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Volumn 103, Issue 4, 2002, Pages 370-376

Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation

Author keywords

Alzheimer's disease; Hippocampus; Neurofibrillary tangles; Neuron loss; Quantitation

Indexed keywords

ADULT; AGE; AGED; ALZHEIMER DISEASE; ARTICLE; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMENTIA; DISEASE DURATION; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NERVE CELL LESION; NEUROFIBRILLARY TANGLE; PATHOGENESIS; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; STEREOLOGY;

EID: 0036955813     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-001-0477-5     Document Type: Article
Times cited : (157)

References (63)
  • 1
    • 0017041381 scopus 로고
    • Neurofibrillary tangles and the pathogenesis of dementia: A quantitative study
    • Ball M (1976) Neurofibrillary tangles and the pathogenesis of dementia: a quantitative study. Neuropathol Appl Neurobiol 2: 395-410
    • (1976) Neuropathol. Appl. Neurobiol. , vol.2 , pp. 395-410
    • Ball, M.1
  • 2
    • 0017358355 scopus 로고
    • Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia: A quantitative study
    • Ball MJ (1977) Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia: a quantitative study. Acta Neuropathol 37:111-118
    • (1977) Acta Neuropathol. , vol.37 , pp. 111-118
    • Ball, M.J.1
  • 4
    • 0035060558 scopus 로고    scopus 로고
    • Two dimensional versus three-dimensional cell counting: A practical perspective
    • Benes FM, Lange N (2001) Two dimensional versus three-dimensional cell counting: a practical perspective. Trends Neurosci 24:11-17
    • (2001) Trends Neurosci. , vol.24 , pp. 11-17
    • Benes, F.M.1    Lange, N.2
  • 8
    • 0024804051 scopus 로고
    • Neurofibrillary degeneration and neuronal loss in Alzheimer's disease
    • Bondareff W, Mountjoy C, Roth M, Hauser D (1989) Neurofibrillary degeneration and neuronal loss in Alzheimer's disease. Neurobiol Aging 10:709-715
    • (1989) Neurobiol. Aging , vol.10 , pp. 709-715
    • Bondareff, W.1    Mountjoy, C.2    Roth, M.3    Hauser, D.4
  • 10
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259
    • (1991) Acta Neuropathol. , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 11
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • Braak H, Braak E (1997) Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 18: 351-357
    • (1997) Neurobiol. Aging , vol.18 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 12
    • 0031596284 scopus 로고    scopus 로고
    • Evolution of neuronal changes in the course of Alzheimer's disease
    • Braak H, Braak E (1998) Evolution of neuronal changes in the course of Alzheimer's disease. J Neural Transm Suppl 53:127-140
    • (1998) J. Neural. Transm. Suppl. , vol.53 , pp. 127-140
    • Braak, H.1    Braak, E.2
  • 13
    • 0034920836 scopus 로고    scopus 로고
    • Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer's disease and dementia with Lewy bodies
    • Broe M, Shepherd CE, Milward EA, Halliday GH (2001) Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol 101:616-624
    • (2001) Acta Neuropathol. , vol.101 , pp. 616-624
    • Broe, M.1    Shepherd, C.E.2    Milward, E.A.3    Halliday, G.H.4
  • 14
    • 0028918383 scopus 로고
    • Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein crosslinking in Alzheimer disease
    • Cras P, Smith MA, Richey PL, Siedlak SL, Mulvihill P, Perry G (1995) Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein crosslinking in Alzheimer disease. Acta Neuropathol 89:291-295
    • (1995) Acta Neuropathol. , vol.89 , pp. 291-295
    • Cras, P.1    Smith, M.A.2    Richey, P.L.3    Siedlak, S.L.4    Mulvihill, P.5    Perry, G.6
