메뉴 건너뛰기




Volumn 68, Issue 4, 2000, Pages 1773-1780

Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

EID: 0034106507     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.4.1773-1780.2000     Document Type: Article
Times cited : (71)

References (60)
  • 1
    • 0032554784 scopus 로고    scopus 로고
    • Differences between IL-4Rα and IL-4 deficient mice reveal a novel role of IL-13 in the regulation of T helper 2 cells and protection to nematode infection
    • Barner, M., M. Mohrs, F. Brombacher, and M. Kopf. 1998. Differences between IL-4Rα and IL-4 deficient mice reveal a novel role of IL-13 in the regulation of T helper 2 cells and protection to nematode infection. Curr. Biol. 8:669-672.
    • (1998) Curr. Biol. , vol.8 , pp. 669-672
    • Barner, M.1    Mohrs, M.2    Brombacher, F.3    Kopf, M.4
  • 2
    • 0032433126 scopus 로고    scopus 로고
    • Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism
    • Bix, M., Z. E. Wang, B. Thiel, N. J. Schork, and R. M. Locksley. 1998. Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J. Exp. Med. 188:2289-2299.
    • (1998) J. Exp. Med. , vol.188 , pp. 2289-2299
    • Bix, M.1    Wang, Z.E.2    Thiel, B.3    Schork, N.J.4    Locksley, R.M.5
  • 3
    • 0027135979 scopus 로고
    • Cytokines in leishmaniasis: A complex network of stimulatory and inhibitory interactions
    • Bogdan, C., A. Gessner, and M. Rollinghoff. 1993. Cytokines in leishmaniasis: a complex network of stimulatory and inhibitory interactions. Immunobiology 189:356-396.
    • (1993) Immunobiology , vol.189 , pp. 356-396
    • Bogdan, C.1    Gessner, A.2    Rollinghoff, M.3
  • 4
    • 0026786405 scopus 로고
    • Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control
    • Bouaboula, M., P. Legoux, B. Pessegue, B. Delpech, X. Dumont, M. Piechaczyk, P. Casellas, and D. Shire. 1992. Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control. J. Biol. Chem. 267:21830-21838.
    • (1992) J. Biol. Chem. , vol.267 , pp. 21830-21838
    • Bouaboula, M.1    Legoux, P.2    Pessegue, B.3    Delpech, B.4    Dumont, X.5    Piechaczyk, M.6    Casellas, P.7    Shire, D.8
  • 5
    • 0032858588 scopus 로고    scopus 로고
    • Leishmania major infection in interleukin-4 and interferon-gamma depleted mice
    • Chatelain, R., S. Mauze, K. Varkila, and R. L. Coffman. 1999. Leishmania major infection in interleukin-4 and interferon-gamma depleted mice. Parasite Immunol. 21:423-431.
    • (1999) Parasite Immunol. , vol.21 , pp. 423-431
    • Chatelain, R.1    Mauze, S.2    Varkila, K.3    Coffman, R.L.4
  • 6
    • 0026500979 scopus 로고
    • IL-4 induces a Th2 response in Leishmania major-infected mice
    • Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182-1187.
    • (1992) J. Immunol. , vol.148 , pp. 1182-1187
    • Chatelain, R.1    Varkila, K.2    Coffman, R.L.3
  • 7
    • 0031091727 scopus 로고    scopus 로고
    • Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10 deficient mice
    • Dai, W. D., G. Köhler, and F. Brombacher. 1997. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10 deficient mice. J. Immunol. 158:2259-2267.
    • (1997) J. Immunol. , vol.158 , pp. 2259-2267
    • Dai, W.D.1    Köhler, G.2    Brombacher, F.3
  • 8
    • 0031159107 scopus 로고    scopus 로고
    • Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-γ receptor-deficient mice
    • Dai, W. J., W. Bartens, G. Köhler, M. Hufnagel, M. Kopf, and F. Brombacher. 1997. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-γ receptor-deficient mice. J. Immunol. 158:5297-5304.
    • (1997) J. Immunol. , vol.158 , pp. 5297-5304
    • Dai, W.J.1    Bartens, W.2    Köhler, G.3    Hufnagel, M.4    Kopf, M.5    Brombacher, F.6
  • 9
    • 0023616650 scopus 로고
    • Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation
    • Da Silva, R., and D. L. Sacks. 1987. Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation. Infect. Immun. 55: 2802-2806.
