Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the αvβ3 integrin receptor

Genes and Development

Volumn 12, Issue 1, 1998, Pages 21-33

  Hidai, Chiaki ^b   Zupancic, Thomas ^c   Penta, Kalyani ^a,g   Mikhail, Adel ^c   Kawana, Masatoshi ^b   Quertermous, Elena E ^a   Aoka, Yoshikazu ^a,b,g   Fukagawa, Masafumi ^a,d   Matsui, Yasuhisa ^e   Platika, Doros ^c   Auerbach, Robert ^f   Hogan, Brigid L M ^a   Snodgrass, Ralph ^c   Quertermous, Thomas ^a,g  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c Progenitor Inc   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

^f UNIVERSITY OF WISCONSIN MADISON   (United States)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Cloning; Embryogenesis; Endothelial; Integrin; Vasculature

Indexed keywords

DISCOIDIN; INTEGRIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL ADHESION; CHORIOALLANTOIS; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENE LOCUS; HEMATOPOIETIC CELL; LIGAND BINDING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; VASCULARIZATION;

ANIMALIA; MUS MUSCULUS; VERTEBRATA;

EID: 15444354665     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.1.21     Document Type: Article

References (56)

1. Allen, N.D., D.G. Cran, S.C. Barton, S. Hettle, W. Reik, and M.A. Surani. 1988. Transgenes as probes for active chromosomal domains in mouse development. Nature 333: 852-855.
2. Alves, F., W. Vogel, K. Mossie, B. Millauer, H. Hofler, and A. Ullrich, 1995. Distinct structural characteristics of dicoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene 10: 609-618.
3. Appella, E., I.T. Weber, and F. Blasi. 1988. Structure and function of epidermal growth factor-like regions in proteins. FEBS Lett. 231: 1-4.
4. Artavanis-Tsakonas, S., K. Matsuno, and M.E. Fortini. 1995. Notch signalling. Science 268: 225-232.
5. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl, eds. 1987. Current protocols in molecular biology. Greene/Wiley, New York, NY.
6. Baldwin, H.D., H.M. Shen, H. Yan, H.M. DeLisser, A. Chung, C. Mickanin, T. Trask, N.E. Kischbaum, P.J. Newman, and S.M. Albelda. 1994. Platelet endothelial cell adhesion molecule-1 (PECAM/CD31): Alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development 120: 2539-2552.
7. Brooks, P.C., R.A. Clark, and D.A. Cheresh. 1994a. Requirement of vascular integrin αvβ3 for angiogenesis. Science 264: 569-571.
8. Brooks, P.C., A.M. Montgomery, M. Rosenfeld, R.A. Reisfeld, T. Hu, G. Klier, and D.A. Cheresh. 1994b. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79: 1157-1164.
9. Brooks, P.C., S. Stromblad, L.C. Sanders, T.L. von Schalscha, R.T. Aimes, W.G. Stetler-Stevenson, J.P. Quigley, and D.A. Cheresh. 1997. Localization of matrix metalloproteinase MMp-2 to the surface of invasive cells by interaction with integrin αvβ3. Cell 85: 683-693.
10. Buckler, A.J., D.D. Chang, S.L. Graw, J.D. Brook, D.A. Haber, P.A. Sharp, and D.E. Housman. 1991. Exon amplification: A strategy to isolate mammalian genes based on RNA splicing. Proc. Natl. Acad. Sci 88: 4005-4009.
11. Caprioli, J. 1992. The ciliary epithelia and aqueous humor. In Adler's physiology of the eye (ed. W.M. Hart), pp. 228-242. Mosby-Year Book Publishing, St. Louis, MO.
12. Coffin, J.D. and T.J. Poole. 1991. Endothelial cell origin and migration in embryonic heart and cranial blood vessel development. Anat. Rec. 231: 383-395.
13. Corn, B.J., M.A. Reed, S.L. Dishong, Y. Li, and T.E. Wagner. 1991. Culture and successful transplantation of embryonic yolk-sac cells. Clin. Biotechnol. 3: 15-19.
14. Davis, S., T.H. Aldrich, P.F. Jones, A. Acheson, D.L. Compton, V. Jain, T.E. Ryan, J. Bruno, C. Radjziejewski, P.C. Maisonpierre, and G.D. Yancopoulos. 1996. Isolation of Angiopoietin-1, a ligand for the TIE-2 receptor, by secretion-trap expression cloning. Cell 87: 1161-1169.
