Aquaporin water channels - From atomic structure to clinical medicine

Journal of Physiology

Volumn 542, Issue 1, 2002, Pages 3-16

  Agre, Peter ^a   King, Landon S ^a   Yasui, Masato ^a   Guggino, Wm B ^a   Ottersen, Ole Petter ^b   Fujiyoshi, Yoshinori ^c   Engel, Andreas ^d   Nielsen, Søren ^e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c KYOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF BASEL   (Switzerland)

^e AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN; AQUAPORIN 1; AQUAPORIN 2; AQUAPORIN 3; AQUAPORIN 4; GLYCEROL; HYDROGEN; PROTEIN SUBUNIT; PROTON; TETRAMER; WATER; AQUAGLYCEROPORIN;

ANIMAL CELL; CELL MEMBRANE PERMEABILITY; CLINICAL MEDICINE; CONGENITAL CATARACT; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROGEN BOND; INVERTEBRATE; MAMMAL; MICROORGANISM; NEPHROGENIC DIABETES INSIPIDUS; NONHUMAN; OSMOSIS; PHENOTYPE; PLANT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS; VERTEBRATE; WATER PERMEABILITY; WATER TRANSPORT; PROTEIN FUNCTION; PROTEIN SUBUNIT;

ANIMALS; AQUAPORINS; HUMANS; PROTEIN CONFORMATION; TISSUE DISTRIBUTION; WATER;

EID: 0036661083     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.020818     Document Type: Review

References (111)

1. ADAMS, M. E., MUELLER, H. A. & FROEHNER, S. C. (2001). In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4. Journal of Cell Biology 155, 113-122.
2. AGRE, P. (1997). Molecular physiology of water transport: aquaporin nomenclature workshop. Mammalian aquaporins. Biology of the Cell 189, 255-257.
3. AGRE, P. (1998). Aquaporin null phenotypes: the importance of classical physiology. Proceedings of the National Academy of Sciences of the USA 95, 9061-9063.
4. AGRE, P., BONHIVERS, M. & BORGNIA, M. J. (1998). The aquaporins, blueprints for cellular plumbing systems. Journal of Biological Chemistry 273, 14659-14662.
5. AGRE, P., PRESTON, G. M., SMITH, B. L., JUNG, J. S., RAINA, S., MOON, C., GUGGINO, W. B. & NIELSEN, S. (1993). Aquaporin CHIP: the archetypal molecular water channel. American Journal of Physiology 265, F463-476.
6. AGRE, P., SABOORI, A. M., ASIMOS, A. & SMITH, B. L. (1987). Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen. Journal of Biological Chemistry 262, 17497-17503.
7. BEROUKAS, D., HISCOCK, J., JONSSON, R., WATERMAN, S. A. & GORDON, T. P. (2001). Subcellular distribution of aquaporin 5 in salivary glands in primary Sjogren's syndrome. Lancet 358, 1875-1876.
8. BERRY, V., FRANCIS, P., KAUSHAL, S., MOORE, A. & BHATTACHARYA, S. (2000). Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q. Nature Genetics 25, 15-17.
9. BICHET, D. G. (1998). Nephrogenic diabetes insipidus. American Journal of Medicine 105, 431-442.
10. 2-receptor agonist/antagonist treatment. American Journal of Physiology - Renal Physiology 278, F29-42.
11. DEEN, P. M., VERDIJK, M. A., KNOERS, N. V., WIERINGA, B., MONNENS, L. A., VAN OS, C. H. & VAN OOST, B. A. (1994). Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science 264, 92-95.
12. DE GROOT, B. L., ENGEL, A. & GRUBMULLER, H. (2001). A refined structure of human aquaporin-1. FEBS Letters 504, 206-211.
13. DE GROOT, B. L. & GRUBMULLER, H. (2001). Water permeation across biological membranes: mechanism and dynamics ofaquaporin-1 and GlpF. Science 294, 2353-2357.
