Adenosine Kinase Inhibitors. 3. Synthesis, SAR, and Antiinflammatory Activity of a Series of L-Lyxofuranosyl Nucleosides

Journal of Medicinal Chemistry

Volumn 46, Issue 22, 2003, Pages 4750-4760

  Ugarkar, Bheemarao G ^a   Castellino, Angelo J ^a   DaRe, Jay S ^a   Ramirez Weinhouse, Michele ^a   Kopcho, Joseph J ^a   Rosengren, Sanna ^a   Erion, Mark D ^a  

^a Metabasis Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; 5 IODOTUBERCIDIN; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR STIMULATING AGENT; GP 790; LYXOFURANOSYL NUCLEOSIDE DERIVATIVE; METHANOL; NUCLEOSIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CARDIOVASCULAR DISEASE; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG SYNTHESIS; EDEMA; HUMAN; IC 50; LEUKOCYTE ACTIVATION; NONHUMAN; PAW EDEMA; PHOSPHORYLATION; RAT; RHEUMATOID ARTHRITIS; SKIN DEFECT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADENOSINE KINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; LEUKOCYTE COUNT; NEUTROPHILS; NUCLEOSIDES; PHOSPHORYLATION; RATS; RECEPTORS, PURINERGIC P1; SKIN; STRUCTURE-ACTIVITY RELATIONSHIP; THEOBROMINE;

EID: 0142028908     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030230z     Document Type: Article

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