Adenosine kinase inhibitors

Current Pharmaceutical Design

Volumn 4, Issue 5, 1998, Pages 403-416

  Kowaluk, Elizabeth A ^a   Bhagwat, Shripad S ^a   Jarvis, Michael F ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 3 IODO 1 (5 DEOXY 5 AMINO BETA DEXTRO RIBOFURANOSYL)PYRROLO[3,4 D]PYRIMIDINE; 4 AMINO 5 IODO (5 DEOXY 5 AMINO BETA DEXTRO RIBOFURANOSYL)PYRROLO[2,3 D]PYRIMIDINE; 5' DEOXY 5 IODOTUBERICIDIN; A 134974; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; GP 3269; GP 515; GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROTRANSMITTER; PURINE P2 RECEPTOR; TUBERCIDIN DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIA; ANTICONVULSANT ACTIVITY; BRAIN ISCHEMIA; ENZYME INHIBITION; ENZYMOLOGY; GENE EXPRESSION REGULATION; INFLAMMATION; NEUROPROTECTION; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION; TISSUE REACTION;

ADENOSINE; ADENOSINE KINASE; ANIMALS; CHEMISTRY, PHARMACEUTICAL; ENZYME INHIBITORS; HUMANS; INFLAMMATION; PAIN; WOUNDS AND INJURIES;

EID: 0031752001     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (178)

1. Williams M. Curr. Opin. Invest. Drugs. 1993, 2, 1105-1117.
2. Newby, A.C. Trends Biochem Sci 1984, 2, 42-44.
3. Williams M. Neurochem. Int. 1989, 14, 249-264.
4. Burnstock G. In Cell Membrane Receptors for Drugs and Hormones; Bolis L, Straub RE, Eds., Raven, New York 1978, 107-118.
5. Williams, M.; Burnstock, G. In Purinergic Approaches in Experimental Therapeutics Jacobson, K.A., Jarvis, M.F., Eds. Wiley-Liss, Inc. New York 1997, 3-26.
6. Daval, J.L., Nehlig, A., Nicolas, F Life Sci. 1991, 49, 1325-1453
7. Jarvis, M.F. In Current Protocols in Pharmacology, Enna, S , Williams, M . Eds., Wiley-Liss, New York 1998, 19.1, in press.
8. Londos, C. and Wolff, J. Proc. Natl Acad. Sci. U.S.A. 1977, 74, 5482-5486.
9. Hamprecht, B. and Van Calker, D. Trends in Pharmacol Sci. 1985, 6, 153-154
10. Daly, J.W. J. Med. Chem 1992, 25, 197-207.
11. Jacobson, K., Trivedi, B., Chruchill, P., and Williams, M. Biochem Pharmacol. 1991, 41, 1399-1410
12. Jarvis, M.F. and Williams, M. In: Adenosine and Adenosine Receptors, M Williams, Ed, Humana Press, Clifton, New Jersey. 1990, 423-474.
13. Jacobson, K., van Galen, P., and Williams, M. J. Med. Chem. 1992, 35: 407-422.
14. Jacobson, K.A , Jarvis, M.F Purinergic Approaches in Experimental Therapeutics, Wiley-Liss, New York 1997, 1-585.
15. Mahan, L.C., Mcvittie, L.D., Smyk-Randall, E.M., Nakata, H., Monsma, F.J., Jr., Gerfen, C.R , Sibley, D.R. Mol. Pharmacol 1991, 40, 1-7.
16. Maenhaut C., Van Sande, J., Libert, F., Abramowicz, M., Parmentier, M., Vanderhaegen, J., Dumont, J., Vassart, G., and Schiffmann, S. Biochem. Biophys. Res. Comm. 1990, 173, 1169-1178.
17. Rivkees, S.A. and Reppert, S.M. Mol. Endocrinol. 1992, 6, 1598-1604.
18. Bruns, R F., Lu, G. H., and Pugsley, T A. Mol. Pharmacol. 1986, 29, 331-346.
19. Jarvis, M.F. and Williams, M Eur J Pharmacol. 1989, 168, 243-246.
20. Jarvis, M.F. In Receptor Localization: Ligand Autoradiography, F. Leslie and C.A. Altar, Eds, Alan R. Liss, New York, 1988, 95-113.
