Mice with STAT6-targeted gene disruption develop a Th1 response and control cutaneous leishmaniasis

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 6180-6188

  Stamm, Luisa M ^a   Räisänen Sokolowski, Anne ^a   Okano, Mitsuhiro ^a   Russell, Mary E ^a   David, John R ^a   Satoskar, Abhay R ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DISRUPTION; GENE TARGETING; IMMUNOREGULATION; INOCULATION; LEISHMANIA MEXICANA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTOZOON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INJURY; SKIN LEISHMANIASIS; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CYTOKINES; GENE DELETION; GENE TARGETING; INJECTIONS, SUBCUTANEOUS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; LEISHMANIA MEXICANA; LEISHMANIASIS, CUTANEOUS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; SKIN; STAT6 TRANSCRIPTION FACTOR; TH1 CELLS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0032403565     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Peters, W., and R. Killick-Kendrick. 1987. The Leishmaniases in Biology and Medicine, Vols. 1 and 2. Academic Press, London, p. 941.
2. Blackwell, J. M. 1988. Protozoal infections. In Genetics of Resistance to Bacterial and Parasitic Infections. D. M. Wakelin and J. M. Blackwell, eds. Taylor and Francis, London, p. 103.
3. Alexander, J., and P. M. Kay. 1985. Immunoregulatory pathways mexicana maniasis: different regulatory control during Leishmania mexicana mexicana and Leishmania major infections. Clin. Exp. Immunol. 61:647.
4. + lymphocytes in vivo during healing and progressive of murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011.
5. Scott, P., P. Natovitz, R. L. Coffman, E. Pearce, and A. Sher. 1988. Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 168:1675.
6. Oswald, I. P., R. T. Gazzinelli, A. Sher, and S. L. James. 1992. IL-10 synergizes with IL-4 and transforming growth factor-β to inhibit macrophage cytotoxic activity. J. Immunol. 148:3578.
7. Sher, A., R. T. Gazzinelli, I. P. Oswald, M. Clerici, M. Kullberg, E. J. Pearce, J. A. Berzofsky, T. R. Mosmann, S. L. James, and H. C. Morse. 1992. Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol. Rev. 127:183.
8. Kopf, M., F. Brombacher, G. Köhler, G. Kienzle, K.-H. Widman, K. Lefrang, C. Humborg, B. Ledermann, and W. Solbach. 1996. IL-4-deficient BALB/c mice resist infection with Leishmania major. J. Exp. Med. 184:1127.
9. Satoskar, A., F. Brombacher, W. J. Dai, I. McInnes, F. Y. Liew, J. Alexander, and W. Walker. 1997. SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis. J. Immunol. 159:5005.
10. Satoskar, A., H. Bluethmann, and J. Alexander. 1995. Disruption of the murine interleukin 4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection. Infect. Immun. 63:4894.
11. Güler, M. L., J. D. Gorham, C.-S. Hsieh, A. J. Mackey, R. G. Steen, W. F. Dietrich, and K. M. Murphy. 1996. Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1 cell development. Science 271:984.
12. Afonso, L. C. C., and P. Scott. 1993. Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis. Infect. Immun. 61:2952.
13. Guevara-Mendoza, O., C. Une, P. F. Carreira, and A. Orn. 1997. Experimental infection of BALB/c mice with Leishmania panamensis and Leishmania mexicana: induction of early IFN-γ but not IL-4 is associated with the development of cutaneous lesions. Scand. J. Immunol. 46:35.
14. Paul, W. E. 1997. Interleukin 4: signaling mechanisms and control of T cell differentiation. Ciba Found. Symp. 204:208.
15. Keegan, A. D., K. Nelms, M. White, L.-M. Wang, J. H. Pierce, and W. E. Paul. 1994. An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell 76:811.
16. Witthuhn, B. A., O. Silvennoinen, O. Miura, K. S. Lai, C. Cwik, E. T. Lui, and J. N. Ihle. 1994. Involvement of the Jak-3 Janus kinase in signaling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153.
17. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of STAT6 in IL-4 signaling. Nature 380:627.
18. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. STAT6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4:313.
19. Zurawski, G., and J. E. de Vries. 1994. Interleukin 13 elicits a subset of the activities of its close relative interleukin 4. Stem Cells 12:169.
20. Zurawski, S. M., P. Chomarat, O. Djossou, C. Bidaud, A. N. McKenzie, P. Miossec, J. Banchereau, and G. Zurawski. 1995. The primary binding subunit of human interleukin 4 receptor is also a component of the interleukin 13 receptor. J. Biol. Chem. 270:13869.
21. Takeda, K., M. Kamanaka, T. Tanaka, T. Kishimoto, and S. Akira. 1996. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J. Immunol. 157:3220.
22. Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. A. Vignali, et al. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630.
23. Hart, D. T., K. Vickerman, and G. H. Coombs. 1981. A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers. Parasitology 82: 345.
24. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
25. Snapper, C. M., and W. E. Paul. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944.
26. Coffman, R. L., J. Ohara, M. W. Bond, J. Carty, A. Zlotnick, and W. E. Paul. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136:4538.
27. Russell M. E., A. F. Wallace, L. R. Wyner, J. B. Newell, and M. J. Karnovsky. 1995. Upregulation and modulation of inducible nitric oxide synthesis in rat cardiac allografts with chronic rejection and transplant arteriosclerosis. Circulation 92:457.
28. Räisänen-Sokolowski, A., T. Glysing-Jensen, P. L. Mottram, and M. E. Russell. 1997. Sustained anti-CD4/CD8 treatment blocks inflammatory activation and intimal thickening in mouse hearts allografts. Arterioscler. Thromb. Vasc. Biol. 17:2115.
29. Räisänen-Sokolowski, A., P. L. Mottram, T. Glysing-Jensen, A. Satoskar, and M. E. Russell. 1997. Heart transplants in interferon-γ, interleukin 4, and interleukin 10 knockout mice. J. Clin. Invest. 100:2449.
30. Roux K. 1995. Optimization and troubleshooting in PCR. PCR Methods Appl. 4:S185.
31. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
32. Leal, L. M., D. W. Moss, R. Kuhn, W. Müller, and F. Y. Liew. 1993. Interleukin 4 transgenic mice of resistant background are susceptible to Leishmania major. Eur. J. Immunol. 23:566.
33. Carrera, L., R. T. Gazzinelli, R. Badolato, S. Hieny, W. Müller, R. Kühn, and D. L. Sacks. 1996. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J. Exp. Med. 183:515.
34. + T cells during initiation and infection. J. Exp. Med. 179:447.
35. Noben-Trauth, N., P. Kropf, and I. Müller. 1996. Susceptibility to Leishmania major infection in interleukin 4-deficient mice. Science 271:987.
36. Mattner, F., J. Magram, J. Ferrante, P. Launois, K. Di Padova, R. Behin, M. K. Gately, J. A. Louis, and G. Alber. 1996. Genetically resistant mice lacking interleukin 12 are susceptible to infection with Leishmania major and mount a polarized Th2 response. Eur. J. Immunol. 26:1553.
37. Mattner, F., K. Di Padova, and G. Alber. 1997. Interleukin 12 is indispensable for protective immunity against Leishmania major. Infect. Immun. 65:4378.
38. + effector cells default to the Th2 pathway in interferon-γ-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367.
39. + T cell response. J. Exp. Med. 181:961.
40. Belosevic, M., D. S. Finbloom, P. H. Van Der Meide, M. V. Slayter, and C. A. Nacy. 1989. Administration of monoclonal anti-IFN-γ antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266.
41. Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins, and R. M. Locksley. 1990. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody: evidence for a T cell-dependent, interferon-γ-independent, mechanism J. Exp. Med. 171:115.
42. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
43. McKnight, A. J., G. J. Zimmer, I. Fogelman, S. F. Wolf, and A. K. Abbas. 1994. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152:2171.
44. + T cells to enhance priming for interferon-γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
45. Launois, P., K. G. Swihart, G. Milon, and J. A. Louis. 1997. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J. Immunol. 158:3317.
46. Hart, P. H., G. F. Vitti, D. R. Burgess, G. A. Whitty, D. S. Piccoli, and J. A. Hamilton. 1989. Potential anti-inflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor-α, interleukin 1, and prostaglandin E2. Proc. Natl. Acad. Sci. USA 86:3803.
47. Liew, F. Y., and C. A. O'Donnell. 1993. Immunology of leishmaniasis. Adv. Parasitol. 32:161.
48. Titus, R. G., B. Sherry, and A. Cerami. 1989. Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis. J. Exp. Med. 170:2097.
49. Liew, F. Y., Y. Li, and S. Millott. 1990. TNF-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide. J. Immunol. 145:4306.
50. Nashleanas, M., S. Kanaly, and P. Scott. 1998. Control of Leishmania major infection in mice lacking TNF receptors. J. Immunol. 160:5506.
51. Di Santo, E., C. Meazza, M. Sironi, P. Fruscella, A. Mantovani, J. D. Sipe, and P. Ghezzi. 1997. IL-13 inhibits TNF production but potentiates that of IL-6 in vivo and ex vivo in mice. J. Immunol. 159:379.
52. Sun, X. J., L.-M. Wang, Y. Zhang, L. Yenush, M. G. Myers, Jr., E. Glasheen, W. S. Lane, J. H. Pierce, and M. F. White. 1995. Role of IRS-2 in insulin and cytokine signaling. Nature 377:173.
53. Chomarat, P., and J. Banchereau. 1997. An update on interleukin 4 and its receptor. Eur. Cytokine Netw. 8:333.
54. Zurawski, G., and J. E. de Vries. 1994. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today 15:19.
55. Minty, A., S. Asselin, A. Bensussan, D. Shire, N. Vita, A. Vyakarnam, J. Wijdenes, P. Ferrara, and D. Caput. 1997. The related cytokines interleukin 13 and interleukin 4 are distinguished by differential production and differential effects on T lymphocytes. Eur. Cytokine Netw. 8:203.
56. Malabarba, M. G., H. Rui, H. H. Deutsch, J. Chung, F. S. Kalthoff, W. L. Farrar, and R. A. Kirken. 1996. Interleukin 13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin 2 receptor-γ and interleukin 4 receptor-α. Biochem. J. 319:865.
57. Goebler, M., B. Schnarr, A. Toksoy, M. Kunz, E.-B. Brocker, A. Duschl, and R. Gillitzer. 1997. Interleukin 13 selectively induces monocyte chemoattractant protein-1 synthesis and secretion by human endothelial cells. Involvement of IL-4R α and STAT6 phosphorylation. Immunology 91:450.
58. + T cells. J. Allergy Clin. Immunol. 100:792.
59. Kaplan, M. H., J. R. Whitfield, D. L. Boros, and M. J. Grusby. 1998. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. J. Immunol. 160:1850.
60. Vivetta, E. S., J. Ohara, C. D. Myers, J. E. Layton, P. H. Krammer, and W. E. Paul. 1985. Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J. Exp. Med. 162: 1726.
61. Siemasko, K., A. S. Chong, H. M. Jack, H. Gong, J. W. Williams, and A. Finnegan. 1998. Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. J. Immunol. 160:1581.
62. Solbach, W., P. A. Asmuss, S. Zimmerman, C. Humborg, and M. Rollinghoff. 1995. Protective effect of leflunomide on the natural course of Leishmania major-induced disease in genetically susceptible BALB/c mice. Int. J. Immunopharmacol. 17:481.