Increased potency of an erythropoietin peptide mimetic through covalent dimerization

Nature Biotechnology

Volumn 15, Issue 12, 1997, Pages 1261-1265

  Wrighton, Nicholas C ^a   Balasubramanian, Palaniappan ^a   Barbone, Francis P ^b   Kashyap, Arun K ^c   Farrell, Francis X ^b   Jolliffe, Linda K ^b   Barrett, Ronald W ^a   Dower, William J ^a  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

^b Johnson Pharmaceutical Research Institute   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Protein engineering; Rational design

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR;

ARTICLE; COVALENT BOND; DIMERIZATION; DRUG POTENCY; DRUG SYNTHESIS; ERYTHROPOIESIS; GENETIC ENGINEERING; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RECEPTOR AFFINITY;

AMINO ACID SEQUENCE; ANIMALS; DIMERIZATION; ERYTHROPOIETIN; MICE; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; RECEPTORS, ERYTHROPOIETIN;

EID: 0030717635     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1197-1261     Document Type: Article

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