H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

Molecular and Cellular Biology

Volumn 20, Issue 7, 2000, Pages 2475-2487

  Apolloni, Ann ^a   Prior, Ian A ^a   Lindsay, Margaret ^a   Parton, Robert G ^a   Hancock, John F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN BHK; ENDOPLASMIC RETICULUM; EXOCYTOSIS; GOLGI COMPLEX; NONHUMAN; ONCOGENE H RAS; ONCOGENE K RAS; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; BREFELDIN A; CELL LINE; CELL MEMBRANE; CRICETINAE; ENDOPLASMIC RETICULUM; EXOCYTOSIS; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; PACLITAXEL; PALMITIC ACID; PROTEIN SORTING SIGNALS; RAS PROTEINS; TRANSFECTION;

ANIMALIA;

EID: 0034062812     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.7.2475-2487.2000     Document Type: Article

References (59)

1. Alexandrov, K., H. Horiuchi, O. Steele Mortimer, M. C. Seabra, and M. Zerial. 1994. Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated Rab proteins to their target membranes. EMBO J. 13:5262-5273.
2. Aronheim, A., D. Engelberg, N. Li, N. al Alawi, J. Schlessinger, and M. Karin. 1994. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell 78:949-961.
3. Bijlmakers, M.-J. J. E., and M. Marsh. 1999. Trafficking of an acylated cytosolic protein: newly synthesized p56lck travels to the plasma membrane via the exocytic pathway. J. Cell Biol. 145:457-468.
4. Booden, M. A., T. C. Baker, P. A. Solski, C. J. Der, S. G. Parker, and J. E. Buss. 1999. A non-farnesylated Ha-Ras protein can be palmitylated and trigger potent differentiation and transformation. J. Biol. Chem. 274:1423-1431.
5. Bos, J. L. 1989. ras oncogenes in human cancer: a review. Cancer Res. 49:4682-4689.
6. Boyartchuk, V. L., M. N. Ashby, and J. Rine. 1997. Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science 275:1796-1800.
7. Cadwallader, K., H. Paterson, S. G. Macdonald, and J. F. Hancock. 1994. N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization. Mol. Cell. Biol. 14:4722-4730.
8. Campbell, S. L., R. Khosravi-Far, K. L. Rossman, G. J. Clark, and C. J. Der. 1998. Increasing complexity of Ras signaling. Oncogene 17:1395-1413.
9. Casey, P. J., P. A. Solski, C. J. Der, and J. E. Buss. 1989. p21ras is modified by a farnesyl isoprenoid. Proc. Natl. Acad. Sci. USA 86:8323-8327.
10. Choy, E., V. K. Chiu, J. Silletti, M. Feoktisitov, T. Morimoto, D. Michaelson, I. E. Ivanov, and M. R. Philips. 1999. Endomembrane trafficking of Ras: the CAAX motif targets proteins to the ER and Golgi. Cell 98:69-80.
11. Clarke, S. 1992. Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu. Rev. Biochem. 61:355-386.
12. Dai, Q., E. Choy, V. Chiu, J. Romano, S. R. Slivka, S. A. Seitz, S. Michaelis, and M. R. Philips. 1998. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J. Biol. Chem. 273:15030-15034.
13. Fukumoto, Y., K. Kaibuchi, H. Hori, H. Fujioka, S. Araki, T. Ueda, A. Kikuchi, and Y. Takai. 1990. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene 5:1321-1328.
14. Gruenberg, J., G. Griffiths, and K. E. Howell. 1989. Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle function in vitro. J. Cell Biol. 108:1301-1316.
15. ras is two-step and involves carboxyl-methylation and carboxyl-terminal proteolysis. EMBO J. 8:1093-1098.
16. Hamilton, M., and A. Wolfman. 1998. Ha-Ras and N-ras regulate MAPK activity by distinct mechanisms in vivo. Oncogene 16:1417-1428.
17. Hancock, J. F. 1995. Prenylation and palmitoylation analysis. Methods Enzymol. 255:237-245.
18. Hancock, J. F., K. Cadwallader, H. Paterson, and C. J. Marshall. 1991. A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. EMBO J. 10:4033-4039.
19. Hancock, J. F., A. I. Magee, J. E. Childs, and C. J. Marshall. 1989. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57: 1167-1177.
20. Hancock, J. F., H. Paterson, and C. J. Marshall. 1990. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 63:133-139.
21. Hrycyna, C. A., and S. Clarke. 1990. Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae. Mol. Cell. Biol. 10:5071-5076.
22. Hrycyna, C. A., S. K. Sapperstein, S. Clarke, and S. Michaelis. 1991. The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins. EMBO J. 10: 1699-1709.
23. Iwabuchi, K., K. Handa, and S. Hakomori. 1998. Separation of "glycosphin-golipid signaling domain" from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling. J. Biol. Chem. 273:33766-33773.
24. Johnson, L., D. Greenbaum, K. Cichowski, K. Mercer, E. Murphy, E. Schmitt, R. T. Bronson, H. Umanoff, W. Edelman, R. Kucherlapati, and T. Jacks. 1997. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11:2468-2481.
25. Jones, M. K., and J. H. Jackson. 1998. Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo. J. Biol. Chem. 273:1782-1787.
26. Joneson, T., and D. Bar-Sagi. 1997. Ras effectors and their role in mitogenesis and oncogenesis. J. Mol. Med. 75:587-593.
27. Kawamura, M., K. Kaibuchi, K. Kishi, and Y. Takai. 1993. Translocation of Ki-ras p21 between membrane and cytoplasm by smgGDS. Biochem. Biophys. Res. Commun. 190:832-841.