    • (1987) Infect. Immun. , vol.55 , pp. 2802-2806
    • Da Silva, R.1    Sacks, D.L.2
  • 12
    • 0032845460 scopus 로고    scopus 로고
    • Regulation of the production of soluble IL-4 receptors in murine cutaneous leishmaniasis. The roles of IL-12 and IL-4
    • Fernandez, B. R., P. M. Chilton, B. D. Hondowicz, J. Vetvickova, J. Yan, W. Jones III, and P. Scott. 1999. Regulation of the production of soluble IL-4 receptors in murine cutaneous leishmaniasis. The roles of IL-12 and IL-4. J. Leukoc. Biol. 66:481-488.
    • (1999) J. Leukoc. Biol. , vol.66 , pp. 481-488
    • Fernandez, B.R.1    Chilton, P.M.2    Hondowicz, B.D.3    Vetvickova, J.4    Yan, J.5    Jones W. III6    Scott, P.7
  • 13
    • 0028904642 scopus 로고
    • Linked in vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis
    • Fernandez, B. R., T. A. Wynn, S. Hieny, P. Caspar, P. M. Chilton, and A. Sher. 1995. Linked in vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis. Eur. J. Immunol. 25:649-656.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 649-656
    • Fernandez, B.R.1    Wynn, T.A.2    Hieny, S.3    Caspar, P.4    Chilton, P.M.5    Sher, A.6
  • 14
    • 0029973241 scopus 로고    scopus 로고
    • Control of the production of soluble interleukin-4 receptors: Implications in immunoregulation
    • Fernandez-Botran, R., P. M. Chilton, Y. Ma, J. L. Windsor, and N. E. Street. 1996. Control of the production of soluble interleukin-4 receptors: implications in immunoregulation. J. Leukoc. Biol. 59:499-504.
    • (1996) J. Leukoc. Biol. , vol.59 , pp. 499-504
    • Fernandez-Botran, R.1    Chilton, P.M.2    Ma, Y.3    Windsor, J.L.4    Street, N.E.5
  • 15
    • 0028048136 scopus 로고
    • Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous leishmaniasis
    • Gessner, A., K. Schroppel, A. Will, K. H. Enssle, L. Lauffer, and M. Rollinghoff. 1994. Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous leishmaniasis. Infect. Immun. 62: 4112-4117.
    • (1994) Infect. Immun. , vol.62 , pp. 4112-4117
    • Gessner, A.1    Schroppel, K.2    Will, A.3    Enssle, K.H.4    Lauffer, L.5    Rollinghoff, M.6
  • 17
    • 0030062937 scopus 로고    scopus 로고
    • Selective development of T helper (Th) 2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice
    • Guery, J. C., F. Galbiati, S. Smiroldo, and L. Adorini. 1996. Selective development of T helper (Th) 2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:485-497.
    • (1996) J. Exp. Med. , vol.183 , pp. 485-497
    • Guery, J.C.1    Galbiati, F.2    Smiroldo, S.3    Adorini, L.4
  • 19
    • 0031571196 scopus 로고    scopus 로고
    • T cell genetic background determines maintenance of IL-12 signaling. Effects on Balb/c and B10.D2 T helper cell type 1 phenotype development
    • Guler, M. L., N. G. Jackobson, U. Gubler, and K. M. Murphy. 1997. T cell genetic background determines maintenance of IL-12 signaling. Effects on Balb/c and B10.D2 T helper cell type 1 phenotype development. J. Immunol. 159:1767-1774.
    • (1997) J. Immunol. , vol.159 , pp. 1767-1774
    • Guler, M.L.1    Jackobson, N.G.2    Gubler, U.3    Murphy, K.M.4
  • 20
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
    • Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59-72.