21. Jarvis, M F. In Purinergic Approaches in Experimental Therapeutics, K.A. Jacobson and M.F. Jarvis, Eds, Wiley-Liss, New York 1997, 405-421
22. Jarvis, M.F and Saltzman, A. Drug. Dev. Res 1993, 29, 305-309.
23. Hutchison, K.A., Nevins, B., Perini, F., Fox, I.H. Biochem 1990, 29, 5138-5144
24. Olah, M.E., Stiles, G.L Ann. Rev. Pharmacol. Toxicol. 1995, 35, 581-606.
25. Meyerhof, W., Muller-Brechlin, R., Richter, D. FEBS Lett. 1991, 284, 155-260.
26. Tucker, A.L., Linden, J. Cardiovasc. Res. 1993, 27, 62-67.
27. Zhou, Q., Li, C., Olah, M., Johnson, R., Stiles, G., and Civelli, O. Proc. Natl. Acad Sci. U.S.A. 1992, 89, 7432-7436.
28. Linden, J. Trends Pharmacol. Sci. 1994, 15, 298-306.
29. Sherman, L.P. and Weaver, D.R. Brain Res. 1997, 745, 10-20.
30. van Galen, P.J.M , van Bergen, A.H., Gallo-Rodriguez, C., Melman, N., Olah, M.E., Ijzerman, A.P., Stiles, G L. Mol. Pharmacol., 1994, 45, 1101-1111
31. Salvatore, C.A., Jacobson, M.A., Taylor, M.E., Linden, J Proc. Natl. Acad. Sci., 1993, 90, 10365-10369.
32. Arch JRS, Newsholme EA. Essays Biochem. 1978, 14, 82-123.
33. Davies, L P.; Jamieson, D. D.; Baird-Lambert, J. A ; Kazlauskas, R. Biochem. Pharmacol. 1984, 33, 347-355
34. Newby AC, Holmquist AC, Illingworth J, Pearson JD. Biochem J 1983, 214: 317-323.
35. Pak MA, Haas HL, Decking UKM, Schrader J. Neuropharmacol 1994, 33, 1049-1053.
36. Golembiowska, K.; White, T.D.; Sawynok, J. Eur. J Pharmacol 1996, 307, 157-162.
37. Britton, D R , Mikusa, J., Lee, C.H., Williams, M., Kowaluk, E.A. Soc. Neurosci Abstr. 1996, 22: 617.6.
38. Leibach TK, Spiess GI, Neudecker TJ, Peschke GJ, Puchwein G, Hartmann GR Z Physiol Chem 1971, 352, 328-344.
39. Miller R.L., Adamczyk D.L., Miller W.H., Koszalka G.W., Rideout J.L., Beacham L.M., Chao E.Y., Haggerty J.J., Krenitsky T.A., Elion G.B J Biol Chem 1979, 254, 2346-2352.
40. Palella T.D., Andres C.M., Fox I.H. J Biol Chem 1980, 255, 5264-5269.
41. Yamada, Y., Goto, H., Ogasawara, N. Comp. Biochem. Physiol [B], 1982, 71, 367-372
42. Rottlan P, Miras-Portugal MT Eur. J. Biochem. 1985, 151, 365-371.
43. Lobelle-Rich PA; Reeves RE, Am J Trop Med Hyg 1983, 32, 976-979.
44. Datta AK, Bhaumik D, Chatterjee R: J Biol Chem. 1987, 262, 5515-5521.
45. Andres C.M., Fox, I.H J Biol Chem 1979, 254, 11388-11393.
46. Klobutcher, L.A., Nichols, E.A., Kucherlapati, R S., Ruddle, F.H. Cytogenet. Cell Genet. 1976, 16, 171-174.
47. Chan T, Creagan R.P., Reardon M.P. Somatic Cell Genet 1978, 4, 1-12.
48. Sammuelson, L.C., Farber R.A., Somat. Cell Mol. Genet. 1985, 11, 257-265.
49. McNally, T., Helfrich, R., Cowart, M., Dorvin, S., Meuth, J., Idler, K., Simmer, R., Kowaluk, E., Halbert, D. Biochem. Biophysic. Res. Comm. 1997, 231, 645-650
50. Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS. Proc Natl Acad Sci USA 1996, 93, 1232-1237.
51. [511 Kowaluk EA, Cowart M. Drug Dev Res. 1994, 31, 287.
