Use of the Miniscreen assay to screen novel compounds for bacterial mutagenicity in the pharmaceutical industry

Mutagenesis

Volumn 11, Issue 2, 1996, Pages 201-205

  Burke, D A ^a   Wedd, D J ^a   Burlinson, B ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALOE EMODIN; CARBADOX; CIADOX; CYCLOPHOSPHAMIDE; DANTRON; EMODIN; HYCANTHONE; METRONIDAZOLE; MITOMYCIN C; MUTAGENIC AGENT;

AMES TEST; ARTICLE; ASSAY; DRUG SCREENING; METHODOLOGY; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL;

ANTHRAQUINONES; DRUG EVALUATION, PRECLINICAL; DRUG INDUSTRY; ESCHERICHIA COLI; INTERCALATING AGENTS; MUTAGENICITY TESTS; SALMONELLA TYPHIMURIUM;

EID: 0029960045     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/11.2.201     Document Type: Article

References (5)

1. Brooks,T.M. (1995) The use of a streamlined bacterial mutagenicity assay, the MINISCREEN. Mutagenesis, 10. 447-448.
2. Gatehouse,D.G., Haworth,S., Cebula,T., Gocke,E., Kier,L , Matsushima,T., Melcion,C., Nohm,T., Ohta,T., Venitt,S. and Zeiger,E. (1994) Recommendations for the performance of bacterial mutation assays. Mutat. Res., 312, 217-233.
3. Maron,D.M. and Ames,B.N (1983) Revised methods for the Salmonella mutagenicity test. Mutat. Res., 113, 173-215
4. Westendorf,J., Marquardt,H., Poginski,B., Dominiak,M., Schmidt,J. and Marquardt,H. (1990) Genotoxicity of naturally-occurring hydroxynaphthoquniones. Murat. Res., 240, 1-12.
5. Wilcox,P., Naidoo,A., Wedd,D.J. and Gatehouse,D.G. (1990). Comparison of Salmonella typhimurium TA102 with Escherichia coli WP2 tester strains. Mutagenesis, 5, 285-291.