Adenosine kinase inhibitors: Polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 18, 2003, Pages 3041-3044

  Zheng, Guo Zhu ^a   Mao, Yue ^a   Lee, Chih Hung ^a   Pratt, John K ^a   Koenig, John R ^a   Perner, Richard J ^a   Cowart, Marlon D ^a   Gfesser, Gregory A ^a   McGaraughty, Steve ^a   Chu, Katharine L ^a   Zhu, Chang ^a   Yu, Haixia ^a   Kohlhaas, Kathy ^a   Alexander, Karen M ^a   Wismer, Carol T ^a   Mikusa, Joseph ^a   Jarvis, Michael F ^a   Kowaluk, Elizabeth A ^a   Stewart, Andrew O ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE KINASE INHIBITOR; ANALGESIC AGENT; PYRIMIDINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG DISTRIBUTION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; IC 50; LOCOMOTION; NONHUMAN; PAIN; QUANTUM YIELD; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 12444258740     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00642-5     Document Type: Article

References (20)

1. (a) Williams M., Burnstock G. In Purinergic Approaches in Experimental Therapeutics; Jacobson, K., Jarvis, M., Eds.; Willey-Liss: New York, 1997; p 3.
2. (b) Newby A.C. Trends Biochem. Sci. 2:1984;42.
3. Davies L.P., Jamieson D.D., Baird-Lambert J.A., Kazlauskas R. Biochem. Pharmacol. 33:1984;347.
4. (a) Newby A.C., Holmquist A.C., Illingworth J., Pearson J.D. Biochem. J. 214:1983;317.
5. (b) Holmgren M., Hedner J., Mellstrand T., Nordberg G., Hedner T.H. Naunyn-Schmiedberg's Arch. Pharmacol. 334:1986;290.
6. (c) Keil G.J., DeLander G.E. Life Sci. 51:1992;171.
7. (d) Ahlijanian M.K., Takemori A.E. Eur. J. Pharmacol. 112:1985;171.
8. (e) Poon A., Sawynok J. Eur. J. Pharmacol. 286:1995;177.
9. (f) Sosnowski A., Yaksh T.L. Anesth. Analg. 69:1989;587
10. (g) Yamamoto T., Yaksh T.L. Pain. 1992;121.
11. (a) Cronstein B.N., Naime D., Firestein G. Arth. Rheum. 38:1995;1040.
12. (b) Li E., Perl E. J. Neuro-physiol. 4:1994;1611.
13. Cronstein B.N., Naime D., Firestein G. Arth. Rheum. 38:1995;1040.
14. Lee C.H., Jiang M.Q., Cowart M., Gfesser G., Perner R., Kim K.H., Gu Y.G., Williams M., Jarvis M.F., Kowaluk E.A., Stewart A.O., Bhagwat S.S. J. Med. Chem. 44:2001;2133.
15. McGaraughty S., Chu K.L., Wismer C.T., Mikusa J., Zhu C.Z., Cowart M., Kowaluk E.A., Jarvis M.F. J. Pharm. Exp. Ther. 296:2001;501.
16. Zheng G.Z., Lee C.H., Pratt J.K., Perner R.J., Jiang M.Q., Gomtsyan A., Matulenko M.A., Mao Y., Koening J.R., Kim K.H., Muchmore S., Yu H.X., Kohlhaas K., Alexander K.M., McGaraughty S., Chu K.L., Wismer C.T., Mikusa J., Jarvis M.F., March K., Kowaluk E.A., Bhagwat S.S., Stewart A.O. Bioorg. Med. Lett. 11:2001;2071.
17. (a) Latif N., Assad F.M., Girgis N.S. Indian J. Chem., Sect. B. 20:1981;463.
18. (b) Sturz H.G., Noller C.R. J. Am. Chem. Soc. 71:1949;2949.
19. Kuo D.L. Tetrahedron. 48:1992;9233.
20. Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J. Adv. Drug Deliv. Rev. 23:1997;3.