The green tea, a good choice for cardiovascular disease prevention?;El té verde ¿una buena elección para la prevención de enfermedades cardiovasculares?

Archivos Latinoamericanos de Nutricion

Volumn 54, Issue 4, 2004, Pages 380-394

  Hernández Figueroa, Tania T ^a   Rodríguez Rodríguez, Elena ^a   Sánchez Muniz, Francisco J ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Atherosclerosis; Cardiovascular diseases; Catechins; Endothelial lesion; Green tea; Lipoproteins; Peroxidation; Platelet aggregation

Indexed keywords

CARBOHYDRATE; CATECHIN; CELL ADHESION MOLECULE; FLAVONOID; LOW DENSITY LIPOPROTEIN; MINERAL; POLYPHENOL; PROTEIN; VITAMIN; WATER; ANTIOXIDANT; LIPID;

ADRENERGIC SYSTEM; ANTIOXIDANT ACTIVITY; ASIA; BEVERAGE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHINA; CHOLESTEROL BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DRY WEIGHT; FATTY ACID SYNTHESIS; HARVEST; HUMAN; LIPID PEROXIDATION; MOLECULE; OXIDATION; POPULATION RESEARCH; REVIEW; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; TEA; THROMBOCYTE AGGREGATION; THROMBOSIS; BIOAVAILABILITY; BLOOD; BODY WATER; CHEMISTRY; CLASSIFICATION; DRUG EFFECT; FEMALE; MALE;

CAMELLIA SINENSIS;

ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; BODY WATER; CAMELLIA SINENSIS; CARDIOVASCULAR DISEASES; CATECHIN; FEMALE; HUMANS; LIPID PEROXIDATION; LIPIDS; MALE; TEA;

EID: 20744456714     PISSN: 00040622     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (141)

1. Liao S. The medical action of androgens and green tea epigallocatechin gallate. HKMJ 2001;7: 369-374.
2. Serafini M, Ghiselli A, Ferro-Luzzi A. In vivo antioxidant effect of green and green tea in man. Eur J Clin Nutr 1996;50: 28-32.
3. Van het Hof KH, der Boer HS, Wiseman SA, Lien N, Westrate JA, Tijburg LB. Consumption of green or black tea does not increase resistance of low-density lipoprotein to oxidative modification. Am J Clin Nutr 1997;66: 261-266.
4. Kang WS, Lim IH, Yuk DY. Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate. Thromb Res 1999;96: 229-237.
5. Valcic S, Burr J, Timmermann B , Liebler D. Antioxidant chemistry of green tea catechins. New oxidation products of (-)-epigallocatechin from their reactions with peroxyl radicals. Chem Res Toxicol 2000;13:801-810.
6. Leung LK, Su Y, Chen R, Zhang Z, Huang Y, Chen ZY. Theaflavins in black tea and catechins in green tea are equally effective antioxidants. J Nutr 2001; 131: 2248-2251.
7. Fundación Erosky, 2001. Consultado en www.consumer.esen Mayo, 2004.
8. Oguni I Haray. Green tea has many medicinal activities for preventing disease such as cancer, cardio-vascular diseases and diabetes. Japan: Chunichi-shinbun Nagoya, 1990.
9. Graham NH. Green tea composition, consumption, and polyphenol chemistry. Prev Med 1992;21: 334-350.
10. Devesa JA. Plantas con semillas. In: Izco J, Barreno E, Burgués M, Costa M, Devesa J, Fernández J, Gallardo T, Llinona X, Salvo E, Talaberas S, Valdes B. Botánica. McGraw-Hill: Madrid; 1997: 379-581.
11. Innatia. Consultado en: www.innatia.com/te/te_verde.php Mayo, 2004.
12. Salazarp L. Consultado en: www.nutriinfo.com.ar/pagina/info/ téverde.htlm. Mayo, 2004.
13. Tijburg L, Wiseman S, Meijer G, Weststrate J. Effects of green tea, black tea and dietary lipophylic antioxidants on LDL oxidizability and atherosclerosis in hypercholesterolaemic rabbits. Atherosclerosis 1997;135: 37-47.
