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Volumn 99, Issue 1, 2005, Pages 17-23

T helper (h)1/Th2 and Leishmania: Paradox rather than paradigm

Author keywords

Intracellular infection; Leishmania; Th1 Th2 paradigm

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

EID: 19344362323     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2005.01.009     Document Type: Review
Times cited : (196)

References (83)
  • 1
    • 4844223738 scopus 로고    scopus 로고
    • Does the Leishmania major paradigm of pathogenesis and protection hole for New World cutaneous leishmaniases or the visceral disease?
    • D. McMahon-Pratt, and J. Alexander Does the Leishmania major paradigm of pathogenesis and protection hole for New World cutaneous leishmaniases or the visceral disease? Immunol Rev 201 2004 206 224
    • (2004) Immunol Rev , vol.201 , pp. 206-224
    • McMahon-Pratt, D.1    Alexander, J.2
  • 2
    • 0028933795 scopus 로고
    • The Regulation of immunity to Leishmania major
    • S.L. Reiner, and R.M. Locksley The Regulation of immunity to Leishmania major Ann Rev Immunol 13 1995 151 177
    • (1995) Ann Rev Immunol , vol.13 , pp. 151-177
    • Reiner, S.L.1    Locksley, R.M.2
  • 3
    • 0031963998 scopus 로고    scopus 로고
    • Experimental Cutaneous Leishmaniasis: Induction and regulation of T cells following infection of mice with Leishmania major
    • P. Scott, and J.P. Farrell Experimental Cutaneous Leishmaniasis: induction and regulation of T cells following infection of mice with Leishmania major Chem Immunol 70 1998 60 80
    • (1998) Chem Immunol , vol.70 , pp. 60-80
    • Scott, P.1    Farrell, J.P.2
  • 4
    • 4844231880 scopus 로고    scopus 로고
    • Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice
    • D. Sacks, and C. Anderson Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice Immunol Rev 201 2004 225 238
    • (2004) Immunol Rev , vol.201 , pp. 225-238
    • Sacks, D.1    Anderson, C.2
  • 6
    • 0036773192 scopus 로고    scopus 로고
    • An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infection
    • J. Alexander, F. Brombacher, H.A. McGachy, A.N. McKenzie, W. Walker, and K.C. Carter An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infection Eur J Immunol 32 2002 2923 2933
    • (2002) Eur J Immunol , vol.32 , pp. 2923-2933
    • Alexander, J.1    Brombacher, F.2    McGachy, H.A.3    McKenzie, A.N.4    Walker, W.5    Carter, K.C.6
  • 7
    • 0028787484 scopus 로고
    • Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection
    • A. Satoskar, H. Bluethmann, and J. Alexander Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection Infect Immun 63 1995 4894 4899
    • (1995) Infect Immun , vol.63 , pp. 4894-4899
    • Satoskar, A.1    Bluethmann, H.2    Alexander, J.3
  • 8
    • 0033788429 scopus 로고    scopus 로고
    • Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis
    • J. Alexander, K.C. Carter, N. Al-Fasi, A. Satoskar, and F. Brombacher Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis Eur J Immunol 30 2000 2935 2943
    • (2000) Eur J Immunol , vol.30 , pp. 2935-2943
    • Alexander, J.1    Carter, K.C.2    Al-Fasi, N.3    Satoskar, A.4    Brombacher, F.5
  • 9
    • 0042745627 scopus 로고    scopus 로고
    • Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity
    • S. Stager, J. Alexander, K.C. Carter, F. Brombacher, and P.M. Kaye Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity Infect Immun 71 2003 4804 4807
    • (2003) Infect Immun , vol.71 , pp. 4804-4807
    • Stager, S.1    Alexander, J.2    Carter, K.C.3    Brombacher, F.4    Kaye, P.M.5
  • 12
    • 0034106507 scopus 로고    scopus 로고
    • Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection
    • M. Mohrs, C. Holscher, and F. Brombacher Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection Infect Immun 68 2000 1773 1780
    • (2000) Infect Immun , vol.68 , pp. 1773-1780
    • Mohrs, M.1    Holscher, C.2    Brombacher, F.3
  • 13
    • 0032883457 scopus 로고    scopus 로고
    • Leishmania species: Models of intracellular parasitism
    • J. Alexander, A.R. Satoskar, and D.G. Russell Leishmania species: models of intracellular parasitism J Cell Sci 112 1999 2993 3002
    • (1999) J Cell Sci , vol.112 , pp. 2993-3002
    • Alexander, J.1    Satoskar, A.R.2    Russell, D.G.3
  • 14
    • 0041488744 scopus 로고    scopus 로고
    • Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice
    • E. Von Stebut, J.M. Ehrchen, Y. Belkaid, S.L. Kostka, K. Molle, J. Knop, C. Sunderkotter, and M.C. Udey Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice J Exp Med 198 2003 191 199
    • (2003) J Exp Med , vol.198 , pp. 191-199
    • Von Stebut, E.1    Ehrchen, J.M.2    Belkaid, Y.3    Kostka, S.L.4    Molle, K.5    Knop, J.6    Sunderkotter, C.7    Udey, M.C.8
  • 15
    • 0036398446 scopus 로고    scopus 로고
    • The IL-1 family and inflammatory diseases
    • C.A. Dinarello The IL-1 family and inflammatory diseases Clin Exp Rheumatol 20 2002 S1 S13
    • (2002) Clin Exp Rheumatol , vol.20
    • Dinarello, C.A.1
  • 19
    • 0032520619 scopus 로고    scopus 로고
    • Underproduction of interleukin-12 in susceptible mice during progressive leishmaniasis is due to decreased CD40 activity
    • F.P. Heinzel, R.M. Rerko, and A.M. Hujer Underproduction of interleukin-12 in susceptible mice during progressive leishmaniasis is due to decreased CD40 activity Cellular Immunol 184 1998 124 142
    • (1998) Cellular Immunol , vol.184 , pp. 124-142
    • Heinzel, F.P.1    Rerko, R.M.2    Hujer, A.M.3
  • 20
    • 0242494345 scopus 로고    scopus 로고
    • TRANCE-RANK costimulation is required for IL-12 production and the initiation of a Th1-type response to Leishmania major infection in CD40L-deficient mice
    • U.M. Padigel, N. Kim, Y. Choi, and J.P. Farrell TRANCE-RANK costimulation is required for IL-12 production and the initiation of a Th1-type response to Leishmania major infection in CD40L-deficient mice J Immunol 161 2003 5437 5441
    • (2003) J Immunol , vol.161 , pp. 5437-5441
    • Padigel, U.M.1    Kim, N.2    Choi, Y.3    Farrell, J.P.4
  • 21
    • 0036343130 scopus 로고    scopus 로고
    • Parasite adaptive mechanisms in infection by Leishmania
    • A.C. Cunningham Parasite adaptive mechanisms in infection by Leishmania Exp Molec Pathol 72 2002 132 141
    • (2002) Exp Molec Pathol , vol.72 , pp. 132-141
    • Cunningham, A.C.1
  • 22
  • 23
    • 0031939070 scopus 로고    scopus 로고
    • Protective effect on Leishmania major infection of migration inhibitory factor, TNF-alpha, and IFN-gamma administered orally via attenuated Salmonella typhimurium
    • D. Xu, S.J. McSorley, L. Tetley, S. Chatfield, G. Dougan, W.L. Chan, A. Satoskar, J.R. David, and F.Y.J. Liew Protective effect on Leishmania major infection of migration inhibitory factor, TNF-alpha, and IFN-gamma administered orally via attenuated Salmonella typhimurium Immunology 160 1998 1285 1289
    • (1998) Immunology , vol.160 , pp. 1285-1289
    • Xu, D.1    McSorley, S.J.2    Tetley, L.3    Chatfield, S.4    Dougan, G.5    Chan, W.L.6    Satoskar, A.7    David, J.R.8    Liew, F.Y.J.9
  • 24
    • 0032167393 scopus 로고    scopus 로고
    • Migration inhibitory factor induces killing of Leishmania major by macrophages: Dependence on reactive nitrogen intermediates and endogenous TNF-alpha