52. Yamada Y, Goto H, Ogasawara N. Biochem Biaphys Acta 1980, 616, 199-207.
53. Hawkins CF, Bagnara AS Biochemistry, 1987, 26, 1982-1987
54. Fisher, M.N., Newsholme, E.A. Biochem. J., 1984, 221, 521-528.
55. Lin BB, Hurley MC, Fox IH Mol Pharmacol 1988, 34, 501-505.
56. Elalaoui A, Divita G, Maury G, Imbach JL, Goody R.D. Eur J Biochem. 1994, 221, 839-846.
57. Henderson JF, Mikoshiba A, Chu SY, Caldwell IC J Biol Chem 1972, 247, 11972-11975.
58. Mimouni M, Bontemps F, van den Berghe G. J Biol Chem 1994, 269, 17820-17825.
59. Bhaumik, D , Datta, A.K. Mol. Biochem. Parasitol. 1988, 28, 181-187
60. Chang C.H., Cha S., Brockman R.W., Bennett L.L Jr. Biochemistry 1983, 22, 600-611.
61. Richard, J.P., Carr, M.C., Ives, D H., Frey, P.A. Biochem. Biophys. Res. Comm 1980, 30, 1052-1056.
62. Bennett, L. L.: Hill, D. L. Mol Pharmacol. 1975, 11, 805-808.
63. Iltsch, M H., Uber, S. S , Tankersley, K. O., el Kouni, M. H. Biochem. Pharmacol. 1995, 49, 1501-1512.
64. Kazlauskas, R., Murphy, P. T., Wells, R. J., Baird-Lambert, J. A., Jamieson, D. D. Aust. J. Chem. 1983, 36, 165-170.
65. Cook, A. F.; Holman, M. J. Nucleosides Nucleotides, 1984, 3, 401-411.
66. Davies, L. P , Baird-Lambert, J. A., Marwood, J. F. Biochem. Pharmacol. 1986, 35, 3021-3029.
67. Davies, L. P.; Cook, A. F. Life Sci. 1995, 17, 345-349.
68. Cottam, H. B.; Wasson, D. B.; Shih, H. C.; Raychaudhuri, A.; DiPasquale, G.; Carson, D. A. J. Med. Chem. 1993, 36, 3424-3430.
69. Cottam, H. B Drugs of the Future 1994, 19, 485-491.
70. Sanna, R ; Bong, G. W.; Firestein, G. J Immunol. 1995, 154, 5444-5451.
71. Firestein, G ; Boyle, D.; Bullough, D. A.; Gruber, H. E.; Sajjadi, F.; G.; Montag, A.; Sambol, B.; Mullane, K. M. J. Imunot. 1994, 152, 5853-5859
72. th ACS National Meeting, San Francisco, April 13-17, 1997, Medi 173.
73. Erion, M D ; Ugarker, B. G.: Dare, J. Nucleosides Nucleotides 1997, 16, 1013-1021
74. Kubo, I.: Kim, M., Wood, W F.; Naoki, H Tetrahedron Lett. 1986, 27, 4277-4280
75. Moss, R J.; Petrie, C. R.; Meyer, R. B.; Dee Nord, L.; Willis, R. C., Smith, R. A ; Larson, S. B.; Kim, G D.; Robins, R. K. J. Med. Chem 1988, 31, 786-790
76. Franchetti, P ; Cappellacci, L.; Cristalli, G.; Grifantini, M.; Vittorio, S. Nucleosides Nucleotides, 1991, 10, 543-545.
77. Baxter, A. D.; Penn, C. R.; Storer, R.; Weir, N. G.; Woods, J. M. Nucleosides Nucleotides 1991, 10, 393-396.
78. th ACS National Meeting, Orlando, Florida, Aug 25-29, 1996, Medi 156.
79. Bone, R.; Cheng, Y.-C.; Wolfenden, R. J. Biol. Chem. 1986, 261, 5731-5735.
80. Prescott, M ; McLennan, A. G., Agathocleous, D. C.; Bulman Page, P. C.; Cosstick, R.; Galpin, I. J. Nucleosides Nucleotides 1989, 8, 297-303.
81. Leydier, C., Bellon, L.; Barascut J -L.; Deydier, J., Maury, G.; Pelicano, H.; Abdalaziz El Alaaoui, M.; Imbach, J.-L. Nucleosides Nucleotides 1994, 13, 2035-2050.