15. del Amo, F.F., M. Gendron Maguire, P.J. Swiatek, N.A. Jenkins, N.G. Copeland, and T. Gridley. 1993. Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch. Genomics 15: 259-264.
16. Drake, C.J., L.A. Davis, and C.D. Little. 1992. Antibodies to β-1 integrins cause alterations of aortic vasculogenesis, in vivo. Dev. Biol. 193: 83-91.
17. Drake, C.J., D.A. Cheresh, and C.D. Little. 1995. An antagonist of integrin αvβ3 prevents maturation of blood vessels during embrionic neovascularization. J. Cell Sci. 108: 2655-2661.
18. Dumont, D.J., T.P. Yamaguchi, R.A. Conlon, J. Rossant, and M.L. Breitman. 1992. tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene 7: 1471-1480.
19. Dumont, D.J., G. Gradwohl, G.H. Fong, M.C. Puri, M. Gertsenstein, A. Auerbach, and M. Breitman. 1994. Dominant negative and targeted null mutation in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes & Dev. 8: 1897-1909.
20. Flamme, I., M. von Reutern, H.C.A. Drexler, S. Syed-Ali, and W. Risau. 1995. Overexpression of vascular endothelial growth factor in the avian embryo induces hypervascularization and increases vascular permeability without alterations of embryonic pattern formation. Dev. Biol. 171: 399-414.
21. Fong, G., J. Rossant, and M.L. Breitman. 1995. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66-70.
22. Gilbert, S.F. 1994. Developmental biology. Sinauer Associates, Sunderland, MA.
23. Hallmann, R., R.N. Feinberg, C.H. Latker, J. Sasse, and W. Risau. 1987. Regression of blood vessels precedes cartilage differentiation during chick limb development. Differentiation 34: 98-105.
24. Harlow, E. and D. Lane. 1988. Antibodies: A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
25. Hogan, B.L.M., R. Beddington, F. Constantini, and E. Lacy. 1994. Manipulating the mouse embryo. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
26. Holland, P.W.H., S.J. Harper, J.H. McVey, and B.L.M. Hogan. 1987. In vitro expression of mRNA for the calcium-binding protein SPARC (osteonectin) revealed by in situ hybridization. J. Cell Biol. 105: 473-482.
27. Hursh, D.A., M.E. Andrews, and R.A. Raff. 1987. A sea urchin gene encodes a polypeptide homologous to epidermal growth factor. Science 237: 1487-1490.
28. Hynes, R.O. 1992. Integrins: Modulation, and signalling in cell adhesion. Cell 69: 11-25.
29. Jenny, R.J., D.D. Pittman, J.J. Toole, R.W. Kriz, R.A. Aldape, R.M. Hewich, R.J. Kaufman, and K.G. Mann. 1987. Complete cDNA and derived amino acid sequence of human factor V. Proc. Natl. Acad. Sci. 84: 4846-4850.
30. Maisonpierre, P.C., C. Suri, P.F. Jones, S. Bartunkova, S.J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T.H. Aldrich, N. Papadopoulos, T.J. Daly, S. Davis, T.N. Sato, and G.D. Yancopoulos. 1997. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277: 55-60.
31. Matthews, W., C.T. Jordan, M. Gavin, N.A. Jenkins, N.G. Copeland, and I.R. Lemischka. 1991. A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close linkage to c-kit. Proc. Natl. Acad. Sci. 88: 9026-9030.
32. Millauer, B., S. Wizigmann-Voos, H. Schnurch, R. Martinez, N.P.H. Moller, W. Risau, and A. Ullrich. 1993. High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72: 835-846.
33. Nelson, J., W.E. Allen, W.N. Scott, J.R. Balie, B. Walker, N.V. McFerran, and D.J. Wilson. 1995. Murine epidermal growth factor (EGF) fragment (33-42) inhibits both EGF- and laminin-dependent endothelial cell motility and angiogenesis. Cancer Res. 55: 3772-3776.
34. Noden, D.M. 1989. Embryonic origins and assembly of blood vessels. Am. Rev. Respir. Dis. 140: 1097-1103.
35. Obeso, J., J. Weber, and R. Auerbach. 1990. A hemangioendothelioma-derived cell line: Its use as a model for the study of endothelial cell biology. Lab Invest. 63: 259-269.
