Molecular targets for altering radiosensitivity: Lessons from Ras as a pre-clinical and clinical model

Critical Reviews in Oncology/Hematology

Volumn 55, Issue 2, 2005, Pages 103-116

  Cengel, Keith A ^a   McKenna, W Gillies ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Akt; Farnesyltransferase; Geranylgeranyltransferase; Phosphatidylinositol 3 kinase; Prenyltransferase; Radiation therapy; Radiosensitization; Ras

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; 2 MORPHOLINO 8 PHENYLCHROMONE; CETUXIMAB; DIMETHYLALLYLTRANSFERASE; DNA; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; L 731 734; L 778123; MIDOSTAURIN; MITOGEN ACTIVATED PROTEIN KINASE; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE METHYL ESTER; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE B; RAF PROTEIN; TIPIFARNIB; UNCLASSIFIED DRUG;

CANCER; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURVIVAL; CARCINOGENESIS; CELL SURVIVAL; CLINICAL TRIAL; CORRELATION ANALYSIS; DNA REPAIR; GENE ACTIVATION; GENE AMPLIFICATION; GENE FUNCTION; GENE LOCATION; GENE STRUCTURE; HUMAN; IRRADIATION; MALIGNANT NEOPLASTIC DISEASE; METASTASIS; MOLECULAR CLONING; MUTATION; ONCOGENE RAS; PHENOTYPE; PROGNOSIS; RADIOSENSITIVITY; RADIOSENSITIZATION; REVIEW; SIGNAL TRANSDUCTION; TOXICITY; TUMOR GROWTH;

DIMETHYLALLYLTRANSTRANSFERASE; HUMANS; NEOPLASMS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 22144492563     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2005.02.001     Document Type: Review

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