Role of peroxidases in Parkinson disease: A hypothesis

Free Radical Biology and Medicine

Volumn 38, Issue 10, 2005, Pages 1296-1310

  Everse, Johannes ^a   Coates, Penelope W ^a  

^a TEXAS TECH UNIVERSITY   (United States)

Author keywords

Cytochrome c; Cytotoxicity; Free radicals; Myeloperoxidase; Parkinson disease; Peroxidase

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACETYLSALICYLIC ACID; ANTIOXIDANT; APOMORPHINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME C; DEFEROXAMINE MESYLATE; DOPAMINE; GLUTATHIONE; HEME; HEMIN; HYDROXYL RADICAL; INORGANIC COMPOUND; IRON; IRON CHELATING AGENT; LIPID; MYELOPEROXIDASE; PARGYLINE; PEROXIDASE; PROTEIN; RADICAL; SELEGILINE; SUPEROXIDE; URIC ACID;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CATALYSIS; CELL ACTIVATION; CELL DAMAGE; CELL DESTRUCTION; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STABILITY; HUMAN; HYPOTHESIS; LEWY BODY; METABOLISM; MICROGLIA; NERVE DEGENERATION; NEUROTOXICITY; NITRATION; NONHUMAN; OXIDATION; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; SUBSTANTIA NIGRA; THEORY;

EID: 18044388917     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.01.018     Document Type: Article

References (144)

1. M.B.H. Youdim, E. Grünblatt, and S. Mandel The pivotal role of iron in NF-κB activation and nigrostriatal dopaminergic neurodegeneration Ann. N. Y. Acad. Sci. 890 1999 7 25
2. S.G. Speciale MPTP: insights into parkinsonian neurodegeneration Neurotoxicol. Teratol. 24 2002 607 620
3. D. Kaur, and J.K. Andersen Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility? Aging Cell 1 2002 17 21
4. M.F. Beal Mitochondria, oxidative damage, and inflammation in Parkinson's disease Ann. N. Y. Acad. Sci. 991 2003 120 131
5. H.-M. Gao, B. Liu, W. Zhang, and J.-S. Hong Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease FASEB J. 2003 (August 1) (Express article 10.1096/fj.03-0109fje)
6. H.-M. Gao, B. Liu, W. Zhang, and J.-S. Hong Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease FASEB J. 2003 (August 15) (Express article 10.1096/fj.03-0203fje)
7. J.W. Langston, L.S. Forno, J. Tetrud, A.G. Reeves, J.A. Kaplan, and D. Karluk Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure Ann. Neurol. 46 1999 598 605
8. L.M. Ambani, M.H. Van Woert, and S. Murphy Brain peroxidase and catalase in Parkinson's disease Arch. Neurol. 32 1975 114 118
9. M.T.T. Wong-Riley Endogenous peroxidatic activity in brain stem neurons as demonstrated by their staining with diaminobenzidine in normal squirrel monkeys Brain Res. 108 1976 257 277
10. M.B. Grisham, V.J. Perez, and J. Everse Neuromelanogenic and cytotoxic properties of canine brainstem peroxidase J. Neurochem. 48 1987 876 882
11. F.C. Barone, L.M. Hillegass, W.J. Price, R.F. White, E.V. Lee, G.Z. Feuerstein, H.M. Sarau, R.K. Clark, and D.E. Griswold Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: myeloperoxidase activity assay and histologic verification J. Neurosci. Res. 29 1991 336 345
12. M.R. Okun The role of peroxidase in neuromelanin synthesis: a review Physiol. Chem. Phys. Med. NMR 29 1997 15 22
13. L. Galzigna, M.P. Schiapelli, A. Rigo, and M. Scarpa A rat brain fraction and different purified peroxidases catalyzing the formation of dopaminochrome from dopamine Biochim. Biophys. Acta 1427 1999 329 336
14. L. Galzigna, A. De Iuliis, and L. Zanatta Enzymatic dopamine peroxidation in substantia nigra of human brain Clin. Chim. Acta 300 2000 131 138
15. M.B. Grisham Cytotoxicity of heme proteins: structure-function relationships 1982 Lubbock: Texas Tech Univ. Health Sciences Center (Ph.D. dissertation)
