Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro

Cancer Research

Volumn 62, Issue 19, 2002, Pages 5603-5610

  Fukuda, Tomohiko ^a   Yoshida, Nobuaki ^a   Kataoka, Yuki ^a   Manabe, Ri ichiroh ^a   Mizuno Horikawa, Yoko ^a   Sato, Motohiko ^a   Kuriyama, Kohji ^a   Yasui, Natsuo ^a   Sekiguchi, Kiyotoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; FIBRONECTIN; ISOPROTEIN;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARTILAGE; CELL CULTURE; CELL GROWTH; CONNECTIVE TISSUE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EXON; EXTRACELLULAR MATRIX; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; RNA SPLICING;

AMINO ACID SEQUENCE; ANIMALS; CARTILAGE; CELL DIVISION; CHIMERA; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBRONECTINS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY;

EID: 0036790091     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Hynes, R. O. Fibronectin. New York: Springer-Verlag, 1990.
2. George, E. L., Georges-Labouesse, E. N., Patel-King, R. S., Rayburn, H., and Hynes, R. O. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development (Camb.), 119: 1079-1091, 1993.
3. Georges-Labouesse, E. N., George, E. L., Rayburn, H., and Hynes, R. O. Mesodermal development in mouse embryos mutant for fibronectin. Dev. Dyn., 207: 145-156, 1996.
4. Petersen, T. E., Thogersen, H. C., Skorstengaard, K., Vibe-Pedersen, K., Sahl, P., Sottrup-Jensen, L., and Magnusson, S. Partial primary structure of bovine plasma fibronectin: three types of internal homology. Proc. Natl. Acad. Sci. USA, 80: 137-141. 1983.
5. Schwarzbauer, J. E., Tamkun, J. W., Lemischka, I. R., and Hynes, R. O. Three different fibronectin mRNA arise by alternative splicing within the coding region. Cell, 35: 421-431, 1983.
6. Kornhlihtt, A. R., Vibe-Pedersen, K., and Baralle, F. E. Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains differing in the number of internal repeats. Nucleic Acids Res., 12: 5853-5868, 1984.
7. Zardi, L., Carnemolla, B., Siri, A., Petersen, T. E., Paolella, G., Sebastio, G., and Baralle, F. E. Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon. EMBO J., 6: 2337-2342, 1987.
8. Schwarzbauer, J. E., Patel, R. S., Fonda, D., and Hynes, R. O. Multiple sites of alternative splicing of the rat fibronectin gene transcript. EMBO J., 6: 2573-2580, 1987.
9. Oyama, F., Hirohashi, S., Shimosato, Y., Titani, K., and Sekiguchi, K. Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors. J. Biol. Chem., 264: 10331-10334, 1989.
10. Oyama, F., Murata, Y., Suganuma, N., Kimura, T., Titani, K., and Sekiguchi, K. Patterns of alternative splicing of fibronectin pre-mRNA in human adult and fetal tissues. Biochemistry, 28: 1428-1434, 1989.
11. Carnemolla, B., Balza, E., Siri, A., Zardi, L., Nicotra, M. R., Bigotti, A., and Natali, P. G. A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors. J. Cell Biol., 108: 1139-1148, 1989.
12. Ffrench-Constant, C., and Hynes, R. O. Alternative splicing of fibronectin is temporally and spatially regulated in the chicken embryo. Development (Camb.), 106: 375-388, 1989.
13. Oyama, F., Hirohashi, S., Sakamoto, M., Titani, K., and Sekiguchi, K. Coordinate oncodevelopmental modulation of alternative splicing of fibronectin pre-messenger RNA at ED-A, ED-B, and CSI regions in human liver tumors. Cancer Res., 53: 2005-2011, 1993.
14. Peters, J. H., Chen, G. E., and Hynes, R. O. Fibronectin isoform distribution in the mouse. II. Differential distribution of the alternatively spliced EIIIB, EIIIA, and V segments in the adult mouse. Cell Adhes. Commun., 4: 127-148, 1996.
15. Manabe, R., Oh-e, N., Maeda, T., Fukuda, T., and Sekiguchi, K. Modulation of cell-adhesive activity of fibronectin by the alternatively spliced EDA segment. J. Cell Biol., 139: 295-307, 1997.
16. Manabe, R., Oh-e, N., and Sekiguchi, K. Alternatively spliced EDA segment regulates fibronectin-dependent cell cycle progression and mitogenic signal transduction. J. Biol. Chem., 274: 5919-5924, 1999.