  • 15
    • 0028025230 scopus 로고
    • A novel nickel peroxidase method for the histochemical visualization of neurofibrillary tangles, senile plaques and neuropil threads
    • Cullen K (1994) A novel nickel peroxidase method for the histochemical visualization of neurofibrillary tangles, senile plaques and neuropil threads. J Histochem Cytochem 42:1383-1391
    • (1994) J. Histochem. Cytochem. , vol.42 , pp. 1383-1391
    • Cullen, K.1
  • 16
    • 0031657896 scopus 로고    scopus 로고
    • Neurofibrillary degeneration and cell loss in the nucleus basalis in comparison to cortical Alzheimer pathology
    • Cullen KM, Halliday GM (1998) Neurofibrillary degeneration and cell loss in the nucleus basalis in comparison to cortical Alzheimer pathology. Neurobiol Aging 19:297-306
    • (1998) Neurobiol. Aging , vol.19 , pp. 297-306
    • Cullen, K.M.1    Halliday, G.M.2
  • 17
    • 0030175758 scopus 로고    scopus 로고
    • Improved specificity and sensitivity in the visualization of neurofibrillary tangles, senile plaques and neuropil threads
    • Cullen KM, Halliday GM, Cartwright H, Kril JJ (1996) Improved specificity and sensitivity in the visualization of neurofibrillary tangles, senile plaques and neuropil threads. Neurodegeneration 5:177-187
    • (1996) Neurodegeneration , vol.5 , pp. 177-187
    • Cullen, K.M.1    Halliday, G.M.2    Cartwright, H.3    Kril, J.J.4
  • 18
    • 0026544937 scopus 로고
    • The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation
    • Davies DC, Horwood N, Isaacs SL, Mann DMA (1992) The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation. Acta Neuropathol 83:510-517
    • (1992) Acta Neuropathol. , vol.83 , pp. 510-517
    • Davies, D.C.1    Horwood, N.2    Isaacs, S.L.3    Mann, D.M.A.4
  • 19
    • 0031959496 scopus 로고    scopus 로고
    • p53-and CD95-associated apoptosis in neurodegenerative diseases
    • De la Monte SM, Sohn YK, Ganju N, Wands JR (1998) p53-and CD95-associated apoptosis in neurodegenerative diseases. Lab Invest 78:401-411
    • (1998) Lab. Invest. , vol.78 , pp. 401-411
    • De la Monte, S.M.1    Sohn, Y.K.2    Ganju, N.3    Wands, J.R.4
  • 21
    • 0032588815 scopus 로고    scopus 로고
    • ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration
    • ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration. Neuroscience 91:1-5
    • (1999) Neuroscience , vol.91 , pp. 1-5
    • Gartner, U.1    Holzer, M.2    Arendt, T.3
  • 22
    • 0025858704 scopus 로고
    • Rapid, reliable and economical silver stain for neurofibrillary tangles and senile plaques
    • Garvey W, Fathi A, Bigelow F, Jimenez CL, Carpenter BF (1991) Rapid, reliable and economical silver stain for neurofibrillary tangles and senile plaques. J Histotechnol 14:39-42
    • (1991) J. Histotechnol. , vol.14 , pp. 39-42
    • Garvey, W.1    Fathi, A.2    Bigelow, F.3    Jimenez, C.L.4    Carpenter, B.F.5
  • 25
    • 0035139540 scopus 로고    scopus 로고
    • Staging of neurofibril lary degeneration caused by human tau overexpression in unique cellular model of human tauopathy
    • Hall GF, Lee VM, Lee G, Yao J (2001) Staging of neurofibril lary degeneration caused by human tau overexpression in unique cellular model of human tauopathy. Am J Pathol 158: 235-246
    • (2001) Am. J. Pathol. , vol.158 , pp. 235-246
    • Hall, G.F.1    Lee, V.M.2    Lee, G.3    Yao, J.4
  • 26
    • 0031874688 scopus 로고    scopus 로고
    • Simplified neuropathological diagnosis of dementia with Lewy bodies
    • Harding AJ, Halliday GM (1998) Simplified neuropathological diagnosis of dementia with Lewy bodies. Neuropathol Appl Neurobiol 24:195-201
    • (1998) Neuropathol. Appl. Neurobiol. , vol.24 , pp. 195-201
    • Harding, A.J.1    Halliday, G.M.2