16. Klebanoff, S. J.; Clark, R. A. The neutrophil: function and clinical disorders. Amsterdam: North Holland; 1978.
17. K.V. Biagas, M.W. Uhl, J.K. Schiding, E.M. Nemoto, and P.M. Kochanek Assessment of posttraumatic polymorphonuclear leukocyte accumulation in rat brain using tissue myeloperoxidase assay and vinblastine treatment J. Neurotrauma 9 1992 363 371
18. R.M. Nagra, B. Becher, W.W. Tourtellotte, J.P. Antel, D. Gold, T. Paladino, R.A. Smith, J.R. Nelson, and W.F. Reynolds Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis J. Neuroimmunol. 78 1997 97 107
19. P.L. McGeer, and E.G. McGeer Innate immunity, local inflammation, and degenerative disease 2002 (24 July) Science's SAGE KE online at http://sageke.sciencemag.org/cgi/content/full/sageke;2002/29/re3
20. D.-C. Wu, P. Teismann, K. Tieu, M. Vila, V. Jackson-Lewis, H. Ischiropoulos, and S. Przedborski NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease Proc. Natl. Acad. Sci. USA 100 2003 6145 6150
21. W.F. Reynolds, J. Rhees, D. Maciejewski, T. Paladino, H. Sieburg, R.A. Maki, and E. Masliah Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease Exp. Neurol. 155 1999 31 41
22. W.F. Reynolds, M. Hiltunen, M. Pirskanen, A. Mannermaa, S. Helisalmi, M. Lehtovirta, I. Alafuzoff, and H. Soininen MPO and APOEε4 polymorphisms interact to increase risk for AD in Finnish males Neurology 55 2000 1284 1290
23. G. Ramsaransing, A. Teelken, V.M. Prokopenko, A.V. Arutjunyan, and J. De Keiser Low leucocyte myeloperoxidase activity in patients with multiple sclerosis J. Neurol. Neurosurg. Psychiatry 74 2003 953 955
24. A. Van der Vliet, M.N. Nguyen, M.K. Shigenaga, J.P. Eiserich, G.P. Marelich, and C.E. Cross Myeloperoxidase and protein oxidation in cystic fibrosis Am. J. Physiol. Lung Cell Mol. Physiol. 279 2000 L537 L546
25. M. Brennan, A. Gaur, A. Pahuja, A.J. Lusis, and W.F. Reynolds Mice lacking myeloperoxidase are more susceptible to experimental autoimmune encephalomyelitis J. Neuroimmunol. 112 2001 97 105
26. W.F. Reynolds, E. Chang, D. Douer, E.D. Ball, and V. Kanda An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia Blood 90 1997 2730 2737
27. M.B. Schabath, M.R. Spitz, X. Zhang, G.L. Delclos, and X. Wu Genetic variants of myeloperoxidase and lung cancer risk Carcinogenesis 21 2000 1163 1166
28. I. Cascorbi, S. Henning, J. Brockmöller, J. Gephart, C. Meisel, J.M. Müller, R. Loddenkemper, and I. Roots Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant-463A of the myeloperoxidase gene Cancer Res. 60 2000 644 649
29. J.J.M. Hoozemans, A.J.M. Rozemuller, I. Janssen, C.J.A. De Groot, R. Veerhuis, and P. Eikelenboom Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain Acta Neuropathol. 101 2001 2 8
30. S.D. Hurley, J.A. Olschowka, and M.K. O'Banion Cyclooxygenase inhibition as a strategy to ameliorate brain injury J. Neurotrauma 19 2002 1 15
31. P. Teismann, M. Vila, D.-K. Choi, K. Tieu, D.C. Wu, V. Jackson-Lewis, and S. Przedborski COX-2 and neurodegeneration in Parkinson's disease Ann. N. Y. Acad. Sci. 991 2003 272 277
32. L. Minghetti Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases J. Neuropathol. Exp. Neurol. 63 2004 901 910
33. C.M. Markey, A. Alward, P.E. Weller, and L.J. Marnett Quantitative studies of hydroperoxide reduction by prostaglandin H synthase J. Biol. Chem. 262 1987 6266 6279