    • S. Juttner, J. Bernhagen, C.N. Metz, M. Rollinghoff, R. Bucala, and A. Gessner Migration inhibitory factor induces killing of Leishmania major by macrophages: dependence on reactive nitrogen intermediates and endogenous TNF-alpha J Immunol 161 1998 2383 2390
    • (1998) J Immunol , vol.161 , pp. 2383-2390
    • Juttner, S.1    Bernhagen, J.2    Metz, C.N.3    Rollinghoff, M.4    Bucala, R.5    Gessner, A.6
  • 28
    • 0029933509 scopus 로고    scopus 로고
    • Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity
    • M. Kamanaka, P. Yu, T. Yasui, K. Yoshida, T. Kawabe, T. Horii, T. Kishimoto, and H. Kikutani Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity Immunity 4 1996 275 281
    • (1996) Immunity , vol.4 , pp. 275-281
    • Kamanaka, M.1    Yu, P.2    Yasui, T.3    Yoshida, K.4    Kawabe, T.5    Horii, T.6    Kishimoto, T.7    Kikutani, H.8
  • 29
    • 0036856585 scopus 로고    scopus 로고
    • Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent
    • L.U. Buxbaum, J.E. Uzonna, M.H. Goldschmidt, and P. Scott Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent Eur J Immun 32 2002 3206 3215
    • (2002) Eur J Immun , vol.32 , pp. 3206-3215
    • Buxbaum, L.U.1    Uzonna, J.E.2    Goldschmidt, M.H.3    Scott, P.4
  • 30
    • 0036719846 scopus 로고    scopus 로고
    • Endogenous interleukin-12 is critical for controlling the late but not the early stage of Leishmania mexicana infection in C57BL/6 mice
    • F. Aguilar Torrentera, J.D. Laman, M. Van Meurs, L. Adorini, E. Muraille, and Y. Carlier Endogenous interleukin-12 is critical for controlling the late but not the early stage of Leishmania mexicana infection in C57BL/6 mice Infect Immun 70 2002 5075 5080
    • (2002) Infect Immun , vol.70 , pp. 5075-5080
    • Aguilar Torrentera, F.1    Laman, J.D.2    Van Meurs, M.3    Adorini, L.4    Muraille, E.5    Carlier, Y.6
  • 32
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: Evidence for expansion of distinct helper T cell subsets
    • F.P. Heinzel, M.D. Sadick, B.J. Holaday, R.L. Coffman, and R.M. Locksley Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets J Exp Med 169 1989 59 72
    • (1989) J Exp Med , vol.169 , pp. 59-72
    • Heinzel, F.P.1    Sadick, M.D.2    Holaday, B.J.3    Coffman, R.L.4    Locksley, R.M.5
  • 35
    • 0030298147 scopus 로고    scopus 로고
    • Early IL-4 production does not predict susceptibility to Leishmania major
    • P. Scott, A. Eaton, W.C. Gause, X. di Zhou, and B. Hondowicz Early IL-4 production does not predict susceptibility to Leishmania major Exp Parasitol 84 1996 178 187
    • (1996) Exp Parasitol , vol.84 , pp. 178-187
    • Scott, P.1    Eaton, A.2    Gause, W.C.3    Di Zhou, X.4    Hondowicz, B.5
  • 37
    • 0030023112 scopus 로고    scopus 로고
    • Susceptibility to Leishmania major infection in interleukin-4-deficient mice
    • N. Noben-Trauth, P. Kropf, and I. Muller Susceptibility to Leishmania major infection in interleukin-4-deficient mice Science 271 1996 987 990
    • (1996) Science , vol.271 , pp. 987-990
    • Noben-Trauth, N.1    Kropf, P.2    Muller, I.3
  • 38
    • 0346095267 scopus 로고    scopus 로고
    • Factors influencing Leishmania major infection in IL-4-deficient BALB/c mice
    • P. Kropf, S. Herath, V. Weber, M. Modolell, and I. Muller Factors influencing Leishmania major infection in IL-4-deficient BALB/c mice Parasite Immunol 25 2003 439 447
    • (2003) Parasite Immunol , vol.25 , pp. 439-447
    • Kropf, P.1    Herath, S.2    Weber, V.3    Modolell, M.4    Muller, I.5
  • 41
    • 0031255049 scopus 로고    scopus 로고
    • Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4
