Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido [2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor

Journal of Medicinal Chemistry

Volumn 44, Issue 13, 2001, Pages 2133-2138

  Lee, C H ^a   Jiang, M ^a   Cowart, M ^a   Gfesser, G ^a   Perner, R ^a   Ki Hwan Kim, ^a   Yu Gui Gu, ^a   Williams, M ^a   Jarvis, M F ^a   Kowaluk, E A ^a   Stewart, A O ^a   Bhagwat, S S ^a,b  

^a ABBOTT LABORATORIES   (United States)

^b Signal Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5 (3 BROMOPHENYL) 7 (6 MORPHOLINOPYRIDIN 3 YL)PYRIDO[2,3 D]PYRIMIDINE; ABT 702; ADENOSINE; ADENOSINE KINASE; ADENOSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PAIN; RAT; TISSUE INJURY;

ADENOSINE KINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG DESIGN; ENZYME INHIBITORS; FORMALDEHYDE; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MORPHOLINES; PAIN MEASUREMENT; PYRIMIDINES; RATS; TUMOR CELLS, CULTURED;

EID: 0035927430     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000314x     Document Type: Article

References (17)

1. Purinergic and pyrimidinergic receptors as potential drug targets
2. Receptors for purines and pyrimidines
3. Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accumulation. The role of N-methyl-D-aspartate receptors
4. Turnover of adenosine in plasma of human and dog blood
5. Adenosine, The signal of life
6. The control of the metabolism and the hormonal role of ADO
7. Adenosine kinase inhibitors augment release of adenosine from spinal cord slices
8. Manipulation of endogenous adenosine in the rat piriform cortex modulates seizure susceptibility
9. Spinally mediated antinociception is induced in mice by an adenosine kinase, but not an adenosine deaminase inhibitor
10. Structural requirements for activity of nucleosides as substrates for adenosine kinase: Orientation of substitutents on the pentafuranosyl ring
11. Halogenated pyrrolopymidine analogues of adenosine from marine organisms: Pharmacological activities and potent inhibition of adenosine kinase
12. Clitocine, a new insecticidal nucleoside from the mushroom clitocybe inversa
13. Design, synthesis and anticonvulsant activity of the potent ADO kinase inhibitor GP3269
14. Synthesis of Potential Antimalarial Agents. VII. Azaquinolines. I. The preparation of Some Pteridines and Pyrido[3,4-b]pyrazines
15. Novel condensation products of 2-amino-3-cyano-4,6-disubstituted pyridine with urea, thiourea, formamide and carboc disulfide
16. ABT 702 (4-amino-5- (3-bromophenyl)-7-(6-morpholino-pyridin-3-yl) pyrido [2, 3,-d] pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and antiinflammatory properties. I. In vitro characterization and acute antinociceptive effects in the mouse
17. ABT-702 (4-amino-5- (3-bromophenyl)-7-(6-morpholino-pyridin-3-yl) pyrido [2,3,-d]pyrlmidine): A novel orally effective adenosine kinase inhibitor with analgesic and antiinflammatory properties. II. In vivo characterization in the rat