14. DELPORTE, C., O'CONNELL, B. C., HE, X., AMBUDKAR, I. S., AGRE, P. & BAUM, B. J. (1996). Adenovirus-mediated expression of aquaporin-5 in epithelial cells. Journal of Biological Chemistry 271, 22070-22075.
15. DENKER, B. M., SMITH, B. L., KUHAJDA, F. P. & AGRE, P. (1988). Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. Journal of Biological Chemistry 263, 15634-15642.
16. EBIHARA, L., BEYER, E. C., SWENSON, K. I., PAUL, D. L. & GOODENOUGH, D. A. (1989). Cloning and expression of a Xenopus embryonic gap junction protein. Science 243, 1194-1195.
17. ECELBARGER, C. A., TERRIS, J., FRINDT, G., ECHEVARRIA, M., MARPLES, D., NIELSEN, S. & KNEPPER, M. A. (1995). Aquaporin-3 water channel localization and regulation in rat kidney. American Journal of Physiology 269, F663-672.
18. ECHEVARRIA, M., WINDHAGER, E. E., TATE, S. S. & FRINDT, G. (1994). Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney. Proceedings of the National Academy of Sciences of the USA 91, 10997-11001.
19. FOTIADIS, D., HASLER, L., MULLER, D. J., STAHLBERG, H., KISTLER, J. & ENGEL, A. (2000). Surface tongue-and-groove contours on lens MIP facilitate cell-to-cell adherence. Journal of Molecular Biology 300, 779-789.
20. FRANCIS, P., CHUNG, J. J., YASUI, M., BERRY, V., MOORE, A., WYATT, M. K., WISTOW, G., BHATTACHARYA, S. S. & AGRE, P. (2000). Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Human Molecular Genetics 9, 2329-2334.
21. FRIGERI, A., NICCHIA, G. P., NICO, B., QUONDAMATTEO, F., HERKEN, R., RONCALI, L. & SVELTO, M. (2001). Aquaporin-4 deficiency in skeletal muscle and brain of dystrophic mdx mice. FASEB Journal 15, 90-98.
22. FRIGERI, A., NICCHIA, G. P., VERBAVATZ, J. M., VALENTI, G. & SVELTO, M. (1998). Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle. Journal of Clinical Investigation 102, 695-703.
23. FU, D., LIBSON, A., MIERCKE, L. J., WEITZMAN, C., NOLLERT, P., KRUCINSKI, J. & STROUD, R. M. (2000). Structure of a glycerol-conducting channel and the basis for its selectivity. Science 290, 481-486.
24. FUSHIMI, K., UCHIDA, S., HARA, Y., HIRATA, Y., MARUMO, F. & SASAKI, S. (1993). Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature 361, 549-552.
25. GORIN, M., YANCEY, S., CLINE, J., REVEL, J. & HORWITZ, J. (1984). The major intrinsic protein (MIP) of the bovine lens fiber membrane. Cell 39, 49-59.
26. GRESZ, V., KWON, T. H., HURLEY, P. T., VARGA, G., ZELLES, T., NIELSEN, S., CASE, R. M. & STEWARD, M. C. (2001). Identification and localization of aquaporin water channels in human salivary glands. American Journal of Physiology - Gastrointestinal and Liver Physiology 281, G247-254.
27. HAMANN, S., ZEUTHEN, T., LA COUR, M., NAGELHUS, E. A., OTTERSEN, O. P., AGRE, P. & NIELSEN, S. (1998). Aquaporins in complex tissues: distribution of aquaporins 1-5 in human and rat eye. American Journal of Physiology 274, C1332-1345.
28. HAN, Z., WAX, M. B. & PATIL, R. V. (1998). Regulation of aquaporin-4 water channels by phorbol ester-dependent protein phosphorylation. Journal of Biological Chemistry 273, 6001-6004.
29. HASEGAWA, H., MA, T., SKACH, W., MATTHAY, M. A. & VERKMAN, A. S. (1994). Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. Journal of Biological Chemistry 269, 5497-5500.