82. Harms, H. H., Wardeh, G. and Mulder, A. H. Eur. J Pharmacol 1978, 49, 305-309.
83. Berne, R. M (1963) J. Physiol. (Lond.) 1963, 204, 317-322
84. Berne, R. M., Knabb, R. M , Ely, S. W., and Rubio, R. Fed. Proc. 1983, 42, 3136-3142.
85. Berne, R. M., Rubio, R. and Cornish, R. R. Circ. Res. 1974, 32, 262-271.
86. Winn, R. H , Rubio, G R., and Berne, R. M J. Cerebr. Blood Flow Metab. 1981, 1, 239-247.
87. Onodera, H., Sato, K., Kogure, K. Neurosci. Lett 1986, 24, 169-174.
88. Phillis, J. W. and O'Regan, M. H.Trends in Pharmacol. Sci. 1988, 9, 153-154.
89. Dunwiddie, T.V., Worth, T. J. Pharmacol. Exp. Ther. 1982, 220, 70-76
90. Dragunow, M., Goddard, G. V., and Laverty, R. Epilepsia.1985, 26, 480-487.
91. Marangos, P. J. and Boulenger, J. P.Neurosci. Biobehav. Rev., 1985, 9, 421-430.
92. Knutsen, L.J.S., Murray, T.F. In Purinergic Approaches in Experimental Therapeutics, K.A. Jacobson and M F. Jarvis, Eds, Wiley-Liss, New York, 1997, 423-448.
93. Maitre, M., Ciesielski, L., Lehman, A., Kempf, E., Mandel, P. Biochem. Pharmacol. 1974, 23, 2807.
94. Lewin, E., Bleck, V. Epilepsia, 1981, 22, 557-581.
95. Winn, H.R., Welsh, J.E., Rubio, G.R., Berne, R.M. Circ. Res 1980, 47, 568-577.
96. During, M.J and Spencer, D.D., Ann Neurol, 1992, 32, 618-624
97. Rudolphi, K.A , Schubert, P., Parkinson, F.E., Fredholm, B.B. Cerebrovasc. Brain Metab. Rev. 1992, 4, 346-360.
98. Albertson, T. E., Joy, R. M., and Stark, L. G. Pharmacol., Biochem Behav. 1993, 19, 339-343.
99. Barraco, R. A., Swanson, T. H., Phillis, J. W. , and Berman, R. F. Neurosci. Lett 1984, 46, 317-322.
100. Murray, T F. and Szot, P. In Neurotransmitters, Seizures, and Epilepsy III (G. Nistico Eds) Raven Press, 1986, 341-353.
101. Murray, T. F., Sylvester, D., Schultz, C. S., Szot, P. (1985) Neuropharmacol. 1985, 24, 761-766.
102. Niglio, T., Popoli, P., Caporali, M. G., de Carolis, S. Pharmacol. Res. Comm. 1988, 20, 561-572.
103. Seale, T.W., Johnson, P., Roderick, T.H., Carney, J.M. Pharmacol. Biochem.Behav. 1985, 23, 275-278.
104. Popoli, P., Benedetti, M., and de Carolis, A. Pharmacol. , Biochem., and Behav 1988, 29, 533-539.
105. Berman, R.F., Jarvis, M.F., Lupica, C.R. Kindling 1990, 4, 423-440.
106. Albertson, T.E. Pharmacol., Biochem. Behav., 1986, 24, 1599-1603.
107. Szot, P., Sanders, R.C and Murray, T. F. Neuropharmacol. 1987, 26, 1173-1180
108. Kleinsorge, R.J., Bowers, L. M., Jarvis, M.F., Berman, R.F. Drug Dev Res. 1993, 29, 287-291
109. Zhang, G.; Franklin, P.H.; Murray, T.F. J. Pharmacol Exp. Ther. 1993, 264, 1415-1424.
110. Murray, T.F.; Zhang, G.; Franklin, P H. Drug. Dev. Res. 1993, 28, 410-415.
111. Kowaluk, E A.; Kohlhaas, K.L.; Daanen, J.; Lee, C H., Drug Dev Res. 1996, 37, 190
112. Weisner JB, Zimring ST, Castellino AJ, Ugarkar BG, Shea M, Erion MD, Foster AC. Epilepsia 1995, 36, 86
113. Zimring, S.T., Miller, L.P., Babb, M J., Hill, G.M., DaRe, J., Ramirez Weinhouse, M.M., Ugarkar, B G , Gruger, H.E., Foster, A.C , Wiesner, J.B. Soc Neurosci. Abstr. 1996, 21, 151.1.
