5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d] pyrimidin-4-ylamine: Structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 11, 2005, Pages 3705-3720

  Matulenko, Mark A ^a   Lee, Chih Hung ^a   Jiang, Meiqun ^a   Frey, Robin R ^a   Cowart, Marlon D ^a   Bayburt, Erol K ^a   DiDomenico Jr , Stanley ^a   Gfesser, Gregory A ^a   Gomtsyan, Arthur ^a   Guo, Zhu Zheng ^a   McKie, Jeffery A ^a,b   Stewart, Andrew O ^a   Yu, Haixia ^a   Kohlhaas, Kathy L ^a   Alexander, Karen M ^a   McGaraughty, Steve ^a   Wismer, Carol T ^a   Mikusa, Joseph ^a   Marsh, Kennan C ^a   Snyder, Ronald D ^a,c   Diehl, Marilyn S ^a   Kowaluk, Elizabeth A ^a   Jarvis, Michael F ^a   Bhagwat, Shripad S ^a,d   more..

^a ABBOTT LABORATORIES   (United States)

^b Celgene   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d Ambit Biosciences   (United States)

Author keywords

Adenosine kinase; Inhibitor; Pyridopyrimidine

Indexed keywords

1 (2 CHLORO 5 PYRIMIDINYL)ETHANONE; 1 (5 BROMO 2 PYRIDINYL)ETHANONE; 1 (6 CHLORO 3 PYRIDAZINYL)ETHANONE; 1 [1 METHYL 2 (4 MORPHOLINYL) 1H IMIDAZOL 4 YL]ETHANONE; 1 [2 (4 MORPHOLINYL) 1,3 OXAZOL 5 YL]ETHANONE; 1 [2 (4 MORPHOLINYL) 1,3 THIAZOL 4 YL]ETHANONE; 1 [2 (4 MORPHOLINYL) 1,3 THIAZOL 5 YL)ETHANONE; 1 [2 (4 MORPHOLINYL) 5 PYRIMIDINYL]ETHANONE; 1 [5 (4 MORPHOLINYL) 2 PYRAZINYL]ETHANONE; 1 [5 (4 MORPHOLINYL) 2 PYRIDINYL]ETHANONE; 1 [5 (4 MORPHOLINYL) 2 THIENYL]ETHANONE; 1 [6 (4 MORPHOLINYL) 3 PYRIDAZINYL]ETHANONE; 2 AMINO 4 (3 BROMOPHENYL) 6 [2 (4 MORPHOLINYL) 1,3 THIAZOL 5 YL]NICOTINITRILE; 2 AMINO 4 (3 BROMOPHENYL) 6 [2 (4 MORPHOLINYL) 5 PYRIDYL]NICOTINONITRILE; 5 (3 BROMOPHENYL) 7 (6 MORPHOLIN 4 YLPYRIDIN 3 YL)PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [1 METHYL 2 (4 MORPHOLINYL) 1H IMIDAZOL 4 YL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [2 (4 MORPHOLINYL) 1,3 OXAZOL 5 YL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [2 (4 MORPHOLINYL) 1,3 THIAZOL 4 YL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [2 (4 MORPHOLINYL) 1,3 THIAZOL 5 YL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [2 (4 MORPHOLINYL) 5 PYRIDINYL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [4 (4 MORPHOLINYL)PHENYL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [5 (4 MORPHOLINYL) 2 PYRAZINYL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [5 (4 MORPHOLINYL) 2 PYRIDINYL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [5 (4 MORPHOLINYL) 2 THIENYL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [6 (4 MORPHOLINYL) 3 PYRIDAZINYL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; 5 (3 BROMOPHENYL) 7 [6 (4 MORPHOLINYL) 3 PYRIDINYL]PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINE; ADENOSINE KINASE INHIBITOR; N [4 (3 BROMOPHENYL) 3 CYANO 6 (2 MORPHOLIN 4 YLTHIAZOL 5 YL)PYRIDIN 2 YL]FORMAMIDINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MUTAGENIC ACTIVITY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 20944443303     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.03.023     Document Type: Article

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