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Volumn 16, Issue 1, 2004, Pages 44-49

Tumor endothelial markers: New targets for cancer therapy

Author keywords

Angiogenesis; Gene expression; Tumor endothelial markers (TEMs)

Indexed keywords

ANTHRAX TOXIN RECEPTOR; BEVACIZUMAB; IMMUNOTOXIN; MOLECULAR MARKER; RECEPTOR; TUMOR ENDOTHELIUM MARKER 1; TUMOR ENDOTHELIUM MARKER 5; TUMOR ENDOTHELIUM MARKER 7; TUMOR ENDOTHELIUM MARKER 8; TUMOR MARKER; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; TUMOR PROTEIN;

EID: 2442620564     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-200401000-00009     Document Type: Review
Times cited : (138)

References (59)
  • 1
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R, Folkman J: Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2002, 2:727-739. Excellent review on the status of anti-angiogenic agents in the clinic and what these studies have taught us.
    • (2002) Nat Rev Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 2
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    • Lyden D, Hattori K, Dias S, et al.: Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 2001, 7:1194-1201.
    • (2001) Nat Med , vol.7 , pp. 1194-1201
    • Lyden, D.1    Hattori, K.2    Dias, S.3
  • 3
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 4
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990, 82:4-6.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 5
    • 0034665166 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice
    • Brekken RA, Overholser JP, Stastny VA, et al.: Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice. Cancer Res 2000, 60:5117-5124.
    • (2000) Cancer Res , vol.60 , pp. 5117-5124
    • Brekken, R.A.1    Overholser, J.P.2    Stastny, V.A.3
  • 6
    • 0033119833 scopus 로고    scopus 로고
    • Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
    • Grunstein J, Roberts WG, Mathieu-Costello O, et al.: Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Res 1999, 59:1592-1598.
    • (1999) Cancer Res , vol.59 , pp. 1592-1598
    • Grunstein, J.1    Roberts, W.G.2    Mathieu-Costello, O.3
  • 7
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J: The biology of VEGF and its receptors. Nat Med 2003, 9:669-676. Great review of the role of VEGF and its receptors in angiogenesis as well as of the current status of clinical trials that target VEGF.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 8
    • 0042967959 scopus 로고    scopus 로고
    • Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors
    • Viloria-Petit A, Miquerol L, Yu JL, et al.: Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors. EMBO J 2003, 22:4091-4102. This important paper is the first to provide good evidence for the existence of VEGF-independent tumors.
    • (2003) EMBO J , vol.22 , pp. 4091-4102
    • Viloria-Petit, A.1    Miquerol, L.2    Yu, J.L.3
  • 9
    • 0036491615 scopus 로고    scopus 로고
    • VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis
    • Inoue M, Hager JH, Ferrara N, et al.: VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell 2002, 1:193-202. Supports a central role for VEGF in tumor angiogenesis occurring in the RIP1-Tag2 mouse model of pancreatic islet carcinoma.
    • (2002) Cancer Cell , vol.1 , pp. 193-202
    • Inoue, M.1    Hager, J.H.2    Ferrara, N.3
  • 10
    • 0033554723 scopus 로고    scopus 로고
    • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
    • Lyden D, Young AZ, Zagzag D, et al.: Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 1999, 401:670-677.
    • (1999) Nature , vol.401 , pp. 670-677
    • Lyden, D.1    Young, A.Z.2    Zagzag, D.3
  • 11
    • 0032031861 scopus 로고    scopus 로고
    • Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
    • Itoh T, Tanioka M, Yoshida H, et al.: Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res 1998, 58:1048-1051.
    • (1998) Cancer Res , vol.58 , pp. 1048-1051
    • Itoh, T.1    Tanioka, M.2    Yoshida, H.3
  • 12
    • 0141594945 scopus 로고    scopus 로고
    • Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo
    • Ishida T, Kundu RK, Yang E, et al.: Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. J Biol Chem 2003, 278:34598-34604.
    • (2003) J Biol Chem , vol.278 , pp. 34598-34604
    • Ishida, T.1    Kundu, R.K.2    Yang, E.3
  • 13
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • Kerbel RS: Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays 1991, 13:31-36.