114. Berman, R F.; Cortese, B., Wiesner, J.B. Soc. Neurosci. Abstr. 1997, 23, 840.3.
115. Rudolphi, K.A., Keil, M. and Hinze, H.J. Neurosci. Lett. 1987, 84, 307-311.
116. Miller, L.P and Hsu, C., J. Neurotrauma, 1992, 9, S563-S577.
117. Onodera, H., Sato, G , Kogure, K. Brain Res. 1987, 415, 309-322.
118. Evans, M. C., Swan, J H. and Meldrum, B S. Neurosci. Lett. 1987, 83, 287-292
119. Goldberg, M.P., Monyer, H., Weiss, H H. and Choi, D.W. Neurosci. Lett 1988, 89, 323-327.
120. von Lubitz, D.K.J.E., Dambrosia, J.M., Kempski, O., and Redmond, D.J. Stroke, 1988, 19, 1133-1139.
121. Zhou, J., Meno, J.R., Hsu S. S.-F. and Winn, H R., J. Cereb. Blood Flow Metab. 1994, 14, 166-173.
122. Block, G.A., Pulsinelli, W.A., J Cerebro. Blood Flow Metab 1987, 7, S258.
123. Bielenberg, G.W., J. Cerebro Blood Flow Metab. 1989, 9, 645.
124. Duncan, P. M., Jarvis, M. F. and Freeman, F. G Pharmacol. Biochem. Behav., 1982, 16, 1009-1011.
125. Simon, R.P., Swan, J.H., Griffiths, T., Meldrum, B.S Science, 1984, 226, 850-852.
126. Foster, A.C. Nature, 1987, 329, 395-396.
127. Jarvis, M. F., Murphy, D. E , Williams, M., Gerhardt, S C., Boast, C. A. Synapse. 1988, 2, 577-584.
128. Deckert, J. and Jorgensen, M B. (1988) Brain Res 1988, 446, 161-164.
129. Dolphin, A. C. and Prestwich, S. A Nature (Lond.) 1985, 316, 148-150.
130. Craig G.G., White, T D. J. Neurochem. 1993 60 1073-1080.
131. White T.D., Eur. J. Pharmacol. 1996, 303, 27-38.
132. Hosli, L., Hosli, E., Della Briotta, G. Neurosci. Lett. 1987, 79, 108-112.
133. Cronstein, B. N., Kramer, S B , Rosenstein, E. D., Weissmann, G. and Hirschhorn, R. J. Exp. Med. 1983, 158, 1160-1177.
134. Cronstein BN, Naime D, Ostad E. J. Clin. Invest., 1993, 92: 2675-2682.
135. Cronstein B.N. J Invest Med 1995, 43, 50-57.
136. Phillis JW, Smith-Barbour M Life Sci 1993, 53, 497-502.
137. Miller, L.P., Jelovich, L.A., Yao, L., DaRae, J., Ugarkar, B. and Foster, A.C., Neurosci Lett., 1996, 220, 73-76.
138. Jiang, N., Kowaluk, E.A., Lee, C-H., Mazdiyasni, H. and Chopp, M., Eur. J. Pharmacol., 1997, 320, 131-137.
139. Choca, J. L.; Proudfit, H.K.; Green, R.D. J. Pharmacol. Exp. Ther. 1987, 242, 905-910.
140. Geiger JD, Nagy JI. J. Neurosci., 1986, 6: 2707-2714.
141. Geiger, J.D., Parkinson, F., Kowaluk, E.A. In: Purinergic Approaches in Experimental Therapeutics Jacobson, K.A.; Jarvis, M.F., Eds Wiley-Liss, Inc. New York, 1977, 55-84.