    • P. Kropf, R. Etges, L. Schopf, C. Chung, J. Sypek, and I. Muller Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4 J Immunol 159 1997 3434 3443
    • (1997) J Immunol , vol.159 , pp. 3434-3443
    • Kropf, P.1    Etges, R.2    Schopf, L.3    Chung, C.4    Sypek, J.5    Muller, I.6
  • 42
    • 0031981961 scopus 로고    scopus 로고
    • Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: Selective impairment of IL-12 induction in Leishmania-infected cells
    • Y. Belkaid, B. Butcher, and D.L. Sacks Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells Eur J Immunol 28 1998 1389 1400
    • (1998) Eur J Immunol , vol.28 , pp. 1389-1400
    • Belkaid, Y.1    Butcher, B.2    Sacks, D.L.3
  • 43
    • 0031820396 scopus 로고    scopus 로고
    • Differential regulation of the interleukin-12 receptor during the innate immune response to Leishmania major
    • D. Jones, M.M. Elloso, L. Showe, D. Williams, G. Trinchieri, and P. Scott Differential regulation of the interleukin-12 receptor during the innate immune response to Leishmania major Infect Immun 66 1998 3818 3824
    • (1998) Infect Immun , vol.66 , pp. 3818-3824
    • Jones, D.1    Elloso, M.M.2    Showe, L.3    Williams, D.4    Trinchieri, G.5    Scott, P.6
  • 44
    • 0042991289 scopus 로고    scopus 로고
    • + T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells
    • + T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells J Exp Med 198 2003 201 209
    • (2003) J Exp Med , vol.198 , pp. 201-209
    • Filippi, C.1    Hughes, S.2    Cazareth, J.3    Julia, N.4    Glaichenhaus, N.5    Ugolini, S.6
  • 46
    • 0031569531 scopus 로고    scopus 로고
    • Crossregulation between T helper cell (Th) 1 and Th2: Inhibition of Th2 proliferation by IFN-γ involves interference with IL-1
    • T.B. Oriss, S.A. McCarthy, B.F. Morel, M.A. Campana, and P.A. Morel Crossregulation between T helper cell (Th) 1 and Th2: inhibition of Th2 proliferation by IFN-γ involves interference with IL-1 J Immunol 158 1997 3666 3672
    • (1997) J Immunol , vol.158 , pp. 3666-3672
    • Oriss, T.B.1    McCarthy, S.A.2    Morel, B.F.3    Campana, M.A.4    Morel, P.A.5
  • 48
    • 0031573221 scopus 로고    scopus 로고
    • Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response
    • B.D. Hondowicz, T.M. Scharton-Kersten, D.E. Jones, and P. Scott Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response J Immunol 159 1997 5024 5031
    • (1997) J Immunol , vol.159 , pp. 5024-5031
    • Hondowicz, B.D.1    Scharton-Kersten, T.M.2    Jones, D.E.3    Scott, P.4
  • 49
    • 0035337992 scopus 로고    scopus 로고
    • BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling
    • R. Nishikomori, S. Gurunathan, K. Nishikomori, and W. Strober BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling J Immunol 166 2001 6776 6783
    • (2001) J Immunol , vol.166 , pp. 6776-6783
    • Nishikomori, R.1    Gurunathan, S.2    Nishikomori, K.3    Strober, W.4
  • 51
    • 4944266186 scopus 로고    scopus 로고
    • A role for the immunological synapse in lineage commitment of CD4 lymphocytes
    • R.A. Maldonado, D.J. Irvine, R. Schreiber, and L.H. Glimcher A role for the immunological synapse in lineage commitment of CD4 lymphocytes Nature 431 2004 527 532
    • (2004) Nature , vol.431 , pp. 527-532
    • Maldonado, R.A.1    Irvine, D.J.2    Schreiber, R.3    Glimcher, L.H.4
  • 52
    • 0033564686 scopus 로고    scopus 로고
    • Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling
    • M. Mohrs, B. Ledermann, G. Kohler, A. Dorfmuller, A. Gessner, and F. Brombacher Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling J Immunol 162 1999 7302 7308