34. T.E. Eling, D.C. Thompson, G.L. Foureman, J.F. Curtis, and M.F. Hughes Prostaglandin H synthase and xenobiotic oxidation Annu. Rev. Pharmacol. Toxicol. 30 1990 1 45
35. T.G. Hastings Enzymatic oxidation of dopamine: the role of prostaglandin H synthase J. Neurochem. 64 1995 919 924
36. H. Lin, and J. Everse The cytotoxic activity of hematoheme: evidence for two different mechanisms Anal. Biochem. 161 1987 323 331
37. H. Lin, S.J. McFaul, J.C. Brady, and J. Everse The mechanism of peroxidase-mediated cytotoxicity: II. Role of the heme moiety Proc. Soc. Exp. Biol. Med. 187 1988 7 13
38. S.J. Klebanoff, and R.G. Luebke The anti-lactobacillus system of saliva: role of salivary peroxidase Proc. Soc. Exp. Biol. Med. 118 1965 483 486
39. R.J. McRipley, and A.J. Sbarra Role of the phagocyte in host-parasite interactions: XII. Hydrogen peroxide-myeloperoxidase bactericidal system in the phagocyte J. Bacteriol. 94 1967 425 1430
40. P.J. Edelson, and Z.A. Cohn Peroxidase-mediated mammalian cell cytotoxicity J. Exp. Med. 138 1973 318 323
41. 2-halide system: cytotoxic effect on human blood leukocytes Blood 50 1977 65 70
42. K.E. Everse, H. Lin, E.L. Stuyt, J.C. Brady, F. Buddingh, and J. Everse Antitumor activity of peroxidases Br. J. Cancer 51 1985 743 746
43. S.J. Klebanoff Myeloperoxidase: occurrence and biological function J. Everse K.E. Everse M.B. Grisham Peroxidases in chemistry and biology Vol. I. 1991 CRC Press Boca Raton 1 35
44. W.R. Henderson Jr. Eosinophil peroxidase: occurrence and biological function J. Everse K.E. Everse M.B. Grisham Peroxidases in chemistry and biology Vol. I 1991 CRC Press Boca Raton 105 121
45. E.L. Thomas, P.M. Bozeman, and D.B. Learn Lactoperoxidase: structure and biological function J. Everse K.E. Everse M.B. Grisham Peroxidases in chemistry and biology Vol. I 1991 CRC Press Boca Raton 123 142
46. M.B. Grisham, and J. Everse Prooxidant activity of hemoglobin and myoglobin J. Everse K.E. Everse M.B. Grisham Peroxidases in chemistry and biology Vol. I 1991 CRC Press Boca Raton 335 344
47. J. Everse, M.C. Johnson, and M.A. Marini Peroxidative activities of hemoglobin and hemoglobin derivatives J. Everse K.D. Vandegriff R.M. Winslow Methods in enzymology Hemoglobins, part B Vol. 231 1994 Academic Press San Diego 547 561
48. J. Everse, and N. Hsia The toxicities of native and modified hemoglobins Free Radic. Biol. Med. 22 1997 1075 1099
49. + opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism Biochim. Biophys. Acta 1453 1999 49 62
50. F. Darios, O. Corti, C.B. Lücking, M.-P. Hampe, N. Abbas, W.-J. Gu, E.C. Hirsch, T. Rooney, M. Ruberg, and A. Brice Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death Hum. Mol. Genet. 12 2003 517 526
51. D.P. Barr, and R.P. Mason Mechanism for radical production from the reaction of cytochrome c with organic hydroperoxides J. Biol. Chem. 270 1995 12709 12716
52. A.M. Almeida, E.J.H. Bechara, A.E. Vercesi, and I.L. Nantes Diphenylacetaldehyde-generated excited states promote damage to isolated rat liver mitochondrial DNA, phospholipids, and proteins Free Radic. Biol. Med. 27 1999 744 751
