Vascular endothelial growth factor as a marker of tumor endothelium

Cancer Research

Volumn 58, Issue 9, 1998, Pages 1952-1959

  Brekken, Rolf A ^a   Huang, Xianming ^a   King, Steven W ^a,b   Thorpe, Philip E ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Techniclone Corporation   (United States)

^c Maine Medical Center Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; RECEPTOR ANTIBODY; TUMOR MARKER; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ARTICLE; GENE MUTATION; HUMAN; HUMAN TISSUE; HYBRIDOMA; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GUINEA PIGS; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOTHERAPY; LYMPHOKINES; MICE; MICE, INBRED C57BL; MICE, SCID; NEOPLASMS, EXPERIMENTAL; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SEVERE COMBINED IMMUNODEFICIENCY; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032080427     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Burrows, F. J., Watanabe, Y., and Thorpe, P. E. A murine model for antibody-directed targeting of vascular endothelial cells in solid tumors. Cancer Res., 52: 5954-5962, 1992.
2. Dvorak, H. F., Nagy, J. A., and Dvorak, A. M. Structure of solid tumors and their vasculature: implications for therapy with monoclonal antibodies. Cancer Cells, 3: 77-85, 1991.
3. Baxter, L. T., and Jain, R. K. Transport of fluid and macromolecules in tumors. Microvasc. Res., 41: 5-23, 1991.
4. Burrows, F. J., and Thorpe, P. E. Vascular targeting: a new approach to the therapy of solid tumors. Pharmacol. Ther., 64: 155-174, 1994.
5. Burrows, F. J., and Thorpe, P. E. Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature. Proc. Natl. Acad. Sci. USA, 90: 8996-9000, 1994.
6. Huang, X., Molema, G., King, S., Watkins, L., Edgington, T. S., and Thorpe, P. E. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science (Washington DC), 275: 547-550, 1997.
7. Ke-Lin, Qu-Hong, Nagy, J. A., Eckelhoefer, I. A., Masse, E. M., Dvorak, A. M., and Dvorak, H. F. Vascular targeting of solid and ascites tumours with antibodies to vascular endothelial growth factor. Eur. J. Cancer, 32A: 2467-2473, 1996.
8. Dvorak, H. F., Sioussat, T. M., Brown, L. F., Berse, B., Nagy, J. A., Sotrel, A., Manseau, E. J., Vandewater, L., and Senger, D. R. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J. Exp. Med., 174: 1275-1278, 1991.
9. Ferrara, N. The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res. Treat., 36: 127-137, 1995.
10. Potgens, A. J. G., Westphal, H. R., DeWaal, R. M. W., and Ruiter, D. J. The role of vascular permeability factor and basic fibroblast growth factor in tumor angiogenesis. Biol. Chem. Hoppe-Seyler, 376: 57-70, 1995.
11. Senger, D. R., Galli, S. J., Dvorak, A. M., Perruzzi, C. A., Harvey, V. S., and Dvorak, H. F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (Washington DC), 219: 983-985, 1983.
12. 2-terminal amino acid sequence of guinea pig tumor secreted vascular permeability factor. Cancer Res., 50: 1774-1778, 1990.
13. Senger, D. R., Perruzzi, C. A., Feder, J., and Dvorak, H. F. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res., 46: 5629-5632, 1986.
14. Keck, P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Connolly, D. T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science (Washington DC), 246: 1309-1312, 1989.
15. Connolly, D. T., Heuvelman, D. M., Nelson, R., Olander, J. V., Eppley, B. L., Delfino, J. J., Siegel, N. R., Leimgruber, R. M., and Feder, J. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J. Clin. Invest., 84: 1470-1478, 1989.
16. Thomas, K. A. Vascular endothelial growth factor, a potent and selective angiogenic agent. J. Biol. Chem., 271: 603-606, 1996.
17. Houck, K. A., Ferrara, N., Winer, J., Cachianes, G., Li, B., and Leung, D. W. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol., 5: 1806-1814, 1991.