    • (1991) Bioessays , vol.13 , pp. 31-36
    • Kerbel, R.S.1
  • 14
    • 0037900611 scopus 로고    scopus 로고
    • Antiangiogenesis drug promising for metastatic colorectal cancer
    • McCarthy M: Antiangiogenesis drug promising for metastatic colorectal cancer. Lancet 2003, 361:1959.
    • (2003) Lancet , vol.361 , pp. 1959
    • McCarthy, M.1
  • 15
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, et al.: A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003, 349:427-434.
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 16
    • 0037303885 scopus 로고    scopus 로고
    • E2100: A phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer
    • Miller KD: E2100: a phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer. Clin Breast Cancer 2003, 3:421-422.
    • (2003) Clin Breast Cancer , vol.3 , pp. 421-422
    • Miller, K.D.1
  • 17
    • 0037615112 scopus 로고    scopus 로고
    • Monoclonal antibody drug immunoconjugates for targeted treatment of cancer
    • Trail PA, King HD, Dubowchik GM: Monoclonal antibody drug immunoconjugates for targeted treatment of cancer. Cancer Immunol Immunother 2003, 52:328-337.
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 328-337
    • Trail, P.A.1    King, H.D.2    Dubowchik, G.M.3
  • 18
    • 0038057332 scopus 로고    scopus 로고
    • Angiogenesis inhibitors suffer new setback
    • Garber K: Angiogenesis inhibitors suffer new setback. Nat Biotechnol 2002, 20:1067-1068.
    • (2002) Nat Biotechnol , vol.20 , pp. 1067-1068
    • Garber, K.1
  • 19
    • 0037934449 scopus 로고    scopus 로고
    • Regression of established tumors and metastases by potent vascular endothelial growth factor blockade
    • Huang J, Frischer JS, Serur A, et al.: Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci U S A 2003, 100:7785-7790. Demonstrates potent antitumor activity using a receptor-mediated VEGF trap.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7785-7790
    • Huang, J.1    Frischer, J.S.2    Serur, A.3
  • 20
    • 0035884219 scopus 로고    scopus 로고
    • Clinical trials of antiangiogenic drugs: Opportunities, problems, and assessment of initial results
    • Kerbel RS: Clinical trials of antiangiogenic drugs: opportunities, problems, and assessment of initial results. J Clin Oncol 2001, 19:45S-51S.
    • (2001) J Clin Oncol , vol.19
    • Kerbel, R.S.1
  • 21
    • 0030858765 scopus 로고    scopus 로고
    • Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin
    • Seon BK, Matsuno F, Haruta Y, et al.: Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin. Clin Cancer Res 1997, 3:1031-1044.
    • (1997) Clin Cancer Res , vol.3 , pp. 1031-1044
    • Seon, B.K.1    Matsuno, F.2    Haruta, Y.3
  • 22
    • 0032971818 scopus 로고    scopus 로고
    • Induction of lasting complete regression of preformed distinct solid tumors by targeting the tumor vasculature using two new anti-endoglin monoclonal antibodies
    • Matsuno F, Haruta Y, Kondo M, et al.: Induction of lasting complete regression of preformed distinct solid tumors by targeting the tumor vasculature using two new anti-endoglin monoclonal antibodies. Clin Cancer Res 1999, 5:371-382.
    • (1999) Clin Cancer Res , vol.5 , pp. 371-382
    • Matsuno, F.1    Haruta, Y.2    Kondo, M.3
  • 23
    • 0036194917 scopus 로고    scopus 로고
    • Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature
    • Halin C, Rondini S, Nilsson F, et al.: Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature. Nat Biotechnol 2002, 20:264-269.
    • (2002) Nat Biotechnol , vol.20 , pp. 264-269
    • Halin, C.1    Rondini, S.2    Nilsson, F.3
  • 24
    • 10744221996 scopus 로고    scopus 로고
    • Selective targeted delivery of TNFα to tumor blood vessels
    • Epub ahead of print
    • Borsi L, Balza E, Carnemolla B, et al.: Selective targeted delivery of TNFα to tumor blood vessels. Blood 2003 [Epub ahead of print].