    • (1999) J Immunol , vol.162 , pp. 7302-7308
    • Mohrs, M.1    Ledermann, B.2    Kohler, G.3    Dorfmuller, A.4    Gessner, A.5    Brombacher, F.6
  • 53
    • 0033563135 scopus 로고    scopus 로고
    • IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains
    • N. Noben-Trauth, W.E. Paul, and D.L. Sacks IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains J Immunol 162 1999 6132 6140
    • (1999) J Immunol , vol.162 , pp. 6132-6140
    • Noben-Trauth, N.1    Paul, W.E.2    Sacks, D.L.3
  • 55
    • 0038560975 scopus 로고    scopus 로고
    • The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major
    • N. Noben-Trauth, R. Lira, H. Nagase, W.E. Paul, and D.L. Sacks The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major J Immunol 170 2003 5152 5158
    • (2003) J Immunol , vol.170 , pp. 5152-5158
    • Noben-Trauth, N.1    Lira, R.2    Nagase, H.3    Paul, W.E.4    Sacks, D.L.5
  • 56
    • 0035863867 scopus 로고    scopus 로고
    • The role of IL-10 in promoting disease progression in leishmaniasis
    • M.M. Kane, and D.M. Mosser The role of IL-10 in promoting disease progression in leishmaniasis J Immunol 166 2001 1141 1147
    • (2001) J Immunol , vol.166 , pp. 1141-1147
    • Kane, M.M.1    Mosser, D.M.2
  • 57
    • 0036717722 scopus 로고    scopus 로고
    • Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases
    • P. McGuirk, and K.H. Mills Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases Trends Immunol 23 2002 450 455
    • (2002) Trends Immunol , vol.23 , pp. 450-455
    • McGuirk, P.1    Mills, K.H.2
  • 58
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of Immune Response by TGF-β
    • J.J. Letterio, and A.B. Roberts Regulation of Immune Response by TGF-β Ann Rev Immunol 16 1998 137 161
    • (1998) Ann Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 59
    • 1542298831 scopus 로고    scopus 로고
    • The murine model of infection with Leishmania major and its importance for the deciphering of mechanisms underlying differences in Th cell differentiation in mice from different genetic backgrounds
    • A. Gumy, J.A. Louis, and P. Launois The murine model of infection with Leishmania major and its importance for the deciphering of mechanisms underlying differences in Th cell differentiation in mice from different genetic backgrounds Int J Parasitol 34 2004 433 444
    • (2004) Int J Parasitol , vol.34 , pp. 433-444
    • Gumy, A.1    Louis, J.A.2    Launois, P.3
  • 60
    • 0034234710 scopus 로고    scopus 로고
    • IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection
    • D.E. Jones, L.U. Buxbaum, and P. Scott IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection J Immunol 165 2000 364 372
    • (2000) J Immunol , vol.165 , pp. 364-372
    • Jones, D.E.1    Buxbaum, L.U.2    Scott, P.3
  • 61
    • 0033401855 scopus 로고    scopus 로고
    • TGF-β in infections and infectious diseases
    • S.G. Reed TGF-β in infections and infectious diseases Microb Infect 1 1999 1313 1325
    • (1999) Microb Infect , vol.1 , pp. 1313-1325
    • Reed, S.G.1
  • 62
    • 0035914841 scopus 로고    scopus 로고
    • The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    • Y. Belkaid, K.F. Hoffmann, S. Mendez, S. Kamhawi, M.C. Udey, T.A. Wynn, and D.L. Sacks The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure J Exp Med 194 2001 1497 1506
    • (2001) J Exp Med , vol.194 , pp. 1497-1506
    • Belkaid, Y.1    Hoffmann, K.F.2    Mendez, S.3    Kamhawi, S.4    Udey, M.C.5    Wynn, T.A.6    Sacks, D.L.7
  • 63
    • 0036719846 scopus 로고    scopus 로고
    • Endogenous interleukin-12 is critical for controlling the late but not the early stage of Leishmania mexicana infection in C57BL/6 mice
