Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions

Biochemistry

Volumn 42, Issue 29, 2003, Pages 8756-8761

  Zhang, Qinghai ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONSERVATIVE MUTATION;

AMINO ACIDS; PH EFFECTS; SYNTHESIS (CHEMICAL);

BIOCHEMISTRY;

AMYLOID; CYSTEINE; DISULFIDE; GLUTATHIONE; GLYCINE; ISOPROTEIN; PREALBUMIN;

ACIDITY; AMYLOIDOSIS; ARTICLE; CHEMICAL MODIFICATION; COMPLEX FORMATION; PATHOGENESIS; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN DENATURATION; PROTEIN FOLDING; TITRIMETRY;

AMYLOID; CYSTEINE; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; PEPTIDES; PREALBUMIN; PROTEIN FOLDING; PROTEIN ISOFORMS; TEMPERATURE; TIME FACTORS; UREA;

EID: 0042848710     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030077a     Document Type: Article

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