ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidi ne), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 3, 2000, Pages 1165-1174

  Kowaluk, Elizabeth A ^a   Mikusa, Joe ^a   Wismer, Carol T ^a   Zhu, Chang Z ^a   Schweitzer, Edmund ^a   Lynch, James J ^a   Lee, Chih Hung ^a   Jiang, Meiqun ^a   Bhagwat, Shripad S ^a,b   Gomtsyan, Arthur ^a   McKie, Jeff ^a   Cox, Bryan F ^a   Polakowski, James ^a   Reinhart, Glenn ^a   Williams, Michael ^a   Jarvis, Michael F ^a  

^a ABBOTT LABORATORIES   (United States)

^b Signal Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5 (3 BROMOPHENYL) 7 (6 MORPHOLINOPYRIDIN 3 YL)PYRIDO[2,3 D]PYRIMIDINE; ADENOSINE; ADENOSINE KINASE; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR BLOCKING AGENT; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTINOCICEPTIVE AGENT; CARRAGEENAN; FORMALDEHYDE; MORPHINE; NALOXONE; STREPTOZOCIN; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG TOLERANCE; ENZYME INHIBITION; HEART RATE; HYPERALGESIA; MALE; MEAN ARTERIAL PRESSURE; NERVE INJURY; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT;

ADENOSINE KINASE; ADMINISTRATION, ORAL; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DIABETES MELLITUS, EXPERIMENTAL; EDEMA; ENZYME INHIBITORS; FORMALDEHYDE; HEMODYNAMIC PROCESSES; HYPERALGESIA; MALE; MORPHOLINES; MOTOR ACTIVITY; PAIN; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; STREPTOZOCIN;

EID: 0033697042     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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