    • F. Aguilar Torrentera, J.D. Laman, M. Van Meurs, L. Adorini, E. Muraille, and Y. Carlier Endogenous interleukin-12 is critical for controlling the late but not the early stage of Leishmania mexicana infection in C57BL/6 mice Infect Immun 70 2002 5075 5080
    • (2002) Infect Immun , vol.70 , pp. 5075-5080
    • Aguilar Torrentera, F.1    Laman, J.D.2    Van Meurs, M.3    Adorini, L.4    Muraille, E.5    Carlier, Y.6
  • 64
    • 4143091399 scopus 로고    scopus 로고
    • Cysteine peptidases as virulence factors of Leishmania
    • J.C. Mottram, G.H. Coombs, and J. Alexander Cysteine peptidases as virulence factors of Leishmania Curr Opin Microbiol 7 2004 375 381
    • (2004) Curr Opin Microbiol , vol.7 , pp. 375-381
    • Mottram, J.C.1    Coombs, G.H.2    Alexander, J.3
  • 65
    • 0031573080 scopus 로고    scopus 로고
    • SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis
    • A. Satoskar, F. Brombacher, W.J. Dai, I. McInnes, F.Y. Liew, J. Alexander, and W. Walker SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis J Immunol 159 1997 5005 5013
    • (1997) J Immunol , vol.159 , pp. 5005-5013
    • Satoskar, A.1    Brombacher, F.2    Dai, W.J.3    McInnes, I.4    Liew, F.Y.5    Alexander, J.6    Walker, W.7
  • 66
    • 4844226951 scopus 로고    scopus 로고
    • Leishmaniasis: Does IL-13 play a significant role in the disease process?
    • Brombacher Landes Bioscience
    • J. Alexander, and A.R. Satoskar Leishmaniasis: does IL-13 play a significant role in the disease process? Brombacher Interleukin-13 2003 Landes Bioscience 25 38
    • (2003) Interleukin-13 , pp. 25-38
    • Alexander, J.1    Satoskar, A.R.2
  • 67
    • 0141886173 scopus 로고    scopus 로고
    • The role of interleukin-10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis
    • U.M. Padigel, J. Alexander, and J.P. Farrell The role of interleukin-10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis J Immunol 171 2003 3705 3710
    • (2003) J Immunol , vol.171 , pp. 3705-3710
    • Padigel, U.M.1    Alexander, J.2    Farrell, J.P.3
  • 69
    • 0032534577 scopus 로고    scopus 로고
    • Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response
    • J. Alexander, G.H. Coombs, and J.C. Mottram Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response J Immunol 161 1998 6794 6801
    • (1998) J Immunol , vol.161 , pp. 6794-6801
    • Alexander, J.1    Coombs, G.H.2    Mottram, J.C.3
  • 70
    • 0032403565 scopus 로고    scopus 로고
    • Mice with STAT6-targeted gene disruption develop a Th1 response and control cutaneous leishmaniasis
    • L.M. Stamm, A. Raisanen-Sokolowski, M. Okano, M.E. Russell, J.R. David, and A.R. Satoskar Mice with STAT6-targeted gene disruption develop a Th1 response and control cutaneous leishmaniasis J Immunol 161 1998 6180 6188
    • (1998) J Immunol , vol.161 , pp. 6180-6188
    • Stamm, L.M.1    Raisanen-Sokolowski, A.2    Okano, M.3    Russell, M.E.4    David, J.R.5    Satoskar, A.R.6
  • 71
    • 0034234710 scopus 로고    scopus 로고
    • IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection
    • D.E. Jones, L.U. Buxbaum, and P. Scott IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection J Immunol 165 2000 364 372
    • (2000) J Immunol , vol.165 , pp. 364-372
    • Jones, D.E.1    Buxbaum, L.U.2    Scott, P.3
  • 72
    • 0141955100 scopus 로고    scopus 로고
    • CPB cysteine proteases of Leishmania mexicana inhibit host Th1 responses and protective immunity
    • L.U. Buxbaum, D. Hubert, G.H. Coombs, J. Alexander, J.C. Mottram, and P. Scott CPB cysteine proteases of Leishmania mexicana inhibit host Th1 responses and protective immunity J Immunol 171 2003 3711 3717