14. Hodgson JM, Puddey IB, Croft KD, Burke V, Mori VB, Cacceta R, Beilin L. Acute effects of ingestion of black and green tea on lipoprotein oxidation. Am J Clin Nutr 2000;71: 1103-1107.
15. Yamamoto T, Juneja LR, Chu DC, Kim M, editors. Chemistry and applications of green tea. New York: CRC Press, 1997.
16. Liang Y, Ma W, Lu J, Wu Y. Comparison of chemical compositions of Ilex latifolia Thumb and Camellia sinensis L. Food Chemistry 2001;75: 339-343.
17. Lill G, Voit S, Schrör K, Weber AA. Complex effects of different green tea catechins on human platelets. FEBS Letters 2003;546: 265-270.
18. Astill C, Birch MR, Dacombe C, Humphrey PG, Martin PT. Factors affecting the caffeine and polyphenol contents of black and green tea infusions. J Agric Food Chem 2001;49: 5340-5347.
19. Wang H. Determination of flavonols in green and black tea leaves and green tea infusions by high performance liquid chromatography. Food Research Int 2001;34: 223-227.
20. Bhagwat S, Beecher GR, Haytowitz DB, Holden JM, Dwyer J, Peterson J, Gebhardt SE, Elridge AL, Agarwal S, Balentine DA. Flavonoid composition of tea: Comparison of black and green teas. Agricultural Research Service, 2003. En: http://www.nal.usda.gov/fnic/foodcomp/Data/Other/IFT2003_TeaFlav.pdf
21. Chen ZY, Zhu QY, Tsang D, Huang Y. Degradation of green tea catechins in tea drinks. J Agric Food Chem 2001;49: 477-482.
22. Lin YL, Juan IM, Chen YL, Liang YC, Lin JK. Composition of polyphenols in fresh tea leaves and association of their oxygen radical-absorbing capacity with antiproliferative actions in fibroblast cell. J Agric Food Chem 1996;44: 1387-1394.
23. Lin YS, Tsai YJ, Tsay JS, Lin JK. Factors affecting the levels of tea polyphenols and caffeine in tea leaves. J Agric Chem 2003;51: 1864-1873.
24. Stagg GV, Millin DJ. The nutritional and therapeutic value of tea-a review. J Sci Food Agric 1975;26: 1439-1459.
25. Yang CS, Landau JM. Effects of tea consumption nutrition health. J Nutr 2000; 130: 2409-2412.
26. Mukhtar H, Ahmad N. Tea polyphenols: Prevention of cancer and optimizing health. Am J Clin Nutr 2000;71: 1698S-1704S.
27. He YH, Kies C. Green and black tea consumption by humans: impact on polyphenol concentrations in feces, blood and urine. Plant Foods Hum Nutr 1994;46: 221-229.
28. Yang CS, Chen L, Lee MJ, Balentine D, Kuo MC, Schantz SP. Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epid Bio Prev 1998;7: 351-354.
29. Yang CS, Lee MJ, Chen L. Human salivary tea catechin levels and catechin esterase activities: implications in human cancer prevention studies. Cancer Epidemiol Biomarkers Prev 1999;8: 83-89.
30. Van het Hof KH, Kivits GAA, Westrate JA, Tijburg LBM. Bioavaility of catechins from tea: the effect of milk. Eur J Clin Nutr 1998;52: 356-359.
31. Hollman PCH, Gaag M, Mengelers MJB, Trijp JMP, Vries JHM, Katan MB. Absorption and disposition kinetics of the dietary antioxidant quercetin in man. Free Rad Biol Med 1996;21: 703-707.
32. Brown PJ , Wright WB. An investigation of the interactions between milk proteins and tea poliphenols. J Chromatog 1963;11: 5504-514.
33. Fingl E, Woodbury DM. General principles. In: Goodman LS, Gilman A, editors. The pharmacological basis of therapeutics. New York: Macmillan, 1970:24-25.