53. I.L. Nantes, A. Faljoni-Alario, A.E. Vercesi, K.E. Santos, and E.J.H. Bechara Liposome effect on the cytochrome c-catalyzed peroxidation of carbonyl substrates to triplet species Free Radic. Biol. Med. 25 1998 546 553
54. I.L. Nantes, A. Faljoni-Alario, O.R. Nascimento, B. Bandy, R. Gatti, and E.J.H. Bechara Modifications in heme iron of free and vesicle-bound cytochrome c by tert-butyl hydroperoxide: a magnetic circular dichroism and electron paramagnetic resonance investigation Free Radic. Biol. Med. 28 2000 786 796
55. M. Hashimoto, A. Takeda, L.J. Hsu, T. Takenouchi, and E. Masliah Role of cytochrome c as a stimulator of α-synuclein aggregation in Lewy body disease J. Biol. Chem. 274 1999 28849 28852
56. J. Aron, D.A. Baldwin, H.M. Marques, J.M. Pratt, and P.A. Adams Hemes and hemoproteins. I. Preparation and analysis of the heme-containing octapeptide (microperoxidase-8) and identification of the monomeric form in aqueous solution J. Inorg. Biochem. 27 1986 227 243
57. P.A. Adams, M.P. Byfield, C.R.L. Milton, and J.M. Pratt Oxygen activation and ligand binding by pure heme-octapeptide microperoxidase-8 (MP-8) J. Inorg. Biochem. 34 1988 167 175
58. P.A. Adams, M.P. Byfield, R.D. Goold, and A.E. Thumser Kinetics of heme octapeptide (microperoxidase-8; MP-8) formation studied by high-pressure liquid chromatography (HPLC) monitoring of the peptic and tryptic hydrolysis of horse heart cytochrome c J. Inorg. Biochem. 35 1989 55 59
59. P.A. Adams Microperoxidases and iron porphyrins J. Everse K.E. Everse M.B. Grisham Peroxidases in chemistry and biology Vol. II 1991 CRC Press Boca Raton 171 200
60. W.L. Smith, D.L. DeWitt, and R.M. Garavito Cyclooxygenases: structural, cellular, and molecular biology Annu. Rev. Biochem. 69 2000 145 182
61. M.E. Hemler, and W.E.M. Lands Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis J. Biol. Chem. 255 1980 6253 6261
62. 2-mediated crosslinking of lens crystallins catalyzed by the heme-undecapeptide from cytochrome c Arch. Biochem. Biophys. 231 1984 461 469
63. I. Solar, J. Dulitzky, and N. Shaklai Hemin-promoted peroxidation of red cell cytoskeletal proteins Arch. Biochem. Biophys. 283 1990 81 89
64. 2-generated myoglobin radical in crosslinking of myosin Free Radic. Res. 22 1995 215 227
65. Y.I. Miller, Y. Felikman, and N. Shaklai Hemoglobin induced apolipoprotein B crosslinking in low-density lipoprotein peroxidations Arch. Biochem. Biophys. 326 1996 252 260
66. J. Ara, S. Przedborski, A.B. Naini, V. Jackson-Lewis, R.R. Trifiletti, J. Horwitz, and H. Ischiropoulos Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) Proc. Natl. Acad. Sci. USA 95 1998 7659 7663
67. R.J. Ferrante, P. Hantraye, E. Brouillet, and M.F. Beal Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP-treated baboons is blocked by inhibition of neuronal nitric oxide synthase Brain Res. 823 1999 177 182
68. S. Przedborski, V. Jackson-Lewis, M. Vila, D.C. Wu, P. Teismann, K. Tieu, D.-K. Choi, and O. Cohen Free radical and nitric oxide toxicity in Parkinson's disease Parkinson's Dis. Adv. Neurol. 91 2003 83 94
69. E.C. Hirsch, T. Breidert, E. Rousselet, S. Hunot, A. Hartman, and P.P. Michel The role of glial reaction and inflammation in Parkinson's disease Ann. N. Y. Acad. Sci. 991 2003 214 228
