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Volumn 17, Issue 5, 1998, Pages 1217-1227

A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway

Author keywords

Antibiotic peptides; Drosophila; GFP; Innate immunity; Local immune response

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; DROSOMYCIN; GREEN FLUORESCENT PROTEIN; UNCLASSIFIED DRUG;

EID: 0032473360     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.5.1217     Document Type: Article
Times cited : (316)

References (46)
  • 1
    • 0029278804 scopus 로고
    • Identification of early genes in the Drosophila immune response by PCR-based differential display; the attacin A gene and the evolution of attacin-like proteins
    • Asling,B., Dushay,M.S. and Hultmark,D. (1995) Identification of early genes in the Drosophila immune response by PCR-based differential display; the attacin A gene and the evolution of attacin-like proteins. Insect Biochem. Mol. Biol., 25, 511-518.
    • (1995) Insect Biochem. Mol. Biol. , vol.25 , pp. 511-518
    • Asling, B.1    Dushay, M.S.2    Hultmark, D.3
  • 2
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: Ten years after
    • Baeuerle,P. and Baltimore,D. (1996) NF-κB: ten years after. Cell, 87, 13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.1    Baltimore, D.2
  • 3
    • 0027311062 scopus 로고
    • Role of the integument in insect immunity: Epicuticular abrasion and induction of cecropin synthesis in cuticular epithelial cells
    • Brey,P.T., Lee,W.J., Yamakawa,M., Koizumi,Y., Perrot,S., Francois,M. and Ashida,M. (1993) Role of the integument in insect immunity: epicuticular abrasion and induction of cecropin synthesis in cuticular epithelial cells. Proc. Natl Acad. Sci. USA, 90, 6275-6279.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6275-6279
    • Brey, P.T.1    Lee, W.J.2    Yamakawa, M.3    Koizumi, Y.4    Perrot, S.5    Francois, M.6    Ashida, M.7
  • 5
    • 23444431611 scopus 로고
    • Green fluorescent protein as a marker for gene expression
    • Chalfie,M., Tu,Y., Euskirchen,G., Ward,W.W. and Prasher,D.C. (1994) Green fluorescent protein as a marker for gene expression. Science, 263, 802-805.
    • (1994) Science , vol.263 , pp. 802-805
    • Chalfie, M.1    Tu, Y.2    Euskirchen, G.3    Ward, W.W.4    Prasher, D.C.5
  • 6
    • 0030003347 scopus 로고    scopus 로고
    • Cloning of the gene encoding the antibacterial peptide drosocin involved in Drosophila immunity. Expression studies during the immune response
    • Charlet,M., Lagueux,M., Reichhart,J.-M., Hoffmann,J.A., Braun,A. and Meister,M. (1996) Cloning of the gene encoding the antibacterial peptide drosocin involved in Drosophila immunity. Expression studies during the immune response. Eur. J. Biochem., 241, 699-706.
    • (1996) Eur. J. Biochem. , vol.241 , pp. 699-706
    • Charlet, M.1    Lagueux, M.2    Reichhart, J.-M.3    Hoffmann, J.A.4    Braun, A.5    Meister, M.6
  • 7
    • 0029973636 scopus 로고    scopus 로고
    • FACS-optimized mutants of the green fluorescent protein (GFP)
    • Cormack,B.P., Valdivia,R.H. and Falkow,S. (1996) FACS-optimized mutants of the green fluorescent protein (GFP). Gene, 173, 33-38.
    • (1996) Gene , vol.173 , pp. 33-38
    • Cormack, B.P.1    Valdivia, R.H.2    Falkow, S.3
  • 8
    • 0027298895 scopus 로고
    • Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene
    • Diamond,G., Jones,D.E. and Bevins,C.L. (1993) Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc. Natl Acad. Sci. USA, 90, 4596-4600.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 4596-4600
    • Diamond, G.1    Jones, D.E.2    Bevins, C.L.3
  • 9
    • 0029900207 scopus 로고    scopus 로고
    • Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells
    • Diamond,G., Russel,J.P. and Bevins,C.L. (1996) Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc. Natl Acad. Sci. USA, 93, 5156-5160.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 5156-5160