    • (2003) J Immunol , vol.171 , pp. 3711-3717
    • Buxbaum, L.U.1    Hubert, D.2    Coombs, G.H.3    Alexander, J.4    Mottram, J.C.5    Scott, P.6
  • 73
    • 4344613395 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: The role of cysteine peptidases and the NF-kappaB signaling pathway
    • P. Cameron, A. McGachy, M. Anderson, A. Paul, G.H. Coombs, J.C. Mottram, J. Alexander, and R. Plevin Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway J Immunol 173 2004 3297 3304
    • (2004) J Immunol , vol.173 , pp. 3297-3304
    • Cameron, P.1    McGachy, A.2    Anderson, M.3    Paul, A.4    Coombs, G.H.5    Mottram, J.C.6    Alexander, J.7    Plevin, R.8
  • 74
    • 0029155778 scopus 로고
    • Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells
    • S. De Souza Leao, T. Lang, E. Prina, R. Hellio, and J.C. Antoine Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells J Cell Sci 108 1995 3219 3231
    • (1995) J Cell Sci , vol.108 , pp. 3219-3231
    • De Souza Leao, S.1    Lang, T.2    Prina, E.3    Hellio, R.4    Antoine, J.C.5
  • 75
    • 0027272777 scopus 로고
    • Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes
    • E. Prina, C. Jouanne, S. de Souza Lao, A. Szabo, J.G. Guillet, and J.C. Antoine Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes J Immunol 151 1993 2050 2061
    • (1993) J Immunol , vol.151 , pp. 2050-2061
    • Prina, E.1    Jouanne, C.2    De Souza Lao, S.3    Szabo, A.4    Guillet, J.G.5    Antoine, J.C.6
  • 76
    • 0025752328 scopus 로고
    • Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis
    • P.M. Kaye, A.J. Curry, and J.M. Blackwell Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis J Immunol 146 1991 2763 2770
    • (1991) J Immunol , vol.146 , pp. 2763-2770
    • Kaye, P.M.1    Curry, A.J.2    Blackwell, J.M.3
  • 77
    • 0027522629 scopus 로고
    • Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis
    • M. Kemp, J.A. Kurtzhals, K. Bendtzen, L.K. Poulsen, M.B. Hansen, D.K. Koech, A. Kharazmi, and T.G. Theander Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis Infect Immun 61 1993 1069 1073
    • (1993) Infect Immun , vol.61 , pp. 1069-1073
    • Kemp, M.1    Kurtzhals, J.A.2    Bendtzen, K.3    Poulsen, L.K.4    Hansen, M.B.5    Koech, D.K.6    Kharazmi, A.7    Theander, T.G.8
  • 78
    • 0031937065 scopus 로고    scopus 로고
    • Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani
    • C.R. Engwerda, M.L. Murphy, S.E. Cotterell, S.C. Smelt, and P.M. Kaye Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani Eur J Immunol 28 1998 669 680
    • (1998) Eur J Immunol , vol.28 , pp. 669-680
    • Engwerda, C.R.1    Murphy, M.L.2    Cotterell, S.E.3    Smelt, S.C.4    Kaye, P.M.5
  • 81
    • 0037067762 scopus 로고    scopus 로고
    • Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta
    • A. Somanna, V. Mundodi, and L. Gedamu Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta J Biol Chem 277 2002 25305 25312
    • (2002) J Biol Chem , vol.277 , pp. 25305-25312
    • Somanna, A.1    Mundodi, V.2    Gedamu, L.3
  • 83
    • 0024324640 scopus 로고
    • The induction of protective immunity to Leishmania major in the BALB/c mouse by interleukin 4 treatment
    • K.C. Carter, G. Gallagher, A.J. Baillie, and J. Alexander The induction of protective immunity to Leishmania major in the BALB/c mouse by interleukin 4 treatment Eur J Immunol 19 1989 779 782
    • (1989) Eur J Immunol , vol.19 , pp. 779-782
    • Carter, K.C.1    Gallagher, G.2    Baillie, A.J.3    Alexander, J.4


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