Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 1, 2001, Pages 83-86

  Cowart, Marlon ^a   Lee, Chih Hung ^a   Gfesser, Gregory A ^a   Bayburt, Erol K ^a   Bhagwat, Shripad S ^a   Stewart, Andrew O ^a   Yu, Haixia ^a   Kohlhaas, Kathy L ^a   McGaraughty, Steve ^a   Wismer, Carol T ^a   Mikusa, Joseph ^a   Zhu, Chang ^a   Alexander, Karen M ^a   Jarvis, Michael F ^a   Kowaluk, Elizabeth A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 PYRIDOPYRIMIDINE; ADENOSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE TRANSPORT; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HYPERALGESIA; NOCICEPTION; NONHUMAN; PHOSPHORYLATION; RAT; STRUCTURE ACTIVITY RELATION; THERMAL EXPOSURE;

ADENOSINE KINASE; ADMINISTRATION, ORAL; ANIMALS; CELL MEMBRANE PERMEABILITY; ENZYME INHIBITORS; HYPERALGESIA; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PAIN; PAIN MEASUREMENT; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0035825362     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00602-8     Document Type: Article

References (16)