    • (2003) Blood
    • Borsi, L.1    Balza, E.2    Carnemolla, B.3
  • 25
    • 0032943892 scopus 로고    scopus 로고
    • Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells
    • Arora N, Masood R, Zheng T, et al.: Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells. Cancer Res 1999, 59:183-188.
    • (1999) Cancer Res , vol.59 , pp. 183-188
    • Arora, N.1    Masood, R.2    Zheng, T.3
  • 26
    • 0033778445 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: Differential effect on proliferating endothelial cells
    • Wild R, Dhanabal M, Olson TA, Ramakrishnan S: Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: differential effect on proliferating endothelial cells. Br J Cancer 2000, 83:1077-1083.
    • (2000) Br J Cancer , vol.83 , pp. 1077-1083
    • Wild, R.1    Dhanabal, M.2    Olson, T.A.3    Ramakrishnan, S.4
  • 27
    • 0032532656 scopus 로고    scopus 로고
    • Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • Ran S, Gao B, Duffy S, et al.: Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature. Cancer Res 1998, 58:4646-4653.
    • (1998) Cancer Res , vol.58 , pp. 4646-4653
    • Ran, S.1    Gao, B.2    Duffy, S.3
  • 28
    • 0031026481 scopus 로고    scopus 로고
    • Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • Huang X, Molema G, King S, et al.: Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science 1997, 275:547-550.
    • (1997) Science , vol.275 , pp. 547-550
    • Huang, X.1    Molema, G.2    King, S.3
  • 29
    • 0035863566 scopus 로고    scopus 로고
    • Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice
    • Nilsson F, Kosmehl H, Zardi L, Neri D: Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice. Cancer Res 2001, 61:711-716.
    • (2001) Cancer Res , vol.61 , pp. 711-716
    • Nilsson, F.1    Kosmehl, H.2    Zardi, L.3    Neri, D.4
  • 30
    • 0042014566 scopus 로고    scopus 로고
    • Comparison of three different targeted tissue factor fusion proteins for inducing tumor vessel thrombosis
    • Hu P, Yan J, Sharifi J, et al.: Comparison of three different targeted tissue factor fusion proteins for inducing tumor vessel thrombosis. Cancer Res 2003, 63:5046-5053. First study to compare the effectiveness of different tissue-factor fusion proteins.
    • (2003) Cancer Res , vol.63 , pp. 5046-5053
    • Hu, P.1    Yan, J.2    Sharifi, J.3
  • 31
    • 0037189380 scopus 로고    scopus 로고
    • Tumor regression by targeted gene delivery to the neovasculature
    • Hood JD, Bednarski M, Frausto R, et al.: Tumor regression by targeted gene delivery to the neovasculature. Science 2002, 296:2404-2407.
    • (2002) Science , vol.296 , pp. 2404-2407
    • Hood, J.D.1    Bednarski, M.2    Frausto, R.3
  • 33
    • 0035889654 scopus 로고    scopus 로고
    • Lack of specificity of endoglin expression for tumor blood vessels
    • Balza E, Castellani P, Zijlstra A, et al.: Lack of specificity of endoglin expression for tumor blood vessels. Int J Cancer 2001, 94:579-585.
    • (2001) Int J Cancer , vol.94 , pp. 579-585
    • Balza, E.1    Castellani, P.2    Zijlstra, A.3
  • 34
    • 0036289044 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor receptors 1, 2, and 3 in quiescent endothelia
    • Witmer AN, Dai J, Weich HA, et al.: Expression of vascular endothelial growth factor receptors 1, 2, and 3 in quiescent endothelia. J Histochem Cytochem 2002, 50:767-777.
    • (2002) J Histochem Cytochem , vol.50 , pp. 767-777
    • Witmer, A.N.1    Dai, J.2    Weich, H.A.3
  • 35
    • 0032885894 scopus 로고    scopus 로고
    • Quantification of murine endothelial cell adhesion molecules in solid tumors
    • Langley RR, Russell J, Eppihimer MJ, et al.: Quantification of murine endothelial cell adhesion molecules in solid tumors. Am J Physiol 1999, 277:H1156-H1166.