  • 27
    • 0028213822 scopus 로고
    • Practical considerations for the use of the optical disector in estimating neuronal number
    • Harding AJ, Halliday GM, Cullen K (1994) Practical considerations for the use of the optical disector in estimating neuronal number. J Neurosci Methods 51:83-89
    • (1994) J. Neurosci. Methods , vol.51 , pp. 83-89
    • Harding, A.J.1    Halliday, G.M.2    Cullen, K.3
  • 28
    • 0031029788 scopus 로고    scopus 로고
    • Chronic alcohol consumption does not cause hippocampal neuron loss in humans
    • Harding AJ, Wong A, Svoboda M, Kril JJ, Halliday GM (1997) Chronic alcohol consumption does not cause hippocampal neuron loss in humans. Hippocampus 7:78-87
    • (1997) Hippocampus , vol.7 , pp. 78-87
    • Harding, A.J.1    Wong, A.2    Svoboda, M.3    Kril, J.J.4    Halliday, G.M.5
  • 29
    • 0031792823 scopus 로고    scopus 로고
    • Variation in hippocampal neuron number with age and brain volume
    • Harding AJ, Halliday GM, Kril JJ (1998) Variation in hippocampal neuron number with age and brain volume. Cereb Cortex 8:710-718
    • (1998) Cereb. Cortex , vol.8 , pp. 710-718
    • Harding, A.J.1    Halliday, G.M.2    Kril, J.J.3
  • 30
    • 0033950447 scopus 로고    scopus 로고
    • A simplified Braak tangle staging method for routine pathological screening
    • Harding AJ, Kril JJ, Halliday GM (2000) A simplified Braak tangle staging method for routine pathological screening. Acta Neuropathol 99:199-208
    • (2000) Acta Neuropathol. , vol.99 , pp. 199-208
    • Harding, A.J.1    Kril, J.J.2    Halliday, G.M.3
  • 31
    • 0021889216 scopus 로고
    • Brain shrinkage in chronic alcoholics - A pathological study
    • Harper CG, Kril JJ, Holloway RL (1985) Brain shrinkage in chronic alcoholics - a pathological study. Br Med J 290:501-504
    • (1985) Br. Med. J. , vol.290 , pp. 501-504
    • Harper, C.G.1    Kril, J.J.2    Holloway, R.L.3
  • 36
    • 0028326935 scopus 로고
    • Visual cortex in Alzheimer's disease: Occurrence of neuronal death and glial proliferation, and correlation with pathological hallmarks
    • Leuba G, Kraftsik R (1994) Visual cortex in Alzheimer's disease: occurrence of neuronal death and glial proliferation, and correlation with pathological hallmarks. Neurobiol Aging 15: 29-43
    • (1994) Neurobiol. Aging , vol.15 , pp. 29-43
    • Leuba, G.1    Kraftsik, R.2
  • 37
    • 0032901904 scopus 로고    scopus 로고
    • Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease
    • Love S, Barber R, Wilcock GK (1999) Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease. Brain 122:247-253
    • (1999) Brain , vol.122 , pp. 247-253
    • Love, S.1    Barber, R.2    Wilcock, G.K.3
  • 38
    • 0033600242 scopus 로고    scopus 로고
    • The propyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein
    • Lu P-J, Wulf G, Zhou XZ, Davies P, Lu KP (1999) The propyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature 399:784-788
    • (1999) Nature , vol.399 , pp. 784-788
    • Lu, P.-J.1    Wulf, G.2    Zhou, X.Z.3    Davies, P.4    Lu, K.P.5
  • 39
    • 0006164301 scopus 로고    scopus 로고
    • Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
    • McKeith IG, Galasko D, Kosaka K, et al (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47:1113-1124
    • (1996) Neurology , vol.47 , pp. 1113-1124
    • McKeith, I.G.1    Galasko, D.2    Kosaka, K.3
  • 40
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardisation of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, Belle G van, Berg L (1991) The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardisation of the neuropathologic assessment of Alzheimer's disease. Neurology 41:479-486
