal rabbit colon is different. J. Membr. Biol. 150:83-88
136. Cherbut C, Ferrier L, Roze C, Anini Y, Blottiere H, et al. 1998. Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat. Am. J. Physiol.Gastrointest. Liver Physiol. 275:G1415-22
137. Musch MW, Bookstein C, Xie Y, Sellin JH, Chang EB. 2001. SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. Am. J. Physiol. Gastrointest. Liver Physiol. 280:G687-93
138. Harig JM, Soergel KH, Barry JA, Ramaswamy K. 1991. Transport of propionate by human ileal brush-border membrane vesicles. Am. J. Physiol. Gastrointest. Liver Physiol. 260:G776-82
139. Tappenden KA, Drozdowski LA, Thomson AB, McBurney MI. 1998. Short-chain fatty acid-supplemented total parenteral nutrition alters intestinal structure, glucose transporter 2 (GLUT2) mRNA and protein, and proglucagon mRNA abundance in normal rats. Am. J. Clin. Nutr. 68:118-25
140. Cuff MA, Lambert DW, Shirazi-Beechey SP. 2002. Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J. Physiol. 539:361-71
141. Bai L, Merchant JL. 2000. Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells. J. Biol. Chem. 275:30725-33
142. Ren H, Musch MW, Kojima K, Boone D, Ma A, Chang EB. 2001. Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells. Gastroenterology 121:631-39
143. Ferraris RP, Diamond J. 1997. Regulation of intestinal sugar transport. Physiol. Rev. 77:257-302
144. Selvaraj NG, Prasad R, Stephan B, Vidyasagar D, Rao MC. 1999. Segmental differences in cGMP signaling in rabbit colon is due to the cGMP protein kinase-II (PKG-II). Gastroenterology 116:G4040
145. - transport. Am. J. Physiol. Cell Physiol. 280:C646-58
146. Mathews CJ, MacLeod RJ, Zheng SX, Hanrahan JW, Bennett HP, Hamilton JR. 1999. Characterization of the inhibitory effect of boiled rice on intestinal chloride secretion in guinea pig crypt cells. Gastroenterology 116:1342-47
147. Gabriel SE, Davenport SE, Steagall RJ, Vimal V, Carlson T, Rozhon EJ. 1999. A novel plant-derived inhibitor of cAMP-mediated fluid and chloride secretion. Am. J. Physiol. Gastrointest. Liver Physiol. 276:G58-63
148. Oi H, Matsuura D, Miyake M, Ueno M, Takai I, et al. 2002. Identification in traditional herbal medications and confirmation by synthesis of factors that inhibit cholera toxin-induced fluid accumulation. Proc. Natl. Acad. Sci. USA 99:3042-46
149. Shanahan F. 2001. Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics. Gastroenterology 120:622-35
150. Vanderhoof JA, Young RJ. 1998. Use of probiotics in childhood gastrointestinal disorders. J. Pediatr. Gastroenterol. Nutr. 27:323-32
151. Fedorak RN, Madsen KL. 2000. Application of probiotics for GI diseases. Monograph
152. Fuller R, Gibson GR. 1997. Modification of the intestinal microflora using probiotics and prebiotics. Scand J. Gastroenterol. Suppl. 222:28-31
153. Guandalini S, Pensabene L, Zikri MA, Dias JA, Casali LG, et al. 2000. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial. J. Pediatr. Gastroenterol. Nutr. 30:54-60
154. Guandalini S, Gupta P. 2002. The role of probiotics in gastrointestinal disorders of infancy and childhood. In Infant Formula: Closer to the Reference, ed. NCR Raiha, F Rubaltelli, pp. 29-45. Philadelphia: Vevey/Lippincott, Williams & Wilkins
155. Gionchetti P, Rizzello F, Helwig U, Venturi A, Lammers KM, et al. 2003. Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 124: 1202-9
156. Madsen K, Cornish A, Soper P, McKaigney C, Jijon H, et al. 2001. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 121:580-91
157. Hogenauer C, Santa Ana CA, Porter JL, Fordtran JS. 2000. Discrepancies between effects of recombinant human growth hormone on absorption and secretion of water and electrolytes on the human jejunum compared to results reported on rat jejunum. Dig. Dis. Sci. 45:457-61
158. Farthing MJ. 2002. Novel targets for the control of secretory diarrhoea. Gut 50(Suppl. 3):15-18
159. Hogenauer C, Aichbichler B, Santa Ana C, Porter J, Fordtran J. 2002. Effect of octreotide on fluid absorption and secretion by the normal human jejunum and ileum in vivo. Aliment. Pharmacol. Ther. 16:769-77
160. Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, Gutierrez M. 2000. Racecadotril in the treatment of acute watery diarrhea in children. N. Engl. J. Med. 343:463-67
161. Galietta LJ, Springsteel MF, Eda M, Niedzinski EJ, By K, et al. 2001. Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavorte and benzoquinolizinium lead compounds. J. Biol. Chem. 276:19723-28
162. Galietta LV, Jayaraman S, Verkman AS. 2001. Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. Am. J. Physiol. Cell Physiol. 281:C1734-42
163. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, et al. 2002. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J. Clin. Invest. 110:1651-58