30. HATAKEYAMA, S., YOSHIDA, Y., TANI, T., KOYAMA, Y., NIHEI, K., OHSHIRO, K., KAMIIE, J. I., YAOITA, E., SUDA, T., HATAKEYAMA, K. & YAMAMOTO, T. (2001). Cloning of a new aquaporin (AQP1O). abundantly expressed in duodenum and jejunum. Biochemical and Biophysical Research Communications 287, 814-819.
31. HEITMAN, J. & AGRE, P. (2000). A new face of the Rhesus antigen. Nature Genetics 26, 258-259.
32. HOHMANN, I., BILL, R. M., KAYINGO, I. & PRIOR, B. A. (2000). Microbial MIP channels. Trends in Microbiology 8, 33-38.
33. HURLEY, P. T., FERGUSON, C. J., KWON, T. H., ANDERSEN, M. L., NORMAN, A. G., STEWARD, M. C., NIELSEN, S. & CASE, R. M. (2001). Expression and immunolocalization of aquaporin water channels in rat exocrine pancreas. American Journal of Physiology - Gastrointestinal and Liver Physiology 280, G701-709.
34. ISHIBASHI, K., KUWAHARA, M., GU, Y., KAGEYAMA, Y., TOHSAKA, A., SUZUKI, F., MARUMO, F. & SASAKI, S. (1997). Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. Journal of Biological Chemistry 272, 20782-20786.
35. ISHIBASHI, K., SASAKI, S., FUSHIMI, K., UCHIDA, S., KUWAHARA, M., SAITO, H., FURUKAWA, T., NAKAJIMA, K., YAMAGUCHI, Y. & GOJOBORI, T. (1994). Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells. Proceedings of the National Academy of Sciences of the USA 91, 6269-6273.
36. JOHANSSON, I., KARLSSON, M., JOHANSON, U., LARSSON, C. & KJELLBOM, P. (2000). The role of aquaporins in cellular and whole plant water balance. Biochimica et Biophysica Acta 1465, 324-342.
37. JUNG, J. S., BHAT, R. V., PRESTON, G. M., GUGGINO, W. B., BARABAN, J. M. & AGRE, P. (1994a). Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Proceedings of the National Academy of Sciences of the USA 91, 13052-13056.
38. JUNG, J. S., PRESTON, G. M., SMITH, B. L., GUGGINO, W. B. & AGRE, P. (1994b). Molecular structure of the water channel through aquaporin CHIP. The hourglass model. Journal of Biological Chemistry 269, 14648-14654.
39. KATSURA, T., VERBAVATZ, J. M., FARINAS, J., MA, T., AUSIELLO, D. A., VERKMAN, A. S. & BROWN, D. (1995). Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells. Proceedings of the National Academy of Sciences of the USA 92, 7212-7216.
40. KING, L. S., CHOI, M., FERNANDEZ, P. C., CARTRON, J. P. & AGRE, P. (2001). Defective urinary-concentrating ability due to a complete deficiency of aquaporin-1. New England Journal of Medicine 345, 175-179.
41. KING, L. S., NIELSEN, S. & AGRE, P. (1996). Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. Journal of Clinical Investigation 97, 2183-2191.
42. KING, L. S., NIELSEN, S. & AGRE, P. (1997). Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat. American Journal of Physiology 273, C1541-1548.
43. KING, L. S., NIELSEN, S., AGRE, P. & BROWN, R. H. (2002). Decreased pulmonary vascular permeability in aquaporin-1-null humans. Proceedings of the National Academy of Sciences of the USA 99, 1059-1063.
44. KISHIDA, K., KURIYAMA, H., FUNAHASHI, T., SHIMOMURA, I., KIHARA, S., OUCHI, N., NISHIDA, M., NISHIZAWA, H., MATSUDA, M., TAKAHASHI, M., HOTTA, K., NAKAMURA, T., YAMASHITA, S., TOCHINO, Y. & MATSUZAWA, Y. (2000). Aquaporin adipose, a putative glycerol channel in adipocytes. Journal of Biological Chemistry 275, 20896-20902.