70. A.J. Herrera, A. Castaño, J.L. Venero, J. Cano, and A. Machado The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system Neurobiol. Dis. 7 2000 429 447
71. H.M. Gao, J. Jiang, B. Wilson, W. Zhang, J.S. Hong, and B. Liu Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease J. Neurochem. 81 2002 1285 1297
72. D.M. Bronstein, I. Perez-Otano, V. Sun, S.B. Mullis Savin, J. Chan, G.C. Wu, P.M. Hudson, L.Y. Kong, J.S. Hong, and M.K. McMillian Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures Brain Res. 704 1995 112 116
73. N. Aubin, O. Curet, A. Deffois, and C. Carter Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice J. Neurochem. 71 1998 1635 1642
74. A. Castaño, A.J. Herrera, J. Cano, and A. Machado The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha. IL-1beta and IFN-gamma J. Neurochem. 81 2002 150 157
75. J. Everse, and P.W. Coates The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds Free Radic. Biol. Med. 37 2004 839 849
76. F. Vilhardt, O. Plastre, M. Sawada, K. Suzuki, M. Wiznerowicz, E. Kiyokawa, D. Trono, and K.-H. Krause The HIV-1 Nef protein and phagocyte NADPH oxidase activation J. Biol. Chem. 277 2002 42136 42143
77. P.L. McGeer, S. Itagaki, B.E. Boyes, and E.G. McGeer Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains Neurology 38 1988 1285 1291
78. S.-H. Choi, E.H. Joe, S.U. Kim, and B.K. Jin Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo J. Neurosci. 23 2003 5877 5886
79. S. Pennathur, V. Jackson-Lewis, S. Przedborski, and J.W. Heinecke Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- treated mice, a model of oxidative stress in Parkinson's disease J. Biol. Chem. 274 1999 34621 34628
80. C.D. Smith, J.M. Carney, P.E. Starke-Reed, C.N. Oliver, E.R. Stadtman, R.A. Floyd, and W.R. Markesbery Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease Proc. Natl. Acad. Sci. USA 88 1991 10540 10543
81. E.R. Stadtman Protein oxidation and aging Science 257 1992 1220 1224
82. E.R. Stadtman, and R.L. Levine Protein oxidation Ann. N. Y. Acad. Sci. 899 2000 191 208
83. J.W. Heineke, L. Wei, A.F. Gordon, and J.A. Goldstein Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins J. Clin. Invest. 91 1993 2866 2872
84. C. Jolivalt, B. Leininger-Muller, R. Drozdz, J.W. Naskalski, and G. Siest Apolipoprotein E is highly susceptible to oxidation by myeloperoxidase, an enzyme present in the brain Neurosci. Lett. 210 1996 61 64
85. P.F. Good, A. Hsu, P. Werner, D.P. Perl, and C.W. Olanow Protein nitration in Parkinson's disease J. Neuropathol. Exp. Neurol. 57 1998 338 342
86. F. Torreilles, S. Salman-Tabcheh, M. Guerin, and J. Torreilles Neurodegenerative disorders: the role of peroxynitrite Brain Res. Rev. 30 1999 153 163
87. A. Van der Vliet, J.P. Eiserich, B. Halliwell, and C.E. Cross Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite: a potential additional mechanism of nitric oxide-dependent toxicity J. Biol. Chem. 272 1997 7617 7625
88. M.-L. Brennan, W. Wu, X. Fu, Z. Shen, W. Song, H. Frost, C. Vadseth, L. Narine, E. Lenkiewicz, M.T. Borchers, A.J. Lusis, and S.L. Hazen A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species J. Biol. Chem. 277 2002 17415 17427
89. D.M. Kuhn, C.W. Aretha, and T.J. Geddes Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration J. Neurosci. 19 1999 10289 10294