    • (1999) Am J Physiol , vol.277
    • Langley, R.R.1    Russell, J.2    Eppihimer, M.J.3
  • 36
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ: Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003, 9:677-684. Good review on hypoxia-regulated genes such as VEGF and their role in angiogenesis.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 37
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G: Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003, 3:401-410. Excellent overview of the phenotypic differences between normal physiological angiogenesis and tumor angiogenesis.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 38
    • 0037314650 scopus 로고    scopus 로고
    • Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer
    • Santimaria M, Moscatelli G, Viale GL, et al.: Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer. Clin Cancer Res 2003, 9:571-579. Demonstrates that an antibody against the ED-B domain of fibronectin can target primary tumors and metastatic lesions in cancer patients.
    • (2003) Clin Cancer Res , vol.9 , pp. 571-579
    • Santimaria, M.1    Moscatelli, G.2    Viale, G.L.3
  • 39
    • 0036488496 scopus 로고    scopus 로고
    • Specialization of tumour vasculature
    • Ruoslahti E: Specialization of tumour vasculature. Nat Rev Cancer 2002, 2:83-90.
    • (2002) Nat Rev Cancer , vol.2 , pp. 83-90
    • Ruoslahti, E.1
  • 40
    • 0033847353 scopus 로고    scopus 로고
    • Human antibodies in cancer and autoimmune disease
    • Ditzel HJ: Human antibodies in cancer and autoimmune disease. Immunol Res 2000, 21:185-193.
    • (2000) Immunol Res , vol.21 , pp. 185-193
    • Ditzel, H.J.1
  • 42
    • 0033950895 scopus 로고    scopus 로고
    • Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
    • Pasqualini R, Koivunen E, Kain R, et al.: Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res 2000, 60:722-727.
    • (2000) Cancer Res , vol.60 , pp. 722-727
    • Pasqualini, R.1    Koivunen, E.2    Kain, R.3
  • 43
    • 0034682892 scopus 로고    scopus 로고
    • Genes expressed in human tumor endothelium
    • St Croix B, Rago C, Velculescu V, et al.: Genes expressed in human tumor endothelium. Science 2000, 289:1197-1202.
    • (2000) Science , vol.289 , pp. 1197-1202
    • St Croix, B.1    Rago, C.2    Velculescu, V.3
  • 44
    • 0035884593 scopus 로고    scopus 로고
    • Cell surface tumor endothelial markers are conserved in mice and humans
    • Carson-Walter EB, Watkins DN, Nanda A, et al.: Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res 2001, 61:6649-6655.
    • (2001) Cancer Res , vol.61 , pp. 6649-6655
    • Carson-Walter, E.B.1    Watkins, D.N.2    Nanda, A.3
  • 45
    • 0035914327 scopus 로고    scopus 로고
    • Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo
    • Opavsky R, Haviernik P, Jurkovicova D, et al.: Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo. J Biol Chem 2001, 276:38795-38807.
    • (2001) J Biol Chem , vol.276 , pp. 38795-38807
    • Opavsky, R.1    Haviernik, P.2    Jurkovicova, D.3
  • 46
    • 0026469991 scopus 로고
    • Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer
    • Rettig WJ, Garin-Chesa P, Healey JH, et al.: Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. Proc Natl Acad Sci U S A 1992, 89:10832-10836.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10832-10836
    • Rettig, W.J.1    Garin-Chesa, P.2    Healey, J.H.3
  • 47
    • 0035831506 scopus 로고    scopus 로고
    • Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium
    • Christian S, Ahorn H, Koehler A, et al.: Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. J Biol Chem 2001, 276:7408-7414.
    • (2001) J Biol Chem , vol.276 , pp. 7408-7414
    • Christian, S.1    Ahorn, H.2    Koehler, A.3
  • 49
    • 0036804995 scopus 로고    scopus 로고
    • Orphan G protein-coupled receptors and beyond
    • Im DS: Orphan G protein-coupled receptors and beyond. Jpn J Pharmacol 2002, 90:101-106.