45. KONG, Y. & MA, J. (2001). Dynamic mechanisms of the membrane water channel aquaporin-1 (AQP1). Proceedings of the National Academy of Sciences of the USA 983 14345-14349.
46. KRANE, C. M., MELVIN, J. E., NGUYEN, H. V., RICHARDSON, L., TOWNE, J. E., DOETSCHMAN, T. & MENON, A. G. (2001). Salivary acinar cells from aquaporin 5 deficient mice have decreased membrane permeability and altered cell volume regulation. Journal of Biological Chemistry 276, 23413-23420.
47. KREDA, S. M., GYNN, M. C., FENSTERMACHER, D. A., BOUCHER, R. C. & GABRIEL, S. E. (2001). Expression and localization of epithelial aquaporins in the adult human lung. American Journal of Respiratory Cellular and Molecular Biology 24, 224-234.
48. KWON, T. H., HAGER, H., NEJSUM, L. N., ANDERSEN, M. L., FROKIAER, J. & NIELSEN, S. (2001). Physiology and pathophysiology of renal aquaporins. Seminars in Nephrology 21, 231-238.
49. LE CAHEREC, F., DESCHAMPS, S., DELAMARCHE, C., PELLERIN, I., BONNEC, G., GUILLAM, M. T., THOMAS, D., GOURANTON, J. & HUBERT, J. F. (1996). Molecular cloning and characterization of an insect aquaporin functional comparison with aquaporin 1. European Journal of Biochemistry 241, 707-715.
50. LEE, M. D., BHAKTA, K. Y., RAINA, S., YONESCU, R., GRIFFIN, C. A., COPELAND, N. G., GILBERT, D. J., JENKINS, N. A., PRESTON, G. M. & AGRE, P. (1996). The human aquaporin-5 gene. Molecular characterization and chromosomal localization. Journal of Biological Chemistry 271, 8599-8604.
51. LEITCH, V., AGRE, P. & KING, L. S. (2001). Altered ubiquitination and stability of aquaporin-1 in hypertonic stress. Proceedings of the National Academy of Sciences of the USA 98, 2894-2898.
52. LIU, Z., SHEN, J., CARBREY, J. M., MUKHOPADHYAY, R., AGRE, P. & ROSEN, B. (2002). Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proceedings of the National Academy of Sciences of the USA 99, 6053-6058.
53. MA, T., FRIGERI, A., HASEGAWA, H. & VERKMAN, A. S. (1994). Cloning of a water channel homolog expressed in brain meningeal cells and kidney collecting duct that functions as a stilbene-sensitive glycerol transporter. Journal of Biological Chemistry 269, 21845-21849.
54. MA, T., SONG, Y., GILLESPIE, A., CARLSON, E. J., EPSTEIN, C. J. & VERKMAN, A. S. (1999). Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. Journal of Biological Chemistry 274, 20071-20074.
55. MA, T., YANG, B., KUO, W. L. & VERKMAN, A. S. (1996). cDNA cloning and gene structure of a novel water channel expresed exclusively in human kidney. Genomics 35, 543-550.
56. MANLEY, G. T., FUJIMURA, M., MA, T., NOSHITA, N., FILIZ, F., BOLLEN, A. W., CHAN, P. & VERKMAN, A. S. (2000). Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nature Medicine 6, 159-163.
57. MARINELLI, R. A., PHAM, L., AGRE, P. & LARUSSO, N. F. (1997). Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane. Evidence for a secretin-induced vesicular translocation of aquaporin-1. Journal of Biological Chemistry 272, 12984-12988.
58. MAUNSBACH, A. B., MARPLES, D., CHIN, E., NING, G., BONDY, C., AGRE, P. & NIELSEN, S. (1997). Aquaporin-1 water channel expression in human kidney. Journal of the American Society of Nephrology 8, 1-14 (published erratum appears in Journal of the American Society of Nephrology 8, 358-360).
