IL-10 mediates susceptibility to Leishmania donovani infection

European Journal of Immunology

Volumn 31, Issue 10, 2001, Pages 2848-2856

  Murphy, Michaela L ^a   Wille, Ulrike ^a   Villegas, Eric N ^a   Hunter, Christopher A ^a   Farrell, Jay P ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cytokine; IL 12; Leishmania donovani; Th1 response; Visceral leishmaniasis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; NEUTRALIZING ANTIBODY; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE COURSE; DISEASE SEVERITY; FATALITY; FEMALE; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IN VIVO STUDY; INFECTION RESISTANCE; INFECTION SENSITIVITY; LEISHMANIA DONOVANI; MACROPHAGE ACTIVATION; MOUSE; MOUSE STRAIN; NONHUMAN; PARASITE; PARASITISM; PRIORITY JOURNAL; SYSTEMIC DISEASE; VISCERAL LEISHMANIASIS;

ANIMALS; FEMALE; GRANULOMA; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; LIVER DISEASES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II;

EID: 0034776386     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2001010)31:10<2848::AID-IMMU2848>3.0.CO;2-T     Document Type: Article

References (47)

1. The interaction of Leishmania species with macrophages
2. Parasitic infections and the immune system
3. Immunology of leishmaniasis
4. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
5. Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis
6. An in vivo analysis of cytokine production during Leishmania donovani infection in scid mice
7. Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control of Leishmania donovani
8. Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis
9. Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection
10. Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani
11. Circulating T helper 1 (Th1) cell- and Th2 cell-associated cytokines in Indian patients with visceral leishmaniasis
12. In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma
13. Splenic cytokine responses in Indian kala-azar before and after treatment
14. Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis
15. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
16. Potential role for interleukin-10 in the immunosuppression associated with kala azar
17. Presence of circulating levels of interferon-gamma, interleukin-10 and tumor necrosis factor-alpha in patients with visceral leishmaniasis
18. Destruction of follicular dendritic cells during chronic visceral leishmaniasis
19. Host resistance to the genus Leishmania
20. Intracellular antimicrobial activity in the absence of interferon- gamma: Effect of interleukin-12 in experimental visceral leishmaniasis in interferon-gamma gene-disrupted mice
21. Macrophage microbicidal mechanisms in vivo: Reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani
22. The dynamics of granuloma formation in experimental visceral leishmaniasis
23. Acquired resistance and granuloma formation in experimental visceral leishmaniasis. Differential T cell and lymphokine roles in initial versus established immunity
24. Role and effect of TNF-alpha in experimental visceral leishmaniasis
25. Experimental visceral leishmaniasis: Role of endogenous IFN-gamma in host defense and tissue granulomatous response
26. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
27. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi
28. Role of interleukin-10 in regulation of T cell-dependent and T cell-independent mechanisms of resistance to Toxoplasma gondii
29. Behavior of visceral Leishmania donovani in an experimentally induced T helper cell 2 (Th2)-associated response model
30. The importance of TGF-beta in murine visceral leishmaniasis
31. The role of IL-10 in promoting disease progression in leishmaniasis
32. Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia
33. Interleukin-10 downregulates protective immunity to Brucella abortus
34. Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans
35. IL-10 mediates susceptibility to Trypanosoma cruzi infection
36. IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections
37. IL-12 enhances Th1-type responses in human Leishmania donovani infections
38. Interleukin 10 production correlates with pathology in human Leishmania donovani infections
39. High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis
40. T cell response in human leishmaniasis
41. Interleukin-12 regulates the response to chemotherapy in experimental visceral leishmaniasis
42. Interleukin-12 acts as an adjuvant for humoral immunity through interferon-gamma-dependent and -independent mechanisms
43. IFN-gamma-dependent and -independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12
44. Role of IFN-gamma in the inhibition of the allergic airway inflammation caused by IL-12
45. Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice
46. Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production
47. 15N]nitrate in biological fluids