90. B. Blanchard-Fillion, J.M. Souza, T. Friel, G.C.T. Jiang, K. Vrana, V. Sharov, L. Barrón, C. Schöneich, C. Quijano, B. Alvarez, R. Radi, S. Przedborski, G.S. Fernando, J. Horwitz, and H. Ischiropoulos Nitration and inactivation of tyrosine hydroxylase by peroxynitrite J. Biol. Chem. 276 2001 46017 46023
91. D.M. Kuhn, M. Sadidi, X. Liu, C. Kreipke, T. Geddes, C. Borges, and J.T. Watson Peroxynitrite-induced nitration of tyrosine hydroxylase J. Biol. Chem. 277 2002 14336 14342
92. J.S. Beckman, and J.P. Crow Pathological implications of nitric oxide superoxide and peroxynitrite formation Biochem. Soc. Trans. 21 1993 330 334
93. J.B. Schulz, R.T. Matthews, M.M.K. Muqit, S.E. Browne, and M.F. Beal Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice J. Neurochem. 64 1995 936 939
94. P. Hantraye, E. Broillet, R. Ferrante, S. Palfi, R. Dolan, R.T. Matthews, and M.F. Beal Inhibition of neuronal nitric oxide synthase prevents MPTP-induced Parkinsonism in baboons Nat. Med. 2 1996 1017 1021
95. S. Przedborski, V. Jackson-Lewis, R. Yokoyama, T. Shibata, V.L. Dawson, and T.M. Dawson Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity Proc. Natl. Acad. Sci. USA 93 1996 4565 4571
96. R. Castellani, M.A. Smith, P.L. Richey, and G. Perry Glycoxidation and oxidative stress in Parkinson's disease and diffuse Lewy body disease Brain Res. 737 1996 195 200
97. H.M. Schipper, A. Liberman, and E.G. Stopa Neural heme oxygenase-1 expression in idiopathic Parkinson's disease Exp. Neurol. 150 1998 60 68
98. K.A. Jellinger Recent developments in the pathology of Parkinson's disease J. Neural Transm. Suppl. 62 2002 347 376
99. G.C. Davis, A.C. Williams, S.P. Markey, M.H. Ebert, E.D. Caine, C.M. Reichert, and I.J. Kopin Chronic Parkinsonism secondary to intravenous injection of meperidine analogues Psychiatry Res. 1 1979 249 254
100. J.W. Langston, P. Ballard, J.W. Tetrud, and I. Irwin Chronic parkinsonism in humans due to a product of meperidine-analog synthesis Science 219 1983 979 980
101. S. Przedborski, and M. Vila The 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease Ann. N. Y. Acad. Sci. 991 2003 189 198
102. R.A. Mayer, M.V. Kindt, and R.E. Heikkila Prevention of the nigrostriatal toxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport J. Neurochem. 47 1986 1073 1079
103. D.M. Donovan, L.L. Miner, M.P. Perry, R.S. Revay, L.G. Sharpe, S. Przedborski, V. Kostic, R.M. Philpot, C.L. Kirstein, C.W. Schindler, and G.R. Uhl Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression Brain Res. Mol. Brain Res. 73 1999 37 49
104. L.Y. Zang, and H.P. Misra Generation of reactive oxygen species during the monoamine oxidase-catalyzed oxidation of the neuroreactant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine J. Biol. Chem. 268 1993 16504 16512
105. B.M. Babior NADPH oxidase: an update Blood 93 1999 1464 1476
106. J. Lotharius, and K.L. O'Malley The Parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation-a novel mechanism of toxicity J. Biol. Chem. 275 2000 38581 38588
107. K. Nakamura, V.P. Bindokas, J.D. Marks, D.A. Wright, D.M. Frim, R.J. Miller, and U.J. Kang The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited Mol. Pharmacol. 58 2000 271 278