    • (1989) J. Exp. Med. , vol.169 , pp. 59-72
    • Heinzel, F.P.1    Sadick, M.D.2    Holaday, B.J.3    Coffman, R.L.4    Locksley, R.M.5
  • 21
    • 0025768733 scopus 로고
    • Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis
    • Heinzel, F. P., M. D. Sadick, S. S. Mutha, and R. M. Locksley. 1991. Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011-7015.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7011-7015
    • Heinzel, F.P.1    Sadick, M.D.2    Mutha, S.S.3    Locksley, R.M.4
  • 23
    • 0032403583 scopus 로고    scopus 로고
    • The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12
    • Himmelrich, H., L. C. Parra, C. F. Tacchini, J. A. Louis, and P. Launois. 1998. The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12. J. Immunol. 161:6156-6163.
    • (1998) J. Immunol. , vol.161 , pp. 6156-6163
    • Himmelrich, H.1    Parra, L.C.2    Tacchini, C.F.3    Louis, J.A.4    Launois, P.5
  • 24
    • 0031913243 scopus 로고    scopus 로고
    • Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase
    • Hölscher, C., G. Köhler, U. Müller, H. Mossmann, G. A. Schaub, and F. Brombacher. 1997. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect. Immun. 66:1208-1215.
    • (1997) Infect. Immun. , vol.66 , pp. 1208-1215
    • Hölscher, C.1    Köhler, G.2    Müller, U.3    Mossmann, H.4    Schaub, G.A.5    Brombacher, F.6
  • 25
    • 0028906593 scopus 로고
    • T cell genetic background determines default T helper phenotype development in vitro
    • Hsieh, C. S., S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1995. T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181:713-721.
    • (1995) J. Exp. Med. , vol.181 , pp. 713-721
    • Hsieh, C.S.1    Macatonia, S.E.2    O'Garra, A.3    Murphy, K.M.4
  • 26
    • 0027336689 scopus 로고
    • Development of T(H)1 CD4(+) T cells through IL-12 produced by Listeria-induced macrophages
    • Hsieh, C. S., S. E. Macatonia, C. S. Tripp, S. F. Wolf, A. O'Garra, and K. M. Murphy. 1993. Development of T(H)1 CD4(+) T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549.
    • (1993) Science , vol.260 , pp. 547-549
    • Hsieh, C.S.1    Macatonia, S.E.2    Tripp, C.S.3    Wolf, S.F.4    O'Garra, A.5    Murphy, K.M.6
  • 27
    • 0029560990 scopus 로고
    • Quantitative measurement of mouse cytokine mRNA by polymerase chain reaction
    • Jia, G. Q., and J. C. Gutierrez-Ramos. 1995. Quantitative measurement of mouse cytokine mRNA by polymerase chain reaction. Eur. Cytokine Netw. 6:253-255.
    • (1995) Eur. Cytokine Netw. , vol.6 , pp. 253-255
    • Jia, G.Q.1    Gutierrez-Ramos, J.C.2
  • 28
    • 0033024881 scopus 로고    scopus 로고
    • Enhancement of human IL-4 activity by soluble IL-4 receptors in vitro
    • Jung, T., K. Wagner, C. Neumann, and C. H. Heusser. 1999. Enhancement of human IL-4 activity by soluble IL-4 receptors in vitro. Eur. J. Immunol. 29:864-871.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 864-871
    • Jung, T.1    Wagner, K.2    Neumann, C.3    Heusser, C.H.4
  • 30
  • 31
    • 0031255049 scopus 로고    scopus 로고
    • Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4
    • Kropf, P., R. Etges, L. Schopf, C. Chung, J. Sypek, and I. Muller. 1997. Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4. J. Immunol. 159:3434-3443.
    • (1997) J. Immunol. , vol.159 , pp. 3434-3443
    • Kropf, P.1    Etges, R.2    Schopf, L.3    Chung, C.4    Sypek, J.5    Muller, I.6
  • 32
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kuhn, R., K. Rajewsky, and W. Muller. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254:707-710.
    • (1991) Science , vol.254 , pp. 707-710
    • Kuhn, R.1    Rajewsky, K.2    Muller, W.3
  • 34
    • 0029584457 scopus 로고
    • In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1
    • Launois, P., T. Ohteki, K. Swihart, H. R. MacDonald, and J. A. Louis. 1995. In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1 -. Eur. J. Immunol. 25:3298-3307.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 3298-3307
    • Launois, P.1    Ohteki, T.2    Swihart, K.3    MacDonald, H.R.4    Louis, J.A.5
  • 35
    • 0031114125 scopus 로고    scopus 로고
    • Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness
    • Launois, P., K. G. Swihart, G. Milon, and J. A. Louis. 1997. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J. Immunol. 158:3317-3324.
