Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature

Nature Biotechnology

Volumn 20, Issue 3, 2002, Pages 264-269

  Halin, C ^a   Rondini, S ^a   Nilsson, F ^a   Berndt, A ^b   Kosmehl, H ^b   Zardi, L ^c   Neri, D ^a  

^a ETH ZURICH   (Switzerland)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGRAPHY; ANTIBODIES; CLINICAL LABORATORIES; FUSION REACTIONS; IMMUNOLOGY; PROTEINS; TUMORS;

ANTITUMOR ACTIVITY;

BIOTECHNOLOGY;

FIBRONECTIN; GAMMA INTERFERON; HYBRID PROTEIN; INTERLEUKIN 12; INTERLEUKIN 12 SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY FUSION PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER MODEL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; IMMUNOTHERAPY; LUNG METASTASIS; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SOLID TUMOR; TERATOCARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBRONECTINS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-12; KILLER CELLS, NATURAL; LUNG NEOPLASMS; LYMPHOCYTES; MACROPHAGES; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0036194917     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0302-264     Document Type: Article

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