    • (2002) Jpn J Pharmacol , vol.90 , pp. 101-106
    • Im, D.S.1
  • 50
    • 0034213071 scopus 로고    scopus 로고
    • LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors
    • Stacey M, Lin HH, Gordon S, McKnight AJ: LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors. Trends Biochem Sci 2000, 25:284-289.
    • (2000) Trends Biochem Sci , vol.25 , pp. 284-289
    • Stacey, M.1    Lin, H.H.2    Gordon, S.3    McKnight, A.J.4
  • 51
    • 0030820210 scopus 로고    scopus 로고
    • Extracellular cysteines of the corticotropin-releasing factor receptor are critical for ligand interaction
    • Mosc
    • Qi LJ, Leung AT, Xiong Y, et al.: Extracellular cysteines of the corticotropin-releasing factor receptor are critical for ligand interaction. Biochemistry (Mosc) 1997, 36:12442-12448.
    • (1997) Biochemistry , vol.36 , pp. 12442-12448
    • Qi, L.J.1    Leung, A.T.2    Xiong, Y.3
  • 52
    • 0035829509 scopus 로고    scopus 로고
    • Identification of the cellular receptor for anthrax toxin
    • Bradley KA, Mogridge J, Mourez M, et al.: Identification of the cellular receptor for anthrax toxin. Nature 2001, 414:225-229.
    • (2001) Nature , vol.414 , pp. 225-229
    • Bradley, K.A.1    Mogridge, J.2    Mourez, M.3
  • 53
    • 0038303163 scopus 로고    scopus 로고
    • Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
    • Scobie HM, Rainey GJ, Bradley KA, Young JA: Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A 2003, 100:5170-5174. This important paper establishes that CMG2, the closest TEM8 homologue, is a second receptor for anthrax toxin.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5170-5174
    • Scobie, H.M.1    Rainey, G.J.2    Bradley, K.A.3    Young, J.A.4
  • 54
  • 55
    • 0035957358 scopus 로고    scopus 로고
    • Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways
    • Duesbery NS, Resau J, Webb CP, et al.: Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways. Proc Natl Acad Sci U S A 2001, 98:4089-4094.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4089-4094
    • Duesbery, N.S.1    Resau, J.2    Webb, C.P.3
  • 56
    • 0037022666 scopus 로고    scopus 로고
    • Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase
    • Koo HM, VanBrocklin M, McWilliams MJ, et al.: Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A 2002, 99:3052-3057.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 3052-3057
    • Koo, H.M.1    VanBrocklin, M.2    McWilliams, M.J.3
  • 57
    • 0037457895 scopus 로고    scopus 로고
    • Potent antitumor activity of a urokinase-activated engineered anthrax toxin
    • Liu S, Aaronson H, Mitola DJ, et al.: Potent antitumor activity of a urokinase-activated engineered anthrax toxin. Proc Natl Acad Sci U S A 2003, 100:657-662. This important study demonstrates that the therapeutic window for treating tumors with anthrax toxin can be increased by incorporating a urokinase piasminogen activator cleavage site into the protective antigen sequence.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 657-662
    • Liu, S.1    Aaronson, H.2    Mitola, D.J.3
  • 58
    • 0038376001 scopus 로고    scopus 로고
    • Imaging of angiogenesis: From microscope to clinic
    • McDonald DM, Choyke PL: Imaging of angiogenesis: from microscope to clinic. Nat Med 2003, 9:713-725. Excellent overview of some of the latest technologies available for imaging angiogenesis.
    • (2003) Nat Med , vol.9 , pp. 713-725
    • McDonald, D.M.1    Choyke, P.L.2
  • 59
    • 0037134709 scopus 로고    scopus 로고
    • Clinical application of antiangiogenic therapy: Microvessel density, what it does and doesn't tell us
    • Hlatky L, Hahnfeldt P, Folkman J: Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us. J Natl Cancer Inst 2002, 94:883-893. Important review highlighting the limitations of using microvessel density as a prognostic indicator.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 883-893
    • Hlatky, L.1    Hahnfeldt, P.2    Folkman, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.