    • (1997) J. Immunol. , vol.158 , pp. 3317-3324
    • Launois, P.1    Swihart, K.G.2    Milon, G.3    Louis, J.A.4
  • 36
    • 0025082313 scopus 로고
    • Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
    • Le Gros, G., S. S. Ben, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921-929.
    • (1990) J. Exp. Med. , vol.172 , pp. 921-929
    • Le Gros, G.1    Ben, S.S.2    Seder, R.3    Finkelman, F.D.4    Paul, W.E.5
  • 37
    • 0029825437 scopus 로고    scopus 로고
    • In vivo alterations in cytokine production following interleukin-12 (IL-12) and anti-IL-4 antibody treatment of CB6F1 mice with chronic cutaneous leishmaniasis
    • Li, J., P. Scott, and J. P. Farrell. 1996. In vivo alterations in cytokine production following interleukin-12 (IL-12) and anti-IL-4 antibody treatment of CB6F1 mice with chronic cutaneous leishmaniasis. Infect. Immun. 64:5248-5254.
    • (1996) Infect. Immun. , vol.64 , pp. 5248-5254
    • Li, J.1    Scott, P.2    Farrell, J.P.3
  • 38
    • 0027488625 scopus 로고
    • Helper T cells without CD4: Control of leishmaniasis in CD4-deficient mice
    • Locksley, R., S. L. Reiner, F. Hatam, D. R. Littman, and N. Killeen. 1993. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 261:1448-1451.
    • (1993) Science , vol.261 , pp. 1448-1451
    • Locksley, R.1    Reiner, S.L.2    Hatam, F.3    Littman, D.R.4    Killeen, N.5
  • 40
    • 0030002111 scopus 로고    scopus 로고
    • Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
    • Mattner, F., J. Magram, J. Ferrante, P. Launois, P. K. Di, R. Behin, M. K. Gately, J. A. Louis, and G. Alber. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26:1553-1559.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1553-1559
    • Mattner, F.1    Magram, J.2    Ferrante, J.3    Launois, P.4    Di, P.K.5    Behin, R.6    Gately, M.K.7    Louis, J.A.8    Alber, G.9
  • 42
    • 0033577811 scopus 로고    scopus 로고
    • Simultaneous disruption of Interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses
    • McKenzie, G. J., P. Fallon, C. L. Emson, R. Grencis, and A. N. McKenzie. 1999. Simultaneous disruption of Interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J. Exp. Med. 189: 1565-1572.
    • (1999) J. Exp. Med. , vol.189 , pp. 1565-1572
    • McKenzie, G.J.1    Fallon, P.2    Emson, C.L.3    Grencis, R.4    McKenzie, A.N.5
  • 43
    • 0028962552 scopus 로고
    • Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4
    • Mocci, S., and R. L. Coffman. 1995. Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. J. Immunol. 154:3779-3787.
    • (1995) J. Immunol. , vol.154 , pp. 3779-3787
    • Mocci, S.1    Coffman, R.L.2
  • 44
    • 0031568540 scopus 로고    scopus 로고
    • The mechanism of in vitro T helper cell type 1 to T helper cell type 2 switching in highly polarized Leishmania major-specific T cell populations
    • Mocci, S., and R. L. Coffman. 1997. The mechanism of in vitro T helper cell type 1 to T helper cell type 2 switching in highly polarized Leishmania major-specific T cell populations. J. Immunol. 158:1559-1564.
    • (1997) J. Immunol. , vol.158 , pp. 1559-1564
    • Mocci, S.1    Coffman, R.L.2
  • 45
    • 0033564686 scopus 로고    scopus 로고
    • Differences between IL-4 and IL-4Rα deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling
    • Mohrs, M., B. Lederman, G. Koehler, A. Dorfmueller, A. Gessner, and F. Brombacher. 1999. Differences between IL-4 and IL-4Rα deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J. Immunol. 162:7302-7308.