59. MOON, C., PRESTON, G. M., GRIFFIN, C. A., JABS, E. W. & AGRE, P. (1993). The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization. Journal of Biological Chemistry 268, 15772-15778.
60. MULDERS, S. M., BICHET, D. G., RIJSS, J. P., KAMSTEEG, E. J., ARTHUS, M. F., LONERGAN, M., FUJIWARA, M., MORGAN, K., LEIJENDEKKER, R., VAN DER SLUIJS. P., VAN OS, C. H. & DEEN, P. M. (1998). An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex. Journal of Clinical Investigation 102, 57-66.
61. MULDERS, S. M., PRESTON, G. M., DEEN, P. M., GUGGINO, W. B., VAN OS, C. H. & AGRE, P. (1995). Water channel properties of major intrinsic protein of lens. Journal of Biological Chemistry 270, 9010-9016.
62. MURATA, K., MITSUOKA, K., HIRAI, T., WALZ, T., AGRE, P., HEYMANN, J. B., ENGEL, A. & FUJIYOSHI, Y. (2000). Structural determinants of water permeation through aquaporin-1. Nature 407, 599-605.
63. + siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia 26, 47-54.
64. NAGELHUS, E. A., VERUKI, M. L., TORP, R., HAUG, F. M., LAAKE, J. H., NIELSEN, S., AGRE, P. & OTTERSEN, O. P. (1998). Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Muller cells and fibrous astrocytes. Journal of Neuroscience 18, 2506-2519.
65. NEELY, J. D., AMIRY-MOGHADDAM, M., OTTERSEN, O. P., FROEHNER, S. C., AGRE, P. & ADAMS, M. E. (2001). Syntrophin-dependent expression and localization of aquaporin-4 water channel protein. Proceedings of the National Academy of Sciences of the USA 98, 14108-14113.
66. NEJSUM, L. N., KWON, T. H., JENSEN, U. B., FUMAGALLI, O., FROKIAER, J., KRANE, C. M., MENON, A. G., KING, L. S., AGRE, P. C. & NIELSEN, S. (2002). Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proceedings of the National Academy of Sciences of the USA 99, 511-516.
67. NIELSEN, S. & AGRE, P. (1995). The aquaporin family of water channels in kidney. Kidney International 48, 1057-1068.
68. NIELSEN, S., CHOU, C. L., MARPLES, D., CHRISTENSEN, E. I., KISHORE, B. K. & KNEPPER, M. A. (1995). Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proceedings of the National Academy of Sciences of the USA 92, 1013-1017.
69. NIELSEN, S., DIGIOVANNI, S. R., CHRISTENSEN, E. I., KNEPPER, M. A. & HARRIS, H. W. (1993a). Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Proceedings of the National Academy of Sciences of the USA 90, 11663-11667.
70. NIELSEN, S., KING, L. S., CHRISTENSEN, B. M. & AGRE, P. (1997a). Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. American Journal of Physiology 273, C1549-1561.
71. NIELSEN, S., NAGELHUS, E. A., AMIRY-MOGHADDAM, M., BOURQUE, C., AGRE, P. & OTTERSEN, O. P. (1997b). Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. Journal of Neuroscience 17, 171-180.
72. NIELSEN, S., SMITH, B. L., CHRISTENSEN, E. I. & AGRE, P. (1993b). Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proceedings of the National Academy of Sciences of the USA 90, 7275-7279.
73. NIELSEN, S., SMITH, B. L., CHRISTENSEN, E. I., KNEPPER, M. A. & AGRE, P. (1993c). CHIP28 water channels are localized in constitutively water-permeable segments of the nephron. Journal of Cell Biology 120, 371-383.
74. PALLONE, T. L., KISHORE, B. K., NIELSEN, S., AGRE, P. & KNEPPER, M. A. (1997). Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta. American Journal of Physiology 272, F587-596.
