Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 18, 2001, Pages 2419-2422

  Lee, Chih Hung ^a   Daanen, Jerome F ^a   Jiang, Meiqun ^a   Yu, Haixia ^a   Kohlhaas, Kathy L ^a   Alexander, Karen ^a   Jarvis, Michael F ^a   Kowaluk, Elizabeth L ^a   Bhagwat, Shripad S ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCARBOXYLATE DERIVATIVE; 5' DEOXY 5 IODOTUBERCIDIN; 5' DEOXY 5' AMINO CLITOCINE; ADENOSINE; ADENOSINE KINASE; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR STIMULATING AGENT; AMIDE; BENZENE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CLITOCYBE INVERSA EXTRACT; ESTER DERIVATIVE; OXAZOLINE DERIVATIVE; PLANT EXTRACT; SULFONE DERIVATIVE; SULFOXIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CLITOCYBE INVERSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; MUSHROOM; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADENOSINE KINASE; ANIMALS; BIOCHEMISTRY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; PYRIMIDINE NUCLEOSIDES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

BASIDIOMYCOTA; CLITOCYBE;

EID: 0035903904     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00454-1     Document Type: Article

References (15)