34. Bastida S, Sánchez-Muniz FJ. Nutrición y obesidad. Rev Nutr Practica, 1999, 3: 49-58.
35. Sánchez-Muniz FJ, Varela Gallego P, Bastida Codina S, González Lorenzo JM Enfermedad cardiovascular. Hipertensión arterial. Dislipemia. En Cuidados farmacológicos y nutricionales en el paciente de edad avanzada. Carbajal A y Varela P, editors. Tema 2. Fundación General de la Universidad Complutense 2001: 1-47.
36. Bastida S, Sánchez-Muniz FJ. Fitoterapia en el control del exceso de peso. En Plantas medicinales en su farmacia. Formación sobre plantas medicinales por el farmacéutico. Edufarm y Consejo General de Colegios Oficiales de Farmacéuticos, 2000: 37-46.
37. Dulloo A, Duret D, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Nutr 1999;70: 1040-1045.
38. Bretón I. ¿Por qué nos hacemos obesos? Rev Nutr Practica 2004;6: 9-13.
39. Dulloo AG. Strategies to counteract readjustments towards lower metabolic rates during obesity management. Nutrition 1993;9: 366-372.
40. Landsberg L, Young JB. Sympathoadrenal activity and obesity: physiological rationale for the use of adrenergic thermogenic drugs. Int Obes Relat Metab Disord 1993;65: S29-S34.
41. 3-adrenoceptor agonists in the treatment of obesity and diabetes. Int J Obes Relat Metab Disord 1996;20: 191-199.
42. Liao S, Liang T. Methods and compositions for inhibiting 5α-reductase activity. US patent 5, 605, 909,1997.
43. Kao YH, Hiipakka RA, Liao S. Modulation of obesity by a green tea catechin. Am J Clin Nutr 2000; 72: 1232-1234.
44. Borchardt RT, Huber JA. Catechol-o-methyltransferase: structure-activity relationship for inhibition by flavonoids. J Med Chem 1975;18: 120-122.
45. Palou A. Los genes de la obesidad. Formación Continuada en Nutrición y Obesidad 1998;6: 280-298.
46. Dulloo AG, Seydoux J, Girardier L. Potentiation of the thermogenic antiobesity effects of ephedrine by dietary methylxanthines: adenosine antagonism or phosphodiesterase inhibition? Metabolism. 1992;41:1 233-41.
47. Dullo A, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord 2000;24: 252-258.
48. Dulloo AG, Seydoux J, Girardier L. Tealine and thermogenesis: interactions between polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord 1996;20: 71-79.
49. Lee MJ, Wang ZY, Li H, Chen L, Sun Y, Gobbo S, Balentine DA, Yang CS. Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prev 1995;44: 93-399.
50. Hollman PCH, Tijburg LBM, Yang CS. Bioavailability of flavonoids from tea. Crit Rev Food Science Nutr 1997;37: 719-738.
51. Kao YH, Hiipakka RA, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 2000a;141: 980-987.
52. Watanabe J, Kawabata J, Niki R. Isolation and identification of acetyl-CoA carboxylase inhibitors from green tea (Camellia sinensis). Biosci Biotechnol Biochem 1998;62: 532-534.
53. Muramatsu K, Fukuyo M, Hara Y. Effect of green tea catechins on plasma cholesterol level in cholesterol- fed rats. J Nutr Sci Vitaminol 1986;32: 613-622.
54. Matsuda H, Chisaka T, Kubomura Y, Yamahara J, Sawada T, Fujimura H, Kimura H. Effects of crude drugs on experimental hypercholesterolemia. Tea and its active principles. J Ethnopharmacol 1986;17: 213-224.
55. Ando T, Nishimura T, Matsubayashi A, Ejiri H, Inoue K, Nakayama Y, Uchiyama S, Kakuda T, Mukai I. Effects of tea catechins on cholesterol absorption with exogenously hypercholesterolemic rat (ExHC-Ta). Bull Kanagawa Dent Coll 1989;17: 21-23.
56. Ikeda I, Imasato Y, Sasaki E, Nakayama M, Nagao H, Takeo T, Yayabe F, Sugano M. Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in rats. Biochim Biophys Acta 1992;1127: 141-146.
57. Yang TT, Koo MW. Chinese green tea lowers cholesterol level trough an increased in fecal lipid excretion. Life Sci 2000;66: 411-423.