28. Kim, E., P. Ambroziac, J. C. Otto, B. Taylor, M. Ashby, K. Shannon, P. J. Casey, and S. G. Young. 1999. Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras in cells. J. Biol. Chem. 274:8383-8390.
29. Kishida, S., S. Kuyama, K. Matsubara, M. Kishida, Y. Matsuura, and A. Kikuchi. 1997. Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator. Oncogene 15:2899-2907.
30. Klippel, A., C. Reinhard, W. M. Kavanaugh, G. Apell, M.-A. Escobedo, and L. T. Williams. 1996. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol. 16:4117-4127.
31. Leevers, S. J., H. F. Paterson, and C. J. Marshall. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369:411-414.
32. Marais, R., and C. J. Marshall. 1996. Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv. 27:101-125.
33. Martinez-Menarguez, J. A., H. J. Geuze, J. W. Slot, and J. Kluperman. 1999. Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COP1-coated vesicles. Cell 98:81-90.
34. Matsui, Y., A. Kikuchi, S. Araki, Y. Hata, J. Kondo, Y. Teranishi, and Y. Takai. 1990. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein. Mol. Cell. Biol. 10:4116-4122.
35. Melkonian, K. A., A. G. Ostermeyer, J. Z. Chen, M. G. Roth, and D. A. Brown. 1999. Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. J. Biol. Chem. 274:3910-3917.
36. Mitchell, D. A., L. Farh, T. K. Marshall, and R. J. Deschenes. 1994. A polybasic domain allows non-prenylated Ras proteins to function in S. cerevisiae. J. Biol. Chem. 269:21540-21546.
37. Morrison, D. K., and R. E. Cutler. 1997. The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9:174-179.
38. Niv, H., O. Gutman, Y. I. Henis, and Y. Kloog. 1998. Membrane interactions of constitutively active GFP-Ki-Ras4B and their role in signaling. J. Biol. Chem. 274:1606-1613.
39. Okamoto, T., A. Schlegel, P. E. Scherer, and M. P. Lisanti. 1998. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J. Biol. Chem. 273:5419-5422.
40. Otto, J. C., E. Kim, S. G. Young, and P. J. Casey. 1999. Cloning and characterization of a mammalian prenyl protein specific protease. J. Biol. Chem. 274:8379-8382.
41. Parton, R. G., M. Way, N. Zorzi, and E. Stang. 1997. Caveolin-3 associates with developing T-tubules during muscle differentiation. J. Cell Biol. 136: 137-154.
42. Presley, J., N. Cole, T. Schroer, K. Hirschberg, K. Zaal, and J. Lippincott-Schwartz. 1997. ER-to-Golgi transport visualized in living cells. Nature 389: 81-85.
43. Rabouille, C., N. Hui, F. Hunte, K. Kieckbusch, E. Berger, G. Warren, and T. Nilsson. 1995. Mapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharides. J Cell Sci. 108:1617-1627.
44. ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell 62:81-88.
45. Roy, S., A. Lane, J. Yan, R. McPherson, and J. F. Hancock. 1997. Activity of plasma membrane recruited Raf-1 is regulated by Ras via the Raf zinc finger. J. Biol. Chem. 272:20139-20145.
46. Roy, S., R. Luetterforst, A. Harding, A. Apolloni, M. Etheridge, E. Stang, B. Rolls, J. F. Hancock, and R. G. Parton. 1999. Dominant-negative cavcolin inhibits H-ras function by disrupting cholesterol-rich plasma membrane domains. Nat. Cell Biol. 1:98-105.
47. Silvius, J. R., and F. l'Heureux. 1994. Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers. Biochemistry 33:3014-3022.
48. Simons, K., and E. Ikonen. 1997. Functional rafts in membranes. Nature 387:569-572.
49. Stokoe, D., S. G. Macdonald, K. Cadwallader, M. Symons, and J. F. Hancock. 1994. Activation of Raf as a result of recruitment to the plasma membrane. Science 264:1463-1467.
50. Thissen, J., J. Gross, K. Subramanian, T. Meyer, and P. Casey. 1997. Prenylation dependent association of Ki-Ras with microtubules. J. Biol. Chem. 272:30367-30370.
51. Thissen, J. A., and P. J. Casey. 1993. Microsomal membranes contain a high affinity binding site for prenylated peptides. J. Biol. Chem. 268:13780-13783.
52. Tognon, C. E., H. E. Kirk, L. A. Passmore, I. P. Whitehead, C. J. Der, and R. J. Kay. 1998. Regulation of RasGRP via a phorbol ester-responsive C1 domain. Mol. Cell. Biol. 18:6995-7008.
53. Traverse, S., P. Cohen, H. Paterson, C. Marshall, U. Rapp, and R. J. Grand. 1993. Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells. Oncogene 8:3175-3181.
54. Ullrich, O., S. Reinsch, S. Urbe, M. Zerial, and R. G. Parton. 1996. Rab11 regulates recycling through the pericentriolar recycling endosome. J. Cell Biol. 135:913-924.
55. Ullrich, O., H. Stenmark, K. Alexandrov, L. A. Huber, K. Kaibuchi, T. Asasaki, Y. Takai, and M. Zerial. 1993. Rah GDI as a general regulator for the membrane association of Rab proteins. J. Biol. Chem. 268:18143-18150.
56. Umanoff, H., W. Edelmann, A. Pellicer, and R. Kucherlapati. 1995. The murine N-ras gene is not essential for growth and development. Proc. Natl. Acad. Sci. USA 92:1709-1713.
57. Urano, T., R. Emkey, and L. A. Feig. 1995. Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. EMBO J. 15:810-816.
58. ras C-terminus is required for transformation and membrane association. Nature 310:583-586.
59. Yan, J., S. Roy, A. Apolloni, A. Lane, and J. F. Hancock. 1998. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J. Biol. Chem. 273:24052-24056.