    • Diamond, G.1    Russel, J.P.2    Bevins, C.L.3
  • 10
    • 0028208333 scopus 로고
    • Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity
    • Dimarcq,J.L., Hoffmann,D., Meister,M., Bulet,P., Lanot,R., Reichhart,J.M. and Hoffmann,J.A. (1994) Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity. Eur. J. Biochem., 221, 201-209.
    • (1994) Eur. J. Biochem. , vol.221 , pp. 201-209
    • Dimarcq, J.L.1    Hoffmann, D.2    Meister, M.3    Bulet, P.4    Lanot, R.5    Reichhart, J.M.6    Hoffmann, J.A.7
  • 11
    • 0030867913 scopus 로고    scopus 로고
    • Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites
    • Dimopoulos,G., Richman,A., Miiller,H.-M. and Kafatos,F.C. (1997) Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites. Proc. Natl Acad. Sci. USA, 94, 11508-11513.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 11508-11513
    • Dimopoulos, G.1    Richman, A.2    Miiller, H.-M.3    Kafatos, F.C.4
  • 12
    • 0025182099 scopus 로고
    • Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen
    • Driever,W., Siegel,V. and Nüsslein-Volhard,C. (1990) Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen. Development, 109, 811-820.
    • (1990) Development , vol.109 , pp. 811-820
    • Driever, W.1    Siegel, V.2    Nüsslein-Volhard, C.3
  • 13
    • 0030831201 scopus 로고    scopus 로고
    • Seeking wisdom in innate immunity
    • Fearon,D.T. (1997) Seeking wisdom in innate immunity. Nature, 388, 323-324.
    • (1997) Nature , vol.388 , pp. 323-324
    • Fearon, D.T.1
  • 14
    • 0028587829 scopus 로고
    • Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides
    • Fehlbaum,P., Bulet,P., Michaut,L., Lagueux,M., Brockaert,W.F., Hétru,C. and Hoffmann,J.A. (1995) Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. J. Biol. Chem., 269, 33159-33163.
    • (1995) J. Biol. Chem. , vol.269 , pp. 33159-33163
    • Fehlbaum, P.1    Bulet, P.2    Michaut, L.3    Lagueux, M.4    Brockaert, W.F.5    Hétru, C.6    Hoffmann, J.A.7
  • 16
    • 0030949875 scopus 로고    scopus 로고
    • Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
    • Goldman,M.J., Anderson,G.M., Stolzenberg,E.D., Prasad Kari,U., Zasloff,M. and Wilson,J.M. (1997) Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell, 88, 553-560.
    • (1997) Cell , vol.88 , pp. 553-560
    • Goldman, M.J.1    Anderson, G.M.2    Stolzenberg, E.D.3    Prasad Kari, U.4    Zasloff, M.5    Wilson, J.M.6
  • 17
    • 0028921834 scopus 로고
    • Improved green fluorescence
    • Heim,R., Cubitt,A.B. and Tsien,R.Y. (1995) Improved green fluorescence. Nature, 373, 663-664.
    • (1995) Nature , vol.373 , pp. 663-664
    • Heim, R.1    Cubitt, A.B.2    Tsien, R.Y.3
  • 18
    • 0023684064 scopus 로고
    • A general method of in vitro preparation and specific mutagenesis of DNA fragments: Study of protein and DNA interactions
    • Higuchi,R., Krummel,B. and Saiki,R.K. (1988) A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucleic Acids Res., 16, 7351-7364.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 7351-7364
    • Higuchi, R.1    Krummel, B.2    Saiki, R.K.3
  • 21
    • 0028032840 scopus 로고
    • Dorsal developments
    • Ingham,P. (1994) Dorsal developments. Nature, 372, 500-501.
    • (1994) Nature , vol.372 , pp. 500-501
    • Ingham, P.1
  • 23
    • 0028985037 scopus 로고
    • NF-κB and Rel proteins in innate immunity
    • Kopp,E.B. and Ghosh,S. (1995) NF-κB and Rel proteins in innate immunity. Adv. Immunol., 58, 1-27.
    • (1995) Adv. Immunol. , vol.58 , pp. 1-27
    • Kopp, E.B.1    Ghosh, S.2
  • 24
    • 0030955296 scopus 로고    scopus 로고
    • Trade-off between parasitoid resistance and larval competitive ability in Drosophila melanogaster
    • Kraaijeveld,A.R. and Godfray,H.C.J. (1997) Trade-off between parasitoid resistance and larval competitive ability in Drosophila melanogaster. Nature, 389, 278-280.
    • (1997) Nature , vol.389 , pp. 278-280
    • Kraaijeveld, A.R.1    Godfray, H.C.J.2
