IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 6132-6140

  Noben Trauth, Nancy ^a   Paul, William E ^a   Sacks, David L ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; HELPER CELL; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; ULCER;

ANIMALS; DISEASE SUSCEPTIBILITY; IMMUNOGLOBULIN ISOTYPES; INTERFERON TYPE II; INTERLEUKIN-13; INTERLEUKIN-4; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; RECEPTORS, INTERLEUKIN-4; SPECIES SPECIFICITY; TH1 CELLS; TH2 CELLS;

EID: 0033563135     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
2. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
3. + T-cell subsets in the regulation of parasite immunity and disease. Immunol. Rev. 112:161.
4. Belosevic, M., D. S. Finbloom, P. H. Van Der Meide, M. V. Slayter, and C. A. Nacy. 1989. Administration of monoclonal anti-IFN-γ antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266.
5. + effector cells default to the Th2 pathway in interferon γ-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367.
6. + T cell response. J. Exp. Med. 181:961.
7. Mattner, F., J. Magram, J. Ferrante, P. Launois, K. Di Padova, R. Behin, M. K. Gately, J. A. Louis, and G. Alber. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26:1553.
8. Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins, and R. M. Locksley. 1990. Cure of murine leishmaniasis with anti-interleukm 4 monoclonal antibody: evidence for a T cell-dependent, interferon γ-independent mechanism. J. Exp. Med. 171:115.
9. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania mayor-infected mice. J. Immunol. 148:1182.
10. Noben-Trauth, N., P. Kropf, and I. Muller. 1996. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 271:987.
11. + T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc. Natl. Acad. Sci. USA 94:10838.
12. Beckmann, M. P., D. Cosman, W. Fanslow, C. R. Maliszewski, and S. D. Lyman, 1992. The interleukin-4 receptor: structure, function, and signal transduction. In Interleukins: Molecular Biology and Immunology. T. Kishimoto, ed. Karger, Basel, p. 107.
13. Keegan, A. D., K. Nelms, L. M. Wang, J. H. Pierce, and W. E. Paul. 1994. Interleukin 4 receptor: signaling mechanisms. Immunol. Today 15:423.
14. Kondo, M., T. Takeshita, N. Ishii, M. Nakamura, S. Watanabe, K.-I. Arai, and K. Sugamura. 1993. Sharing of the interleukin-2 (IL 2) receptor γ chain between receptors for IL-2 and IL-4. Science 262:1874.
15. Russell, S. M., A. D. Keegan, N. Harada, Y. Nakamura, M. Noguchi, P. Leland, M. C. Friedmann, A. Miyajima, R. K. Puri, W. E. Paul, and W. J. Leonard. 1993. Interleukin-2 receptor γ chain is a functional component of the interleukin-4 receptor. Science 262:1880.
16. Zurawski, G., and J. E. de Vries. 1994. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today 15:19.
17. Aman, M. J., N. Tayebi, N. I. Obiri, R. K. Puri, W. S. Modi, and W. J. Leonard. 1996. cDNA cloning and characterization of the human interleukin 13 receptor α chain. J. Biol. Chem. 271:29265.
18. Hilton, D. J., J.-G. Zhang, D. Metcalf, W. S. Alexander, N. A. Nicola, and T. A. Willson. 1996. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93:497.
19. Miloux, B., P. Laurent, O. Bonnin, J. Lupker, D. Caput, N. Vita, and P. Ferrara. 1997. Cloning of the human IL-13Rα1 chain and reconstitution with the IL4R α of a functional IL-4/IL-13 receptor complex. FEBS Lett. 401:163.
20. Gauchat, J. F., E. Schlagenhauf, N. P. Feng, R. Moser, M. Yamage, P. Jeannin, S. Alouani, G. Elson, L. D. Notarangelo, T. Wells, H. P. Eugster, and J. Y. Bonnefoy. 1997. A novel 4-kb interleukin-13 receptor α mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin 4/ interleukin-13 receptor. Eur J. Immunol. 27:971.
21. Beebe, A. M., S. Mauze, N. J. Schork, and R. L. Coffman. 1997. Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity 6:551.
22. Louis, J., H. Himmelrich, C. Parra-Lopez, F. Tacchini-Cottier, and P. Launois. 1998. Regulation of protective immunity against Leishmania major in mice. Curr. Opin. Immunol. 10:459.
23. Launois, P., J. A. Louis, and G. Milon. 1997. The fate and persistence of Leishmania major in mice of different genetic backgrounds: an example of exploitation of the immune system by intracellular parasites. Parasitology 115:S25.
24. Wei, X. Q., I. G. Charles, A. Smith, J. Ure, G. J. Feng, F. P. Huang, D. Xu, W. Muller, S. Moncada, and F. Y. Liew. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:408.
25. Julia, V., M. Rassoulzadegan, and N. Glaichenhaus. 1996. Resistance to Leishmania major induced by tolerance to a single antigen. Science 274:421.
26. + T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 6:541.