    • (1999) J. Immunol. , vol.162 , pp. 7302-7308
    • Mohrs, M.1    Lederman, B.2    Koehler, G.3    Dorfmueller, A.4    Gessner, A.5    Brombacher, F.6
  • 46
    • 0030931043 scopus 로고    scopus 로고
    • An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice
    • Noben-Trauth, N., L. D. Shultz, F. Brombacher, J. F. Urban, H. Gu, and W. E. Paul. 1997. An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc. Natl. Acad. Sci. USA 94:10838-10843.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10838-10843
    • Noben-Trauth, N.1    Shultz, L.D.2    Brombacher, F.3    Urban, J.F.4    Gu, H.5    Paul, W.E.6
  • 47
    • 0030023112 scopus 로고    scopus 로고
    • Susceptibility to Leishmania major infection in interleukin-4-deficient mice
    • Noben-Trauth, N. P., P. Kropf, and I. Mueller. 1996. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 271:987-990.
    • (1996) Science , vol.271 , pp. 987-990
    • Noben-Trauth, N.P.1    Kropf, P.2    Mueller, I.3
  • 49
    • 0027156562 scopus 로고
    • Adoptive transfer of low numbers of CD4+ T cells into SCID mice chronically treated with soluble IL-4 receptor does not prevent engraftment of IL-4-producing T cells
    • Rudolphi, A., K. H. Enssle, M. H. Claesson, and J. Reimann. 1993. Adoptive transfer of low numbers of CD4+ T cells into SCID mice chronically treated with soluble IL-4 receptor does not prevent engraftment of IL-4-producing T cells. Scand. J. Immunol. 38:57-64.
    • (1993) Scand. J. Immunol. , vol.38 , pp. 57-64
    • Rudolphi, A.1    Enssle, K.H.2    Claesson, M.H.3    Reimann, J.4
  • 50
    • 0025133974 scopus 로고
    • Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism
    • Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins, and R. M. Locksley. 1990. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J. Exp. Med. 171:115-127.
    • (1990) J. Exp. Med. , vol.171 , pp. 115-127
    • Sadick, M.D.1    Heinzel, F.P.2    Holaday, B.J.3    Pu, R.T.4    Dawkins, R.S.5    Locksley, R.M.6
  • 52
    • 0031573080 scopus 로고    scopus 로고
    • SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis
    • Satoskar, A., F. Brombacher, W. J. Dal, I. McInnes, F. Y. Liew, J. Alexander, and W. Walker. 1997. SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis. J. Immunol. 159:5005-5013.
    • (1997) J. Immunol. , vol.159 , pp. 5005-5013
    • Satoskar, A.1    Brombacher, F.2    Dal, W.J.3    McInnes, I.4    Liew, F.Y.5    Alexander, J.6    Walker, W.7
  • 53
    • 0027491655 scopus 로고
    • Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
    • Seder, R. A., R Gazzinelli, A. Sher, and W. E. Paul. 1993. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188-10192.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10188-10192
    • Seder, R.A.1    Gazzinelli, R.2    Sher, A.3    Paul, W.E.4
  • 54
    • 0000841337 scopus 로고
    • Open exchange of reagents and information useful for the measurement of cytokine mRNA levels by PCR
    • Shire, D. 1993. Open exchange of reagents and information useful for the measurement of cytokine mRNA levels by PCR. Eur. Cytokine Netw. 4:161-162.
    • (1993) Eur. Cytokine Netw. , vol.4 , pp. 161-162
    • Shire, D.1
  • 55
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain, S. L., A. D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796-3806.
    • (1990) J. Immunol. , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 57
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R beta2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-12R beta2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817-824.
    • (1997) J. Exp. Med. , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 59
    • 0022400673 scopus 로고
    • Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice
    • Titus, R. G., R. Ceredig, J. C. Cerottini, and J. A. Louis. 1985. Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice. J. Immunol. 135:2108-2114.
    • (1985) J. Immunol. , vol.135 , pp. 2108-2114
    • Titus, R.G.1    Ceredig, R.2    Cerottini, J.C.3    Louis, J.A.4
  • 60
    • 0028176655 scopus 로고
    • Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
    • Zurawski, G., and J. E. de Vries. 1994. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today 15:19-26.
    • (1994) Immunol. Today , vol.15 , pp. 19-26
    • Zurawski, G.1    De Vries, J.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.