  • 25
    • 0025190557 scopus 로고
    • The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection
    • Kylsten,P., Samakovlis,C. and Hultmark,D. (1990) The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection. EMBO J., 9, 217-224.
    • (1990) EMBO J. , vol.9 , pp. 217-224
    • Kylsten, P.1    Samakovlis, C.2    Hultmark, D.3
  • 26
    • 0030845264 scopus 로고    scopus 로고
    • Midgut-specific immune molecules are produced by the blood-sucking insect, Stomoxis calcitrant
    • Lehane,M.J., Wu,D. and Lehane,S.M. (1997) Midgut-specific immune molecules are produced by the blood-sucking insect, Stomoxis calcitrant. Proc. Natl Acad. Sci. USA, 94, 11502-11507.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 11502-11507
    • Lehane, M.J.1    Wu, D.2    Lehane, S.M.3
  • 27
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre,B., Nicolas,E., Michaut,L., Reichhart,J.M. and Hoffmann,J.A. (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell, 86, 973-983.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 28
    • 0028884812 scopus 로고
    • Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties
    • Levashina,E.A., Ohresser,S., Bulet,P., Reichhart,J.-M., Hetru,C. and Hoffmann,J.A. (1995) Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties. Eur. J. Biochem., 233, 694-700.
    • (1995) Eur. J. Biochem. , vol.233 , pp. 694-700
    • Levashina, E.A.1    Ohresser, S.2    Bulet, P.3    Reichhart, J.-M.4    Hetru, C.5    Hoffmann, J.A.6
  • 30
    • 0031278978 scopus 로고    scopus 로고
    • Juvenile hormone regulates the expression of the gene encoding ceratotoxin A, an antibacterial peptide from the female reproductive accessory glands of the medfly Ceratitis capitata
    • Manetti,A.G.O., Rosetto,M., de Filippis,T., Marchini,D., Baldari,C.T. and Dallai,R. (1997) Juvenile hormone regulates the expression of the gene encoding ceratotoxin A, an antibacterial peptide from the female reproductive accessory glands of the medfly Ceratitis capitata. J. Insect Physiol., 43, 1161-1167.
    • (1997) J. Insect Physiol. , vol.43 , pp. 1161-1167
    • Manetti, A.G.O.1    Rosetto, M.2    De Filippis, T.3    Marchini, D.4    Baldari, C.T.5    Dallai, R.6
  • 31
    • 0000062167 scopus 로고
    • Development of the Drosophila tracheal system
    • Bate,M. and Martinez-Arias,A. (eds), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Manning,G. and Krasnow,M.A. (1993) Development of the Drosophila tracheal system. In Bate,M. and Martinez-Arias,A. (eds), The Development of Drosophila melanogaster. Vol. 1. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1993) The Development of Drosophila Melanogaster , vol.1
    • Manning, G.1    Krasnow, M.A.2
  • 32
    • 0031050034 scopus 로고    scopus 로고
    • Innate immunity: Impact on the adaptive immune response
    • Medzhitov,R. and Janeway,C.A. (1997) Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol., 9, 4-9.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 4-9
    • Medzhitov, R.1    Janeway, C.A.2
  • 33
    • 0029591416 scopus 로고
    • Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo
    • Morisato,D. and Anderson,K. (1995) Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Annu. Rev. Genet., 29, 371-399.
    • (1995) Annu. Rev. Genet. , vol.29 , pp. 371-399
    • Morisato, D.1    Anderson, K.2
  • 34
    • 0029819784 scopus 로고    scopus 로고
    • Paneth cell defensins: Endogenous peptide components of intestinal host defense
    • Ouelette,A.J. and Selsted,M.E. (1996) Paneth cell defensins: endogenous peptide components of intestinal host defense. FASEB J., 10, 1280-1289.
    • (1996) FASEB J. , vol.10 , pp. 1280-1289
    • Ouelette, A.J.1    Selsted, M.E.2
  • 35
    • 0029858808 scopus 로고    scopus 로고
    • Molecular characterization of ceratotoxin C, a novel antibacterial female-specific peptide of the ceratotoxin family from the medfly Ceratitis capitata