75. PRESTON, G. M. & AGRE, P. (1991). Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family. Proceedings of the National Academy of Sciences of the USA 88, 11110-11114.
76. PRESTON, G. M., CARROLL, T. P., GUGGINO, W. B. & AGRE, P. (1992). Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 256, 385-387.
77. PRESTON, G. M., JUNG, J. S., GUGGINO, W. B. & AGRE, P. (1993). The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel. Journal of Biological Chemistry 268, 17-20.
78. PRESTON, G. M., JUNG, J. S., GUGGINO, W. B. & AGRE, P. (1994a). Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis. Journal of Biological Chemistry 269, 1668-1673.
79. PRESTON, G. M., SMITH, B. L., ZEIDEL, M. L., MOULDS, J. J. & AGRE, P. (1994b). Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. Science 265, 1585-1587.
80. PROMENEUR, D., KWON, T. H., YASUI, M., KIM, G. H., FROKIAER, J., KNEPPER, M. A., AGRE, P. & NIELSEN, S. (2000). Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance. American Journal of Physiology - Renal Physiology 279, F1014-1026.
81. RAINA, S., PRESTON, G. M., GUGGINO, W. B. & AGRE, P. (1995). Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues. Journal of Biological Chemistry 270, 1908-1912.
82. RAO, Y., JAN, L. Y. & JAN, Y. N. (1990). Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature 345, 163-167.
83. RASH, J. E., YASUMURA, T., HUDSON, C. S., AGRE, P. & NIELSEN, S. (1998). Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proceedings of the National Academy of Sciences of the USA 953 11981-11986.
84. REN, G., REDDY, V. S., CHENG, A., MELNYK, P. & MITRA, A. K. (2001). Visualization of a water-selective pore by electron crystallography in vitreous ice. Proceedings of the National Academy of Sciences of the USA 98, 1398-1403.
85. SANTONI, V., GERBEAU, P., JAVOT, H. & MAUREL, C. (2000). The high diversity of aquaporins reveals novel facets of plant membrane functions. Current Opinion in Plant Biology 3, 476-481.
86. SCHREIBER, R., NITSCHKE, R., GREGER, R. & KUNZELMANN, K. (1999). The cystic fibrosis transmembrane conductance regulator activates aquaporin 3 in airway epithelial cells. Journal of Biological Chemistry 274, 11811-11816.
87. SCHRIER, R. W., OHARA, M., ROGACHEV, B., XU, L. & KNOTEK, M. (1998). Aquaporin-2 water channels and vasopressin antagonists in edematous disorders. Molecular Genetics of Metabolism 65, 255-263.
88. SMITH, B. L. & AGRE, P. (1991). Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins. Journal of Biological Chemistry 266, 6407-6415.
89. SMITH, B. L., PRESTON, G. M., SPRING, F. A., ANSTEE, D. J. & AGRE, P. (1994). Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens. Journal of Clinical Investigation 94, 1043-1049.
90. SONG, Y., SONAWANE, N. & VERKMAN, A. S. (2002). Localization of aquaporin-5 in sweat glands and functional analysis using knockout mice. Journal of Physiology 541, 561-568.
91. SONG, Y. & VERKMAN, A. S. (2001). Aquaporin-5 dependent fluid secretion in airway submucosal glands. Journal of Biological Chemistry 276, 41288-41292.
92. SONG YANG, Z., FANNING, A. S., FU, C., XU, J., MARFATIA, S. M., CHISHTI, A. H., CROMPTON, A., CHAN, A. C., ANDERSON, J. M. & CANTLEY, L. C. (1997). Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275, 73-77.
93. STEINFELD, S., COGAN, E., KING, L. S., AGRE, P., KISS, R. & DELPORTE, C. (2001). Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjogren's syndrome patients. Laboratory Investigation 81, 143-148.