36. Okane, C.J., and W.J. Gehring. 1987. Detection in situ of genomic regulatory elements in Drosophila. Proc. Natl. Acad. Sci. 84: 9123-9127.
37. O'Reilly, M.S., L. Holmgren, C. Chen, and J. Folkman. 1996. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nature Med. 2: 689-692.
38. Pardanaud, L., F. Yassine, and F. Dieterlen Lievre. 1989. Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny. Development 105: 473-485.
39. Partanen, J., E. Armstrong, T.P. Makela, J. Korhonen, M. Sandberg, R. Penkonen, S. Knuutila, K. Huebner, and K. Alitalo. 1992. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol. Cell Biol. 12: 1698-1707.
40. Peault, B.M., J.P. Thiery, and N. Le Douarin. 1983. Surface marker for hemopoietic and endothelial cell lineages in quail that is defined by a monoclonal antibody. Proc. Natl. Acad. Sci. 80: 2976-2980.
41. Pepper, M.S., R. Montesano, J.D. Vassalli, and L. Orci. 1991. Chondrocytes inhibit endothelial sprout formation in vitro: Evidence for involvement of a transforming growth factor-β. J. Cell. Physiol. 146: 170-179.
42. Poole, S., R.A. Firtel, and E. Lamer. 1981. Sequence and expression of the discoidin I gene family in Dictyostelium discoideum. J. Mol. Biol. 153: 273-289.
43. Rao, Z., P. Handford, M. Mayhew, V. Knott, G.G. Brownlee, and D. Stuart. 1995. The structure of a calcium binding epidermal growth factor-like domain: Its role in protein-protein interactions. Cell 82: 131-141.
44. Rebay, I., R.J. Fleming, R.G. Fehon, L. Cherbas, P. Cherbas, and S. Artavanis Tsakonas. 1991. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor. Cell 67: 687-699.
45. Sato, T., Y. Qin, C.A. Kozak, and K.L. Audus. 1993. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc. Natl. Acad. Sci. 90: 9355-9358.
46. Sato, T.N., Y. Tozawa, U. Deutsch, K. Wolburg-Buchholz, Y. Fujiwara, M. Gendron-Maguire, T. Gridley, H. Wolburg, W. Risau, and Y. Qin. 1995. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376: 70-74.
47. Shalaby, F., J. Rossant, T.P. Yamaguchi, M. Gertsenstein, X. Wu, M.L. Breitman, and A. Schuh. 1995. Failure of bloodisland formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66.
48. Smas, C.M., and H. Sul. 1993. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 73: 725-734.
49. Soinen, R., M. Schoor, U. Henseling, C. Tepe, B. Kisters-Woike, J. Rossant, and A. Gossler. 1992. The mouse enhancer trap locus (Etl-1): A novel mammalian gene related to Drosophila and yeast transcriptional regulator genes. Mech. Dev. 39: 111-123.
50. Stubbs, J.D., C. Lekutis, K.L. Singer, A. Bui, D. Yuzuki, U. Srinivasan, and G. Parry. 1990. cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc. Natl. Acad. Sci. 87: 8417-8421.
51. Tepass, U., C. Theres, and E. Knust. 1990. crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61: 787-799.
52. Toole, J.J., J.L. Knopf, J.M. Wozney, L. Sultzman, J.L. Buecker, D.D. Pittman, R.J. Kaufman, E. Brown, C. Shoemaker, E.C. Orr, G.W. Amphlett, W.B. Foster, M.L. Coe, G.J. Knutson, D.N. Fass, and R.M. Hewick. 1984. Molecular cloning of a cDNA encoding human antihaemophilic factor. Nature 312: 342-347.
53. Tripathi, B.J., R.C. Tripathi, A.M. Livingston, and N.S. Borisuth. 1991. The role of growth factors in the embryogenesis and differentiation of the eye. Am. J. Anat. 192: 442-471.
54. von Heijne, G. 1985. Signal sequences: The limits of variation. J. Mol Biol. 184: 99-105.
55. Wei, Y., T. Quertermous, and T.E. Wagner. 1995. Directed endothelial differentiation of cultured embryonic yolk sac cells in vivo provides a novel cell-based system for gene therapy. Stem Cell 13: 541-547.
56. Wilting, J., B. Christ, and M. Bokeloh. 1991. A modified chorioallantoic membrane (CAM) assay for qualitative and quantitative study of growth factors. Anat. Embiyol. 183: 259-271.