108. R. Vijitruth, M. Liu, D.Y. Choi, C.M. Kulik, and G.Y. Bing Selective COX-2 inhibitors reduce MPTP-induced neurotoxicity 2003 abstract viewer/itinerary planner 2003 Society for Neuroscience Washington, DC (Program No. 732.5)
109. P. Teismann, and B. Ferger Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease Synapse 39 2001 167 174
110. P. Teismann, K. Tieu, D.-K. Choi, D.-C. Wu, A. Naini, S. Hunot, M. Vila, V. Jackson-Lewis, and S. Przedborski Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration Proc. Natl. Acad. Sci. USA 100 2003 5473 5478
111. Z.-H. Feng, T.-G. Wang, D.-D. Li, P. Fung, B.C. Wilson, B. Liu, S.F. Ali, R. Langenbach, and J.-S. Hong Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra Neurosci. Lett. 329 2002 354 358
112. K.A. Heidenreich Molecular mechanisms of neuronal cell death Ann. N. Y. Acad. Sci. 991 2003 237 250
113. A. Hartmann, S. Hunot, P.P. Michel, M.-P. Muriel, S. Vyas, B.A. Faucheux, A. Mouatt-Prigent, H. Turmel, A. Srinivasan, M. Ruberg, G.I. Evan, Y. Agid, and E.C. Hirsch Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease Proc. Natl. Acad. Sci. USA 97 2000 2875 2880
114. W.G. Tatton, R. Chalmers-Redman, D. Brown, and N. Tatton Apoptosis in Parkinson's disease: signals for neuronal degradation Ann. Neurol. 53 Suppl. 3 2003 S61 S72
115. F. Blandini, A. Mangiagalli, M. Cosentino, F. Marino, A. Samuele, E. Rasini, R. Fancellu, E. Martignoni, G. Riboldazzi, D. Calandrella, G.M. Frigo, and G. Nappi Peripheral markers of apoptosis in Parkinson's disease: the effect of dopaminergic drugs Ann. N. Y. Acad. Sci. 1010 2003 675 678
116. N. Lev, E. Melamed, and D. Offen Apoptosis and Parkinson's disease Prog. Neuropsychopharmacol. Biol. Psychiatry 27 2003 245 250
117. S. Hayley, S.J. Crocker, P.D. Smith, T. Shree, V. Jackson-Lewis, S. Przedborski, M. Mount, R. Slack, H. Anisman, and D.S. Park Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease J. Neurosci. 24 2004 2045 2053
118. T. Furuya, H. Hayakawa, M. Yamada, K. Yoshimi, S. Hisahara, M. Miura, Y. Mizuno, and H. Mochizuki Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease J. Neurosci. 24 2004 1865 1872
119. S.J. Crocker, P.D. Smith, V. Jackson-Lewis, W.R. Lamba, S.P. Haylay, E. Grimm, S.M. Callaghan, R.S. Slack, E. Melloni, S. Przedborski, G.S. Robertson, H. Anisman, Z. Merali, and D.S. Park Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease J. Neurosci. 23 2003 4081 4091
120. B. Halliwell Reactive oxygen species and the central nervous system J. Neurochem. 59 1992 1609 1623
121. K.L. Double, D. Ben-Shachar, M.B.H. Youdim, L. Zecca, P. Riederer, and M. Gerlach Influence of neuromelanin on oxidative pathways within the human substantia nigra Neurotoxicol. Teratol. 24 2002 621 628
122. P. Jenner, and C.W. Olanow Oxidative stress and the pathogenesis of Parkinson's disease Neurology 47 Suppl. 3 1996 S161 S170
123. J.S. Bains, and C.A. Shaw Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death Brain Res. Rev. 25 1997 335 358
124. J.L. Cadet, and C. Brannock Free radicals and the pathobiology of brain dopamine systems Neurochem. Int. 32 1998 117 131
125. D.S. Cassarino, and J.P. Bennett An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration Brain Res. Rev. 29 1999 1 25
