Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant -463A of the myeloperoxidase gene

Cancer Research

Volumn 60, Issue 3, 2000, Pages 644-649

  Cascorbi, Ingolf ^a   Henning, Stefan ^a   Brockmöller, Jürgen ^a   Gephart, Jürgen ^a   Meisel, Christian ^a   Müller, Joachim M ^a   Loddenkemper, Robert ^b   Roots, Ivar ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Lungenklinik Heckeshorn ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MYELOPEROXIDASE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; FEMALE; GENE ISOLATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LARYNX CANCER; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; PHARYNX CANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RESPIRATORY TRACT CANCER; SMOKING;

EID: 0033951051     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Foster, C. B., Lehrnbecher, T., Mol, F., Steinberg, S. M., Venzon, D. J., Walsh, T. J., Noack, D., Rae, J., Winkelstein, J. A., Curnutte, J. T., and Chanock, S. J. Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease. J. Clin. Investig., 102: 2146-2155, 1998.
2. DeLeo, F. R., Goedken, M., McCormick, S. J., and Nauseef, W. M. A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation. J. Clin. Investig., 101: 2900-2909, 1998.
3. Reynolds, W. F., Chang, E., Douer, D., Ball, E. D., and Kanda, V. An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia. Blood, 90: 2730-2737, 1997.
4. Whiteman, M., Spencer, J. P., Jenner, A., and Halliwell, B. Hypochlorous acid-induced DNA base modification: potentiation by nitrite: biomarkers of DNA damage by reactive oxygen species. Biochem. Biophys. Res. Commun., 257: 572-576, 1999.
5. Mallet, W. G., Mosebrook, D. R., and Trush, M. A. Activation of (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to diolepoxides by human polymorphonuclear leukocytes or myeloperoxidase. Carcinogenesis (Lond.), 12: 521-524, 1991.
6. Kadlubar, F. F., Butler, M. A., Kaderlik, K. R., Chou, H. C., and Lang, N. P. Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis. Environ. Health Perspect., 98: 69-74, 1992.
7. Petruska, J. M., Mosebrook, D. R., Jakab, G. J., and Trush, M. A. Myeloperoxidase-enhanced formation of (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene-DNA adducts in lung tissue in vilro: a role of pulmonary inflammation in the bioactivation of a procarcinogen. Carcinogenesis (Lond.), 13: 1075-1081, 1992.
8. Trush, M. A., Seed, J. L., and Kensler, T. W. An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radical Bio. Med., 10: 201-209, 1991.
9. Nauseef, W., Cogley, M., Bock, S., and Petrides, P. Pattern of inheritance in hereditary myeloperoxidase deficiency associated with the R569W missense mutation. J. Leukoc. Biol., 63: 264-269, 1998.
10. Romano, M., Dri, P., Dadalt, L., Patriarca, P., and Baralle, F. E. Biochemical and molecular characterization of hereditary myeloperoxidase deficiency. Blood, 90: 4126-4134, 1997.
11. Austin, G. E., Lam, L., Zaki, S. R., Chan, W. C., Hodge, T., Hou, J., Swan, D., Zhang, W., Racine, M., Whitsett, C., and Brown, T. Sequence comparison of putative regulatory DNA of the 5′ flanking region of the myeloperoxidase gene in normal and leukemic bone marrow cells. Leukemia, (Baltimore) 7: 1445-1450, 1993.
12. Piedrafita, F. J., Molander, R. B., Vansant, G., Orlova, E. A., Pfahl, M., and Reynolds, W. F. An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element. J. Biol. Chem., 271: 14412-14420, 1996.
13. London, S. J., Lehman, T. A., and Taylor, J. A. Myeloperoxidase genetic polymorphism and lung cancer risk. Cancer Res., 57: 5001-5003, 1997.
14. Maier, H., de Vries, N., and Weidauer, H. Occupation and cancer of the oral cavity, pharynx, and larynx. HNO, 38: 271-278, 1990.
15. Hashinaka, K., Nishio, C., Hur, S. J., Sakiyama, F., Tsunasawa, S., and Yamada, M. Multiple species of myeloperoxidase messenger RNAs produced by alternative splicing and differential polyadenylation. Biochemistry, 27: 5906-5914, 1988.
16. Johnson, K., Gemperlein, I., Hudson, S., Shane, S., and Rovera, G. Complete nucleotide sequence of the human myeloperoxidase gene. Nucleic Acids Res., 17: 7985-7986, 1989.