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Belle, G.9    van Berg, L.10
  • 41
    • 0032953541 scopus 로고    scopus 로고
    • Premature death in transgenic mice that over express a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis
    • Moechars D, Lorent K, Leuven F van (1999) Premature death in transgenic mice that over express a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. Neuroscience 91:819-830
    • (1999) Neuroscience , vol.91 , pp. 819-830
    • Moechars, D.1    Lorent, K.2    van Leuven, F.3
  • 42
    • 0027749448 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). Part IV. Rates of cognitive change in the longitudinal assessment of probable Alzheimer's disease
    • Morris JC, Edland S, Clark C, Galasko D, Koss E, Mohs R, Belle G van, Fillenbaum G, Heyman A (1993) The consortium to establish a registry for Alzheimer's disease (CERAD). Part IV. Rates of cognitive change in the longitudinal assessment of probable Alzheimer's disease. Neurology 43:2457-2465
    • (1993) Neurology , vol.43 , pp. 2457-2465
    • Morris, J.C.1    Edland, S.2    Clark, C.3    Galasko, D.4    Koss, E.5    Mohs, R.6    Belle, G.7    van Fillenbaum, G.8    Heyman, A.9
  • 45
    • 0030681215 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
    • National Institute on Aging and Reagan Institute Working Group on diagnostic criteria for the neuropathological diagnosis of Alzheimer's disease
    • National Institute on Aging and Reagan Institute Working Group on diagnostic criteria for the neuropathological diagnosis of Alzheimer's disease (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol Aging 18(Suppl 4):S1-S3
    • (1997) Neurobiol. Aging , vol.18 , Issue.SUPPL. 4
  • 47
    • 0029077257 scopus 로고
    • Decreased activity of hippocampal neurons in Alzheimer's disease is not related to the presence of neurofibrillary tangles
    • Salehi A, Ravid R, Gonatas NK, Swaab DF (1995) Decreased activity of hippocampal neurons in Alzheimer's disease is not related to the presence of neurofibrillary tangles. J Neuropathol Exp Neurol 54:704-709
    • (1995) J. Neuropathol. Exp. Neurol. , vol.54 , pp. 704-709
    • Salehi, A.1    Ravid, R.2    Gonatas, N.K.3    Swaab, D.F.4
  • 48
    • 0031679427 scopus 로고    scopus 로고
    • Pyramidal neuron loss is matched by ghost tangle increase in Guam parkinsonism-dementia hippocampus
    • Schwab C, Steele JC, McGeer PL (1998) Pyramidal neuron loss is matched by ghost tangle increase in Guam parkinsonism-dementia hippocampus. Acta Neuropathol 96:409-416
    • (1998) Acta Neuropathol. , vol.96 , pp. 409-416
    • Schwab, C.1    Steele, J.C.2    McGeer, P.L.3
  • 49
    • 0032805805 scopus 로고    scopus 로고
    • On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonian dementia complex of Guam
    • Schwab C, Schulzer M, Steele JC, McGeer PL (1999) On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonian dementia complex of Guam. Neurobiol Aging 20:57-63
    • (1999) Neurobiol. Aging , vol.20 , pp. 57-63
    • Schwab, C.1    Schulzer, M.2    Steele, J.C.3    McGeer, P.L.4
  • 50
    • 0035110036 scopus 로고    scopus 로고
    • Neurofilament-immunoreactive neurons are not selectively vulnerable in Alzheimer's disease
    • Shepherd CE, Thiel E, McCann H, Halliday GM (2001) Neurofilament-immunoreactive neurons are not selectively vulnerable in Alzheimer's disease. Neurobiol Dis 8:136-146
    • (2001) Neurobiol. Dis. , vol.8 , pp. 136-146
    • Shepherd, C.E.1    Thiel, E.2    McCann, H.3    Halliday, G.M.4
  • 51
    • 0031046970 scopus 로고    scopus 로고
    • Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease
    • Simic G, Kostovic I, Winblad B, Bogdanovic N (1997) Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease. J Comp Neurol 379:482-494
