Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 17266-17274

  Furukawa, Yoshiaki ^a   O'Halloran, Thomas V ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; BIOCHEMISTRY; CATALYSIS; ENZYMES; MOLECULAR BIOLOGY; OLIGOMERS; PHYSIOLOGY; TOXICITY;

AMYOTROPHIC LATERAL SCLEROSIS (ALS); PROTEIN AGGREGATION;

OXIDATION;

APOENZYME; COPPER ZINC SUPEROXIDE DISMUTASE; CYSTEINE; DISULFIDE; ISOENZYME; METAL; MUTANT PROTEIN; POLYPEPTIDE; CROSS LINKING REAGENT; OXYGEN; PEPTIDE; SUPEROXIDE DISMUTASE; THIOL DERIVATIVE; ZINC;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CROSS LINKING; ENZYME ACTIVITY; ENZYME DENATURATION; ENZYME STABILITY; ESCHERICHIA COLI; FAMILIAL DISEASE; GENE MUTATION; HUMAN; METAL BINDING; NEUROTOXICITY; NONHUMAN; OLIGOMERIZATION; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; REDUCTION; THERMOSTABILITY; BIOLOGICAL MODEL; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DOSE RESPONSE; GEL CHROMATOGRAPHY; GENETICS; KINETICS; METABOLISM; MUTATION; PH; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN PROCESSING; TEMPERATURE; THERMODYNAMICS;

AMYOTROPHIC LATERAL SCLEROSIS; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, GEL; CROSS-LINKING REAGENTS; CYSTEINE; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, BIOLOGICAL; MUTATION; OXYGEN; PEPTIDES; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE; TEMPERATURE; THERMODYNAMICS; ZINC;

EID: 20444504724     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500482200     Document Type: Article

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