17. Reynolds, W. F., Rhees, J., Maciejewski, D., Paladino, T., Sieburg, H., Maki, R. A., and Masliah, E. Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease. Exp. Neurol., 155: 31-41, 1999.
18. Morishita, K., Kubota, N., Asano, S., Kaziro, Y., and Nagata, S. Molecular cloning and characterization of cDNA for human myeloperoxidase. J. Biol. Chem., 262: 3844-3851, 1987.
19. Brockmöller, J., Cascorbi, I., Kerb, R., and Roots, I. Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferase M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res., 56: 3915-3925, 1996.
20. Cascorbi, I., Brockmöller, J., Mrozikiewicz, P. M., Bauer, S., Loddenkemper, R., and Roots, I. Homozygous rapid arylamine N-acetyltransferase NAT2 genotype as susceptibility factor for lung cancer. Cancer Res., 56: 3961-3966, 1996.
21. Henning, S., Cascorbi, I., Münchow, B., Jahnke, V., and Roots, I. Association of arylamine N-acetyltransferases NAT1 and NAT2 genotypes to laryngeal cancer risk. Pharmacogenetics, 9: 103-111, 1999.
22. Bouchardy, C., Mitrunen, K., Wikman, H., Husgafvel-Pursiainen, K., Dayer, P., Benhamou, S., and Hirvonen, A. N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk. Pharmacogenetics, 8: 291-298, 1998.
23. Kawajiri, K., Nakachi, K., Imai, K., Watanabe, J., and Hayashi, S. I. The CYP1A1 gene and cancer susceptibility. Crit. Rev. Oncol. Hematol., 14: 77-87, 1993.
24. Hirvonen, A., Husgafvel-Pursiainen, K., Karjalainen, A., Anttila, S., and Vainio, H. Point-mutational MspI, and Ile-Val polymorphisms closely linked in the CYP1A1 gene. Lack of association with susceptibility to lung cancer in a Finnish study population. Cancer Epidemiol. Biomark. Prev., 1: 485-489, 1992.
25. Crofts, F., Taioli, E., Trachman, J., Cosma, G. N., Currie, D. M., Toniolo, P., and Garte, S. J. Functional significance of different human CYP1A1 genotypes. Carcinogenesis (Lond.), 15: 2961-2963, 1994.
26. Alexandrie, A. K., Ingelman-Sundberg, M., Seidegard, J., Tornling, G., and Rannug, A. Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1 a study on host factors in relation to age at onset, gender, and histological cancer types. Carcinogenesis (Lond.), 15: 1785-1790, 1994.
27. Drakoulis, N., Cascorbi, I., Brockmöller, J., Gross, C. R., and Roots, I. Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation 4889 A to G, and a T to C mutation in the 3′-flanking region. Clin. Investig., 72: 240-248, 1994.
28. Cascorbi, I., Brockmöller, J., and Roots, I. A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages and the impact on lung cancer susceptibility. Cancer Res., 56: 4965-4969, 1996.
29. Hirvonen, A., Husgafvel-Pursiainen, K., Anttila, S., and Vainio, H. The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung. Carcinogenesis (Lond.), 14: 1479-1481, 1993.
30. Anttila, S., Hirvonen, A., Husgafvel-Pursiainen, K., Karjalainen, A., Nurminen, T., and Vainio, H. Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer. Carcinogenesis (Lond.), 15: 1133-1135, 1994.
31. Katoh, T., Inatomi, H., Nagaoka, A., and Sugita, A. Cytochrome P4501A1 gene polymorphism and homozygous deletion of the glutathione S-transferase M1 gene in urothelial cancer patients. Carcinogenesis (Lond.), 16: 655-657, 1995.
32. Rojas, M., Alexandrov, K., Cascorbi, I., Brockmöller, J., Likhachev, A., Pozharisski, K., Bouvier, G., Auburtin, G., Mayer, L., Koop-Schneider, A., Roots, I., and Bartsch, H. High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from subjects with combined CYP1A1 MspI/MspI-GSTM1*0/*0 genotypes. Pharmacogenetics, 8: 109-118, 1998.
33. Nauseef, W. M., Brigham, S., and Cogley, M. Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan. J. Biol. Chem., 269: 1212-1216, 1994.
34. Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., and van der Vliet, A. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature (Lond.), 391: 393-397, 1998.
35. Klebanoff, S. J. Reactive nitrogen intermediates and antimicrobial activity: role of nitrite. Free Radic. Biol. Med., 14: 351-360, 1993.