58. Löest HB, Noh SK, Koo SI. Green tea extract inhibits the lymphatic absorption of cholesterol and α-tocopherol in ovaridectomized rats. Am Soc Nutr Sci 2002;132: 1282-1288.
59. Raederstorff DG, Schlachter MF, Elste V, Weber P. Effect of EGCG on lipid absorption and plasma lipid levels in rats. J Nutr Biochem 2003;14: 326-332.
60. Tsubono Y, Tsugane S. Green tea intake in relation to serum lipid levels in middle-aged Japanese men and women. Ann Epidemiol 1997;7: 280-284.
61. Tokunaga S, White I, Frost C, Tanaka K, Kono S, Tokudome S, Akamatsu T, Moriyama T, Zakouji H. Green tea consumption and serum lipids and lipoproteins in a population of healthy workers in Japan. Ann Epidemiol 2002;12: 157-165.
62. Yang TT, Koo MW. Hypocholesterolemic effects of Chinese tea. Pharmacol Res 1997;35: 505-512.
63. Ros E. Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk. Atherosclerosis 2000;151: 357-379.
64. Caniparoli JP, Gains N, Zulauf M. Influence of stigmastanyl phosphorylcholine on the size, mass, and shape of taurocholate/lecithin/ cholesterol mixed micelles. Prog Colloid Polym Sci 1992;89: 268-270.
65. Hashimoto T, Kumazawa S, Nanjo F, Hara Y, Nakayama T. Interaction of tea catechins with lipid bilayers investigated with liposome systems. Biosci Biotechnol Biochem 1999;63: 2252-2255.
66. Tsuchiya. Effects of green tea catechins on membrane fluidity. Pharmacology 1999;59: 34-44.
67. Yokozawa T, Nakawa T, Kitani K. Antioxidative activity of green tea polyphenol in cholesterol fed-rats. J Agric Food Chem 2002;50: 3549-3552.
68. Chang PT, Fong WP, Cheung YL, Huang Y, Ho WK, Chen ZY. Jasmine green tea epicatechins are hypolipedemic in hamsters (Misocricetus auratus) fed a high fat diet. J Nutr 1999;129: 1094-1101.
69. Juhel C, Armand M, Pafum Y, Rosier C, Vandermander J, Lairon D. Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro. J Nutr Biochem 2002;11: 45-51.
70. Chisaka T, Matsuda H, Kuboruma Y, Mochizuki M, Yamahara J, Fujimura H. The effect of crude drugs on experimental hypercolesterolemia: mode of action of (-)-epigallocatechin gallate in tea leaves. Chem Pharm Bull 1988;36: 227-233.
71. Kono S, Shinchi K, Ikeda N, Yanai F, Imanishi K. Green tea consumption and serum lipid profiles: a cross- sectional study in northen Kyushu, Japan. Prev Med 1992;21: 526-531.
72. Imai K. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. BMJ 1995;310: 693-696.
73. Kono S, Shinchi K, Wakabayashi K, Honjo S, Todoroki I, Sakurai Y, Imanishi K, Nishikawa H, Ogawa S, Katsurada M. Relation of green tea consumption to serum lipids and lipoproteins in Japanese men. J Epidemiol 1996;6: 128-133.
74. Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ 1994;308: 367-372.
75. Chen Z, Peto R, Collins R, MacMahon S, Lu J, Li W. Serum cholesterol concentration and coronary disease in a population with low cholesterol concentrations. BMJ 1991;303: 276-282.
76. Steinberg DM, Parthasarathy S, Carew TE, Khoo C, Witztum J. Beyond cholesterol: modifications of low density lipoprotein that increase its atherogenecity. N Engl J Med 1989;320: 915-924.
77. Frankel EN, Kanner J, German JB, Parks E, Kinsella JE. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 1993;34: 454-457.
78. Chung KT, Wong TY, Huang YW, Lin Y. Tannis and human health: a review. Crit Rev Food Sci Nutr 1998;38: 421-464.
79. Kalkan Yildirim H, Delen Akcay Y, Guvenc U, Yildirim Sozmen E. Protection capacity against low-density lipoprotein oxidation and antioxidant potential of some organic and non-organic wines. Int J Food Sci Nutr 2004;55: 351-362.