94. SUI, H., HAN, B. G., LEE, J. K., WALIAN, P. & JAP, B. K. (2001). Structural basis of water-specific transport through the AQP1 water channel. Nature 414, 872-878.
95. TAJKHORSHID, E., NOLLERT, P., JENSEN, M. O., MIERCKE, L. J., O'CONNELL, J., STROUD, R. M. & SCHULTEN, K. (2002). Control of the selectivity of the aquaporin water channel family by global orientational tuning. Science 296, 525-530.
96. TSUBOTA, K., HIRAI, S., KING, L. S., AGRE, P. & ISHIDA, N. (2001). Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjogren's syndrome. Lancet 357, 688-689.
97. TSUKAGUCHI, H., SHAYAKUL, C., BERGER, U. V., MACKENZIE, B., DEVIDAS, S., GUGGINO, W. B., VAN HOEK, A. N. & HEDIGER, M. A. (1998). Molecular characterization of a broad selectivity neutral solute channel. Journal of Biological Chemistry 273, 24737-24743.
98. VAN DORT, H. M., KNOWLES, D. W., CHASIS, J. A., LEE, G., MOHANDAS, N. & LOW, P. S. (2001). Analysis of integral membrane protein contributions to the deformability and stability of the human erythrocyte membrane. Journal of Biological Chemistry 276, 46968-46974.
99. VERKMAN, A. S. (2000). Physiological importance of aquaporins: lessons from knockout mice. Current Opinion in Nephrology and Hypertension 9, 517-522.
100. WALZ, T., SMITH, B. L., AGRE, P. & ENGEL, A. (1994a). The three-dimensional structure of human erythrocyte aquaporin CHIP. EMBO Journal 13, 2985-2993.
101. WALZ, T., SMITH, B. L., ZEIDEL, M. L., ENGEL, A. & AGRE, P. (1994b) Biologically active two-dimensional crystals of aquaporin CHIP. Journal of Biological Chemistry 269, 1583-1586.
102. YAMAMOTO, T. & SASAKI, S. (1998). Aquaporins in the kidney: emerging new aspects. Kidney International 54, 1041-1051.
103. YANG, B., MA, T. & VERKMAN, A. S. (2001). Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. Journal of Biological Chemistry 276, 624-628.
104. YASUI, M., HAZAMA, A., KWON, T. H., NIELSEN, S., GUGGINO, W. B. & AGRE, P. (1999a). Rapid gating and anion permeability of an intracellular aquaporin. Nature 402, 184-187.
105. YASUI, M., KWON, T. H., KNEPPER, M. A., NIELSEN, S. & AGRE, P. (1999b). Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia. Proceedings of the National Academy of Sciences of the USA 96, 5808-5813.
106. YASUI, M., SERLACHIUS, E., LOFGREN, M., BELUSA, R., NIELSEN, S. & APERIA, A. (1997). Perinatal changes in expression of aquaporin-4 and other water and ion transporters in rat lung. Journal of Physiology 505, 3-11.
107. ZAMPIGHI, G. A., HALL, J. E., EHRING, G. R. & SIMON, S. A. (1989). The structural organization and protein composition of lens fiber junctions. Journal of Cell Biology 108, 2255-2275.
108. ZEIDEL, M. L., AMBUDKAR, S. V., SMITH, B. L. & AGRE, P. (1992). Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry 31, 7436-7440.
109. ZEIDEL, M. L., NIELSEN, S., SMITH, B. L., AMBUDKAR, S. V., MAUNSBACH, A. B. & AGRE, P. (1994). Ultrastructure, pharmacologic inhibition, and transport selectivity of aquaporin channel-forming integral protein in proteoliposomes. Biochemistry 33, 1606-1615.
110. ZELINSKI, T., KAITA, H., GILSON, T., COGHLAN, G., PHILIPPS, S. & LEWIS, M. (1990). Linkage between the Colton blood group locus and ASSP11 on chromosome 7. Genomics 6, 623-625.
111. +. Journal of Biological Chemistry 274, 21631-21636.