18. Ferrara, N., Houck, K. A., Jakeman, L. B., Winer, J., and Leung, D. W. The vascular endothelial growth factor family of polypeptides. J. Cell. Biochem., 47: 211-218, 1991.
19. Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J. C., and Abraham, J. A. The human gene for vascular endothelial growth factor. J. Biol. Chem., 266: 11947-11954, 1991.
20. deVries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N., and Williams, L. T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science (Washington DC), 255: 989-991, 1992.
21. Olander, J. V., Connolly, D. T., and DeLarco, J. E. Specific binding of vascular permeability factor to endothelial cells. Biochem. Biophys. Res. Commun., 175: 68-76, 1991.
22. Terman, B. I., Dougher-Vermazen, M., Carrion, M. E., Dimitrov, D., Armellino, D. C., Gospodarowicz, D., and Bohlen, P. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun., 187: 1579-1586, 1992.
23. Mustonen, T., and Alitalo, K. Endothelial receptor tyrosine kinases involved in angiogenesis. J. Cell Biol., 129: 895-898, 1995.
24. Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M., and Heldin, C-H. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem., 43: 26988-26995, 1994.
25. Guo, D., Jia, Q., Song, H-Y., Warren, R. S., and Donner, D. B. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. J. Biol. Chem., 270: 6729-6733, 1995.
26. Fong, G-H., Rossant, J., Gertsenstein, M., and Breitman, M. L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature (Lond.), 376: 66-70, 1995.
27. Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X-F., Breitman, M. L., and Schuh, A. C. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature (Lond.), 376: 62-66, 1995.
28. Frank, S., Hubner, G., Breier, G., Longaker, M. T., Greenhalgh, D. G., and Werner, S. Regulaton of vascular endothelial growth factor expression in cultured growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J. Biol. Chem., 270: 12607-12613, 1995.
29. Burke, P. A., Lehmann-Bruinsma, K., and Powell, J. S. Vascular endothelial growth factor causes endothelial proliferation after vascular injury. Biochem. Biophys. Res. Commun., 207: 348-354, 1995.
30. Alon, T., Hemo, I., Itin, A., Pe'er, J., Stone, J., and Keshet, E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med., 1: 1024-1028, 1995.
31. Malecaze, F., Clamens, S., Simorre-Pinatel, V., Mathis, A., Chollet, P., Favard, C., Bayard, F., and Plouet, J. Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch. Ophthalmol., 112: 1476-1482, 1994.
32. Detmar, M., Brown, L. F., Claffey, K. P., Yeo, K-T., Kocher, O., Jackman, R. W., Berse, B., and Dvorak, H. F. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J. Exp. Med., 180: 1141-1146, 1994.
33. Plate, K. H., Breier, G., Weich, H. A., Mennel, H. D., and Risau, W. Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int. J. Cancer, 59: 520-529, 1994.
34. Claffey, K. P., Brown, L. F., del Aguila, L. F., Tognazzi, K., Yeo, K-T., Manseau, E. J., and Dvorak, H. F. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res., 56: 172-181, 1996.
35. Kim, K. J., Li, B., Houck, K., Winer, J., and Ferrara, N. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors, 7: 53-64, 1992.
36. Presta, L. G., Chen, H., O'Connor, S. J., Chisholm, V., Meng, Y. G., Krummen, L., Winkler, M., and Ferrara, N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res., 57: 4593-4599, 1997.
37. Sioussat, T. M., Dvorak, H. F., Brock, T. A., and Senger, D. R. Inhibition of vascular permeability factor (vascular endothelial growth factor) with antipeptide antibodies. Arch. Biochem. Biophys., 301: 15-20, 1993.
38. Kondo, S., Asano, M., and Suzuki, H. Significance of vascular endothelial growth factor/vascular permeability factor for solid tumor growth, and its inhibition by the antibody. Biochem. Biophys. Res. Commun., 194: 1234-1241, 1993.