    • (1997) J. Comp. Neurol. , vol.379 , pp. 482-494
    • Simic, G.1    Kostovic, I.2    Winblad, B.3    Bogdanovic, N.4
  • 54
    • 0030043292 scopus 로고    scopus 로고
    • In Alzheimer's disease the Golgi apparatus of a population of neurons without neurofibrillary tangles is fragmented and atrophic
    • Stieber A, Mourelatos Z, Gonatas NK (1996) In Alzheimer's disease the Golgi apparatus of a population of neurons without neurofibrillary tangles is fragmented and atrophic. Am J Pathol 148:415-426
    • (1996) Am. J. Pathol. , vol.148 , pp. 415-426
    • Stieber, A.1    Mourelatos, Z.2    Gonatas, N.K.3
  • 55
    • 0033033228 scopus 로고    scopus 로고
    • Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Aβ
    • Thal DR, Sassin I, Schultz C, Haass C, Braak E, Braak H (1999) Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Aβ. J Neuropathol Exp Neurol 58:210-216
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 210-216
    • Thal, D.R.1    Sassin, I.2    Schultz, C.3    Haass, C.4    Braak, E.5    Braak, H.6
  • 57
    • 0023833603 scopus 로고
    • The NINCDS-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer's disease: A clinicopathological study of 57 cases
    • Tierney MC, Fisher RH, Lewis AJ, Zorzitto ML, Snow WG, Reid DW, Nieuwstraten P (1988) The NINCDS-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathological study of 57 cases. Neurology 38:359-364
    • (1988) Neurology , vol.38 , pp. 359-364
    • Tierney, M.C.1    Fisher, R.H.2    Lewis, A.J.3    Zorzitto, M.L.4    Snow, W.G.5    Reid, D.W.6    Nieuwstraten, P.7
  • 58
    • 0032822184 scopus 로고    scopus 로고
    • Systematic bias in an "unbiased" neuronal counting technique
    • Von Bartheld CS (1999) Systematic bias in an "unbiased" neuronal counting technique. Anat Rec 257:119-20
    • (1999) Anat. Rec. , vol.257 , pp. 119-120
    • Von Bartheld, C.S.1
  • 59
    • 0034282067 scopus 로고    scopus 로고
    • Conformational change as one of the earliest alterations of tau in Alzheimer's disease
    • Weaver CL, Espinoza M, Kress Y, Davies P (2000) Conformational change as one of the earliest alterations of tau in Alzheimer's disease. Neurobiol Aging 21:719-727
    • (2000) Neurobiol. Aging , vol.21 , pp. 719-727
    • Weaver, C.L.1    Espinoza, M.2    Kress, Y.3    Davies, P.4
  • 60
    • 0027164617 scopus 로고
    • Regionally specific loss of neurons in the aging human hippocampus
    • West MJ (1993) Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 14:287-293
    • (1993) Neurobiol. Aging , vol.14 , pp. 287-293
    • West, M.J.1
  • 61
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • West MJ, Coleman PD, Flood DG, Troncoso JC (1994) Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344:769-772
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncoso, J.C.4
  • 62
    • 0033930916 scopus 로고    scopus 로고
    • The CA1 region of the human hippocampus is a hot spot in Alzhimer's disease
    • West MJ, Kawas CH, Martin LJ, Troncoso JC (2000) The CA1 region of the human hippocampus is a hot spot in Alzhimer's disease. Ann N Y Acad Sci 908:255-259
    • (2000) Ann. N. Y. Acad. Sci. , vol.908 , pp. 255-259
    • West, M.J.1    Kawas, C.H.2    Martin, L.J.3    Troncoso, J.C.4
  • 63
    • 0033036691 scopus 로고    scopus 로고
    • β-Amyloid peptide fragment 31-35 induces apoptosis in cultured cortical neurons
    • Yan X-Z, Qiao J-T, Dou Y, Qiao Z-D (1999) β-Amyloid peptide fragment 31-35 induces apoptosis in cultured cortical neurons. Neuroscience 92:177-184
    • (1999) Neuroscience , vol.92 , pp. 177-184
    • Yan, X.-Z.1    Qiao, J.-T.2    Dou, Y.3    Qiao, Z.-D.4


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