5,6,7-Trisubstituted 4-Aminopyrido[2,3-d]pyrimidines as Novel Inhibitors of Adenosine Kinase

Journal of Medicinal Chemistry

Volumn 46, Issue 24, 2003, Pages 5249-5257

  Perner, Richard J ^a   Gu, Yu Gui ^a   Lee, Chih Hung ^a   Bayburt, Erol K ^a   McKie, Jeffery ^a,b   Alexander, Karen M ^a   Kohlhaas, Kathy L ^a   Wismer, Carol T ^a   Mikusa, Joe ^a   Jarvis, Michael F ^a   Kowaluk, Elizabeth A ^a   Bhagwat, Shripad S ^a,b  

^a ABBOTT LABORATORIES   (United States)

^b CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO[2,3 D]PYRIMIDINE DERIVATIVE; ADENOSINE KINASE INHIBITOR; AMINOPYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADENOSINE KINASE; ANALGESICS; ANIMALS; CELL LINE, TUMOR; HUMANS; MICE; PAIN MEASUREMENT; PHOSPHORYLATION; PYRIDINES; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0242607609     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030327l     Document Type: Article

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