80. Esterbauer H, Gebicki J, Puhl H, Jurgens G. The role of lipid peroxidation and antioxidants in the oxidative modification of LDL. Free Radic Biol Med 1992;13: 341-390.
81. Heinecke JW. Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low-density lipoprotein hypothesis. Atherosclerosis 1998;141: 1-15.
82. Young IS, McEneny J. Lipoprotein oxidation and atherosclerosis. Bio Soc Trans 2001;29: 358-362.
83. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993;91: 2546-2551.
84. Ortega H, Carrero P, Martínez-Botas J, Gómez-Coronado D, Lasunción MA. Propiedades antioxidantes del vino y de los flavonoides. In: De Oya M, Garcés C, editors. Metabolismo lipídico: Sociedad y Colesterol. Madrid: IDEPSA, 1997:210-214.
85. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 1997;272: 20963-20966.
86. Devaraj S, Jialal I. Oxidized low density lipoprotein and atherosclerosis. Int J Lab Res 1996;26: 178-184.
87. Sánchez-Muniz FJ, Sánchez-Montero JM. Enzymatic methods for the study of thermally oxidized oils and fats. In: Boskou D, Elmadfa I, editors. Frying of food. USA: TechnomicPublishing Co, 1999: 105-141.
88. Yang M, Leake D, Rice-Evans A. Non-oxidative modification of native low-density lipoprotein by oxidized low-density lipoprotein. Biochem J 1996;316: 377-380.
89. Tanaka K, Iguchi H, Taketani S, Nakata R, Tokumaru S, Sugimoto T, Kojo S. Facile degradation of apolipoprotein B by radical reactions and the presence of cleaved proteins in serum. J Biochem 1999;125: 173-176.
90. Terao J, Piskula M, Yao Q. Protective effect of epicatechin, epicatechin gallate, and quercetin on lipid peroxidation in phospholipid bilayers. Arch Biochem Biophys 1994;308: 278-284.
91. Salah N, Miller NJ, Paganga G, Tijburg L, Bolwell GP, Rice C. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Arch Biochem Biophys 1995;322: 339-346.
92. Nanjo F, Goto K, Seto R, Suzuki M, Sakai M, Hara Y. Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical. Free Radical Biol Med 1996;21: 895-902.
93. Da Silva EL, Piskula M, Terao J. Enhancement of antioxidative ability of rat plasma by oral administration of (-)-epicatechin. Free Radical Biol Med 1998;24: 1209-1216.
94. Guo Q, Zhao B, Shen S, Hou J, Hu J, Xin W. ESR study on the structure- antioxidant relationship of tea catechins and their epimers. Biochim Biophys Acta 1999;1427: 13-23.
95. Kondo K, Kurihara M, Miyata N, Suzuki T, Toyoda M. Scavenging mechanism of (-) -epigallocatechin gallate and (-)-epicatechin gallate on peroxyl radicals and formation of superoxide during the inhibitory action. Free Radical Biol Med 1999;27: 855-863.
96. Da Silva PA, Nave JA, Pereira VA. Antioxidant protection of low density lipoprotein by procyanidins: structure/ activity relationships. Bio Pharm 2003;66: 947-954.
97. McAnlis GT, McEneny J, Pearce J, Young IS. Black tea consumption does not protect low density lipoprotein from oxidative modification. Eur J Clin Nutr 1998;52: 202-206
98. Hodgson JM, Mori TA, Puddey IB, Croft KD, Beilin LJ. In vitro antioxidant activity of black and green tea: effects on lipoprotein oxidation in human serum. J Sci Food Agric 1999;79: 561-566.
99. Ishikawa T, Suzukawa M, Ito T, Yoshida H, Ayaori M, Nishiwaki M, Yonemura A, Hara Y, Nakamura H. Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification. Am J Clin Nutr 1997;66: 261-266.