39. Asano, M., Yukita, A., Matsumoto, T., Kondo, S., and Suzuki, H. Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor. Cancer Res., 55: 5296-5301, 1995.
40. Kendall, R. L., and Thomas, K. A. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci. USA, 90: 10705-10709, 1993.
41. Aiello, L. P., Pierce, E. A., Foley, E. D., Takagi, H., Chen, H., Riddle, L., Ferrara, N., King, G. L., and Smith, L. E. H. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. USA, 92: 10457-10461, 1995.
42. Lin, P., Sankar, S., Shan, S-q., Dewhirst, M. W., Polverini, P. J., Quinn, T. Q., and Peters, K. G. Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. Cell Growth Differ., 9: 49-58, 1998.
43. Millauer, B., Longhi, M. P., Plate, K. H., Shawver, L. K., Risau, W., Ullrich, A., and Strawn, L. M. Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo. Cancer Res., 56: 1615-1620, 1996.
44. Saleh, M., Stacker, S. A., and Wilks, A. F. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res., 56: 393-401, 1996.
45. Cheng, S-Y., Huang, H-J., Nagane, M., Ji, X-D., Wang, D., Shih, C. C-Y., Arap, W., Huang, C-M., and Cavenee, W. K. Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor. Proc. Natl. Acad. Sci. USA, 93: 8502-8507, 1996.
46. Mazure, N. M., Chen, E. Y., Yeh, P., Laderoute, K. R., and Giaccia, A. J. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res., 56: 3436-3440, 1996.
47. Forsythe, J. A., Jiang, B-H., Iyer, N. V., Agani, P., Leung, S. W., Koos, R. D., and Semenza, G. L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol., 16: 4604-4613, 1996.
48. Waltenberger, J., Mayr, U., Pentz, S., and Hombach, V. Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia. Circulation, 94: 1647-1654, 1996.
49. Gerber, H-P., Condorelli, F., Park, J., and Ferrara, N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. J. Biol. Chem., 272: 23659-23667, 1997.
50. Kremer, C., Breier, G., Risau, W., and Plate, K. H. Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system. Cancer Res., 57: 3852-3859, 1997.
51. Morrow, K. J., Unuvar, E., King, S. W., and Mleczko, J. B. Techniques for the production of monoclonal and polyclonal antibodies. In: M. A. Hayat (ed.), Colloidal Gold: Principles, Methods and Applications, pp. 31-57. Orlando: Academic Press, 1990.
52. Crowther, J. R. ELISA Theory and Practice, pp. 35-50. Totowa, NJ: Humana Press, 1995.
53. Tessler, S., Rockwell, P., Hicklin, D., Cohen, T., Levi, B-Z., Witte, L., Lemischka, I. R., and Neufeld, G. Heparin modulates the interaction of VEGF 165 with soluble and cell associated flk-1 receptors. J. Biol. Chem., 269: 12456-12461, 1994.
54. Buttke, T. M., McCabrey, J. A., and Owen, J. C. Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines. J. Immunol. Methods, 157: 233-240, 1993.
55. Burrows, F. J., Derbyshire, E. J., Tazzari, P. L., Amlot, P., Gazdar, A. F., King, S. W., Letarte, M., Vitetta, E. S., and Thorpe, P. E. Endoglin is an endothelial cell proliferation marker that is up-regulated in tumor vasculature. Clin. Cancer Res., 1: 1623-1634, 1995.
56. Yuan, F., Chen, Y., Dellian, M., Safabakhsh, N., Ferrara, N., and Jain, R. K. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/ vascular permeability factor antibody. Proc. Natl. Acad. Sci. USA, 93: 14765-14770, 1996.
57. Hong, G., Nagy, J. A., Senger, D. R., Dvorak, H. F., and Dvorak, A. M. Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium. J. Histochem. Cytochem., 43: 381-389, 1995.