Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

Science

Volumn 271, Issue 5248, 1996, Pages 515-518

  Wiedau Pazos, Martina ^a   Goto, Joy J ^a   Rabizadeh, Shahrooz ^a,b   Gralla, Edith B ^a   Roe, James A ^c   Lee, Michael K ^d   Valentine, Joan S ^a   Bredesen, Dale E ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BURNHAM INSTITUTE   (United States)

^c LOYOLA MARYMOUNT UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHELATING AGENT; DIETHYLDITHIOCARBAMIC ACID; HYDROGEN PEROXIDE; PENICILLAMINE; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CATALYSIS; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; NERVE CELL; NEUROPATHOLOGY; OXIDATION; PRIORITY JOURNAL;

EID: 0029671220     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5248.515     Document Type: Article

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36. We thank C. J Epstein and T -T. Huang for the WT CuZnSOD genomic clone; D. R. Borchett, P. C. Wang, and S. S. Sisodia for the mutant CuZnSOD genomic clones; R H. Brown Jr, T B. Usdin, M. J. Brownstein, and D. McKenna-Yasek for mutant CuZnSOD complementary DMAs; K. F Faull for assistance with electrospray mass spectrometry; E. M. Landaw for assistance with statistical evaluation of the data; M. Durand and D. C. Chugani for CSM14.1 cells; J. Shi for technical assistance, and R. Y. N Ho for technical advice. Supported by NIH grants AG12282 (D E.B.), GM28222 (J S V.), and DK46828 (J.S.V.) and grants from the Amyotrophic Lateral Sclerosis Association (E.B.G.) and VivoRx Corp (S R.)