100. Princen HM, van Duyvenvoorde W, Buytenhek R, Blonk C, Tijburg L, Langius J, Meinders A, Pijl H. No effect of consumption of green and black tea on plasma lipid and antioxidants levels and on LDL oxidation in smokers. Arterioscler Thromb Vasc Biol 1998;18: 833-841.
101. Osada K, Takahashi M, Hoshima S, Nakamura M, Nakamura S, Sugano M. Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro. Com Biochem Physio 2001;128: 153-164.
102. 2+ induced low-density lipoprotein in propagation phase. FEBS Lett 1997;401: 230-234.
103. Yokozawa T, Dong E. Influence of green tea and its three major components upon low-density lipoprotein oxidation. Exp Toxic Pathol 1997;49: 329-335.
104. 2+-mediated modification of low-density lipoprotein. Biol Pharm Bull 1995;18: 1-4.
105. Vinson JA, Dabbagh YH, Serry MM, Jang J. Plant flavonoids, especially tea flavonoids, are powerful antioxidants using an in vitro oxidation model for heart disease. J Agric Food Chem 1995;43: 2800-2802.
106. Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationship of flavonoids and phenolic acids. Free Rad Biol Med 1996;20: 933-956.
107. Ho CT, Chen Q, Shu H, Zhang KQ, Rosen RT. Antioxidative effect of polyphenol extract prepared from various Chinese Teas. Prev Med 1992;21: 520-525.
108. Hashimoto R, Yaita M, Tanaka K, Hara Y, Kojo S. Inhibition of radical reaction of apolipoprotein B-100 and α-tocopherol in human plasma by green tea catechins. J Agric Food Chem 2000;48: 6380-6383.
109. 2+ ions: implications for their antioxidant properties. Biochem J. 1998;330: 1173-1178.
110. Liu ZQ, Ma LP, Zhou B, Yang L, Liu ZL. Antioxidative effects of green tea polyphenols on free radical initiated and photosensitized peroxidation of human low density lipoprotein. Chem Phys Lipids 2000;106: 53-63.
111. Lotito SB, Fraga CG. (+)-Catechin prevents human plasma oxidation. Free Rad Biol Med 1998;24: 435-441.
112. Hayakawa F, Kimura T, Maeda T, Fujita M, Sohmiya H, Fujii M, Ando T. DNA cleavage reaction and linolenic acid peroxidation induced by tea catechins in the presence of cupric ion. Biochim Biophys Acta 1997;1336: 123-131.
113. Frei B. Cardiovascular disease and nutrient antioxidants: role of low-density lipoprotein oxidation. CRC Crit Rev Food Sci Nutr 1995;35: 83-98.
114. Kasaoka S, Hase K, Morita T, Kiriyama S. Green tea flavonoids inhibit the LDL oxidation in osteogenic disordered rats fed a marginal ascorbic acid in diet. J Nutr Biochem 2002;13: 96-102.
115. Miura J, Chiba T, Miura S, Tomita I, Umegaki K, Ikeda M, Tomita T. Green tea polyphenols (flavan 3-ols) prevent oxidative modification of low density lipoproteins: an ex vivo study in humans. J Nutr Biochem 2000;11: 216-222.
116. Cybulsky MI, Iiyama K, Li H et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001;107:1255-1262.
117. Cybulsky MI , Gimbrone MA. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherosclerosis. Science 1991;251: 788-791.
118. Lenardo MJ, Baltimore D. NF-kappa B: a pleitropic mediator of inducible and tissue specific gene control. Cell 1989;58: 227-229.
119. Mauri N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 1993;92: 1866-1874.
120. Ludwig A, Lorenz M, Grimbo N, Steinle F, Meiners S, Bartsch C, Stangl K, Baumann G, Stangl V. The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. Biochem Biophy Res Com 2004;316: 659-665.
121. Murase T, Kume N, Hase Y, Shibuya Y, Nishizawa Y, Tokimitsu I, Kita T. Gallates inhibit cytokine-induced nuclear translocation of NF-kappa B and expression of leukocyte adhesion molecules in vascular endothelial cells. Atheroscler Thromb Vasc Biol 1999;19: 1412-1420.