126. J.L. Venero, M. Revuelta, L. Atiki, M. Santiago, M.C. Toms-Camardiel, J. Cano, and A. Machado Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy Free Radic. Biol. Med. 34 2003 111 123
127. J.P. Kehrer The Haber-Weiss reaction and mechanisms of toxicity Toxicity 149 2000 43 50
128. C.C. Chiueh, R.-M. Wu, K.P. Mohanakumar, L.M. Sternberger, G. Krishna, T. Obata, and D.L. Murphy In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia Ann. N. Y. Acad. Sci. 738 1994 25 36
129. M. Grootveld, and B. Halliwell Aromatic hydroxylation as a potential measure of hydroxyl radical formation in vivo: identification of hydroxylated derivatives of salicylate in human body fluids Biochem. J. 237 1986 499 504
130. + J. Neural Transm. Gen. Sect. 89 1992 139 145
131. P. Teismann, and B. Ferger The salicylate hydroxylation assay to measure hydroxyl free radicals induced by local application of glutamate in vivo or induced by the Fenton reaction in vitro Brain Res. Brain Res. Protocols 5 2000 204 210
132. E. Sofic, P. Riederer, H. Heinsen, H. Beckmann, G.P. Reynolds, G. Hebenstreit, and M.B.H. Youdim Increased iron(III) and total iron content in postmortem substantia nigra of Parkinsonian brain J. Neural Transm. 74 1988 199 205
133. E. Sofic, W. Paulus, K. Jellinger, P. Riederer, and M.B.H. Youdim Selective increase of iron in substantia nigra zona compacta of Parkinsonian brains J. Neurochem. 56 1991 978 982
134. H. Mochizuki, H. Imai, K. Endo, K. Yokomizo, Y. Murata, N. Hattori, and Y. Mizuno Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys Neurosci. Lett. 168 1994 251 253
135. J.A. Temlett, J.P. Landsberg, F. Watt, and G.W. Grime Increased iron in the substantia nigra pars compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental analysis J. Neurochem. 62 1994 134 146
136. + toxicity of striatal dopaminergic terminals J. Neurochem. 68 1997 732 738
137. D. Berg, M. Gerlach, M.B.H. Youdim, K.L. Double, L. Zecca, P. Riederer, and G. Becker Brain iron pathways and their relevance to Parkinson's disease J. Neurochem. 79 2001 225 236
138. Y. He, P.S. Thong, T. Lee, S.K. Leong, B.Y. Mao, F. Dong, and F. Watt Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys Free Radic. Biol. Med. 35 2003 540 547
139. A. Campa Biological roles of plant peroxidases: known and potential functions J. Everse K.E. Everse M.B. Grisham Peroxidases in chemistry and biology Vol. II 1991 CRC Press Boca Raton 25 50
140. J. Everse K.E. Everse M.B. Grisham Peroxidases in chemistry and biology Vols. I and II 1991 CRC Press Boca Raton
141. P.G. Furtmüller, J. Arnhold, W. Jantschko, H. Pichler, and C. Obinger Redox properties of the couples compound I/compound II and compound II/native enzyme of human myeloperoxidase Biochem. Biophys. Res. Commun. 301 2003 551 557
142. J. Arnhold, P.G. Furtmüller, G. Regelsberger, and C. Obinger Redox properties of the couple compound I/native enzyme of myeloperoxidase and eosinophil peroxidase Eur. J. Biochem. 268 2001 5124 5148
143. J. Arnhold, P.G. Furtmüller, and C. Obinger Redox properties of myeloperoxidase Redox Rep. 8 2003 179 186
144. A.M. Cassina, R. Hodara, J.M. Souza, L. Thomson, L. Castro, H. Ischiropoulos, B.A. Freeman, and R. Radi Cytochrome c nitration by peroxynitrite J. Biol. Chem. 275 2000 21409 21415