Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues

Journal of Medicinal Chemistry

Volumn 43, Issue 15, 2000, Pages 2883-2893

  Ugarkar, Bheemarao G ^a   DaRe, Jay M ^a   Kopcho, Joseph J ^a   Browne III, Clinton E ^a   Schanzer, Juergen M ^a   Wiesner, James B ^a   Erion, Mark D ^a  

^a Metabasis Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 IODOTUBERCIDIN; 5' AMINO 5' DEOXYADENOSINE; ADENOSINE KINASE INHIBITOR; TUBERCIDIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; GLYCOSYLATION; NONHUMAN; RAT; REACTION ANALYSIS; SEIZURE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADENOSINE KINASE; ANIMALS; ANTICONVULSANTS; ELECTROSHOCK; ENZYME INHIBITORS; HUMANS; MALE; RATS; RECOMBINANT PROTEINS; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBERCIDIN;

EID: 0034721186     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000024g     Document Type: Article

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