122. Di Minno G, Silver MJ. Mouse antithrombotic assay: A simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol. J Pharmacol Exp Ther 1983; 225:57-60.
123. 2+ and protein kinase C is the major factor in determining the level of secretion from human platelets. Biochem J 1993;289: 277-282.
124. Kang WS, Chung KH, Chung JH, Lee JY, Park JB, Zhang YH, Yoo HS, Yun YP. Antiplatelet activity of green tea catechins is mediated by inhibition of cytoplasmatic calcium increase. J Cardiovasc Pharmacol 2001;38: 875-884
125. Sachinidis A, Skach RA, Seul C, Ko Y, Hescheler J, Ahn H, Fingerler J. Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins. FASEB 2002;16: 893-895.
126. Watson S, Berlanga O, Best D, Frampton J. Update on collagen receptor interactions in platelets: is the two-state model still valid? Platelets 2000;11: 252-258.
127. Ozdener F, Kunapuli SP, Daniel JL. Carboxyl terminal sequence of human phospholipase Cgamma2. Platelets 2001;12: 121-123.
128. Deana R, Turetta L, Donella-Deana A, Dona M, Brunati AM, De Michiel L, Garbisa S. Green tea epigallocatechin-3-gallate inhibits platelet signalling pathways triggered by both proteolytic and non-proteolytic agonists. Thromb Haemost 2003;89: 866-874.
129. Hodgson JM, Devine A, Puddey IB, Chan SY, Beilin LJ, Prince RL. Tea intake is inversely related to blood pressure in older women. Asia Pac J Clin Nutr 2003;12: S18.
130. Kaundun SS, Matsumoto S. Identification of processed Japanese green tea based on polymorphisms generated by STS-RFLP analysis. J Agric Food Chem. 2003;51: 1765-1770.
131. Beynen AC, Katan MB, Van Zutphen LF. Hypo- and hyperresponders: individual differences in the response of serum cholesterol concentration to changes in diet. Adv Lipid Res. 1987;22: 115-171.
132. Ordovas JM. The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins. Proc Nutr Soc. 2004; 63:145-152.
133. De Roos B. Metabolic and mechanistic facts regarding the coffe diterpenes cafestol and Kahweol. In: Vaquero P, García-Arias T, Carbajal A, Sánchez-Muníz F, editors. Bioavaility of Micronutrients and Minor Dietary Compounds. Metabolic and Technologycal Aspects. India: Research Signpost, 2003:147-160.
134. Vittal R, Selvanayagam ZE, Sun Y, Hong J, Liu F, Chin KV, Yang CS. Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3- gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray. Mol Cancer Ther 2004;3: 1091-1099.
135. Kaul D, Sikand K, Shukla AR. Effect of green tea polyphenols on the genes with atherosclerotic potential. Phytother Res 2004;18: 177-179.
136. Sasazuki S, Kodama H, Yoshimasu K, Liu Y, Washio M, Tanaka K, Tokunaga S, Kono S, Arai H, Doi Y, Kawano T, Nakagaki O, Takada K, Koyanagi S, Hiyamuta K, Nii T, Shirai K, Ideishi M, Arakawa K, Mohri M, Takeshita A. Relation between green tea consumption and the severity of coronary atherosclerosis among Japanese men and women. Ann Epidemiol 2000; 10: 401-408.
137. Riemersma RA, Rice-Evans CA, Tyrrell RM, Clifford MN, Lean ME. Tea flavonoids and cardiovascular health. QJM 2001;94: 277-282.
138. Crawford RS, Kirk EA, Rosenfeld ME, LeBoeuf RC, Chait A. Dietary antioxidants inhibit development of fatty streak lesions in the LDL receptor-deficient mouse. Arterioscler Thromb Vasc Biol 1998;18: 1506-1513.
139. Li M , Xie B, Evaluation of the antioxidant and pro-oxidant effects of tea catechin oxipolymers. J Agric Food Chem 2000;48: 6362-6366.
140. Portaluppi F, Boari B, Manfredini R. Oxidative stress in essential hypertension. Curr Pharm Des 2004;10: 1695-1698.
141. Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y, Yamori Y. Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J Nutr 2004 ;134: 38-42.