142. Geiger JD, Labella FS, Nagy JL. J Neurosci., 1984, 4, 2303-2310
143. Geiger JD, Nagy JI. Brain Res., 1985, 347: 321-327.
144. Sawynok J, Sweeney MI, White TD. Br. J. Pharmac., 1986, 88, 923-930.
145. Reeve AJ, Dickenson AH. Br. J. Pharmacol., 1995, 116, 2221-2228.
146. Brundege, J M. and Dunwiddie, T.V., Adv. Pharm., 1997, 39, 353-391.
147. rd Ed. Wall, P., Melzack, R.D. Eds, Churchill Livingstone, Edinburgh, 1994, 101-112.
148. rd Ed. Wall, P., Melzack, R.D. Eds, Churchill Livingstone, Edinburgh, 1994, 225-241.
149. Sjolund KF, Sollevi A, Segerdahl M, Lundeberg T. Anesth. Analg., 1997, 85, 627-632.
150. DeLander, G. E. and Wahl, J. J. J. Pharmacol. Exp. Ther. 1988, 246, 565-570.
151. Li E, Perl E. J Neurophysiol, 1994, 4: 1611-1621.
152. Poon, A., Sawynok, J. Pain,1998, 74, 235-245.
153. Herrick-Davis, K., Chippari, S., Luttinger, D., Ward, S.J. Eur. J. Pharmacol. 1989, 162, 365-369.
154. Fredholm BB, Dunwiddie TV. Trends Pharmacol. Sci., 1988, 9: 130-134.
155. Dunwiddie, T.V.; Fredholm, B.B. In: Purinergic Approaches in Experimental Therapeutics. Jacobson, K A.; Jarvis, M.F. Eds. Wiley-Liss, Inc. New York, 1997, 359-382.
156. Holmgren M, Hedner J, Mellstrand T, Nordberg G, Hedner Th. Naunyn-Schmiedeberg's Arch Pharmacol., 1986, 334, 290-293.
157. Keil GJ, DeLander GE. Life Sci., 1992, 51, 171-176.
158. Ahlijanian MK, Takemori AE. Eur J. Pharmacol. 1985, 112, 171-179
159. Poon A, Sawynok J. Eur J. Pharmacol., 1995, 286, 177-184.
160. Sosnowski, Yaksh TL. Anesth. Analg., 1989, 69, 587-592.
161. Yamamoto T, Yaksh TL. Pain, 1992, 121-128.
162. Lee YL, Yaksh TL. J. Pharmacol. Exp. Ther., 1996, 277, 1642-1648.
163. Karlsten R, Gordh T Anesth. Analg., 1995, 80, 844-847.
164. Segerdahl M, Ekblom A, Sollevi A Anesth. Analg. 1994, 79, 787-791.
165. Segerdahl M, Ekblom A, Sjolund KF et al. NeuroReport 1995, 6, 753-756.
166. Ekbolm A, Segerdahl M, Sollevi A Acta Anesth. Scand , 1995, 39, 717-722.
167. Bellfrage M, Sollevi A, Segerdahl M. et al. Anesth. Analg. 1995, 81, 713-717.
168. Segerdahl M, Irestedt L, Sollevi A. Acta Anesth. Scand., 1997, 41, 180-185.
169. Kowaluk , E.A., Bannon, A., Gunther, K., Kohlhaas, K., Lynch, J., Jarvis, M.F. Soc. Neurosci. Abstr. 1996, 22, 617.6.
170. Kowaluk, E.A., Mikusa, J., Wismer, C., Jarvis, M.F. Drug Dev. Res. 1998, 43, 148.
171. Lynch, J., Jarvis, M.F., Kowaluk, E.A. Soc. Neurosci. Abstr 1997, 23, 403.4.
172. Firestein GS. Drug Dev. Res., 1996, 39: 371-376.
173. Munro, R., Ressner, R., Stone, M., Gessner, G., Jarvis, M.F , and Saltzman, A. Drug. Dev. Res. 1998, in press.
174. Firestein GS, Paine MM, Boyle DL Arth. Rheum., 1994, 37, 193-200.
175. Rosengren S, Bong GW, Firestein GS. J. Immunol., 1995, 154, 5444-5451.
176. Lesch ME, Ferin MA, Wright CD, Schrier DJ. Agents Actions. 1991, 34, 25-27.
177. Schrier DJ, Lesch ME, Wright CD, Gilbertsen RB. J. Immunol , 1990, 145, 1874-1879.
178. Bong GW, Rosengren S, Firestein GS. J. Clin Invest., 1996, 98, 1-7.