    • Rosetto,M., Manetti,A.G., Giordano,P.C., Marri,L., Amons,R., Baldari,C.T., Marchini,D. and Dallai,R. (1996) Molecular characterization of ceratotoxin C, a novel antibacterial female-specific peptide of the ceratotoxin family from the medfly Ceratitis capitata. Eur. J. Biochem., 241, 330-337.
    • (1996) Eur. J. Biochem. , vol.241 , pp. 330-337
    • Rosetto, M.1    Manetti, A.G.2    Giordano, P.C.3    Marri, L.4    Amons, R.5    Baldari, C.T.6    Marchini, D.7    Dallai, R.8
  • 36
    • 0029877550 scopus 로고    scopus 로고
    • Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha
    • Russell,J.P., Diamond,G., Tarver,A.P., Scanlin,T.F. and Bevins,C.L. (1996) Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect. Immun., 64, 1565-1568.
    • (1996) Infect. Immun. , vol.64 , pp. 1565-1568
    • Russell, J.P.1    Diamond, G.2    Tarver, A.P.3    Scanlin, T.F.4    Bevins, C.L.5
  • 37
    • 0025959246 scopus 로고
    • The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster
    • Samakovlis,C., Kylsten,P., Kimbrell,D.A., Engström,A., and Hultmark,D. (1991) The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster. EMBO J., 10, 163-169.
    • (1991) EMBO J. , vol.10 , pp. 163-169
    • Samakovlis, C.1    Kylsten, P.2    Kimbrell, D.A.3    Engström, A.4    Hultmark, D.5
  • 38
    • 0028902757 scopus 로고
    • Epithelial antibiotics induced at sites of inflammation
    • Schonwetter,B.S., Stolzenberg,E.D. and Zasloff,M.A. (1995) Epithelial antibiotics induced at sites of inflammation. Science, 267, 1645-1648.
    • (1995) Science , vol.267 , pp. 1645-1648
    • Schonwetter, B.S.1    Stolzenberg, E.D.2    Zasloff, M.A.3
  • 39
    • 0029870085 scopus 로고    scopus 로고
    • Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
    • Smith,JJ., Travis,S.M., Greenberg,E.P. and Welsh,M.J. (1996) Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell, 85, 229-236.
    • (1996) Cell , vol.85 , pp. 229-236
    • Smith, J.J.1    Travis, S.M.2    Greenberg, E.P.3    Welsh, M.J.4
  • 40
    • 43949151585 scopus 로고
    • The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein
    • Steel,D.M. and Whitehead,A.S. (1994) The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol. Today, 15, 81-88.
    • (1994) Immunol. Today , vol.15 , pp. 81-88
    • Steel, D.M.1    Whitehead, A.S.2
  • 42
    • 0026541180 scopus 로고
    • CecC, a cecropin gene expressed during metamorphosis in Drosophila pupae
    • Tryselius,Y., Samakovlis,C., Kimbrell,D.A. and Hultmark,D. (1992) CecC, a cecropin gene expressed during metamorphosis in Drosophila pupae. Eur. J. Biochem., 204, 395-399.
    • (1992) Eur. J. Biochem. , vol.204 , pp. 395-399
    • Tryselius, Y.1    Samakovlis, C.2    Kimbrell, D.A.3    Hultmark, D.4
  • 44
    • 0028227833 scopus 로고
    • Implications for bed mRNA localization from spatial distribution of exu protein in Drosophila oogenesis
    • Wang,S. and Hazelrigg,T. (1994) Implications for bed mRNA localization from spatial distribution of exu protein in Drosophila oogenesis. Nature, 369, 400-403.
    • (1994) Nature , vol.369 , pp. 400-403
    • Wang, S.1    Hazelrigg, T.2
  • 45
    • 0025642716 scopus 로고
    • Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides
    • Wicker,C., Reichhart,J.M., Hoffmann,D., Hultmark,D., Samakovlis,C. and Hoffmann,J.A. (1990) Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides. J. Biol. Chem., 265, 22493-22498.
    • (1990) J. Biol. Chem. , vol.265 , pp. 22493-22498
    • Wicker, C.1    Reichhart, J.M.2    Hoffmann, D.3    Hultmark, D.4    Samakovlis, C.5    Hoffmann, J.A.6
  • 46
    • 0030569343 scopus 로고    scopus 로고
    • Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells
    • Zhao,C., Wang,I. and Lehrer,R.I. (1996) Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett., 396, 319-322.
    • (1996) FEBS Lett. , vol.396 , pp. 319-322
    • Zhao, C.1    Wang, I.2    Lehrer, R.I.3


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