Short-chain fatty acids inhibit cAMP-mediated chloride secretion in rat colon

American Journal of Physiology - Cell Physiology

Volumn 271, Issue 6 40-6, 1996, Pages

  Dagher, Pierre C ^a,b   Egnor, Richard W ^a   Taglietta Kohlbrecher, Angelagrace ^a   Charney, Alan N ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

adenosine 3',5' cyclic monophosphate; butyrate; forskolin; intracellular pH; nystatin; T84 cells

Indexed keywords

ACETIC ACID; BUCLADESINE; BUTYRIC ACID; CARBACHOL; CHLORIDE ION; CYCLIC AMP; GLUCONIC ACID; ISOBUTYRIC ACID; NYSTATIN; PROPIONIC ACID; SHORT CHAIN FATTY ACID;

ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CELL LINE; CELL MEMBRANE TRANSPORT; CELL METABOLISM; CELL PH; CHLORIDE TRANSPORT; COLON MUCOSA; CONTROLLED STUDY; DESCENDING COLON; HUMAN; HUMAN CELL; INTESTINE CELL; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT CIRCUIT CURRENT;

EID: 0030449118     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.271.6.c1853     Document Type: Article

References (23)

1. Binder, H. J., and P. Mehta. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 96: 989-996, 1989.
2. Binder, H. J., and P. Mehta. Characterization of butyratedependent electroneutral Na-Cl absorption in the rat distal colon. Pfluegers Arch. 417: 365-369, 1990.
3. Bowling, T. E., A. H. Raimundo, G. K. Grimble, and D. B. Silk. Reversal by short-chain fatty acids of colonic fluid secretion induced by enterai feeding. Lancet 342: 1266-1268, 1993.
4. Bugaut, M. Occurrence, absorption and metabolism of short-chain fatty acids in the digestive tract of mammals. Comp. Biochem. Physiol. B Comp. Biochem. 86B: 439-472, 1987.
5. Chu, S., and M. H. Montrose. Extracellular pH regulation in microdomains of colonic crypts: effects of short-chain fatty acids. Proc. Natl. Acad. Sci. USA 92: 3303-3307, 1995.
6. +-independent short-chain fatty acid transporter contributes to intracellular pH regulation in murine colonocytes. J. Gen. Physiol. 105: 589-615, 1995.
7. Dagher, P. C., L. Balsam, J. T. Weber, R. W. Egnor, and A. N. Charney. Modulation of chloride secretion in the rat colon by intracellular bicarbonate. Gastroenterology 103: 120-127, 1992.
8. Dagher, P. C., R. W. Egnor, and A. N. Charney. Effect of intracellular acidification on colonic NaCl absorption. Am. J. Physiol. 264 (Gastrointest. Liver Physiol. 27): G569-G575, 1993.
9. Dagher, P. C., T. Z. Morton, C. J. Joo, A. Taglietta-Kohlbrecher, R. W. Egnor, and A. N. Charney. Modulation of secretagogue-induced chloride secretion by intracellular bicarbonate. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G929-G934, 1994.
10. DeSoignie, R., and J. H. Sellin. Propionate-initiated changes in intracellular pH in rabbit colonocytes. Gastroenterology 107: 347-356, 1994.
11. Diener, M., C. Helmle-Kolb, H. Murer, and E. Scharrer. Effect of pH short-chain fatty acids on cell volume and intracellular pH in rat distal colon. Pfluegers Arch. 424: 216-223, 1993.
12. Holtug, K., A. Shipley, V. Dantzer, O. Sten-Knudsen, and E. Skadhauge. Localization of sodium absorption and chloride secretion in an intestinal epithelium. J. Membr. Biol. 122: 215-229, 1991.
13. Huflejt, M. E., R. A. Blum, S. G. Miller, H. H. Moore, and T. Machen. Regulated Cl transport, K and Cl permeability, and exocytosis in T84 cells. J. Clin. Invest. 93: 1900-1910, 1994.
14. Kockerling, A., and M. Fromm. Origin of cAMP-dependent Cl secretion from both crypts and surface epithelia of rat intestine. Am. J. Physiol. 264 (Cell Physiol. 33): C1294-C1301, 1993.
15. Kunzelmann, K., M. Tilmann, C. P. Hansen, and R. Greger. Inhibition of epithelial chloride channels by cytosol. Pfluegers Arch. 418: 479-490, 1991.
16. Mascolo, N., V. M. Rajendran, and H. J. Binder. Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon. Gastroenterology 101: 331-338, 1991.
17. Rajendran, V. M., and H. J. Binder. Apical membrane Cl-butyrate exchange: mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. J. Membr. Biol. 141: 51-58, 1994.
18. Ramakrishna, B. S., S. H. Nance, I. C. Roberts-Thomson, and W. E. W. Roediger. The effects of enterotoxins and short-chain fatty acids on water and electrolyte fluxes in ileal and colonic loops in vivo in the rat. Digestion 45: 93-101, 1990.
19. Rolston, D. D. K., M. J. Kelly, M. M. Borodo, A. M. Dawson, and M. J. G. Farthing. Effect of bicarbonate, acetate, and citrate on water and sodium movement in normal and cholera toxin-treated rat small intestine. Scaned. J. Gastroenterol. 24: 1-8, 1989.
20. + exchange function is pliable in response to transepithelial gradients of propionate. Proc. Natl. Acad. Sci. USA 91: 6166-6170, 1994.
21. Schmitt, M. G., K. H. Soergel, C. M. Wood, and J. J. Stepp. Absorption of short-chain fatty acids from the human ileum. J. Dig. Dis. 22: 340-347, 1977.
22. Schwiebert, E. M., M. E. Egan, T. Hwang, S. B. Fulmer, S. S. Allen, G. R. Cutting, and W. B. Guggino. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involvingATP. Cell 81: 1063-1073, 1995.
23. Seamon, K. B., W. Padgett, and J. W. Daly. Forskolin: unique diterpene acivator of adenylate cyclase in membranes and intact cells. Proc. Natl. Acad. Sci. USA 78: 3363-3367, 1981.