17. Jarnagin, W. R., Rockey, D. C., Koteliansky, V. E., Wang, S. S., and Bissell, D. M. Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J. Cell Biol., 127: 2037-2048, 1994.
18. Saito, S., Yamaji, N., Yasunaga, K., Saito, T., Matsumoto, S., Katoh, M., Kobayashi, S., and Masuho, Y. The fibronectin extra domain A activates matrix metalloproteinase gene expression by an interleukin-1-dependent mechanism. J. Biol. Chem., 274: 30756-30763, 1999.
19. Guan, J. L., Trevithick, J. E., and Hynes, R. O. Retroviral expression of alternatively spliced forms of rat fibronectin. J. Cell Biol., 110: 833-847, 1990.
20. Sauer, B., and Henderson, N. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc. Natl. Acad. Sci. USA, 85: 5166-5170, 1988.
21. Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., and Rajewsky, K. Deletion of a DNA polymerase β gene segment in T cells using cell type specific gene targeting. Science (Wash. DC), 265: 103-106, 1994.
22. Hedman, K., Kurkinen, M., Alitalo, K., Vaheri, A., Johansson, S., and Hook, M. Isolation of the pericellular matrix of human fibroblast cultures. J. Cell Biol., 81: 83-91, 1979.
23. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head ofthe bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
24. Sekiguchi, K., and Titani, K. Probing molecular polymorphism of fibronectin with antibodies directed to the alternatively spliced peptide segment. Biochemistry, 28: 3293-3298, 1989.
25. Kagan, A., and Glick, M. Oxytocin. In: B. M. Jaffe and H. R. Behrman (eds.), Methods of Hormone Radioimmunoassay, pp. 327-339. New York: Academic Press, 1979.
26. Nakase, T., Nomura, S., Yoshikawa, H., Hashimoto, J., Hirota, S., Kitamura, Y., Oikawa, S., Ono, K., and Takaoka, K. Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing. J. Bone Miner. Res., 9: 651-659, 1994.
27. Castellani, P., Viale, G., Dorcaratto, A., Nicolo, G., Kaczmarek, J., Querze, G., and Zardi, L. The fibronectin isoform containing the ED-B oncofetal domain: a marker of angiogenesis. Int. J. Cancer, 59: 612-618, 1994.
28. Carnemolla, B., Neri, D., Castellani, P., Leprini, A., Neri, G., Pini, A., Winter, G., and Zardi, L. Phage antibodies with pan-species recognition of the oncofetal angiogenesis marker fibronectin ED-B domain. Int. J. Cancer, 68: 397-405, 1996.
29. Huh, G. S., and Hynes, R. O. Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes Dev., 8: 1561-1574, 1994.
30. Mackie, E. J., and Tucker, R. P. The tenascin-C knockout revisited. J. Cell Biol., 112: 3847-3853, 1999.
31. Ffrench-Constant, C. Alternative splicing of fibronectin: many different proteins but few different functions. Exp. Cell Res., 221: 261-271, 1995.
32. Kaczmarek, J., Castellani, P., Nicolo, G., Spina, B., Allemanni, G., and Zardi, L. Distribution of oncofetal fibronectin isoforms in normal hyperplastic and neoplastic human breast tissues. Int. J. Cancer, 58: 11-16, 1994.
33. Fattorusso, R., Pellecchia, M., Viti, F., Neri, P., Neri, D., and Wuthrich, K. NMR structure of the human oncofetal fibronectin ED-B domain, a specific marker for angiogenesis. Structure (London), 7: 381-390, 1999.
34. Mariani, G., Lasku, A., Balza, E., Gaggero, B., Motta, C., Di Luca, L., Dorcaratto, A., Viale, G. A., Neri, D., and Zardi, L. Tumor targeting potential of the monoclonal antibody BC-1 against oncofetal fibronectin in nude mice bearing human tumor implants. Cancer (Phila.), 80: 2378-2384, 1997.
35. Nilsson, F., Losmehl, H., Zardi, L., and Neri, D. Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice. Cancer Res., 61: 711-716, 2001.
36. Midulla, M., Verma, R., Pignatelli, M., Ritter, M. A., Courtenay-Luck, N. S., and George, A. J. T. Source of oncofetal ED-B-containing fibronectin: implications of production by both tumor and endothelial cells. Cancer Res., 60: 164-169, 2000.
37. Zang, D. W., Burton-Wurster, N., and Lust, G. Antibody specific for extra domain B of fibronectin demonstrates elevated levels of both extra domain B(+) and B(-) fibronectin in osteoarthritic canine cartilage. Matrix Biol., 14: 623-633, 1995.
38. 1 phase cell-cycle progression. Curr. Opin. Genet. Dev., 11: 48-53, 2001.