27. Noben-Trauth, N., G. Köhler, K. Bürki, and B. Ledermann. 1996. Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line. Transgenic Res. 5:487.
28. Sacks, D. L., S. Hieny, and A. Sher. 1985. Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes. J. Immunol. 135:564.
29. Ohara, J., and W. E. Paul. 1985. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature 315:333.
30. Curry, R. C., P. A. Kiener, and G. L. Spitalny. 1987. A sensitive immunochemical assay for biologically active MuIFN-γ J. Immunol. Methods 104:137.
31. Mosmann, T. R., and T. A. Fong. 1989. Specific assays for cytokine production by T cells. J. Immunol. Methods 116:151.
32. Rizro, L. V., R. H. DeKruyff, and D. T. Umetsu. 1992. Generation of B cell memory and affinity maturation: induction with ThI and Th2 clones. J. Immunol. 148:3733.
33. Chu, C. C., E. E. Max, and W. E. Paul. 1993. DNA rearrangement can account for in vitro switching to IgG1. J. Exp. Med. 178:1381.
34. Kopf, M., F. Brombacher, G. Kohler, G. Kienzle, K. H. Widmann, K. Lefrang, C. Humborg, B. Ledermann, and W. Solbach. 1996. IL-4-deficient Balb/c mice resist infection with Leishmania major. J. Exp. Med. 184:1127.
35. Moore, K. W., A. O'Garra, R. de Waal Malefyt, P. Vieìra, and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165.
36. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. Urban, Jr., M. P. Beckmann, L. S. Park, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303.
37. von der Weid, T., M. Kopf, G. Kohler, and J. Langhorne. 1994. The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice. Eur. J. Immunol. 24:2285.
38. Morawetz, R. A., L. Gabriele, L. V. Rizzo, N. Noben-Trauth, R. Kühn, K. Rajewsky, W. Müller, T. M. Doherty, F. Finkelman, R. L. Coffman, and H. C. Morse, III. 1996. Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse. J. Exp. Med. 184:1651.
39. Pearce, E. J., A. Cheever, S. Leonard, M. Covalesky, R. Fernandez-Botran, G. Kohler, and M. Kopf. 1996. Schistosoma mansoni in IL-4-deficient mice. Int. Immunol. 8:435.
40. Urban, J. F., Jr., N. Noben-Trauth, D. D. Donaldson, K. B. Madden, S. C. Morris, M. Collins, and F. D. Finkelmar. 1998. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8:255.
41. Bancroft, A. J., A. N. McKenzie, and R. K. Grencis. 1998. A critical role for IL-13 in resistance to intestinal nematode infection. J. Immunol. 160:3453.
42. Chiaramonte, M. G., L. R. Schopf, T. Y. Neben, A. W. Cheever, D. D. Donaldson, and T. A. Wynn. 1999. IL-13 is a key regulatory cytokine for T helper 2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. J. Immunol. 162:920.
43. Caput, D., P. Laurent, M. Kaghad, J. M. Lelias, S. Lefort, N. Vita, and P. Ferrara. 1996. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor α chain. J. Biol. Chem. 271:16921.
44. Donaldson, D. D., M. J. Whitters, L. J. Fitz, T. Y. Neben, H. Finnerty, S. L. Henderson, R. M. O'Hara, Jr., D. R. Beier, K. J. Turner, C. R. Wood, and M. Collins. 1998. The murine IL-13 receptor α2: molecular cloning, characterization, and comparison with murine IL-13 receptor α1. J. Immunol. 161:2317.
45. Kropf, P., R. Etges, L. Schopf, C. Chung, J. Sypek, and I. Muller. 1997. Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4. J. Immunol. 159:3434.
46. + T cells. Int. Immunol. 3:587.
47. + T cells. Annu. Rev. Immunol. 12:635.
48. Erb, K. J., C. Blank, and H. Moll. 1996. Susceptibility to Leishmania major in IL-4 transgenic mice is not correlated with the lack of a Th1 immune response. Immunol. Cell Biol. 74:239.
49. Sjolander, A., T. M. Baldwin, J. M. Curtis, and E. Handman. 1998. Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis. J. Immunol. 160:3949.
50. Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817.
51. + T helper type 1 cell responses to Candida albicans. J. Exp. Med. 187:307.
52. Bogdan, C., S. Stenger, M. Rollinghoff, and W. Solbach. 1991. Cytokine interactions in experimental cutaneous leishmaniasis: interleukin 4 synergizes with interferon-γ to activate murine macrophages for killing of Leishmania major amastigotes. Eur. J. Immunol. 21:327.
53. Belosevic, M., C. E. Davis, M. S. Meltzer, and C. A. Nacy. 1988. Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-γ for induction of resistance to infection. J. Immunol. 141:890.
54. Carter, K. C., G. Gallagher, A. J. Baillie, and J. Alexander. 1989. The induction of protective immunity to Leishmania major in the BALB/c mouse by interleukin 4 treatment. Eur. J. Immunol. 19:779.
55. Kamogawa, Y., L. -A. Minasi, S. R. Carding, K. Bottomly, and R. A. Flavell. 1993. The relationship of IL-4-and IFN γ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 75:985.